JP2014526246A5 - - Google Patents
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- Publication number
- JP2014526246A5 JP2014526246A5 JP2014529633A JP2014529633A JP2014526246A5 JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5 JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5
- Authority
- JP
- Japan
- Prior art keywords
- filter
- sample
- virus
- population
- parvovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 24
- 238000001914 filtration Methods 0.000 claims 5
- 241000125945 Protoparvovirus Species 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 239000004627 regenerated cellulose Substances 0.000 claims 4
- 241000701447 unidentified baculovirus Species 0.000 claims 4
- 210000002845 virion Anatomy 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 claims 3
- 238000011210 chromatographic step Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- -1 polytetrafluoroethylene Polymers 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 239000000020 Nitrocellulose Substances 0.000 claims 1
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920001220 nitrocellulos Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 238000011045 prefiltration Methods 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532176P | 2011-09-08 | 2011-09-08 | |
| US61/532,176 | 2011-09-08 | ||
| EP11180594.1 | 2011-09-08 | ||
| EP11180594 | 2011-09-08 | ||
| PCT/NL2012/050619 WO2013036118A1 (en) | 2011-09-08 | 2012-09-07 | Removal of contaminating viruses from aav preparations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Division JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526246A JP2014526246A (ja) | 2014-10-06 |
| JP2014526246A5 true JP2014526246A5 (https=) | 2015-10-01 |
| JP6198278B2 JP6198278B2 (ja) | 2017-09-20 |
Family
ID=47832422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529633A Expired - Fee Related JP6198278B2 (ja) | 2011-09-08 | 2012-09-07 | Ａａｖ調製物からの混入ウイルスの除去 |
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9840694B2 (https=) |
| EP (3) | EP2990477B8 (https=) |
| JP (2) | JP6198278B2 (https=) |
| KR (1) | KR101961347B1 (https=) |
| CN (2) | CN107502597A (https=) |
| AU (1) | AU2012304993B2 (https=) |
| BR (1) | BR112014005255A2 (https=) |
| CA (1) | CA2847604A1 (https=) |
| DK (1) | DK2744895T3 (https=) |
| EA (1) | EA027511B1 (https=) |
| ES (1) | ES2558168T3 (https=) |
| HU (1) | HUE026579T2 (https=) |
| IL (1) | IL231398A (https=) |
| MX (1) | MX349601B (https=) |
| PL (1) | PL2744895T3 (https=) |
| PT (1) | PT2744895E (https=) |
| SI (1) | SI2744895T1 (https=) |
| WO (1) | WO2013036118A1 (https=) |
| ZA (1) | ZA201401714B (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6198278B2 (ja) * | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
| CN105745326A (zh) | 2013-10-24 | 2016-07-06 | 优尼科Ip有限公司 | 用于基因治疗神经疾病的aav-5假型载体 |
| EP3151866B1 (en) | 2014-06-09 | 2023-03-08 | Voyager Therapeutics, Inc. | Chimeric capsids |
| RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| WO2016077687A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| HUE046643T2 (hu) * | 2014-11-28 | 2021-11-29 | Uniqure Ip Bv | DNS szennyezõdések parvovirális virionokat tartalmazó készítményben |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| HRP20190992T1 (hr) | 2014-12-24 | 2019-09-20 | Uniqure Ip B.V. | Suprimiranje gena za huntingtin inducirano s rnai |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| KR102427379B1 (ko) | 2016-05-18 | 2022-08-02 | 보이저 테라퓨틱스, 인크. | 헌팅톤 질환을 치료하기 위한 조성물 및 방법 |
| WO2018044933A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| JP2020518258A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 筋萎縮性側索硬化症（ａｌｓ）治療組成物および方法 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CA3070087A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | Trajectory array guide system |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| EP3697908A1 (en) | 2017-10-16 | 2020-08-26 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| SI3740222T1 (sl) | 2018-01-17 | 2023-11-30 | Meiragtx Uk Ii Limited | Modificiran kapsidni protein raav za gensko terapijo |
