JP2014520140A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014520140A5 JP2014520140A5 JP2014516459A JP2014516459A JP2014520140A5 JP 2014520140 A5 JP2014520140 A5 JP 2014520140A5 JP 2014516459 A JP2014516459 A JP 2014516459A JP 2014516459 A JP2014516459 A JP 2014516459A JP 2014520140 A5 JP2014520140 A5 JP 2014520140A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- compound
- hydrogen
- compound according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(CN(C1)[C@](C[C@]2c3c(*)c(*)c(*)c(*)c3*)c3c2ccc(Cl)c3)N(C(*)(*)*)C1(*)I Chemical compound CC(C)(CN(C1)[C@](C[C@]2c3c(*)c(*)c(*)c(*)c3*)c3c2ccc(Cl)c3)N(C(*)(*)*)C1(*)I 0.000 description 6
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498651P | 2011-06-20 | 2011-06-20 | |
| US61/498,651 | 2011-06-20 | ||
| US201161537103P | 2011-09-21 | 2011-09-21 | |
| US61/537,103 | 2011-09-21 | ||
| PCT/IB2012/001386 WO2012176066A1 (en) | 2011-06-20 | 2012-06-19 | Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520140A JP2014520140A (ja) | 2014-08-21 |
| JP2014520140A5 true JP2014520140A5 (https=) | 2014-10-02 |
| JP5668177B2 JP5668177B2 (ja) | 2015-02-12 |
Family
ID=46682855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516459A Active JP5668177B2 (ja) | 2011-06-20 | 2012-06-19 | 統合失調症の治療のための重水素化１−ピペラジノ−３−フェニルインダン |
Country Status (40)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3135656T3 (pl) | 2011-06-20 | 2019-07-31 | H. Lundbeck A/S | Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii |
| AR094054A1 (es) * | 2012-12-19 | 2015-07-08 | H Lundbeck As | 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma |
| PT3679018T (pt) | 2017-09-07 | 2022-04-05 | Otsuka Pharma Co Ltd | Processo industrial de monoalquilação de um nitrogénio de piperidina em derivados de piperidina com alquilo deuterado |
| EP3873885A1 (en) * | 2018-10-29 | 2021-09-08 | H. Lundbeck A/S | Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts |
| EP3891134A1 (en) | 2018-12-03 | 2021-10-13 | H. Lundbeck A/S | Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine |
| EP3897507A4 (en) * | 2018-12-21 | 2022-09-14 | Terran Biosciences, Inc. | DEUTERED FORMS AND DERIVATIVES OF VOLINANSERIN |
| JP7455810B2 (ja) * | 2019-03-13 | 2024-03-26 | 大塚製薬株式会社 | 二級アミンを含有する化合物のアミン部分に重水素低級アルキルを導入する方法 |
| CN117164518A (zh) * | 2022-05-26 | 2023-12-05 | 四川大学 | 一种制备氘代咪唑类化合物的方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50867B1 (en) * | 1980-02-29 | 1986-08-06 | Kefalas As | Indane derivatives |
| GB8427125D0 (en) | 1984-10-26 | 1984-12-05 | Lundbeck & Co As H | Organic compounds |
| EP0216785B1 (en) | 1984-12-04 | 1991-01-30 | Sandoz Ag | Indene analogs of mevalonolactone and derivatives thereof |
| DK286990D0 (da) | 1990-12-04 | 1990-12-04 | Lundbeck & Co As H | Indanderivater |
| DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CN1087725C (zh) * | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| WO1999015524A1 (en) | 1997-09-23 | 1999-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| SE9904850D0 (sv) | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| RS53369B (sr) * | 2003-08-18 | 2014-10-31 | H.Lundbeck A/S | Sukcinat i malonat soli trans-4-((1r,3s)-6-hloro-3- fenilindan-1-il)-1,2,2-trimetilpiperazin i njihova upotreba kao medikamenta |
| BRPI0413595B8 (pt) | 2003-08-18 | 2021-05-25 | H Lundbeck As | sal de malonato, composição farmacêutica, uso de um sal de malonato, e, método de fabricação de um composto |
