JP2014526244A5 - - Google Patents
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- JP2014526244A5 JP2014526244A5 JP2014529143A JP2014529143A JP2014526244A5 JP 2014526244 A5 JP2014526244 A5 JP 2014526244A5 JP 2014529143 A JP2014529143 A JP 2014529143A JP 2014529143 A JP2014529143 A JP 2014529143A JP 2014526244 A5 JP2014526244 A5 JP 2014526244A5
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- Prior art keywords
- cells
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- 210000004027 cell Anatomy 0.000 claims 71
- 238000000034 method Methods 0.000 claims 36
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 210000004443 dendritic cell Anatomy 0.000 claims 10
- 102000003812 Interleukin-15 Human genes 0.000 claims 9
- 102100030703 Interleukin-22 Human genes 0.000 claims 9
- 102100021592 Interleukin-7 Human genes 0.000 claims 9
- 108010002586 Interleukin-7 Proteins 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 238000012258 culturing Methods 0.000 claims 9
- 210000001519 tissue Anatomy 0.000 claims 9
- 230000000779 depleting effect Effects 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000002054 transplantation Methods 0.000 claims 7
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 6
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 210000001165 lymph node Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 3
- 230000001464 adherent effect Effects 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000003614 tolerogenic effect Effects 0.000 claims 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000004738 parenchymal cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532172P | 2011-09-08 | 2011-09-08 | |
| US61/532,172 | 2011-09-08 | ||
| PCT/IL2012/050354 WO2013035099A1 (en) | 2011-09-08 | 2012-09-06 | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526244A JP2014526244A (ja) | 2014-10-06 |
| JP2014526244A5 true JP2014526244A5 (cg-RX-API-DMAC7.html) | 2015-10-29 |
| JP6196620B2 JP6196620B2 (ja) | 2017-09-13 |
Family
ID=47003163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529143A Active JP6196620B2 (ja) | 2011-09-08 | 2012-09-06 | 抗第三者セントラルメモリーｔ細胞、その作製方法ならびに移植および疾患処置におけるその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20140212398A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2753351B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6196620B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102073901B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103930130B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012305931B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014005355B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2848121C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2640813T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX351226B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2636503C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201400513PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013035099A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201401993B (cg-RX-API-DMAC7.html) |
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| MX351226B (es) | 2011-09-08 | 2017-10-05 | Yeda Res & Dev | Celulas t con memoria central anti tercera parte, metodos para producirlas y uso de las mismas en transplante y tratamiento de enfermedades. |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| US10351824B2 (en) | 2011-12-12 | 2019-07-16 | Cell Medica Limited | Process of expanding T cells |
| EP2812431B1 (en) | 2012-02-09 | 2019-07-17 | Baylor College Of Medicine | Pepmixes to generate multiviral ctls with broad specificity |
| SG11201407819UA (en) * | 2012-06-11 | 2014-12-30 | Wolf Wilson Mfg Corp | Improved methods of cell culture for adoptive cell therapy |
| WO2016168595A1 (en) * | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| CN104946588A (zh) * | 2015-07-07 | 2015-09-30 | 英普乐孚生物技术(上海)有限公司 | 一种抗原特异性t淋巴细胞的分离和高效扩增培养方法 |
| US11179448B2 (en) | 2015-07-16 | 2021-11-23 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory T cells and use of same in immunotherapy |
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| HK1258649A1 (zh) | 2015-09-18 | 2019-11-15 | Baylor College Of Medicine | 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性 |
| US10691773B2 (en) | 2015-12-30 | 2020-06-23 | General Electric Company | Cell processing techniques |
| AU2017283480A1 (en) | 2016-06-13 | 2019-01-24 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| CN109310746B (zh) * | 2016-06-24 | 2023-12-05 | 麦克马斯特大学 | 过继细胞转移与溶瘤病毒组合疗法 |
| MX2019000022A (es) * | 2016-06-27 | 2019-09-18 | Yeda Res & Dev | Células veto generadas a partir de linfocitos t de memoria. |
| US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
| EP3571295B1 (en) * | 2017-01-18 | 2026-01-07 | Yeda Research and Development Co. Ltd | Genetically modified veto cells and use of same in immunotherapy |
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| JP2020511464A (ja) | 2017-03-15 | 2020-04-16 | オルカ バイオシステムズ インコーポレイテッド | 造血幹細胞移植用の組成物および方法 |
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| JP7495137B2 (ja) * | 2018-08-10 | 2024-06-04 | ユーティレックス カンパニー リミテッド | 癌抗原特異的細胞傷害性ｔ細胞 |
| CN109628396B (zh) * | 2019-01-24 | 2021-03-26 | 清华大学 | 记忆性淋巴细胞群在肝癌治疗中的应用 |
| WO2021024264A2 (en) * | 2019-08-06 | 2021-02-11 | Yeda Research And Development Co. Ltd. | Anti-viral central memory cd8+ veto cells in haploidentical stem cell transplantation |
| EP4055146A4 (en) * | 2019-11-05 | 2023-10-18 | Yeda Research and Development Co. Ltd | USE OF VETO CELLS TO TREAT T-CELL-MEDIATED AUTOIMMUNE DISEASES |
| CN114901801A (zh) * | 2019-11-05 | 2022-08-12 | 耶达研究及发展有限公司 | 用于治疗镰状细胞病的数个否决细胞的用途 |
| CN115996732A (zh) * | 2020-05-13 | 2023-04-21 | Ａｇｃ株式会社 | 人专职性抗原提呈细胞的制造方法 |
| MX2023001771A (es) * | 2020-08-11 | 2023-04-25 | Yeda Res & Dev | Celulas car-t de veto. |
| CN116083359A (zh) * | 2021-11-05 | 2023-05-09 | 瑞创生物技术有限公司 | 一种体外大规模扩增富含Tscm和Tcm的双阴性T细胞的方法 |
| US20230287080A1 (en) * | 2022-01-20 | 2023-09-14 | 3T Biosciences, Inc. | T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells |
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2012
- 2012-09-06 MX MX2014002771A patent/MX351226B/es active IP Right Grant
- 2012-09-06 SG SG11201400513PA patent/SG11201400513PA/en unknown
- 2012-09-06 US US14/343,053 patent/US20140212398A1/en not_active Abandoned
- 2012-09-06 EP EP12769743.1A patent/EP2753351B1/en active Active
- 2012-09-06 BR BR112014005355-3A patent/BR112014005355B1/pt active IP Right Grant
- 2012-09-06 JP JP2014529143A patent/JP6196620B2/ja active Active
- 2012-09-06 AU AU2012305931A patent/AU2012305931B2/en active Active
- 2012-09-06 RU RU2014110897A patent/RU2636503C2/ru active
- 2012-09-06 CN CN201280054739.XA patent/CN103930130B/zh active Active
- 2012-09-06 KR KR1020147009267A patent/KR102073901B1/ko active Active
- 2012-09-06 CA CA2848121A patent/CA2848121C/en active Active
- 2012-09-06 ES ES12769743.1T patent/ES2640813T3/es active Active
- 2012-09-06 WO PCT/IL2012/050354 patent/WO2013035099A1/en not_active Ceased
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2014
- 2014-03-19 ZA ZA2014/01993A patent/ZA201401993B/en unknown
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2017
- 2017-11-29 US US15/825,275 patent/US11324777B2/en active Active
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2022
- 2022-05-03 US US17/735,146 patent/US12133866B2/en active Active
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