JP2014526246A5 - - Google Patents
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- Publication number
- JP2014526246A5 JP2014526246A5 JP2014529633A JP2014529633A JP2014526246A5 JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5 JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5
- Authority
- JP
- Japan
- Prior art keywords
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- sample
- virus
- population
- parvovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 24
- 238000001914 filtration Methods 0.000 claims 5
- 241000125945 Protoparvovirus Species 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 239000004627 regenerated cellulose Substances 0.000 claims 4
- 241000701447 unidentified baculovirus Species 0.000 claims 4
- 210000002845 virion Anatomy 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 claims 3
- 238000011210 chromatographic step Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- -1 polytetrafluoroethylene Polymers 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 239000000020 Nitrocellulose Substances 0.000 claims 1
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920001220 nitrocellulos Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 238000011045 prefiltration Methods 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532176P | 2011-09-08 | 2011-09-08 | |
| EP11180594.1 | 2011-09-08 | ||
| EP11180594 | 2011-09-08 | ||
| US61/532,176 | 2011-09-08 | ||
| PCT/NL2012/050619 WO2013036118A1 (en) | 2011-09-08 | 2012-09-07 | Removal of contaminating viruses from aav preparations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Division JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526246A JP2014526246A (ja) | 2014-10-06 |
| JP2014526246A5 true JP2014526246A5 (https=) | 2015-10-01 |
| JP6198278B2 JP6198278B2 (ja) | 2017-09-20 |
Family
ID=47832422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529633A Expired - Fee Related JP6198278B2 (ja) | 2011-09-08 | 2012-09-07 | Ａａｖ調製物からの混入ウイルスの除去 |
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9840694B2 (https=) |
| EP (3) | EP3425044A1 (https=) |
| JP (2) | JP6198278B2 (https=) |
| KR (1) | KR101961347B1 (https=) |
| CN (2) | CN107502597A (https=) |
| AU (1) | AU2012304993B2 (https=) |
| BR (1) | BR112014005255A2 (https=) |
| CA (1) | CA2847604A1 (https=) |
| DK (1) | DK2744895T3 (https=) |
| EA (1) | EA027511B1 (https=) |
| ES (1) | ES2558168T3 (https=) |
| HU (1) | HUE026579T2 (https=) |
| IL (1) | IL231398A (https=) |
| MX (1) | MX349601B (https=) |
| PL (1) | PL2744895T3 (https=) |
| PT (1) | PT2744895E (https=) |
| SI (1) | SI2744895T1 (https=) |
| WO (1) | WO2013036118A1 (https=) |
| ZA (1) | ZA201401714B (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2744895E (pt) * | 2011-09-08 | 2016-02-08 | Uniqure Ip Bv | Remoção de vírus contaminantes de preparações de aav |
| CN120174012A (zh) | 2013-10-24 | 2025-06-20 | 优尼科Ip有限公司 | 用于基因治疗神经疾病的aav-5假型载体 |
| WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
| SG11201703148TA (en) | 2014-11-05 | 2017-05-30 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| CA3193811A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| CN119876138A (zh) | 2014-11-14 | 2025-04-25 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| FI3224376T4 (fi) * | 2014-11-28 | 2023-08-31 | Dna-epäpuhtaudet koostumuksessa, joka käsittää parvovirusvirionin | |
| HK1245326A1 (zh) | 2014-12-12 | 2018-08-24 | Voyager Therapeutics, Inc. | 用於生产scaav的组合物和方法 |
| AU2015370903B2 (en) | 2014-12-24 | 2021-06-17 | Uniqure Ip B.V. | RNAi induced huntingtin gene suppression |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| CA3024448C (en) | 2016-05-18 | 2025-09-09 | Voyager Therapeutics, Inc. | MODULATING POLYNUCLEOTIDES |
| CA3024449A1 (en) | 2016-05-18 | 2017-11-23 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
| WO2018044933A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| EP3618839A4 (en) | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
