JP2014527082A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014527082A5 JP2014527082A5 JP2014530756A JP2014530756A JP2014527082A5 JP 2014527082 A5 JP2014527082 A5 JP 2014527082A5 JP 2014530756 A JP2014530756 A JP 2014530756A JP 2014530756 A JP2014530756 A JP 2014530756A JP 2014527082 A5 JP2014527082 A5 JP 2014527082A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- amino
- hal
- ethyl
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533606P | 2011-09-12 | 2011-09-12 | |
| US61/533,606 | 2011-09-12 | ||
| PCT/US2012/054877 WO2013040044A1 (en) | 2011-09-12 | 2012-09-12 | Aminopyrimidine derivatives for use as modulators of kinase activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527082A JP2014527082A (ja) | 2014-10-09 |
| JP2014527082A5 true JP2014527082A5 (enExample) | 2016-09-29 |
| JP6082011B2 JP6082011B2 (ja) | 2017-02-15 |
Family
ID=46964039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530756A Expired - Fee Related JP6082011B2 (ja) | 2011-09-12 | 2012-09-12 | キナーゼ活性のモジュレーターとして使用するためのアミノピリミジン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US9321760B2 (enExample) |
| EP (1) | EP2755958B9 (enExample) |
| JP (1) | JP6082011B2 (enExample) |
| KR (1) | KR101992505B1 (enExample) |
| CN (2) | CN103930407B (enExample) |
| AU (2) | AU2012308681B2 (enExample) |
| BR (1) | BR112014005468A2 (enExample) |
| CA (1) | CA2844704C (enExample) |
| DK (1) | DK2755958T3 (enExample) |
| EA (1) | EA028057B1 (enExample) |
| ES (1) | ES2646759T3 (enExample) |
| HR (1) | HRP20171655T1 (enExample) |
| HU (1) | HUE034979T2 (enExample) |
| IL (2) | IL231381B (enExample) |
| LT (1) | LT2755958T (enExample) |
| MX (1) | MX347241B (enExample) |
| NO (1) | NO2639780T3 (enExample) |
| PL (1) | PL2755958T3 (enExample) |
| PT (1) | PT2755958T (enExample) |
| RS (1) | RS56486B1 (enExample) |
| SG (1) | SG2014009260A (enExample) |
| SI (1) | SI2755958T1 (enExample) |
| WO (1) | WO2013040044A1 (enExample) |
| ZA (1) | ZA201401007B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2718270T (lt) * | 2011-06-10 | 2022-08-10 | Merck Patent Gmbh | Pirimidino ir piridino junginių, turinčių btk inhibitorinį aktyvumą, kompozicijos ir gamybos būdai |
| EA028057B1 (ru) * | 2011-09-12 | 2017-10-31 | Мерк Патент Гмбх | Производные аминопиримидина для применения в качестве модуляторов киназной активности |
| CN105051043B (zh) | 2012-11-16 | 2017-05-10 | 默克专利有限公司 | 用作激酶活性调节剂的新颖的杂环类衍生物 |
| KR20150124957A (ko) * | 2013-03-11 | 2015-11-06 | 메르크 파텐트 게엠베하 | 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| ES2699354T3 (es) | 2014-01-17 | 2019-02-08 | Novartis Ag | Derivados de 1-(triazin-3-il/piridazin-3-il)-piper(-azin)idina y composiciones de las mismas para inhibir la actividad de SHP2 |
| US10093646B2 (en) | 2014-01-17 | 2018-10-09 | Novartis Ag | 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 |
| JP6560243B2 (ja) * | 2014-02-11 | 2019-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしてのピリミジンイミダゾールアミン |
| EP3420792B1 (en) | 2014-04-30 | 2021-09-22 | LG Electronics Inc. | Lawn mower robot and control method thereof |
| CN106661033B (zh) * | 2014-05-28 | 2018-11-06 | 阿斯利康(瑞典)有限公司 | 用于制备azd5363的方法和在其中使用的新颖中间体 |
| ES2824576T3 (es) | 2015-06-19 | 2021-05-12 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de SHP2 |
| ES2805232T3 (es) | 2015-06-19 | 2021-02-11 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de SHP2 |
| EP3310779B1 (en) | 2015-06-19 | 2019-05-08 | Novartis AG | Compounds and compositions for inhibiting the activity of shp2 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2904615T3 (es) * | 2016-03-16 | 2022-04-05 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones al respecto |
