JP2014527082A5 - - Google Patents
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- Publication number
- JP2014527082A5 JP2014527082A5 JP2014530756A JP2014530756A JP2014527082A5 JP 2014527082 A5 JP2014527082 A5 JP 2014527082A5 JP 2014530756 A JP2014530756 A JP 2014530756A JP 2014530756 A JP2014530756 A JP 2014530756A JP 2014527082 A5 JP2014527082 A5 JP 2014527082A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- amino
- hal
- ethyl
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533606P | 2011-09-12 | 2011-09-12 | |
| US61/533,606 | 2011-09-12 | ||
| PCT/US2012/054877 WO2013040044A1 (en) | 2011-09-12 | 2012-09-12 | Aminopyrimidine derivatives for use as modulators of kinase activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527082A JP2014527082A (ja) | 2014-10-09 |
| JP2014527082A5 true JP2014527082A5 (enExample) | 2016-09-29 |
| JP6082011B2 JP6082011B2 (ja) | 2017-02-15 |
Family
ID=46964039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530756A Expired - Fee Related JP6082011B2 (ja) | 2011-09-12 | 2012-09-12 | キナーゼ活性のモジュレーターとして使用するためのアミノピリミジン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US9321760B2 (enExample) |
| EP (1) | EP2755958B9 (enExample) |
| JP (1) | JP6082011B2 (enExample) |
| KR (1) | KR101992505B1 (enExample) |
| CN (2) | CN106946796B (enExample) |
| AU (2) | AU2012308681B2 (enExample) |
| BR (1) | BR112014005468A2 (enExample) |
| CA (1) | CA2844704C (enExample) |
| DK (1) | DK2755958T3 (enExample) |
| EA (1) | EA028057B1 (enExample) |
| ES (1) | ES2646759T3 (enExample) |
| HR (1) | HRP20171655T1 (enExample) |
| HU (1) | HUE034979T2 (enExample) |
| IL (2) | IL231381B (enExample) |
| LT (1) | LT2755958T (enExample) |
| MX (1) | MX347241B (enExample) |
| NO (1) | NO2639780T3 (enExample) |
| PL (1) | PL2755958T3 (enExample) |
| PT (1) | PT2755958T (enExample) |
| RS (1) | RS56486B1 (enExample) |
| SG (1) | SG2014009260A (enExample) |
| SI (1) | SI2755958T1 (enExample) |
| WO (1) | WO2013040044A1 (enExample) |
| ZA (1) | ZA201401007B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9073947B2 (en) | 2011-06-10 | 2015-07-07 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity |
| ES2646759T3 (es) * | 2011-09-12 | 2017-12-15 | Merck Patent Gmbh | Derivados de aminopirimidina para uso como moduladores de la actividad de la quinasa |
| AR093512A1 (es) | 2012-11-16 | 2015-06-10 | Merck Patent Gmbh | Derivados heterociclicos como moduladores de la actividad de cinasas |
| MX370448B (es) | 2013-03-11 | 2019-12-13 | Merck Patent Gmbh | Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. |
| WO2015107494A1 (en) | 2014-01-17 | 2015-07-23 | Novartis Ag | 1 -(triazin-3-yi_/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions thereof for inhibiting the activity of shp2 |
| ES2699351T3 (es) | 2014-01-17 | 2019-02-08 | Novartis Ag | Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| JP6560243B2 (ja) * | 2014-02-11 | 2019-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしてのピリミジンイミダゾールアミン |
| EP3420792B1 (en) | 2014-04-30 | 2021-09-22 | LG Electronics Inc. | Lawn mower robot and control method thereof |
| KR102518994B1 (ko) * | 2014-05-28 | 2023-04-05 | 아스트라제네카 아베 | Azd5363의 제조 방법 및 그에 사용되는 신규 중간체 |
| WO2016203406A1 (en) | 2015-06-19 | 2016-12-22 | Novartis Ag | Compounds and compositions for inhibiting the activity of shp2 |
| ES2824576T3 (es) | 2015-06-19 | 2021-05-12 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de SHP2 |
| EP3310779B1 (en) | 2015-06-19 | 2019-05-08 | Novartis AG | Compounds and compositions for inhibiting the activity of shp2 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US10160747B2 (en) * | 2016-03-16 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PT3468972T (pt) | 2016-06-14 | 2020-08-21 | Novartis Ag | Compostos e composições para inibir a atividade da shp2 |
| CN110730678B (zh) | 2017-01-10 | 2022-07-15 | 诺华股份有限公司 | 包含alk抑制剂和shp2抑制剂的药物组合 |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| WO2019084395A1 (en) | 2017-10-27 | 2019-05-02 | University Of Virginia Patent Foundation | COMPOUNDS AND METHODS FOR REGULATING, LIMITING OR INHIBITING AVIL EXPRESSION |
| WO2020223715A1 (en) * | 2019-05-02 | 2020-11-05 | University Of Virginia Patent Foundation | Substituted (piperidin-1-yl)aryl analogues for modulating avilactivity |
| US11866421B2 (en) * | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| CN116903592B (zh) * | 2023-07-13 | 2025-08-01 | 特科罗生物科技(成都)有限公司 | 一种嘧啶胺类nuak抑制剂及其制备方法和用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137755A1 (en) * | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| US7547794B2 (en) | 2003-04-03 | 2009-06-16 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| US7189729B2 (en) | 2003-09-30 | 2007-03-13 | Irm Llc | Methods and compositions as protein kinase inhibitors |
