JP2022185107A5 - - Google Patents
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- Publication number
- JP2022185107A5 JP2022185107A5 JP2022163177A JP2022163177A JP2022185107A5 JP 2022185107 A5 JP2022185107 A5 JP 2022185107A5 JP 2022163177 A JP2022163177 A JP 2022163177A JP 2022163177 A JP2022163177 A JP 2022163177A JP 2022185107 A5 JP2022185107 A5 JP 2022185107A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- pharmaceutically acceptable
- acceptable salt
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 15
- 208000035475 disorder Diseases 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 8
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 230000001404 mediated effect Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims 4
- 201000008736 Systemic mastocytosis Diseases 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 2
- ATWOSZOTUJMZLS-UHFFFAOYSA-N 3-[2-[2-(cyclopropanecarbonylamino)-1,3-thiazol-5-yl]ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide Chemical compound C1(CC1)C(=O)NC=1SC(=CN=1)C#CC=1C=C(C(=O)NC2=CC(=C(C=C2)CN2CCN(CC2)C)C(F)(F)F)C=CC=1C ATWOSZOTUJMZLS-UHFFFAOYSA-N 0.000 claims 2
- HMTOGGMYAKLEPV-UHFFFAOYSA-N 3-[2-[2-[[2-methoxyethyl(methyl)carbamoyl]amino]-1,3-thiazol-5-yl]ethynyl]-4-methyl-N-[4-(pyrrolidin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide Chemical compound COCCN(C)C(=O)Nc1ncc(s1)C#Cc1cc(ccc1C)C(=O)Nc1ccc(CN2CCCC2)c(c1)C(F)(F)F HMTOGGMYAKLEPV-UHFFFAOYSA-N 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- AOPRLQFEOLALFP-UHFFFAOYSA-N N-[3-[2-[2-(dimethylcarbamoylamino)-1,3-thiazol-5-yl]ethynyl]-4-methylphenyl]-3-(trifluoromethoxy)benzamide Chemical compound CN(C(NC=1SC(=CN=1)C#CC=1C=C(C=CC=1C)NC(C1=CC(=CC=C1)OC(F)(F)F)=O)=O)C AOPRLQFEOLALFP-UHFFFAOYSA-N 0.000 claims 2
- HSCKGLFXXZHPFO-UHFFFAOYSA-N N-[3-[2-[2-[[2-methoxyethyl(methyl)carbamoyl]amino]-1,3-thiazol-5-yl]ethynyl]phenyl]-4-(trifluoromethyl)pyridine-2-carboxamide Chemical compound COCCN(C(NC=1SC(=CN=1)C#CC=1C=C(C=CC=1)NC(C1=NC=CC(=C1)C(F)(F)F)=O)=O)C HSCKGLFXXZHPFO-UHFFFAOYSA-N 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000009905 Neurofibromatoses Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000007455 central nervous system cancer Diseases 0.000 claims 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
- 210000005002 female reproductive tract Anatomy 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000006512 mast cell neoplasm Diseases 0.000 claims 2
- 208000006971 mastocytoma Diseases 0.000 claims 2
- 208000008585 mastocytosis Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000004931 neurofibromatosis Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 210000004116 schwann cell Anatomy 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024109416A JP2024129146A (ja) | 2016-12-15 | 2024-07-08 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434845P | 2016-12-15 | 2016-12-15 | |
| US62/434,845 | 2016-12-15 | ||
| PCT/US2017/066291 WO2018112136A1 (en) | 2016-12-15 | 2017-12-14 | Aminothiazole compounds as c-kit inhibitors |
| JP2019531932A JP7158382B2 (ja) | 2016-12-15 | 2017-12-14 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531932A Division JP7158382B2 (ja) | 2016-12-15 | 2017-12-14 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109416A Division JP2024129146A (ja) | 2016-12-15 | 2024-07-08 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022185107A JP2022185107A (ja) | 2022-12-13 |