| KR20210019996A (ko) | 2018-05-15 | 2021-02-23 | 보이저 테라퓨틱스, 인크. | 파킨슨병의 치료를 위한 조성물 및 방법 |
| WO2020053258A1 (en) | 2018-09-12 | 2020-03-19 | Uniqure Ip B.V. | Rnai induced c9orf72 suppression for the treatment of als/ftd |
| EP3856762A1 (en) | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| CN112912518A (zh) * | 2018-10-15 | 2021-06-04 | 再生生物股份有限公司 | 用于测量复制缺陷型病毒载体和病毒的感染性的方法 |
| AU2019382824A1 (en) | 2018-11-19 | 2021-06-03 | Uniqure Ip B.V. | Method and means to deliver miRNA to target cells |
| WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| WO2020104295A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | Rnai induced reduction of ataxin-3 for the treatment of spinocerebellar ataxia type 3 |
| CA3119721A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | A companion diagnostic to monitor the effects of gene therapy |
| SG11202107645RA (en) * | 2019-01-18 | 2021-08-30 | Voyager Therapeutics Inc | Methods and systems for producing aav particles |
| CN113728108A (zh) | 2019-02-15 | 2021-11-30 | 桑格摩生物治疗股份有限公司 | 用于生产重组aav的组合物和方法 |
| WO2020219897A1 (en) * | 2019-04-24 | 2020-10-29 | Biogen Ma Inc. | Methods for production of recombinant adeno-associated viruses |
| MX2022000551A (es) | 2019-07-15 | 2022-05-18 | Meiragtx Uk Ii Ltd | Proteínas de la cápside de aav modificadas para el tratamiento de una enfermedad artrítica. |
| EP4031148A1 (en) | 2019-09-16 | 2022-07-27 | uniQure IP B.V. | Targeting misspliced transcripts in genetic disorders |
| EP4069856A1 (en) | 2019-12-04 | 2022-10-12 | Sangamo Therapeutics, Inc. | Novel compositions and methods for producing recombinant aav |
| CN114829371A (zh) * | 2019-12-12 | 2022-07-29 | Emd密理博公司 | 使用透析过滤缓冲液强化的病毒过滤 |
| WO2021154923A2 (en) * | 2020-01-29 | 2021-08-05 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| US20230103302A1 (en) * | 2020-02-28 | 2023-04-06 | Asahi Kasei Medical Co., Ltd. | Method for evaluating viral clearance capability |
| EP4133074A1 (en) | 2020-04-07 | 2023-02-15 | uniQure IP B.V. | Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof |
| EP4305157A1 (en) | 2021-03-09 | 2024-01-17 | Huidagene Therapeutics (Singapore) Pte. Ltd. | Engineered crispr/cas13 system and uses thereof |
| US20240157306A1 (en) * | 2021-03-30 | 2024-05-16 | 3M Innovative Properties Company | Hollow-fiber membrane and method making thereof |
| CN117120152A (zh) * | 2021-03-30 | 2023-11-24 | 3M创新有限公司 | 包含聚砜和聚噁唑啉的中空纤维膜及其制造方法 |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| US20240374755A1 (en) | 2021-06-02 | 2024-11-14 | Uniqure Biopharma B.V. | Adeno-associated virus vectors modified to bind High-Density Lipoprotein |
| WO2022268835A1 (en) | 2021-06-21 | 2022-12-29 | Uniqure Biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| CN117836010A (zh) | 2021-06-21 | 2024-04-05 | 优尼科生物制药有限公司 | 改进的裂解程序 |
| WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| JP2025513066A (ja) | 2022-04-12 | 2025-04-22 | ユニキュアー バイオファーマ ビー．ブイ． | Ａｐｏｅの核酸制御 |
| EP4508215A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Novel systems for nucleic acid regulation |
| EP4508216A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of snca |
| WO2023198702A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of c9orf72 |
| US20240209324A1 (en) * | 2022-12-22 | 2024-06-27 | Cytiva Us Llc | Virus separation |
| WO2024218192A1 (en) | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs |
| WO2024218204A1 (en) | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| WO2024261220A1 (en) | 2023-06-23 | 2024-12-26 | Uniqure Biopharma B.V. | Novel fragile x constructs |
| WO2025051805A1 (en) | 2023-09-04 | 2025-03-13 | Uniqure Biopharma B.V. | Novel neurotropic recombinant adeno-associated virus particles |
