JP2014524246A5 - - Google Patents
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- Publication number
- JP2014524246A5 JP2014524246A5 JP2014524458A JP2014524458A JP2014524246A5 JP 2014524246 A5 JP2014524246 A5 JP 2014524246A5 JP 2014524458 A JP2014524458 A JP 2014524458A JP 2014524458 A JP2014524458 A JP 2014524458A JP 2014524246 A5 JP2014524246 A5 JP 2014524246A5
- Authority
- JP
- Japan
- Prior art keywords
- host
- crocetin
- seq
- set forth
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- PANKHBYNKQNAHN-JTBLXSOISA-N Crocetin Natural products OC(=O)C(\C)=C/C=C/C(/C)=C\C=C\C=C(\C)/C=C/C=C(/C)C(O)=O PANKHBYNKQNAHN-JTBLXSOISA-N 0.000 claims 9
- PANKHBYNKQNAHN-JUMCEFIXSA-N carotenoid dicarboxylic acid Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)O)C=CC=C(/C)C(=O)O PANKHBYNKQNAHN-JUMCEFIXSA-N 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- PANKHBYNKQNAHN-MQQNZMFNSA-N crocetin Chemical compound OC(=O)C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C(O)=O PANKHBYNKQNAHN-MQQNZMFNSA-N 0.000 claims 7
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 3
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 3
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 claims 3
- SEBIKDIMAPSUBY-JAUCNNNOSA-N Crocin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C=CC=C(/C)C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O SEBIKDIMAPSUBY-JAUCNNNOSA-N 0.000 claims 3
- 241000196324 Embryophyta Species 0.000 claims 3
- 102000007317 Farnesyltranstransferase Human genes 0.000 claims 3
- 108010007508 Farnesyltranstransferase Proteins 0.000 claims 3
- 108010091656 beta-carotene hydroxylase Proteins 0.000 claims 3
- 102000000340 Glucosyltransferases Human genes 0.000 claims 2
- 108010055629 Glucosyltransferases Proteins 0.000 claims 2
- 101710173432 Phytoene synthase Proteins 0.000 claims 2
- WMHJCSAICLADIN-MVVLZTAMSA-N Picrocrocin Natural products O=CC=1C(C)(C)C[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)CC=1C WMHJCSAICLADIN-MVVLZTAMSA-N 0.000 claims 2
- 241000235342 Saccharomycetes Species 0.000 claims 2
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 2
- 235000013734 beta-carotene Nutrition 0.000 claims 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 2
- 239000011648 beta-carotene Substances 0.000 claims 2
- 229960002747 betacarotene Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 108010001545 phytoene dehydrogenase Proteins 0.000 claims 2
- WMHJCSAICLADIN-WYWSWGBSSA-N picrocrocin Chemical compound C1C(C)=C(C=O)C(C)(C)C[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 WMHJCSAICLADIN-WYWSWGBSSA-N 0.000 claims 2
- SGAWOGXMMPSZPB-UHFFFAOYSA-N safranal Chemical compound CC1=C(C=O)C(C)(C)CC=C1 SGAWOGXMMPSZPB-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 2
- YHCIKUXPWFLCFN-MTGLMCJBSA-N Crocetin dialdehyde Natural products CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=O)/C)C=O YHCIKUXPWFLCFN-MTGLMCJBSA-N 0.000 claims 1
- 244000124209 Crocus sativus Species 0.000 claims 1
- 235000015655 Crocus sativus Nutrition 0.000 claims 1
- 101100433159 Crocus sativus ZCD gene Proteins 0.000 claims 1
- 102000016680 Dioxygenases Human genes 0.000 claims 1
- 108010028143 Dioxygenases Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 101100262416 Stevia rebaudiana UGT76G1 gene Proteins 0.000 claims 1
- 101100048059 Stevia rebaudiana UGT85C2 gene Proteins 0.000 claims 1
- 235000021466 carotenoid Nutrition 0.000 claims 1
- 150000001747 carotenoids Chemical class 0.000 claims 1