| JP2022185107A5 true JP2022185107A5 (enExample) | 2023-03-27 |
| JP7519416B2 JP7519416B2 (ja) | 2024-07-19 |
Family
ID=60957442
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531932A Active JP7158382B2 (ja) | 2016-12-15 | 2017-12-14 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
| JP2022163177A Active JP7519416B2 (ja) | 2016-12-15 | 2022-10-11 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
| JP2024109416A Pending JP2024129146A (ja) | 2016-12-15 | 2024-07-08 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531932A Active JP7158382B2 (ja) | 2016-12-15 | 2017-12-14 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109416A Pending JP2024129146A (ja) | 2016-12-15 | 2024-07-08 | Ｃ－ｋｉｔ阻害剤としてのアミノチアゾール化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11001580B2 (enExample) |
| EP (1) | EP3555090A1 (enExample) |
| JP (3) | JP7158382B2 (enExample) |
| KR (1) | KR102594476B1 (enExample) |
| CN (3) | CN117105922A (enExample) |
| AU (3) | AU2017376624B2 (enExample) |
| BR (1) | BR112019012239A2 (enExample) |
| CA (1) | CA3047106A1 (enExample) |
| EA (1) | EA201991198A1 (enExample) |
| IL (3) | IL312378A (enExample) |
| MA (1) | MA51878A (enExample) |
| MX (2) | MX390347B (enExample) |
| WO (1) | WO2018112136A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017376624B2 (en) | 2016-12-15 | 2021-11-11 | Ariad Pharmaceuticals, Inc. | Aminothiazole compounds as c-Kit inhibitors |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| CA3159348A1 (en) | 2019-11-08 | 2021-05-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| JP7711068B2 (ja) | 2019-12-24 | 2025-07-22 | カルナバイオサイエンス株式会社 | ジアシルグリセロールキナーゼ調節化合物 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| IL295023A (en) | 2020-02-14 | 2022-09-01 | Jounce Therapeutics Inc | Antibodies and fusion proteins that bind to ccr8 and their uses |
| KR102535840B1 (ko) * | 2020-07-31 | 2023-05-23 | (주)파로스아이바이오 | 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도 |
| EP4274830A1 (en) * | 2021-01-06 | 2023-11-15 | Theseus Pharmaceuticals, Inc. | Aminothiazole compounds as c-kit inhibitors |
| EP4304586A4 (en) | 2021-03-10 | 2025-04-02 | Jnana Therapeutics Inc. | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| AU2022298639C1 (en) | 2021-06-23 | 2025-07-17 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240025616A (ko) | 2021-06-23 | 2024-02-27 | 길리애드 사이언시즈, 인코포레이티드 | 다이아실글리세롤 키나제 조절 화합물 |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| AU2022354321A1 (en) * | 2021-09-29 | 2024-04-04 | Repare Therapeutics Inc. | N-(5-substituted-[(1,3,4-thiadiazolyl) or (thiazolyl)])(substituted)carboxamide compounds and use thereof for inhibiting human polymerase theta |
| JP2024539252A (ja) | 2021-10-28 | 2024-10-28 | ギリアード サイエンシーズ， インコーポレイテッド | ピリジジン－３（２ｈ）－オン誘導体 |
| CA3235986A1 (en) | 2021-10-29 | 2023-05-04 | Gilead Science, Inc. | Cd73 compounds |
| EP4452414A2 (en) | 2021-12-22 | 2024-10-30 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| EP4667056A1 (en) | 2021-12-22 | 2025-12-24 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| LT4245756T (lt) | 2022-03-17 | 2024-11-25 | Gilead Sciences, Inc. | Ikaros cinko pirštų šeimos skaidymo medžiagos ir jų panaudojimas |
| US20230374036A1 (en) | 2022-04-21 | 2023-11-23 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| IL317958A (en) | 2022-07-01 | 2025-02-01 | Gilead Sciences Inc | CD73 compounds |