| US20200263199A1 (en) | 2017-09-29 | 2020-08-20 | Voyager Therapeutics, Inc. | Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| SG11202006056RA (en) | 2018-01-17 | 2020-07-29 | Meiragtx Uk Ii Ltd | A modified raav capsid protein for gene therapy |
| SG11202011296VA (en) | 2018-05-15 | 2020-12-30 | Voyager Therapeutics Inc | Compositions and methods for the treatment of parkinson's disease |
| EP3850098A1 (en) | 2018-09-12 | 2021-07-21 | uniQure IP B.V. | Rnai induced c9orf72 suppression for the treatment of als/ftd |
| US12281321B2 (en) | 2018-09-28 | 2025-04-22 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| JP2022514112A (ja) * | 2018-10-15 | 2022-02-09 | リジェネクスバイオ インコーポレイテッド | 複製欠損型ウイルスベクター及びウイルスの感染性を測定するための方法 |
| WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| CA3119721A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | A companion diagnostic to monitor the effects of gene therapy |
| WO2020104469A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | Method and means to deliver mirna to target cells |
| WO2020104295A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | Rnai induced reduction of ataxin-3 for the treatment of spinocerebellar ataxia type 3 |
| JP2022522995A (ja) * | 2019-01-18 | 2022-04-21 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖ粒子を生成するための方法及びシステム |
| US11718834B2 (en) | 2019-02-15 | 2023-08-08 | Sangamo Therapeutics, Inc. | Compositions and methods for producing recombinant AAV |
| WO2020219897A1 (en) * | 2019-04-24 | 2020-10-29 | Biogen Ma Inc. | Methods for production of recombinant adeno-associated viruses |
| PL3999119T3 (pl) | 2019-07-15 | 2025-02-10 | Meiragtx Uk Ii Limited | Modyfikowane białka kapsydu aav do leczenia choroby zapalnej stawów |
| WO2021053018A1 (en) | 2019-09-16 | 2021-03-25 | Uniqure Ip B.V. | Targeting misspliced transcripts in genetic disorders |
| IL293397A (en) | 2019-12-04 | 2022-07-01 | Sangamo Therapeutics Inc | New preparations and methods for the production of recombinant aav |
| JP7737374B2 (ja) * | 2019-12-12 | 2025-09-10 | イー・エム・デイー・ミリポア・コーポレイシヨン | 透析濾過緩衝液を用いて増強したウイルス濾過 |
| WO2021154923A2 (en) * | 2020-01-29 | 2021-08-05 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| JP7390466B2 (ja) * | 2020-02-28 | 2023-12-01 | 旭化成メディカル株式会社 | ウイルスクリアランス性能の評価方法 |
| CA3174872A1 (en) | 2020-04-07 | 2021-10-14 | Sander Jan Hendrik Van Deventer | Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof |
| CN115427561B (zh) | 2021-03-09 | 2024-06-04 | 辉大(上海)生物科技有限公司 | 工程化CRISPR/Cas13系统及其用途 |
| US20240157306A1 (en) * | 2021-03-30 | 2024-05-16 | 3M Innovative Properties Company | Hollow-fiber membrane and method making thereof |
| CN117120152A (zh) * | 2021-03-30 | 2023-11-24 | 3M创新有限公司 | 包含聚砜和聚噁唑啉的中空纤维膜及其制造方法 |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| CA3219847A1 (en) | 2021-06-02 | 2022-12-08 | Sander Jan Hendrik Van Deventer | Adeno-associated virus vectors modified to bind high-density lipoprotein |
| EP4359525A1 (en) | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| CN117836010A (zh) | 2021-06-21 | 2024-04-05 | 优尼科生物制药有限公司 | 改进的裂解程序 |
| WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| EP4508213A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of apoe |
| EP4508215A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Novel systems for nucleic acid regulation |
| WO2023198663A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of snca |
| WO2023198702A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of c9orf72 |
| US20240209324A1 (en) * | 2022-12-22 | 2024-06-27 | Cytiva Us Llc | Virus separation |
| EP4698555A1 (en) | 2023-04-18 | 2026-02-25 | uniQure biopharma B.V. | Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs |
| WO2024218204A1 (en) | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| AU2024313758A1 (en) | 2023-06-23 | 2026-01-08 | Uniqure Biopharma B.V. | Novel fragile x constructs |
| AU2024337260A1 (en) | 2023-09-04 | 2026-03-12 | Uniqure Biopharma B.V. | Novel neurotropic recombinant adeno-associated virus particles |
| AU2024357870A1 (en) | 2023-10-11 | 2026-04-23 | Uniqure Biopharma B.V. | Further novel systems for nucleic acid regulation |