| WO2025078602A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Nucleic acid regulation of msh3 in repeat expansion disorders |
| AU2024357870A1 (en) | 2023-10-11 | 2026-04-23 | Uniqure Biopharma B.V. | Further novel systems for nucleic acid regulation |
| AU2024360616A1 (en) | 2023-10-11 | 2026-04-23 | Uniqure Biopharma B.V. | Novel nucleic acid regulation of huntingtin gene |
| WO2025114524A1 (en) | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
| WO2025219443A1 (en) | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
| WO2026041782A1 (en) | 2024-08-22 | 2026-02-26 | Uniqure Biopharma B.V. | Novel raav capsids |
| WO2026041788A1 (en) | 2024-08-22 | 2026-02-26 | Uniqure Biopharma B.V | Novel bbb interacting capsids |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| DE122007000092I1 (de) | 1994-10-07 | 2008-03-27 | Univ Loyola Chicago | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
| DE19709186C2 (de) * | 1997-03-06 | 1999-10-14 | Medigene Ag | Filtrationsverfahren zur Trennung von Viren |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| US6593123B1 (en) * | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| AU2003212708A1 (en) | 2002-03-05 | 2003-09-16 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
| US20050009168A1 (en) * | 2003-05-12 | 2005-01-13 | Robbins Joan Marie | Methods and apparatus for Adeno associated virus purification |
| CN103849629B (zh) * | 2006-06-21 | 2017-06-09 | 尤尼克尔Ip股份有限公司 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
| US20080299545A1 (en) * | 2007-03-06 | 2008-12-04 | Shuyuan Zhang | Chromatographic methods for assessing adenovirus purity |
| US20100323429A1 (en) * | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| KR20180000341A (ko) * | 2009-06-16 | 2018-01-02 | 젠자임 코포레이션 | 재조합 ａａｖ 벡터에 대한 개선된 정제 방법 |
| WO2011094198A1 (en) * | 2010-01-28 | 2011-08-04 | The Children's Hospital Of Philadelphia Research Institute, Abramson Research Center | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
| JP6198278B2 (ja) | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
-
2012
- 2012-09-07 JP JP2014529633A patent/JP6198278B2/ja not_active Expired - Fee Related
- 2012-09-07 HU HUE12758663A patent/HUE026579T2/en unknown
- 2012-09-07 CN CN201710697343.1A patent/CN107502597A/zh active Pending
- 2012-09-07 EP EP15186937.7A patent/EP2990477B8/en not_active Revoked
- 2012-09-07 KR KR1020147009146A patent/KR101961347B1/ko not_active Expired - Fee Related
- 2012-09-07 BR BR112014005255A patent/BR112014005255A2/pt active Search and Examination
- 2012-09-07 MX MX2014002733A patent/MX349601B/es active IP Right Grant
- 2012-09-07 EA EA201490583A patent/EA027511B1/ru not_active IP Right Cessation
- 2012-09-07 PT PT127586634T patent/PT2744895E/pt unknown
- 2012-09-07 SI SI201230372T patent/SI2744895T1/sl unknown
- 2012-09-07 CN CN201280049899.5A patent/CN103857790B/zh not_active Expired - Fee Related
- 2012-09-07 AU AU2012304993A patent/AU2012304993B2/en not_active Ceased
- 2012-09-07 US US14/343,884 patent/US9840694B2/en not_active Expired - Fee Related
- 2012-09-07 PL PL12758663T patent/PL2744895T3/pl unknown
- 2012-09-07 EP EP12758663.4A patent/EP2744895B1/en active Active
- 2012-09-07 ES ES12758663.4T patent/ES2558168T3/es active Active
- 2012-09-07 CA CA2847604A patent/CA2847604A1/en not_active Abandoned
- 2012-09-07 DK DK12758663.4T patent/DK2744895T3/en active
- 2012-09-07 WO PCT/NL2012/050619 patent/WO2013036118A1/en not_active Ceased
- 2012-09-07 EP EP18191023.3A patent/EP3425044A1/en not_active Withdrawn
-
2014
- 2014-03-06 IL IL231398A patent/IL231398A/en active IP Right Grant
- 2014-03-07 ZA ZA2014/01714A patent/ZA201401714B/en unknown
-
2017
- 2017-06-27 JP JP2017125458A patent/JP6624690B2/ja not_active Expired - Fee Related
- 2017-12-08 US US15/836,220 patent/US10253301B2/en not_active Expired - Fee Related
-
2019
- 2019-03-20 US US16/359,593 patent/US20190218523A1/en not_active Abandoned
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