| US7816353B2 (en) | 2003-10-24 | 2010-10-19 | Exelixis, Inc. | P70S6 kinase modulators and method of use |
| RU2006121646A (ru) | 2003-11-21 | 2008-01-10 | Новартис АГ (CH) | Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы |
| AU2004293026B2 (en) * | 2003-11-21 | 2012-01-19 | Array Biopharma Inc. | AKT protein kinase inhibitors |
| BRPI0417498A (pt) | 2003-12-09 | 2007-05-29 | Us Gov Health & Human Serv | método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| AU2005322085B2 (en) * | 2004-12-28 | 2012-07-19 | Exelixis, Inc. | [1H-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70S6K, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| EP1838703A2 (en) | 2005-01-19 | 2007-10-03 | Neurogen Corporation | Heteroaryl substituted piperazinyl-pyridine analogues |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2007125321A2 (en) * | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| WO2008012635A2 (en) * | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| EP2131656A4 (en) * | 2006-11-15 | 2011-12-07 | Forest Lab Holdings Ltd | phthalazine |
| JP2010513458A (ja) * | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| KR101699991B1 (ko) | 2009-02-11 | 2017-01-26 | 메르크 파텐트 게엠베하 | 신규의 아미노 아자헤테로시클릭 카르복사미드 |
| WO2011029043A1 (en) * | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Heteroaryl btk inhibitors |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| US9586938B2 (en) | 2010-07-29 | 2017-03-07 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
| EA023821B1 (ru) | 2010-11-24 | 2016-07-29 | Мерк Патент Гмбх | Хиназолинкарбоксамидазетидины, их применение в лечении гиперпролиферативных заболеваний и содержащие их композиции |
| HRP20171554T1 (hr) * | 2011-09-12 | 2017-11-17 | Merck Patent Gmbh | Novi imidazol amini kao modulatori aktivnosti kinaze |
| ES2646759T3 (es) * | 2011-09-12 | 2017-12-15 | Merck Patent Gmbh | Derivados de aminopirimidina para uso como moduladores de la actividad de la quinasa |
| AR093511A1 (es) * | 2012-11-16 | 2015-06-10 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de cinasas |
| JP6560243B2 (ja) * | 2014-02-11 | 2019-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしてのピリミジンイミダゾールアミン |
-
2012
- 2012-09-12 ES ES12766773.1T patent/ES2646759T3/es active Active
- 2012-09-12 US US14/236,405 patent/US9321760B2/en not_active Expired - Fee Related
- 2012-09-12 KR KR1020147007739A patent/KR101992505B1/ko not_active Expired - Fee Related
- 2012-09-12 CN CN201710022892.9A patent/CN106946796B/zh not_active Expired - Fee Related
- 2012-09-12 SI SI201231118T patent/SI2755958T1/sl unknown
- 2012-09-12 HR HRP20171655TT patent/HRP20171655T1/hr unknown
- 2012-09-12 CN CN201280054959.2A patent/CN103930407B/zh not_active Expired - Fee Related
- 2012-09-12 RS RS20171130A patent/RS56486B1/sr unknown
- 2012-09-12 DK DK12766773.1T patent/DK2755958T3/en active
- 2012-09-12 PL PL12766773T patent/PL2755958T3/pl unknown
- 2012-09-12 EP EP12766773.1A patent/EP2755958B9/en active Active
- 2012-09-12 EA EA201400338A patent/EA028057B1/ru not_active IP Right Cessation
- 2012-09-12 HU HUE12766773A patent/HUE034979T2/en unknown
- 2012-09-12 CA CA2844704A patent/CA2844704C/en not_active Expired - Fee Related
- 2012-09-12 WO PCT/US2012/054877 patent/WO2013040044A1/en not_active Ceased
- 2012-09-12 BR BR112014005468A patent/BR112014005468A2/pt not_active IP Right Cessation
- 2012-09-12 LT LTEP12766773.1T patent/LT2755958T/lt unknown
- 2012-09-12 MX MX2014002836A patent/MX347241B/es active IP Right Grant
- 2012-09-12 PT PT127667731T patent/PT2755958T/pt unknown
- 2012-09-12 JP JP2014530756A patent/JP6082011B2/ja not_active Expired - Fee Related
- 2012-09-12 SG SG2014009260A patent/SG2014009260A/en unknown
- 2012-09-12 AU AU2012308681A patent/AU2012308681B2/en not_active Ceased
-
2013
- 2013-03-15 NO NO13001311A patent/NO2639780T3/no unknown
-
2014
- 2014-02-10 ZA ZA2014/01007A patent/ZA201401007B/en unknown
- 2014-03-06 IL IL231381A patent/IL231381B/en active IP Right Grant
-
2016
- 2016-03-03 US US15/060,050 patent/US9662330B2/en not_active Expired - Fee Related
-
2017
- 2017-04-18 US US15/490,370 patent/US10080750B2/en active Active
- 2017-10-09 AU AU2017245469A patent/AU2017245469B2/en not_active Ceased
-
2019
- 2019-05-07 IL IL266510A patent/IL266510B/en active IP Right Grant
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