| AU2024360616A1 (en) | 2023-10-11 | 2026-04-23 | Uniqure Biopharma B.V. | Novel nucleic acid regulation of huntingtin gene |
| WO2025078602A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Nucleic acid regulation of msh3 in repeat expansion disorders |
| WO2025114524A1 (en) | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
| WO2025219443A1 (en) | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
| WO2026041788A1 (en) | 2024-08-22 | 2026-02-26 | Uniqure Biopharma B.V | Novel bbb interacting capsids |
| WO2026041782A1 (en) | 2024-08-22 | 2026-02-26 | Uniqure Biopharma B.V. | Novel raav capsids |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| WO1996011272A2 (de) | 1994-10-07 | 1996-04-18 | Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
| DE19709186C2 (de) | 1997-03-06 | 1999-10-14 | Medigene Ag | Filtrationsverfahren zur Trennung von Viren |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| ES2340230T3 (es) | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
| US6593123B1 (en) * | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| WO2003074714A1 (en) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
| US20050009168A1 (en) * | 2003-05-12 | 2005-01-13 | Robbins Joan Marie | Methods and apparatus for Adeno associated virus purification |
| KR101589259B1 (ko) * | 2006-06-21 | 2016-02-01 | 유니큐어 아이피 비.브이. | 곤충세포 내 ａａｖ의 생산에 유용한 ａａｖ-ｒｅｐ78의 번역을 위한 변형된 개시 코돈을 갖는 벡터 |
| WO2008109721A1 (en) * | 2007-03-06 | 2008-09-12 | Introgen Therapeutics, Inc. | Chromatographic methods for assessing adenovirus purity |
| US20100323429A1 (en) * | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| HUE028341T2 (en) | 2009-06-16 | 2016-12-28 | Genzyme Corp | Improved methods for purification of recombinant aav vectors |
| DK2529020T3 (en) * | 2010-01-28 | 2018-08-06 | Childrens Hospital Philadelphia | SCALABLE PREPARATION PLATF FOR CLEANING VIRAL VECTORS AND CLEANED VIRAL VECTORS FOR USE IN GENTHERAPY |
| PT2744895E (pt) | 2011-09-08 | 2016-02-08 | Uniqure Ip Bv | Remoção de vírus contaminantes de preparações de aav |
-
2012
- 2012-09-07 PT PT127586634T patent/PT2744895E/pt unknown
- 2012-09-07 WO PCT/NL2012/050619 patent/WO2013036118A1/en not_active Ceased
- 2012-09-07 EP EP18191023.3A patent/EP3425044A1/en not_active Withdrawn
- 2012-09-07 SI SI201230372T patent/SI2744895T1/sl unknown
- 2012-09-07 CN CN201710697343.1A patent/CN107502597A/zh active Pending
- 2012-09-07 KR KR1020147009146A patent/KR101961347B1/ko not_active Expired - Fee Related
- 2012-09-07 MX MX2014002733A patent/MX349601B/es active IP Right Grant
- 2012-09-07 EP EP12758663.4A patent/EP2744895B1/en active Active
- 2012-09-07 AU AU2012304993A patent/AU2012304993B2/en not_active Ceased
- 2012-09-07 EP EP15186937.7A patent/EP2990477B8/en not_active Revoked
- 2012-09-07 ES ES12758663.4T patent/ES2558168T3/es active Active
- 2012-09-07 BR BR112014005255A patent/BR112014005255A2/pt active Search and Examination
- 2012-09-07 JP JP2014529633A patent/JP6198278B2/ja not_active Expired - Fee Related
- 2012-09-07 US US14/343,884 patent/US9840694B2/en not_active Expired - Fee Related
- 2012-09-07 EA EA201490583A patent/EA027511B1/ru not_active IP Right Cessation
- 2012-09-07 CN CN201280049899.5A patent/CN103857790B/zh not_active Expired - Fee Related
- 2012-09-07 HU HUE12758663A patent/HUE026579T2/en unknown
- 2012-09-07 PL PL12758663T patent/PL2744895T3/pl unknown
- 2012-09-07 DK DK12758663.4T patent/DK2744895T3/en active
- 2012-09-07 CA CA2847604A patent/CA2847604A1/en not_active Abandoned
-
2014
- 2014-03-06 IL IL231398A patent/IL231398A/en active IP Right Grant
- 2014-03-07 ZA ZA2014/01714A patent/ZA201401714B/en unknown
-
2017
- 2017-06-27 JP JP2017125458A patent/JP6624690B2/ja not_active Expired - Fee Related
- 2017-12-08 US US15/836,220 patent/US10253301B2/en not_active Expired - Fee Related
-
2019
- 2019-03-20 US US16/359,593 patent/US20190218523A1/en not_active Abandoned
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