| CN109415360B (zh) | 2016-06-14 | 2021-11-02 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
| US20190343836A1 (en) | 2017-01-10 | 2019-11-14 | Novartis Ag | Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| WO2019084395A1 (en) | 2017-10-27 | 2019-05-02 | University Of Virginia Patent Foundation | COMPOUNDS AND METHODS FOR REGULATING, LIMITING OR INHIBITING AVIL EXPRESSION |
| US20220213055A1 (en) * | 2019-05-02 | 2022-07-07 | University Of Virginia Patent Foundation | Substituted (piperidin-1-yl)aryl analogues for modulating avil activity |
| US11866421B2 (en) * | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| CN116903592B (zh) * | 2023-07-13 | 2025-08-01 | 特科罗生物科技(成都)有限公司 | 一种嘧啶胺类nuak抑制剂及其制备方法和用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137755A1 (en) * | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| US7547794B2 (en) | 2003-04-03 | 2009-06-16 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| JP2007507531A (ja) | 2003-09-30 | 2007-03-29 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
| JP4800216B2 (ja) | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| EP1684694A2 (en) * | 2003-11-21 | 2006-08-02 | Array Biopharma, Inc. | Akt protein kinase inhibitors |
| PT1687305E (pt) | 2003-11-21 | 2008-10-17 | Novartis Ag | Derivados de 1h-imidazoquinolina como inibidores de proteína quinase |
| ATE447957T1 (de) | 2003-12-09 | 2009-11-15 | Us Gov Health & Human Serv | Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen |
| JP5213229B2 (ja) | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| JP5274842B2 (ja) * | 2004-12-28 | 2013-08-28 | エグゼリクシス， インコーポレイテッド | 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物 |
| EP1838703A2 (en) | 2005-01-19 | 2007-10-03 | Neurogen Corporation | Heteroaryl substituted piperazinyl-pyridine analogues |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| WO2006136821A1 (en) | 2005-06-22 | 2006-12-28 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2007125321A2 (en) * | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| WO2008012635A2 (en) * | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| EP2131656A4 (en) * | 2006-11-15 | 2011-12-07 | Forest Lab Holdings Ltd | phthalazine |
| CA2672373C (en) * | 2006-12-19 | 2011-08-30 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| HRP20141239T1 (xx) | 2009-02-11 | 2015-03-13 | Merck Patent Gmbh | Novi amino azaheterocikliäśki karboksamidi |
| EP2485589A4 (en) * | 2009-09-04 | 2013-02-06 | Biogen Idec Inc | HETEROARYL-BTK INHIBITORS |
| JP6014034B2 (ja) | 2010-07-29 | 2016-10-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 環式アミンアザヘテロ環式カルボキサミド |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| EP2643313B9 (en) | 2010-11-24 | 2017-02-22 | Merck Patent GmbH | Quinazoline carboxamide azetidines |
| EA028057B1 (ru) * | 2011-09-12 | 2017-10-31 | Мерк Патент Гмбх | Производные аминопиримидина для применения в качестве модуляторов киназной активности |
| RS56534B1 (sr) * | 2011-09-12 | 2018-02-28 | Merck Patent Gmbh | Novi imidazol akmini kao modulatori aktivnosti kinaza |
| EP2920154B1 (en) * | 2012-11-16 | 2017-10-11 | Merck Patent GmbH | Novel imidazol-piperidinyl derivatives as modulators of kinase activity |
| JP6560243B2 (ja) * | 2014-02-11 | 2019-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしてのピリミジンイミダゾールアミン |
-
2012
- 2012-09-12 EA EA201400338A patent/EA028057B1/ru not_active IP Right Cessation
- 2012-09-12 CA CA2844704A patent/CA2844704C/en not_active Expired - Fee Related