- YHCIKUXPWFLCFN-QHUUTLAPSA-N crocetin dialdehyde Chemical compound O=CC(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C=O YHCIKUXPWFLCFN-QHUUTLAPSA-N 0.000 claims 1
- -1 crocetin ester Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 235000017509 safranal Nutrition 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521171P | 2011-08-08 | 2011-08-08 | |
| US61/521,171 | 2011-08-08 | ||
| US201161576460P | 2011-12-16 | 2011-12-16 | |
| US61/576,460 | 2011-12-16 | ||
| US201261595450P | 2012-02-06 | 2012-02-06 | |
| US61/595,450 | 2012-02-06 | ||
| PCT/IB2012/001513 WO2013021261A2 (en) | 2011-08-08 | 2012-08-07 | Methods and materials for recombinant production of saffron compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524246A JP2014524246A (ja) | 2014-09-22 |
| JP2014524246A5 true JP2014524246A5 (enExample) | 2015-10-01 |
| JP6126597B2 JP6126597B2 (ja) | 2017-05-10 |
Family
ID=46970359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524458A Active JP6126597B2 (ja) | 2011-08-08 | 2012-08-07 | サフラン化合物の組換え生成のための方法および材料 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140248668A1 (enExample) |
| EP (1) | EP2742131B1 (enExample) |
| JP (1) | JP6126597B2 (enExample) |
| KR (2) | KR101983115B1 (enExample) |
| CN (1) | CN103764818B (enExample) |
| AU (1) | AU2012293402B2 (enExample) |
| BR (1) | BR112014002924A2 (enExample) |
| CA (1) | CA2843549A1 (enExample) |
| HK (1) | HK1199286A1 (enExample) |
| IN (1) | IN2014CN01129A (enExample) |
| RU (1) | RU2676730C2 (enExample) |
| WO (1) | WO2013021261A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| CA2899276C (en) | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| WO2015132411A2 (en) * | 2014-03-07 | 2015-09-11 | Evolva Sa | Methods for recombinant production of saffron compounds |
| EP3134539A1 (en) * | 2014-04-25 | 2017-03-01 | Evolva SA | Methods for recombinant production of saffron compounds |
| CA3109156C (en) * | 2014-05-16 | 2023-08-15 | Academia Sinica | Recombinant polynucleotide sequence for producing astaxanthin and uses thereof |
| US9969989B2 (en) | 2014-07-23 | 2018-05-15 | Agenzia Nazionale Per Le Nuove Tecnologie, L'ener- Gia E Lo Sviluppo Economico Sostenibile (Enea) | Carotenoid dioxygenase and methods for the biotechnological production in microorganisms and plants of compounds derived from saffron |
| MX2017001859A (es) | 2014-08-11 | 2017-04-11 | Evolva Sa | Produccion de glicosidos de esteviol en hospederos recombinantes. |
| JP2017528134A (ja) * | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組み換え宿主におけるステビオールグリコシドの生産 |
| BR112017016338A2 (en) | 2015-01-30 | 2018-03-27 | Evolva Sa | production of steviol glycosides in recombinant hosts |
| CA3255837A1 (en) | 2015-03-16 | 2025-10-30 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| JP2018522569A (ja) | 2015-08-07 | 2018-08-16 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組換え宿主内でのステビオールグリコシドの産生 |
| AU2017205501A1 (en) | 2016-01-07 | 2018-07-05 | Conagen Inc. | Methods of making capsinoids by biosynthetic processes |
| MY198001A (en) | 2016-04-13 | 2023-07-25 | Evolva SA | Production of steviol glycoside in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN105779406B (zh) * | 2016-05-25 | 2019-06-18 | 新疆农业科学院经济作物研究所 | 一种藏红花酸糖基转移酶及其编码基因与应用 |
| CN105950493B (zh) * | 2016-05-25 | 2019-12-27 | 天津大学 | 一种工程菌及其构建方法与在制备藏红花酸中的应用 |
| CN105950580B (zh) * | 2016-05-25 | 2019-03-08 | 新疆农业科学院经济作物研究所 | 一种制备蛋白质UGTCs4的方法 |