| AU2023352129A1 (en) * | 2022-09-29 | 2025-05-01 | Repare Therapeutics Inc. | N-(5-substituted-[(1,3,4-thiadiazolyl) or (1,3-thiazolyl)](substituted)carboxamide compounds, pharmaceutical compositions, and methods of preparing the amide compounds and of their use |
| EP4638436A1 (en) | 2022-12-22 | 2025-10-29 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| EP4695260A1 (en) | 2023-04-11 | 2026-02-18 | Gilead Sciences, Inc. | Kras modulating compounds |
| KR20250175331A (ko) | 2023-04-21 | 2025-12-16 | 길리애드 사이언시즈, 인코포레이티드 | Prmt5 억제제 및 이의 용도 |
| AU2024306338A1 (en) | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| AU2024300557A1 (en) | 2023-07-26 | 2026-02-05 | Gilead Sciences, Inc. | Parp7 inhibitors |
| AU2024297978A1 (en) | 2023-07-26 | 2026-02-05 | Gilead Sciences, Inc. | Parp7 inhibitors |
| WO2025054530A1 (en) | 2023-09-08 | 2025-03-13 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2026039365A1 (en) | 2024-08-12 | 2026-02-19 | Gilead Sciences, Inc. | Kras modulating compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| EP2024366B1 (en) * | 2006-05-08 | 2015-09-16 | Ariad Pharmaceuticals, Inc. | Monocyclic heteroaryl compounds |
| WO2007135626A2 (en) | 2006-05-18 | 2007-11-29 | Nxp B.V. | Method of video coding |
| WO2012089106A1 (zh) | 2010-12-27 | 2012-07-05 | Sun Shuping | 作为蛋白激酶抑制剂的芳炔类衍生物及其医疗用途 |
| CN102584830A (zh) | 2011-12-30 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 二氢化茚酰胺化合物、其药物组合物及其用途 |
| GB2522226A (en) * | 2014-01-17 | 2015-07-22 | Agency Science Tech & Res | Heteroaryl alkyne derivatives and uses thereof |
| AU2017376624B2 (en) | 2016-12-15 | 2021-11-11 | Ariad Pharmaceuticals, Inc. | Aminothiazole compounds as c-Kit inhibitors |
| EP4274830A1 (en) | 2021-01-06 | 2023-11-15 | Theseus Pharmaceuticals, Inc. | Aminothiazole compounds as c-kit inhibitors |
-
2017
- 2017-12-14 AU AU2017376624A patent/AU2017376624B2/en not_active Ceased
- 2017-12-14 EP EP17829077.1A patent/EP3555090A1/en not_active Withdrawn
- 2017-12-14 EA EA201991198A patent/EA201991198A1/ru unknown
- 2017-12-14 WO PCT/US2017/066291 patent/WO2018112136A1/en not_active Ceased
- 2017-12-14 MX MX2019007079A patent/MX390347B/es unknown
- 2017-12-14 CN CN202310911397.9A patent/CN117105922A/zh active Pending
- 2017-12-14 JP JP2019531932A patent/JP7158382B2/ja active Active
- 2017-12-14 CA CA3047106A patent/CA3047106A1/en active Pending
- 2017-12-14 KR KR1020197020016A patent/KR102594476B1/ko active Active
- 2017-12-14 CN CN202310911370.XA patent/CN117050032A/zh active Pending
- 2017-12-14 IL IL312378A patent/IL312378A/en unknown
- 2017-12-14 US US16/469,517 patent/US11001580B2/en not_active Expired - Fee Related
- 2017-12-14 BR BR112019012239-7A patent/BR112019012239A2/pt active Search and Examination
- 2017-12-14 MA MA051878A patent/MA51878A/fr unknown
- 2017-12-14 IL IL291099A patent/IL291099B2/en unknown
- 2017-12-14 CN CN201780085462.XA patent/CN110291086B/zh not_active Expired - Fee Related
-
2019
- 2019-06-12 IL IL267262A patent/IL267262B/en unknown
- 2019-06-14 MX MX2022002579A patent/MX2022002579A/es unknown
-
2021
- 2021-04-09 US US17/226,531 patent/US11753404B2/en active Active
-
2022
- 2022-02-04 AU AU2022200741A patent/AU2022200741B2/en not_active Ceased
- 2022-10-11 JP JP2022163177A patent/JP7519416B2/ja active Active
-
2023
- 2023-07-28 US US18/361,430 patent/US20240208960A1/en not_active Abandoned
-
2024
- 2024-06-06 AU AU2024203831A patent/AU2024203831A1/en not_active Abandoned
- 2024-07-08 JP JP2024109416A patent/JP2024129146A/ja active Pending