| JP2008501749A (ja) | 2004-06-08 | 2008-01-24 | ニューロサーチ スウェーデン アクチボラゲット | ドーパミン及びセロトニン神経伝達のモジュレーターとしての新規なジ置換フェニルピペリジン |
| RU2366654C2 (ru) | 2004-06-08 | 2009-09-10 | ЭнЭсЭйБи, ФИЛИАЛ АФ НЕУРОСЕРЧ СВИДЕН АБ, СВЕРИЙЕ | Новые дизамещенные фенилпиперидины/пиперазины в качестве модуляторов допаминовой нейротрансмиссии |
| TWI376373B (en) | 2005-02-16 | 2012-11-11 | Lundbeck & Co As H | Crystalline base of a pharmaceutical compound |
| TWI453198B (zh) | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
| US20080269248A1 (en) | 2005-02-16 | 2008-10-30 | H. Lundbeck A/S | Tartrate and Malate Salts of Trans-1-((1R,3S)-6-Chloro-3-Phenylindan-1-Yl)-3,3-Dimethylpiperazine |
| CA2616383C (en) | 2005-07-29 | 2015-06-09 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| US7863274B2 (en) | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
| HUE027865T2 (en) | 2005-12-01 | 2016-11-28 | Auspex Pharmaceuticals Inc | Substituted phenyl ethylamines with serotonergic and / or norepinephrine activity |
| JP4986462B2 (ja) | 2006-01-27 | 2012-07-25 | シャープ株式会社 | 太陽電池ストリングおよびその製造方法、ならびに、その太陽電池ストリングを用いる太陽電池モジュール |
| TW200819426A (en) | 2006-08-31 | 2008-05-01 | Lundbeck & Co As H | Novel indane compounds |
| WO2008086158A1 (en) | 2007-01-04 | 2008-07-17 | Smithkline Beecham Corporation | Benzodihydroquinazoline as pi3 kinase inhibitors |
| US8198305B2 (en) | 2007-04-13 | 2012-06-12 | Concert Pharmaceuticals Inc. | 1,2-benzisoxazol-3-yl compounds |
| JP2010524972A (ja) | 2007-04-19 | 2010-07-22 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化したモルホリニル化合物 |
| EP1997479A1 (en) | 2007-05-31 | 2008-12-03 | Helm AG | Stabilized amorphous candesartan cilexetil compositions for oral administration |
| AR066972A1 (es) | 2007-06-12 | 2009-09-23 | Concert Pharmaceuticals Inc | Derivados azapeptidicos |
| US20090062303A1 (en) | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched ziprasidone |
| EA018927B1 (ru) | 2008-05-07 | 2013-11-29 | Х. Лундбекк А/С | Способ лечения когнитивного расстройства, ассоциированного с шизофренией |
| AU2009298264A1 (en) | 2008-10-03 | 2010-04-08 | H. Lundbeck A/S | Oral formulation |
| US20120071554A1 (en) | 2008-10-28 | 2012-03-22 | Liu Julie F | Deuterated 2-propylpentanoic acid compounds |
| US8778401B2 (en) | 2008-10-28 | 2014-07-15 | Agency For Science, Technology And Research | Mesoporous material excipients for poorly aqueous soluble ingredients |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| TW201102370A (en) | 2009-07-07 | 2011-01-16 | Lundbeck & Co As H | Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine |
| US8557994B2 (en) | 2009-07-27 | 2013-10-15 | Daljit Singh Dhanoa | Deuterium-enriched pyridinonecarboxamides and derivatives |
| US8658236B2 (en) * | 2009-08-21 | 2014-02-25 | Deuteria Beverages, Llc | Alcoholic compositions having a lowered risk of acetaldehydemia |
| KR101149529B1 (ko) | 2009-09-11 | 2012-05-25 | 한국화학연구원 | 인덴온 유도체 및 이를 포함하는 약학적 조성물 |
| CN102020522A (zh) * | 2009-09-21 | 2011-04-20 | 陈松源 | 氘代药物的制备方法和应用 |
| US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
| WO2011059080A1 (ja) * | 2009-11-16 | 2011-05-19 | 第一三共株式会社 | 同位体置換されたジアミン誘導体 |
| WO2011084846A1 (en) | 2010-01-07 | 2011-07-14 | Alkermes, Inc. | Quaternary ammonium salt prodrugs |
