JP2014520810A5 - - Google Patents
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- Publication number
- JP2014520810A5 JP2014520810A5 JP2014519138A JP2014519138A JP2014520810A5 JP 2014520810 A5 JP2014520810 A5 JP 2014520810A5 JP 2014519138 A JP2014519138 A JP 2014519138A JP 2014519138 A JP2014519138 A JP 2014519138A JP 2014520810 A5 JP2014520810 A5 JP 2014520810A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pain
- neuralgia
- aryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 208000004296 neuralgia Diseases 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000001931 aliphatic group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 206010029240 Neuritis Diseases 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 208000000094 Chronic Pain Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 206010019233 Headaches Diseases 0.000 claims 3
- 208000005298 acute pain Diseases 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010054048 Postoperative ileus Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000010247 contact dermatitis Diseases 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010003399 Arthropod bite Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010007882 Cellulitis Diseases 0.000 claims 1
- 206010008334 Cervicobrachial syndrome Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010063057 Cystitis noninfective Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 208000004232 Enteritis Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000021965 Glossopharyngeal Nerve disease Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 208000035154 Hyperesthesia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- 206010049949 Intercostal neuralgia Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000002472 Morton Neuroma Diseases 0.000 claims 1
- 208000020059 Morton neuralgia Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 1
- 206010029279 Neurogenic bladder Diseases 0.000 claims 1
- 206010060860 Neurological symptom Diseases 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010068106 Occipital neuralgia Diseases 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 208000026251 Opioid-Related disease Diseases 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
- 206010068319 Oropharyngeal pain Diseases 0.000 claims 1
- 206010034464 Periarthritis Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 206010036105 Polyneuropathy Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- 206010038678 Respiratory depression Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 206010040744 Sinus headache Diseases 0.000 claims 1
- 208000004078 Snake Bites Diseases 0.000 claims 1
- 208000026137 Soft tissue injury Diseases 0.000 claims 1
- 208000003589 Spider Bites Diseases 0.000 claims 1
- 206010042496 Sunburn Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000009692 acute damage Effects 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 201000001352 cholecystitis Diseases 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 201000006145 cocaine dependence Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 208000012790 cranial neuralgia Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 201000005442 glossopharyngeal neuralgia Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 208000008384 ileus Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 210000003127 knee Anatomy 0.000 claims 1
- 208000037805 labour Diseases 0.000 claims 1
- 230000001617 migratory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002756 mu opiate receptor agonist Substances 0.000 claims 1
- 239000002623 mu opiate receptor antagonist Substances 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000009985 neuronitis Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000005040 opiate dependence Diseases 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 208000019629 polyneuritis Diseases 0.000 claims 1
- 208000037821 progressive disease Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000001738 temporomandibular joint Anatomy 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502721P | 2011-06-29 | 2011-06-29 | |
| US61/502,721 | 2011-06-29 | ||
| PCT/US2012/044928 WO2013003720A1 (en) | 2011-06-29 | 2012-06-29 | Peripherally acting opioid compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520810A JP2014520810A (ja) | 2014-08-25 |
| JP2014520810A5 true JP2014520810A5 (https=) | 2015-08-27 |
| JP5981992B2 JP5981992B2 (ja) | 2016-08-31 |
Family
ID=47391264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519138A Expired - Fee Related JP5981992B2 (ja) | 2011-06-29 | 2012-06-29 | 末梢作用オピオイド化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8962646B2 (https=) |
| EP (1) | EP2725908B1 (https=) |
| JP (1) | JP5981992B2 (https=) |
| AU (1) | AU2012275181B2 (https=) |
| CA (1) | CA2840643C (https=) |
| DK (1) | DK2725908T3 (https=) |
| ES (1) | ES2638329T3 (https=) |
| HR (1) | HRP20171251T1 (https=) |
| HU (1) | HUE034326T2 (https=) |
| LT (1) | LT2725908T (https=) |
| PL (1) | PL2725908T3 (https=) |
| PT (1) | PT2725908T (https=) |
| RS (1) | RS56181B1 (https=) |
| SI (1) | SI2725908T1 (https=) |
| SM (1) | SMT201700400T1 (https=) |
| WO (1) | WO2013003720A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201700400T1 (it) * | 2011-06-29 | 2017-09-07 | Alkermes Inc | Composti oppioidi ad azione periferica |
