JP2014527820A5 - - Google Patents
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- Publication number
- JP2014527820A5 JP2014527820A5 JP2014531047A JP2014531047A JP2014527820A5 JP 2014527820 A5 JP2014527820 A5 JP 2014527820A5 JP 2014531047 A JP2014531047 A JP 2014531047A JP 2014531047 A JP2014531047 A JP 2014531047A JP 2014527820 A5 JP2014527820 A5 JP 2014527820A5
- Authority
- JP
- Japan
- Prior art keywords
- hpc
- ficolin
- hsc
- population
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 31
- 238000000034 method Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 5
- 102100024508 Ficolin-1 Human genes 0.000 claims 4
- 101710155257 Ficolin-1 Proteins 0.000 claims 4
- 102100024521 Ficolin-2 Human genes 0.000 claims 4
- 101710155249 Ficolin-2 Proteins 0.000 claims 4
- 102100024520 Ficolin-3 Human genes 0.000 claims 4
- 101710155250 Ficolin-3 Proteins 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 102000036693 Thrombopoietin Human genes 0.000 claims 3
- 108010041111 Thrombopoietin Proteins 0.000 claims 3
- 108700014844 flt3 ligand Proteins 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 229940047122 interleukins Drugs 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 210000002536 stromal cell Anatomy 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011903899A AU2011903899A0 (en) | 2011-09-22 | Cell culture & expansion | |
| AU2011903899 | 2011-09-22 | ||
| PCT/AU2012/001135 WO2013040644A1 (en) | 2011-09-22 | 2012-09-21 | Method for the ex vivo expansion of hematopoietic stem and progenitor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527820A JP2014527820A (ja) | 2014-10-23 |
| JP2014527820A5 true JP2014527820A5 (enExample) | 2015-10-15 |
| JP6112462B2 JP6112462B2 (ja) | 2017-04-12 |
Family
ID=47913674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531047A Expired - Fee Related JP6112462B2 (ja) | 2011-09-22 | 2012-09-21 | 造血幹細胞及び前駆細胞のエクスビボ増殖のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9518250B2 (enExample) |
| EP (1) | EP2748309A4 (enExample) |
| JP (1) | JP6112462B2 (enExample) |
| KR (1) | KR20140063861A (enExample) |
| CN (1) | CN104114694A (enExample) |
| AU (1) | AU2012313347A1 (enExample) |
| CA (1) | CA2885665A1 (enExample) |
| IL (1) | IL231668A0 (enExample) |
| SG (1) | SG11201400851PA (enExample) |
| WO (1) | WO2013040644A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016178914A1 (en) * | 2015-05-01 | 2016-11-10 | Cesca Therapeutics, Inc. | Intramuscular adaminstration of autologous bone marrw for treatment |
| EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| EP3331993A1 (en) * | 2015-08-05 | 2018-06-13 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Use of dermatopontin for maintaining hematopoietic stem and/or progenitor cells in culture |
| US20200392533A1 (en) * | 2017-04-11 | 2020-12-17 | President And Fellows Of Harvard College | In vivo gene editing of blood progenitors |
| CN110093313B (zh) * | 2018-01-29 | 2023-04-14 | 华南生物医药研究院 | 促进造血干/祖细胞分化为红系细胞的诱导培养基及应用 |
| EP3836974A4 (en) | 2018-08-18 | 2022-06-15 | President and Fellows of Harvard College | IN SITU GENE EDIT |
| US20230212516A1 (en) * | 2020-06-02 | 2023-07-06 | Cornell University | Methods for expanding hematopoietic stem cells |
| CN115861151B (zh) * | 2021-09-23 | 2025-10-17 | 鸿海精密工业股份有限公司 | 细胞采收提醒方法及系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132017A1 (en) * | 1996-12-09 | 2002-09-19 | Moore Jeffrey G. | Composition and method for preserving progenitor cells |
| US20050137126A1 (en) * | 2003-04-09 | 2005-06-23 | Natlmmune A/S | Treatment of SARS in individuals |
| IL161903A0 (en) * | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
| US20060205071A1 (en) | 2003-07-17 | 2006-09-14 | Gamida-Cell Ltd. | Methods for ex-vivo expanding stem/progenitor cells |
| CN1297659C (zh) * | 2004-02-11 | 2007-01-31 | 上海伯瑞生物技术发展有限公司 | 一种造血细胞灌注培养方法和装置 |
| US7767453B2 (en) * | 2004-10-20 | 2010-08-03 | Whitehead Institute For Biomedical Research | Cultured hematopoietic stem cells and method for expansion and analysis thereof |
| KR20090009186A (ko) * | 2005-12-06 | 2009-01-22 | 디파트먼트 오브 바이오테크놀러지 | 사람의 조혈 줄기 세포 또는 선조 세포의 보존 방법 |
| JP2008237136A (ja) | 2007-03-28 | 2008-10-09 | Foundation For Biomedical Research & Innovation | ヒト造血細胞の培養方法 |
| WO2008149129A1 (en) | 2007-06-08 | 2008-12-11 | Nova Thera Limited | Cell expansion |
| CN101508975A (zh) * | 2009-03-26 | 2009-08-19 | 大连理工大学 | 一种低氧条件下微囊化成骨细胞支持和调控造血干/祖细胞体外扩增的方法 |
| WO2010142295A1 (en) * | 2009-06-10 | 2010-12-16 | Rigshospitalet | Ficolin-3 assay |
| US20120169643A1 (en) | 2009-09-09 | 2012-07-05 | Sharp Kabushiki Kaisha | Gesture determination device and method of same |
| CN102597223B (zh) * | 2009-09-11 | 2017-05-10 | 宝生物工程株式会社 | 生产天然杀伤细胞的方法 |
-
2012
- 2012-09-21 EP EP12832834.1A patent/EP2748309A4/en not_active Withdrawn
- 2012-09-21 AU AU2012313347A patent/AU2012313347A1/en not_active Abandoned
- 2012-09-21 CA CA2885665A patent/CA2885665A1/en active Pending
- 2012-09-21 CN CN201280052478.8A patent/CN104114694A/zh active Pending
- 2012-09-21 WO PCT/AU2012/001135 patent/WO2013040644A1/en not_active Ceased
- 2012-09-21 JP JP2014531047A patent/JP6112462B2/ja not_active Expired - Fee Related
- 2012-09-21 KR KR1020147010617A patent/KR20140063861A/ko not_active Withdrawn
- 2012-09-21 US US14/346,160 patent/US9518250B2/en not_active Expired - Fee Related
- 2012-09-21 SG SG11201400851PA patent/SG11201400851PA/en unknown
-
2014
- 2014-03-23 IL IL231668A patent/IL231668A0/en unknown
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