| EP2639216B1 (en) | 2010-11-09 | 2018-07-11 | Kaneka Corporation | Halogenated indenones and method for producing optically active indanones or optically active indanols by using same |
| JP2014501771A (ja) | 2011-01-07 | 2014-01-23 | ハー・ルンドベック・アクチエゼルスカベット | ４−（（１ｒ，３ｓ）−６−クロロ−３−フェニル−インダン−１−イル）−１，２，２−トリメチル−ピペラジンと１−（（１ｒ，３ｓ）−６−クロロ−３−フェニル−インダン，１−イル）−３，３−ジメチル−ピペラジンとを分割するための方法 |
| WO2012137225A1 (en) | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
| PL3135656T3 (pl) | 2011-06-20 | 2019-07-31 | H. Lundbeck A/S | Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii |
| US9487500B2 (en) | 2012-10-04 | 2016-11-08 | Inhibikase Therapeutics, Inc. | Compounds and compositions thereof |
| AR094054A1 (es) | 2012-12-19 | 2015-07-08 | H Lundbeck As | 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma |
-
2012
- 2012-06-19 PL PL16179882T patent/PL3135656T3/pl unknown
- 2012-06-19 JO JOP/2012/0161A patent/JO3128B1/ar active
- 2012-06-19 DK DK12748046.5T patent/DK2720989T3/en active
- 2012-06-19 PH PH1/2013/502598A patent/PH12013502598A1/en unknown
- 2012-06-19 LT LTEP16179882.2T patent/LT3135656T/lt unknown
- 2012-06-19 KR KR1020137033717A patent/KR101879474B1/ko active Active
- 2012-06-19 MX MX2013014849A patent/MX339552B/es active IP Right Grant
- 2012-06-19 RS RS20160916A patent/RS55304B1/sr unknown
- 2012-06-19 EP EP19151618.6A patent/EP3508468B1/en active Active
- 2012-06-19 US US13/527,364 patent/US8575174B2/en active Active
- 2012-06-19 ES ES12748046.5T patent/ES2601213T3/es active Active
- 2012-06-19 ME MEP-2019-93A patent/ME03375B/me unknown
- 2012-06-19 AU AU2012273657A patent/AU2012273657B2/en active Active
- 2012-06-19 PE PE2013002857A patent/PE20141113A1/es not_active Application Discontinuation
- 2012-06-19 KR KR1020187018343A patent/KR101939546B1/ko active Active
- 2012-06-19 RS RS20190429A patent/RS58546B1/sr unknown
- 2012-06-19 EA EA201490045A patent/EA024651B1/ru not_active IP Right Cessation
- 2012-06-19 SM SM20190179T patent/SMT201900179T1/it unknown
- 2012-06-19 MY MYPI2021002383A patent/MY196998A/en unknown
- 2012-06-19 ME MEP-2016-226A patent/ME02513B/me unknown
- 2012-06-19 EP EP12748046.5A patent/EP2720989B1/en active Active
- 2012-06-19 HU HUE16179882A patent/HUE044043T2/hu unknown
- 2012-06-19 CN CN201280029731.8A patent/CN103649019B/zh active Active
- 2012-06-19 PT PT127480465T patent/PT2720989T/pt unknown
- 2012-06-19 AP AP2013007338A patent/AP3310A/xx active
- 2012-06-19 SI SI201230744A patent/SI2720989T1/sl unknown
- 2012-06-19 CA CA2837820A patent/CA2837820C/en active Active
- 2012-06-19 JP JP2014516459A patent/JP5668177B2/ja active Active
- 2012-06-19 EP EP16179882.2A patent/EP3135656B1/en active Active
- 2012-06-19 HR HRP20161348TT patent/HRP20161348T1/hr unknown
- 2012-06-19 AR ARP120102179 patent/AR086987A1/es active IP Right Grant
- 2012-06-19 ES ES19151618T patent/ES2939477T3/es active Active
- 2012-06-19 DK DK16179882.2T patent/DK3135656T3/en active
- 2012-06-19 PL PL12748046T patent/PL2720989T3/pl unknown
- 2012-06-19 ES ES16179882T patent/ES2719145T3/es active Active
- 2012-06-19 EP EP23150855.7A patent/EP4215512A1/en active Pending
- 2012-06-19 GE GEAP201213350A patent/GEP201706655B/en unknown
- 2012-06-19 LT LTEP12748046.5T patent/LT2720989T/lt unknown
- 2012-06-19 HU HUE12748046A patent/HUE030883T2/en unknown
- 2012-06-19 MD MDA20140004A patent/MD4538C1/ro active IP Right Grant
