JP2014519935A - バルブ機構 - Google Patents
バルブ機構 Download PDFInfo
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- JP2014519935A JP2014519935A JP2014516335A JP2014516335A JP2014519935A JP 2014519935 A JP2014519935 A JP 2014519935A JP 2014516335 A JP2014516335 A JP 2014516335A JP 2014516335 A JP2014516335 A JP 2014516335A JP 2014519935 A JP2014519935 A JP 2014519935A
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Abstract
Description
a.メイン外部ボディ210
b.第一の内部ボディ220
c.第二の内部ボディ230
d.第一の穿孔針240
e.第二の穿孔針250
f.バルブシール260
g.セプタム270
を含む
ここで一つの実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、酵素、抗体、若しくはこのフラグメント、ホルモン、若しくはオリゴヌクレオチド、又は上記の薬学的に活性な化合物の混合物であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの治療、及び/又は、予防に有用であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の治療、及び/又は、予防のための、少なくとも1つのペプチドを含み、
ここで、更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセンジン−3又はエキセンジン−4、若しくはエキセンジン−3又はエキセンジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と連結してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれかのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
集),Mark Publishing社,Easton, Pa., U.S.A., 1985 及び Encyclopedia of Pharmaceutical Technologyに記載されている。
Claims (14)
- −少なくとも2つの開口部(304,306)を含むチャンネル(302)、
−少なくとも1つの封止領域(308)を含むバルブエレメント(300、300’)、を含んでなる医療デバイス(10,200,400)であって、
−ここで、該バルブエレメント(300,300’)は、少なくとも一部可撓性であり、
−ここで、該バルブエレメント(300,300’)は、閉状態を有するように構成され、ここで、該バルブエレメント(300,300’)の該封止領域(308)が、上記チャンネル(302)の上記開口部(304,306)の1つを封止し、
−ここで、該バルブエレメント(300,300’)は更に、該バルブエレメント(300,300’)が、上記チャンネル(302)内部の媒体(312)の圧力によって開状態にすることができ、そして該媒体(312)が、該バルブエレメント(300,300’)と該チャンネル(302)の間を該チャンネル(302)から流出できるように、該開状態を有するように構成され、そして、
−ここで、該バルブエレメント(300,300’)は、少なくとも部分的に金属で作られる、上記医療デバイス(10,200,400)。 - 前記バルブエレメント(300,300’)の封止領域(308)は、前記閉状態にあるとき、前記チャンネル(302)との直接接触によって該チャンネル(302)の開口部(306)を封止する、請求項1に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)の前記封止領域(308)は、前記チャンネル(302)内部の前記媒体(312)の圧力によって、該チャンネル(302)の軸方向に曲げられ、そして該チャンネル(302)から離れることができる、請求項1又は2に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、少なくとも部分的にチタン又は鋼で作られる、請求項1〜3のいずれかに1項に記載の医療デバイス(10,200,400)。
- 前記チャンネル(302)は少なくとも一部、金属、特にチタン又は鋼で作られる、請求項1〜4のいずれか1項に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、実質的に平坦である、請求項1〜5のいずれか1項に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、その閉状態において、前記チャンネル(302)の方向に湾曲している、請求項1〜6のいずれか1項に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、前記媒体(312)の圧力が閾値未満に低下する場合に、該バルブエレメント(300,300’)が前記閉状態に戻るようにプレストレスが与えられる、請求項1〜7のいずれか1項に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、その開閉中にヒステリシスを示す、請求項1〜8のいずれか1項に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、前記媒体(302)中の圧力が低下した場合でも、前記開状態を実質的に保持するように構成される、請求項9に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、前記媒体(312)中の圧力が第二の閾値より下に低下した場合に、前記開状態から前記閉状態にスイッチバックするように構成される、請求項9又は10項に記載の医療デバイス(10,200,400)。
- 前記バルブエレメント(300,300’)は、その閉位置で凸形状を有し、そしてその開位置では凹形状を有する、請求項1〜11のいずれか1項に記載の医療デバイス(10,200,400)。
- 前記媒体(312)は、気体又は流体、特に薬剤である、請求項1〜12のいずれか1項に記載の医療デバイス(10,200,400)。
