JP2014521673A5 - - Google Patents
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- Publication number
- JP2014521673A5 JP2014521673A5 JP2014523281A JP2014523281A JP2014521673A5 JP 2014521673 A5 JP2014521673 A5 JP 2014521673A5 JP 2014523281 A JP2014523281 A JP 2014523281A JP 2014523281 A JP2014523281 A JP 2014523281A JP 2014521673 A5 JP2014521673 A5 JP 2014521673A5
- Authority
- JP
- Japan
- Prior art keywords
- dioxoisoindoline
- mmol
- cyclohexyl
- white solid
- ice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000012359 Methanesulfonyl chloride Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382263A EP2554544A1 (en) | 2011-08-01 | 2011-08-01 | Pyridin-2(1h)-one derivatives as jak inhibitors |
| EP11382263.9 | 2011-08-01 | ||
| US201161556948P | 2011-11-08 | 2011-11-08 | |
| US61/556,948 | 2011-11-08 | ||
| PCT/EP2012/064426 WO2013017461A1 (en) | 2011-08-01 | 2012-07-23 | Pyridin-2(1h)-one derivatives as jak inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014521673A JP2014521673A (ja) | 2014-08-28 |
| JP2014521673A5 true JP2014521673A5 (https=) | 2015-07-02 |
Family
ID=44512745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014523281A Pending JP2014521673A (ja) | 2011-08-01 | 2012-07-23 | Ｊａｋ阻害剤としてのピリジン−２（１ｈ）−オン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9034311B2 (https=) |
| EP (2) | EP2554544A1 (https=) |
| JP (1) | JP2014521673A (https=) |
| KR (1) | KR20140044865A (https=) |
| CN (1) | CN103702991A (https=) |
| AR (1) | AR087355A1 (https=) |
| AU (1) | AU2012292276A1 (https=) |
| BR (1) | BR112014002245A2 (https=) |
| CA (1) | CA2839805A1 (https=) |
| CL (1) | CL2014000203A1 (https=) |
| CO (1) | CO6852079A2 (https=) |
| CR (1) | CR20140031A (https=) |
| EA (1) | EA201400182A1 (https=) |
| GT (1) | GT201400017A (https=) |
| MX (1) | MX2014000635A (https=) |
| PE (1) | PE20141409A1 (https=) |
| PH (1) | PH12014500103A1 (https=) |
| UY (1) | UY34212A (https=) |
| WO (1) | WO2013017461A1 (https=) |
| ZA (1) | ZA201309187B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| HRP20220522T1 (hr) | 2014-08-04 | 2022-06-10 | Nuevolution A/S | Proizvoljno kondenzirani heterociklil-supstituirani derivati pirimidina koji su korisni za liječenje upalnih, metaboličkih, onkoloških i autoimunih bolesti |
| EP3206691B1 (en) * | 2014-10-14 | 2018-09-19 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
| EA202092441A1 (ru) | 2016-06-07 | 2021-05-21 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| EP3554485B9 (en) * | 2016-12-14 | 2023-09-27 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices |
| KR20240026521A (ko) | 2017-03-23 | 2024-02-28 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| AU2018337138B2 (en) | 2017-09-21 | 2021-04-01 | Beijing Scitech-Mq Pharmaceuticals Limited | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof |
| JP7167146B2 (ja) | 2017-11-06 | 2022-11-08 | ブリストル－マイヤーズ スクイブ カンパニー | Ｈｐｋ１阻害剤として有用なイソフラノン化合物 |
| CN110372664A (zh) * | 2018-04-13 | 2019-10-25 | 华东理工大学 | 选择性jak2抑制剂及其应用 |
| US12030875B2 (en) | 2018-09-07 | 2024-07-09 | PIC Therapeutics, Inc. | EIF4E inhibitors and uses thereof |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| US11685727B2 (en) | 2019-12-20 | 2023-06-27 | Nuevolution A/S | Compounds active towards nuclear receptors |
| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| AU2021230289A1 (en) | 2020-03-03 | 2022-09-29 | PIC Therapeutics, Inc. | eIF4E inhibitors and uses thereof |