- 2012-06-19 PT PT16179882T patent/PT3135656T/pt unknown
- 2012-06-19 SI SI201231582T patent/SI3135656T1/sl unknown
- 2012-06-19 BR BR112013031702-7A patent/BR112013031702B1/pt not_active IP Right Cessation
- 2012-06-19 WO PCT/IB2012/001386 patent/WO2012176066A1/en not_active Ceased
- 2012-06-19 PE PE2015000596A patent/PE20150928A1/es active IP Right Grant
- 2012-06-20 TW TW101122028A patent/TWI627956B/zh active
- 2012-06-20 TW TW107113541A patent/TWI659741B/zh active
- 2012-06-20 TW TW106107563A patent/TWI614234B/zh active
-
2013
- 2013-06-24 US US13/924,849 patent/US9012453B2/en active Active
- 2013-11-26 IL IL229640A patent/IL229640B/en active IP Right Grant
- 2013-12-09 GT GT201300304A patent/GT201300304A/es unknown
- 2013-12-13 CR CR20130654A patent/CR20130654A/es unknown
- 2013-12-16 DO DO2013000305A patent/DOP2013000305A/es unknown
- 2013-12-19 CL CL2013003646A patent/CL2013003646A1/es unknown
- 2013-12-19 CO CO13296680A patent/CO6821965A2/es active IP Right Grant
-
2014
- 2014-01-16 MA MA36688A patent/MA35268B1/fr unknown
- 2014-01-17 EC ECSP14013155 patent/ECSP14013155A/es unknown
-
2015
- 2015-03-13 US US14/656,925 patent/US9216961B2/en active Active
- 2015-11-16 US US14/941,800 patent/US9617231B2/en active Active
-
2016
- 2016-10-26 CY CY20161101089T patent/CY1118158T1/el unknown
- 2016-10-26 SM SM201600383T patent/SMT201600383B/it unknown
-
2017
- 2017-02-17 US US15/435,826 patent/US10118907B2/en active Active
-
2018
- 2018-09-28 US US16/146,625 patent/US10501427B2/en active Active
-
2019
- 2019-03-27 HR HRP20190593TT patent/HRP20190593T1/hr unknown
- 2019-04-02 CY CY20191100368T patent/CY1121514T1/el unknown
- 2019-11-04 US US16/672,870 patent/US11059798B2/en active Active
-
2021
- 2021-06-07 US US17/340,201 patent/US12116355B2/en active Active
-
2024
- 2024-09-11 US US18/882,308 patent/US20250250244A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014520140A5 (https=) | ||
| CN113906013B (zh) | 吡啶氮氧化合物及其制备方法和用途 | |
| JP6505023B2 (ja) | Ｃｎｓおよび他の障害を治療するための、ｐｄｅ４アイソザイムの阻害薬としてのアザベンゾイミダゾール化合物 | |
| JP2009542613A5 (https=) | ||
| PH12018550049A1 (en) | Protein kinase inhibitor, preparation method and medical use thereof | |
| JP2012530779A5 (https=) | ||
| JP2013506670A5 (https=) | ||
| IL255433B2 (en) | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine | |
| CN103249697A (zh) | 适用作多巴胺能稳定剂的普利多匹定(pridopidine)氘化类似物 | |
| JP2014517050A5 (https=) | ||
| JP2014526469A5 (https=) | ||
| JP2005539012A5 (https=) | ||
| JP2014515351A5 (https=) | ||
| JP6236077B2 (ja) | 持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質 | |
| CA2637765A1 (en) | Benzamide and heteroarene derivatives | |
| JP2015509534A5 (https=) | ||
| JP2013536825A5 (https=) | ||
| EP3587394B1 (en) | Aminocarbonylcarbamate compounds and their use in the treatment of hyperkinetic disorders such as adhd | |
| EP3419979B1 (en) | 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | |
| EP3402796B1 (en) | 6,7,8,9-tetrahydro-5h-pyrido[2,3-d]azepine dopamine d3 ligands | |
| CA2890952A1 (en) | Trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-n,n-dimethylcarbamoyl-cyclohexyl amine for treating negative symptoms of schizophrenia | |
| JP2021504326A5 (https=) | ||
| JP2017503753A5 (https=) | ||
| JP2013536853A5 (https=) | ||
| RU2015104056A (ru) | Ингибиторы фермента фосфодиэстеразы 10 |