- 該医療デバイス(10,200,400)が、薬物送達デバイス(10)、薬物送達デバイス(10)用の投薬インターフェース(200)又はニードルハブ(400)である、請求項1〜12のいずれか1項に記載の医療デバイス(10,200,400)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11170898.8 | 2011-06-22 | ||
EP11170898 | 2011-06-22 | ||
PCT/EP2012/061915 WO2012175588A1 (en) | 2011-06-22 | 2012-06-21 | Valve Mechanism |
Publications (1)
Publication Number | Publication Date |
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JP2014519935A true JP2014519935A (ja) | 2014-08-21 |
Family
ID=45498186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2014516335A Ceased JP2014519935A (ja) | 2011-06-22 | 2012-06-21 | バルブ機構 |
Country Status (5)
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US (1) | US20140137966A1 (ja) |
EP (1) | EP2723425A1 (ja) |
JP (1) | JP2014519935A (ja) |
CN (1) | CN103747823A (ja) |
WO (1) | WO2012175588A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102014103508B4 (de) * | 2014-03-14 | 2019-04-18 | Fresenius Medical Care Deutschland Gmbh | Vorgespanntes Ventil für medizinische Funktionsvorrichtung, und medizinische Funktionsvorrichtung |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6075771U (ja) * | 1983-10-28 | 1985-05-27 | 株式会社 京浜精機製作所 | リ−ドバルブ |
JPH0550261U (ja) * | 1991-12-09 | 1993-07-02 | 日立金属株式会社 | 逆止弁 |
JPH10511014A (ja) * | 1994-11-02 | 1998-10-27 | エリー リリー アンド カンパニー | 注入装置用マニホルド |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5147323A (en) * | 1991-03-08 | 1992-09-15 | Habley Medical Technology Corporation | Multiple cartridge syringe |
CA2097709C (en) * | 1990-12-14 | 1998-12-15 | William H. Smedley | Variable proportion dispenser |
US5199949A (en) * | 1991-03-08 | 1993-04-06 | Habley Medical Technology Corp. | Multiple pharmaceutical syringe |
US5423752A (en) * | 1992-07-31 | 1995-06-13 | Habley Medical Technology Corporation | Variable proportion dispenser with cartridge replacement assembly |
ZA941881B (en) * | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
EP1683533B1 (en) * | 2003-11-04 | 2013-03-20 | Terumo Kabushiki Kaisha | Connector |
CN100392245C (zh) * | 2006-01-27 | 2008-06-04 | 吉林大学 | 集成式精密药物输送泵 |
-
2012
- 2012-06-21 US US14/128,023 patent/US20140137966A1/en not_active Abandoned
- 2012-06-21 JP JP2014516335A patent/JP2014519935A/ja not_active Ceased
- 2012-06-21 EP EP12729576.4A patent/EP2723425A1/en not_active Withdrawn
- 2012-06-21 CN CN201280041100.8A patent/CN103747823A/zh active Pending
- 2012-06-21 WO PCT/EP2012/061915 patent/WO2012175588A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6075771U (ja) * | 1983-10-28 | 1985-05-27 | 株式会社 京浜精機製作所 | リ−ドバルブ |
JPH0550261U (ja) * | 1991-12-09 | 1993-07-02 | 日立金属株式会社 | 逆止弁 |
JPH10511014A (ja) * | 1994-11-02 | 1998-10-27 | エリー リリー アンド カンパニー | 注入装置用マニホルド |
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US20140137966A1 (en) | 2014-05-22 |
EP2723425A1 (en) | 2014-04-30 |
CN103747823A (zh) | 2014-04-23 |
WO2012175588A1 (en) | 2012-12-27 |
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