- 2012-09-12 SG SG2014009260A patent/SG2014009260A/en unknown
- 2012-09-12 PT PT127667731T patent/PT2755958T/pt unknown
- 2012-09-12 AU AU2012308681A patent/AU2012308681B2/en not_active Ceased
- 2012-09-12 KR KR1020147007739A patent/KR101992505B1/ko not_active Expired - Fee Related
- 2012-09-12 JP JP2014530756A patent/JP6082011B2/ja not_active Expired - Fee Related
- 2012-09-12 CN CN201280054959.2A patent/CN103930407B/zh not_active Expired - Fee Related
- 2012-09-12 SI SI201231118T patent/SI2755958T1/sl unknown
- 2012-09-12 EP EP12766773.1A patent/EP2755958B9/en active Active
- 2012-09-12 HR HRP20171655TT patent/HRP20171655T1/hr unknown
- 2012-09-12 MX MX2014002836A patent/MX347241B/es active IP Right Grant
- 2012-09-12 ES ES12766773.1T patent/ES2646759T3/es active Active
- 2012-09-12 DK DK12766773.1T patent/DK2755958T3/en active
- 2012-09-12 RS RS20171130A patent/RS56486B1/sr unknown
- 2012-09-12 WO PCT/US2012/054877 patent/WO2013040044A1/en not_active Ceased
- 2012-09-12 HU HUE12766773A patent/HUE034979T2/en unknown
- 2012-09-12 US US14/236,405 patent/US9321760B2/en not_active Expired - Fee Related
- 2012-09-12 PL PL12766773T patent/PL2755958T3/pl unknown
- 2012-09-12 CN CN201710022892.9A patent/CN106946796B/zh not_active Expired - Fee Related
- 2012-09-12 BR BR112014005468A patent/BR112014005468A2/pt not_active IP Right Cessation
- 2012-09-12 LT LTEP12766773.1T patent/LT2755958T/lt unknown
-
2013
- 2013-03-15 NO NO13001311A patent/NO2639780T3/no unknown
-
2014
- 2014-02-10 ZA ZA2014/01007A patent/ZA201401007B/en unknown
- 2014-03-06 IL IL231381A patent/IL231381B/en active IP Right Grant
-
2016
- 2016-03-03 US US15/060,050 patent/US9662330B2/en not_active Expired - Fee Related
-
2017
- 2017-04-18 US US15/490,370 patent/US10080750B2/en active Active
- 2017-10-09 AU AU2017245469A patent/AU2017245469B2/en not_active Ceased
-
2019
- 2019-05-07 IL IL266510A patent/IL266510B/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014527082A5 (enExample) | ||
| HRP20171655T1 (hr) | Derivati aminopirimidina za upotrebu kao modulatori aktivnosti kinaze | |
| CN114430740A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| JP2016513660A5 (enExample) | ||
| CN114430739A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| JP2014520898A5 (enExample) | ||
| JP2016525078A5 (enExample) | ||
| JP2020503297A5 (enExample) | ||
| RU2012151012A (ru) | Циклопропиловые дикарбоксамиды и аналоги, обладающие противораковым и антипролиферативным действием | |
| JP2014531436A5 (enExample) | ||
| JP2019517487A5 (enExample) | ||
| RU2010150786A (ru) | Пирролопиридины как ингибиторы киназы | |
| JP2018138577A5 (enExample) | ||
| JP2008528467A5 (enExample) | ||
| JP2012507566A5 (enExample) | ||
| JP2020503299A5 (enExample) | ||
| RU2015122414A (ru) | Соединения n-пирролидинилмочевины, n'-пиразолилмочевины, тиомочевины, гуанидина и цианогуанидина как ингибиторы киназы trka | |
| IL291590B2 (en) | Novel substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof | |
| RU2015143717A (ru) | 2-Аминопиримидин-6-оны и аналоги, проявляющие противораковые и антипролиферативные действия | |
| JP2017525757A5 (enExample) | ||
| US20130324551A1 (en) | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | |
| JP2013522292A5 (enExample) | ||
| JP2016509583A5 (enExample) | ||
| RU2013147823A (ru) | (альфа-замещенные аралкиламино-и гетероарилалкиламино)пиримидинил-и 1, 3, 5-триазинилбензимидазолы, их фармацевтические композиции и их применение в лечении пролиферативных заболеваний | |
| JP2015512942A5 (enExample) |