CN104114694A - 用于体外扩增造血干细胞和祖细胞的方法 - Google Patents

用于体外扩增造血干细胞和祖细胞的方法 Download PDF

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Publication number
CN104114694A
CN104114694A CN201280052478.8A CN201280052478A CN104114694A CN 104114694 A CN104114694 A CN 104114694A CN 201280052478 A CN201280052478 A CN 201280052478A CN 104114694 A CN104114694 A CN 104114694A
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cells
ficolin
hpcs
hscs
oxygen
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Chinese (zh)
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梅琳达·L·图斯凯
马克·A·柯克兰
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Cytoplasmic Matrix Therapeutics Australia Pty Ltd
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Cytomatrix Pty Ltd
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Priority claimed from AU2011903899A external-priority patent/AU2011903899A0/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/59—Lectins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201280052478.8A 2011-09-22 2012-09-21 用于体外扩增造血干细胞和祖细胞的方法 Pending CN104114694A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2011903899 2011-09-22
AU2011903899A AU2011903899A0 (en) 2011-09-22 Cell culture & expansion
PCT/AU2012/001135 WO2013040644A1 (en) 2011-09-22 2012-09-21 Method for the ex vivo expansion of hematopoietic stem and progenitor cells

Publications (1)

Publication Number Publication Date
CN104114694A true CN104114694A (zh) 2014-10-22

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CN201280052478.8A Pending CN104114694A (zh) 2011-09-22 2012-09-21 用于体外扩增造血干细胞和祖细胞的方法

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Country Link
US (1) US9518250B2 (enExample)
EP (1) EP2748309A4 (enExample)
JP (1) JP6112462B2 (enExample)
KR (1) KR20140063861A (enExample)
CN (1) CN104114694A (enExample)
AU (1) AU2012313347A1 (enExample)
CA (1) CA2885665A1 (enExample)
IL (1) IL231668A0 (enExample)
SG (1) SG11201400851PA (enExample)
WO (1) WO2013040644A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110093313A (zh) * 2018-01-29 2019-08-06 华南生物医药研究院 促进造血干/祖细胞分化为红系细胞的诱导培养基及应用
CN115861151A (zh) * 2021-09-23 2023-03-28 鸿海精密工业股份有限公司 细胞采收提醒方法及系统

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180271908A1 (en) * 2015-05-01 2018-09-27 Cesca Therapeutics, Inc. Intramuscular administraton of autologous bone marrow for treatment
US10669528B2 (en) 2015-06-25 2020-06-02 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
US20180230433A1 (en) * 2015-08-05 2018-08-16 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Use of dermatopontin for maintaining hematopoietic stem and/or progenitor cells in culture
US20200392533A1 (en) * 2017-04-11 2020-12-17 President And Fellows Of Harvard College In vivo gene editing of blood progenitors
WO2020041217A1 (en) 2018-08-18 2020-02-27 President And Fellows Of Harvard College In situ gene editing
US20230212516A1 (en) * 2020-06-02 2023-07-06 Cornell University Methods for expanding hematopoietic stem cells

Citations (10)

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US20020132017A1 (en) * 1996-12-09 2002-09-19 Moore Jeffrey G. Composition and method for preserving progenitor cells
WO2004089394A2 (en) * 2003-04-09 2004-10-21 Natimmune A/S Treatment of severe acute respiratory syndrome (sars)
CN1557947A (zh) * 2004-02-11 2004-12-29 上海伯瑞生物技术发展有限公司 一种造血细胞灌注培养方法和装置
WO2005007073A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs
WO2005007799A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
WO2006045064A2 (en) * 2004-10-20 2006-04-27 Whitehead Institute For Biomedical Research Cultured hematopoietic stem cells and method for expansion and analysis thereof
WO2007066352A1 (en) * 2005-12-06 2007-06-14 Department Of Biotechnology A method for preservation of human hematopoietic stem or progenitor cells
WO2008149129A1 (en) * 2007-06-08 2008-12-11 Nova Thera Limited Cell expansion
CN101508975A (zh) * 2009-03-26 2009-08-19 大连理工大学 一种低氧条件下微囊化成骨细胞支持和调控造血干/祖细胞体外扩增的方法
WO2010142295A1 (en) * 2009-06-10 2010-12-16 Rigshospitalet Ficolin-3 assay

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JP2008237136A (ja) * 2007-03-28 2008-10-09 Foundation For Biomedical Research & Innovation ヒト造血細胞の培養方法
WO2011030581A1 (ja) 2009-09-09 2011-03-17 シャープ株式会社 ジェスチャー判定装置およびその方法
WO2011030851A1 (ja) 2009-09-11 2011-03-17 タカラバイオ株式会社 ナチュラルキラー細胞の製造方法

Patent Citations (10)

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Publication number Priority date Publication date Assignee Title
US20020132017A1 (en) * 1996-12-09 2002-09-19 Moore Jeffrey G. Composition and method for preserving progenitor cells
WO2004089394A2 (en) * 2003-04-09 2004-10-21 Natimmune A/S Treatment of severe acute respiratory syndrome (sars)
WO2005007073A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs
WO2005007799A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
CN1557947A (zh) * 2004-02-11 2004-12-29 上海伯瑞生物技术发展有限公司 一种造血细胞灌注培养方法和装置
WO2006045064A2 (en) * 2004-10-20 2006-04-27 Whitehead Institute For Biomedical Research Cultured hematopoietic stem cells and method for expansion and analysis thereof
WO2007066352A1 (en) * 2005-12-06 2007-06-14 Department Of Biotechnology A method for preservation of human hematopoietic stem or progenitor cells
WO2008149129A1 (en) * 2007-06-08 2008-12-11 Nova Thera Limited Cell expansion
CN101508975A (zh) * 2009-03-26 2009-08-19 大连理工大学 一种低氧条件下微囊化成骨细胞支持和调控造血干/祖细胞体外扩增的方法
WO2010142295A1 (en) * 2009-06-10 2010-12-16 Rigshospitalet Ficolin-3 assay

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GABRIELLA COLUCCI ET AL.: "cDNA cloning of FRIL, a lectin from Dolichos lablab, that preserves hematopoietic progenitors in suspension culture", 《PROC. NATL. ACAD. SCI.》 *
陈勰 等: "纤维蛋白胶凝素-3研究进展", 《中国临床保健杂志》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110093313A (zh) * 2018-01-29 2019-08-06 华南生物医药研究院 促进造血干/祖细胞分化为红系细胞的诱导培养基及应用
CN110093313B (zh) * 2018-01-29 2023-04-14 华南生物医药研究院 促进造血干/祖细胞分化为红系细胞的诱导培养基及应用
CN115861151A (zh) * 2021-09-23 2023-03-28 鸿海精密工业股份有限公司 细胞采收提醒方法及系统
CN115861151B (zh) * 2021-09-23 2025-10-17 鸿海精密工业股份有限公司 细胞采收提醒方法及系统

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Publication number Publication date
EP2748309A1 (en) 2014-07-02
SG11201400851PA (en) 2014-04-28
EP2748309A4 (en) 2015-03-11
JP2014527820A (ja) 2014-10-23
KR20140063861A (ko) 2014-05-27
JP6112462B2 (ja) 2017-04-12
US9518250B2 (en) 2016-12-13
CA2885665A1 (en) 2013-03-28
AU2012313347A1 (en) 2014-05-08
US20140286915A1 (en) 2014-09-25
IL231668A0 (en) 2014-05-28
WO2013040644A1 (en) 2013-03-28

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Address after: Floor 9, Queen Street, Melbourne,, Australia

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