| BR112019000895A2 (pt) | 2016-07-19 | 2019-04-30 | Conagen Inc. | método para a produção microbiana de capsaicinoides naturais específicos |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| IT201700089843A1 (it) * | 2017-08-03 | 2019-02-03 | Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile | Geni e metodi per la produzione e compartimentazione biotecnologica di apocarotenoidi ad elevato valore aggiunto |
| CN110791510A (zh) * | 2018-08-02 | 2020-02-14 | 中国医学科学院药用植物研究所 | 一种参与西红花酸合成的乙醛脱氢酶编码基因的筛选鉴定及应用 |
| WO2020093285A1 (zh) * | 2018-11-07 | 2020-05-14 | 中国医学科学院药用植物研究所 | 用于生物合成西红花苷的酶基因及其应用 |
| CA3118924A1 (en) | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN109943493B (zh) * | 2019-04-17 | 2021-05-18 | 天津大学 | 实现通用酶催化功能多样性的突变体菌株及其构建方法 |
| KR102335035B1 (ko) * | 2019-09-17 | 2021-12-06 | 아주대학교 산학협력단 | 효소반응을 이용한 크로신-4의 생산방법 |
| EP4151732A1 (en) * | 2021-09-15 | 2023-03-22 | Universidad de Castilla-La Mancha | Transgenic plants producing high levels of apocarotenoids compounds and uses thereof |
| CN117467633A (zh) * | 2022-07-28 | 2024-01-30 | 上海中医药大学 | Ugt71a3作为催化剂在制备三萜皂苷中的应用 |
| CN116083288B (zh) * | 2022-11-11 | 2025-02-18 | 泸州品创科技有限公司 | 产2,3-二氢-2,2,6-三甲基苯甲醛的肠膜明串珠菌及其应用 |
| KR20250075325A (ko) * | 2023-11-21 | 2025-05-28 | 아주대학교산학협력단 | 크로신 및 전구체 생산용 재조합 효모 |
| CN118546994B (zh) * | 2024-06-18 | 2025-01-28 | 华南农业大学 | 一种在种子胚乳生产藏红花素的转基因育种方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| DK0747483T3 (da) * | 1995-06-09 | 2004-06-28 | Dsm Ip Assets Bv | Fermentativ carotenoid-produktion |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| ATE242812T1 (de) * | 1996-12-02 | 2003-06-15 | Hoffmann La Roche | Verbesserte fermentative herstellung von carotenoide |
| DE19916140A1 (de) * | 1999-04-09 | 2000-10-12 | Basf Ag | Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten |
| PT1190068E (pt) | 1999-04-15 | 2006-06-30 | Calgene Llc | Sequencias de acidos nucleicos para proteinas envolvidas na sintese de tocoferol |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| EP1532265A2 (de) * | 2002-08-20 | 2005-05-25 | Sungene GmbH & Co. KGaA | Verfahren zur herstellung von ketocarotinoiden in genetisch veränderten organismen |
| JP2006500055A (ja) * | 2002-09-27 | 2006-01-05 | ディーエスエム アイピー アセッツ ビー．ブイ． | ファフィア属によるゼアキサンチンの製造方法 |
| EP1765418B1 (en) | 2004-05-21 | 2011-12-14 | The Regents of the University of California | Method for enhancing production of isoprenoid compounds |
| CN101321859A (zh) * | 2005-12-06 | 2008-12-10 | 东曹株式会社 | 新微生物和使用该微生物生产类胡萝卜素的方法 |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
-
2012
- 2012-08-07 HK HK14112719.9A patent/HK1199286A1/xx unknown
- 2012-08-07 WO PCT/IB2012/001513 patent/WO2013021261A2/en not_active Ceased
- 2012-08-07 RU RU2014109010A patent/RU2676730C2/ru not_active IP Right Cessation
- 2012-08-07 KR KR1020177037475A patent/KR101983115B1/ko not_active Expired - Fee Related
- 2012-08-07 JP JP2014524458A patent/JP6126597B2/ja active Active
- 2012-08-07 US US14/237,542 patent/US20140248668A1/en not_active Abandoned
- 2012-08-07 IN IN1129CHN2014 patent/IN2014CN01129A/en unknown
- 2012-08-07 EP EP12768896.8A patent/EP2742131B1/en not_active Not-in-force
- 2012-08-07 KR KR1020147006130A patent/KR101815063B1/ko not_active Expired - Fee Related
- 2012-08-07 CA CA2843549A patent/CA2843549A1/en not_active Abandoned
- 2012-08-07 CN CN201280038874.5A patent/CN103764818B/zh not_active Expired - Fee Related
- 2012-08-07 AU AU2012293402A patent/AU2012293402B2/en not_active Ceased
- 2012-08-07 BR BR112014002924A patent/BR112014002924A2/pt not_active Application Discontinuation
-
2017
- 2017-05-08 US US15/589,269 patent/US20170306376A1/en not_active Abandoned
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