| WO2015066443A1 (en) * | 2013-11-01 | 2015-05-07 | Mallinckrodt Llc | Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones |
| CA2950567A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| MA40171A (fr) * | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| CA3124115A1 (en) | 2019-01-04 | 2020-07-09 | Aether Therapeutics Inc. | Method for treating drug or alcohol dependency |
| CN113950486A (zh) | 2019-01-28 | 2022-01-18 | 罗德岛大学理事会 | pHLIP®-介导的免疫刺激化合物的细胞内递送 |
| PH12022553378A1 (en) | 2020-06-10 | 2024-03-25 | Univ Leuven Kath | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES252980A1 (es) | 1958-10-30 | 1960-11-01 | Boehringer Sohn Ingelheim | Procedimiento para la obtencion de nuevas sales cuaternarias, terapéuticamente valiosas, de la normorfina y de sus derivados |
| CH581624A5 (https=) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| US4032529A (en) | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| FR2514644A1 (fr) | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
| US4374139A (en) | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US4929622A (en) | 1987-09-24 | 1990-05-29 | Hoechst-Roussel Pharmaceuticals, Inc. | 2,6-Methanopyrrolo-3-benzazocines |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| EP0632041A1 (en) | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| BR9707136A (pt) | 1996-01-10 | 1999-08-31 | Smithkline Beecham Spa | Derivados morfinóides condesados em heterociclo (ii) |
| ES2121553B1 (es) | 1996-12-23 | 1999-06-16 | Univ Santiago Compostela | Nuevos endoperoxidos morfinicos funcionalizados en posiciones c-6 y c-14 del anillo c y procedimiento para su obtencion. |
| GB9709972D0 (en) | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| WO2001012197A1 (en) | 1999-08-13 | 2001-02-22 | Southern Research Institute | Pyridomorphinans, thienomoprhinans and use thereof |
| ES2278647T3 (es) | 1999-11-29 | 2007-08-16 | Adolor Corporation | Nuevos procedimientos y composiciones que comprenden opioides y antagonistas de opioides. |
| JP4340437B2 (ja) * | 2000-10-31 | 2009-10-07 | レンセラール ポリテクニック インスティチュート | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| DE60302157T2 (de) | 2002-05-30 | 2006-07-27 | Eli Lilly And Co., Indianapolis | Opioidrezeptorantagonisten |
| DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| AU2003281060A1 (en) | 2002-07-16 | 2004-02-02 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| JP4202319B2 (ja) | 2002-07-29 | 2008-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ベンゾジオキソール |
| WO2004045562A2 (en) | 2002-11-18 | 2004-06-03 | The Mclean Hospital Corporation | Mixed kappa/mu opioids and uses thereof |
| US20080009478A1 (en) | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
| WO2007030089A1 (en) | 2004-08-05 | 2007-03-15 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| US20060063792A1 (en) | 2004-09-17 | 2006-03-23 | Adolor Corporation | Substituted morphinans and methods of their use |
| PT2251330E (pt) | 2004-11-05 | 2012-07-20 | Rensselaer Polytech Inst | 4-hidroxibenzomorfanos |
| EA011674B1 (ru) | 2004-12-22 | 2009-04-28 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| JP2008543866A (ja) | 2005-06-16 | 2008-12-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式オピオイドモジュレーター |
| WO2007014137A2 (en) | 2005-07-21 | 2007-02-01 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents |
| US8163701B2 (en) | 2005-08-19 | 2012-04-24 | Signature Therapeutics, Inc. | Prodrugs of active agents |
| US20100130512A1 (en) | 2007-05-16 | 2010-05-27 | Rensselaer Polytechnic Institute | Fused-ring heterocycle opioids |
| AU2008286979B2 (en) * | 2007-08-09 | 2013-03-28 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
| CA2731429C (en) * | 2008-07-21 | 2016-12-13 | Mark P. Wentland | Large substituent, non-phenolic amine opioids |
| CN101646168B (zh) * | 2009-08-24 | 2012-01-25 | 华为终端有限公司 | 数据加密方法、解密方法及移动终端 |
| AU2011232628B2 (en) * | 2010-03-22 | 2015-04-09 | Rensselaer Polytechnic Institute | Morphinane derivatives containing a carboxamide group as opioid receptor ligands |
| SMT201700400T1 (it) * | 2011-06-29 | 2017-09-07 | Alkermes Inc | Composti oppioidi ad azione periferica |
-
2012
- 2012-06-29 SM SM20170400T patent/SMT201700400T1/it unknown
- 2012-06-29 RS RS20170823A patent/RS56181B1/sr unknown
- 2012-06-29 ES ES12805087.9T patent/ES2638329T3/es active Active
- 2012-06-29 WO PCT/US2012/044928 patent/WO2013003720A1/en not_active Ceased
- 2012-06-29 AU AU2012275181A patent/AU2012275181B2/en not_active Ceased
- 2012-06-29 US US13/537,544 patent/US8962646B2/en active Active
- 2012-06-29 CA CA2840643A patent/CA2840643C/en not_active Expired - Fee Related
- 2012-06-29 PT PT128050879T patent/PT2725908T/pt unknown
- 2012-06-29 DK DK12805087.9T patent/DK2725908T3/en active
- 2012-06-29 EP EP12805087.9A patent/EP2725908B1/en active Active
- 2012-06-29 SI SI201231033T patent/SI2725908T1/sl unknown
- 2012-06-29 JP JP2014519138A patent/JP5981992B2/ja not_active Expired - Fee Related
- 2012-06-29 HU HUE12805087A patent/HUE034326T2/en unknown
- 2012-06-29 HR HRP20171251TT patent/HRP20171251T1/hr unknown
- 2012-06-29 PL PL12805087T patent/PL2725908T3/pl unknown
- 2012-06-29 LT LTEP12805087.9T patent/LT2725908T/lt unknown
-
2015
- 2015-01-16 US US14/598,678 patent/US9415045B2/en not_active Expired - Fee Related
-
2016
- 2016-07-12 US US15/207,731 patent/US9775840B2/en not_active Expired - Fee Related
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