CN103702991A - 用作jak抑制剂的吡啶-2(1h)-酮衍生物 - Google Patents

用作jak抑制剂的吡啶-2(1h)-酮衍生物 Download PDF

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Publication number
CN103702991A
CN103702991A CN201280036953.2A CN201280036953A CN103702991A CN 103702991 A CN103702991 A CN 103702991A CN 201280036953 A CN201280036953 A CN 201280036953A CN 103702991 A CN103702991 A CN 103702991A
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group
branched
cycloalkyl
alkyl
hydrogen atom
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P·R·伊斯特伍德
J·巴赫塔纳
L·M·帕格斯圣塔卡纳
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Almirall SA
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Almirall SA
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Epidemiology (AREA)
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  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280036953.2A 2011-08-01 2012-07-23 用作jak抑制剂的吡啶-2(1h)-酮衍生物 Pending CN103702991A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11382263A EP2554544A1 (en) 2011-08-01 2011-08-01 Pyridin-2(1h)-one derivatives as jak inhibitors
EP11382263.9 2011-08-01
US201161556948P 2011-11-08 2011-11-08
US61/556,948 2011-11-08
PCT/EP2012/064426 WO2013017461A1 (en) 2011-08-01 2012-07-23 Pyridin-2(1h)-one derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
CN103702991A true CN103702991A (zh) 2014-04-02

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CN201280036953.2A Pending CN103702991A (zh) 2011-08-01 2012-07-23 用作jak抑制剂的吡啶-2(1h)-酮衍生物

Country Status (20)

Country Link
US (1) US9034311B2 (https=)
EP (2) EP2554544A1 (https=)
JP (1) JP2014521673A (https=)
KR (1) KR20140044865A (https=)
CN (1) CN103702991A (https=)
AR (1) AR087355A1 (https=)
AU (1) AU2012292276A1 (https=)
BR (1) BR112014002245A2 (https=)
CA (1) CA2839805A1 (https=)
CL (1) CL2014000203A1 (https=)
CO (1) CO6852079A2 (https=)
CR (1) CR20140031A (https=)
EA (1) EA201400182A1 (https=)
GT (1) GT201400017A (https=)
MX (1) MX2014000635A (https=)
PE (1) PE20141409A1 (https=)
PH (1) PH12014500103A1 (https=)
UY (1) UY34212A (https=)
WO (1) WO2013017461A1 (https=)
ZA (1) ZA201309187B (https=)

Cited By (1)

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CN107735091A (zh) * 2015-06-22 2018-02-23 爱维斯健有限公司 包含伊马替尼作为活性成分的用于预防和治疗干眼病的药物组合物

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EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
CR20170077A (es) 2014-08-04 2017-06-26 Nuevolution As Derivados de heterociclilo opcionalmente condensados de pirimidina útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
WO2016060963A1 (en) * 2014-10-14 2016-04-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
MX388576B (es) 2016-06-07 2025-03-20 Jacobio Pharmaceuticals Co Ltd Derivados heterociclicos novedosos utiles como inhibidores de shp2.
JP2020502126A (ja) * 2016-12-14 2020-01-23 プロジェニティ， インコーポレイテッド 消化管疾病のｊａｋ阻害薬による治療
EA202190196A1 (ru) 2017-03-23 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
JP7117029B2 (ja) * 2017-09-21 2022-08-12 北京賽特明強医薬科技有限公司 ２－置換ピラゾールアミノ－４－置換アミノ－５－ピリミジンホルムアミド系化合物、組成物およびその使用
EP3707138B1 (en) 2017-11-06 2022-07-13 Bristol-Myers Squibb Company Isofuranone compounds useful as hpk1 inhibitors
CN110372664A (zh) * 2018-04-13 2019-10-25 华东理工大学 选择性jak2抑制剂及其应用
WO2020051424A1 (en) 2018-09-07 2020-03-12 Pic Therapeutics Eif4e inhibitors and uses thereof
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
UY38994A (es) 2019-12-20 2021-07-30 Nuevolution As Compuestos activos frente a receptores nucleares
TW202146393A (zh) 2020-03-03 2021-12-16 美商皮克醫療公司 Eif4e抑制劑及其用途
AU2021245397A1 (en) 2020-03-31 2022-10-20 Nuevolution A/S Compounds active towards nuclear receptors
WO2021198956A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
CA3229560A1 (en) 2021-08-25 2023-03-02 Christopher L. Vandeusen Eif4e inhibitors and uses thereof
KR102503968B1 (ko) 2022-09-22 2023-02-28 이진석 실꼬리 절단장치 및 그를 구비하는 양말 편직기

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WO2010085684A1 (en) * 2009-01-23 2010-07-29 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2010090290A1 (ja) * 2009-02-06 2010-08-12 日本新薬株式会社 アミノピラジン誘導体及び医薬

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