| CA3174176A1 (en) | 2020-03-31 | 2021-10-07 | Sanne Schroder Glad | Compounds active towards nuclear receptors |
| EP4126874A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
| WO2021231798A1 (en) | 2020-05-13 | 2021-11-18 | Disc Medicine, Inc. | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| JP2024534127A (ja) | 2021-08-25 | 2024-09-18 | ピク セラピューティクス， インコーポレイテッド | ｅＩＦ４Ｅ阻害剤及びその使用 |
| US12157732B2 (en) | 2021-08-25 | 2024-12-03 | PIC Therapeutics, Inc. | eIF4E inhibitors and uses thereof |
| KR102503968B1 (ko) | 2022-09-22 | 2023-02-28 | 이진석 | 실꼬리 절단장치 및 그를 구비하는 양말 편직기 |
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| TWI372624B (en) | 2004-03-30 | 2012-09-21 | Vertex Pharma | Azaindoles useful as inhibitors of jak and other protein kinases |
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| WO2007049041A1 (en) * | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
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| CN101535276B (zh) * | 2006-10-23 | 2013-08-28 | 赛福伦公司 | 作为ALK和c-MET抑制剂的2,4-二氨基嘧啶稠合双环衍生物 |
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| UY32297A (es) | 2008-12-22 | 2010-05-31 | Almirall Sa | Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico |
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| PL2565193T3 (pl) * | 2009-01-23 | 2014-07-31 | Rigel Pharmaceuticals Inc | Kompozycje i sposoby hamowania szlaku JAK |
| JP5263304B2 (ja) * | 2009-02-06 | 2013-08-14 | 日本新薬株式会社 | アミノピラジン誘導体及び医薬 |
| UA109775C2 (xx) | 2009-10-29 | 2015-10-12 | N-вмісні гетероарильні похідні як інгібітори jak3-кінази | |
| EP2338888A1 (en) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
| UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| EP2397482A1 (en) | 2010-06-15 | 2011-12-21 | Almirall, S.A. | Heteroaryl imidazolone derivatives as jak inhibitors |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
-
2011
- 2011-08-01 EP EP11382263A patent/EP2554544A1/en not_active Withdrawn
-
2012
- 2012-07-23 PH PH1/2014/500103A patent/PH12014500103A1/en unknown
- 2012-07-23 US US14/236,340 patent/US9034311B2/en not_active Expired - Fee Related
- 2012-07-23 PE PE2014000084A patent/PE20141409A1/es not_active Application Discontinuation
- 2012-07-23 KR KR1020147001602A patent/KR20140044865A/ko not_active Withdrawn
- 2012-07-23 BR BR112014002245A patent/BR112014002245A2/pt not_active IP Right Cessation
- 2012-07-23 EP EP12737308.2A patent/EP2739616A1/en not_active Withdrawn
- 2012-07-23 JP JP2014523281A patent/JP2014521673A/ja active Pending
- 2012-07-23 UY UY0001034212A patent/UY34212A/es unknown
- 2012-07-23 MX MX2014000635A patent/MX2014000635A/es not_active Application Discontinuation
- 2012-07-23 WO PCT/EP2012/064426 patent/WO2013017461A1/en not_active Ceased
- 2012-07-23 CN CN201280036953.2A patent/CN103702991A/zh active Pending
- 2012-07-23 EA EA201400182A patent/EA201400182A1/ru unknown
- 2012-07-23 AU AU2012292276A patent/AU2012292276A1/en not_active Abandoned
- 2012-07-23 CA CA2839805A patent/CA2839805A1/en not_active Abandoned
- 2012-07-27 AR ARP120102737A patent/AR087355A1/es unknown
-
2013
- 2013-12-06 ZA ZA2013/09187A patent/ZA201309187B/en unknown
-
2014
- 2014-01-17 CO CO14008772A patent/CO6852079A2/es not_active Application Discontinuation
- 2014-01-22 CR CR20140031A patent/CR20140031A/es unknown
- 2014-01-27 CL CL2014000203A patent/CL2014000203A1/es unknown
- 2014-01-30 GT GT201400017A patent/GT201400017A/es unknown
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