|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
US5811119A
(en)
|
1987-05-19 |
1998-09-22 |
Board Of Regents, The University Of Texas |
Formulation and use of carotenoids in treatment of cancer
|
|
JP3012244B2
(ja)
|
1987-09-21 |
2000-02-21 |
ジェン―プローブ インコーポレイテッド |
ヌクレオチドプローブ用非ヌクレオチド連結試薬
|
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
JP3131222B2
(ja)
|
1991-12-24 |
2001-01-31 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ギャップを有する2′修飾オリゴヌクレオチド
|
|
EP0642589A4
(en)
|
1992-05-11 |
1997-05-21 |
Ribozyme Pharm Inc |
METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
|
|
US6582728B1
(en)
|
1992-07-08 |
2003-06-24 |
Inhale Therapeutic Systems, Inc. |
Spray drying of macromolecules to produce inhaleable dry powders
|
|
EP0786522A2
(en)
|
1992-07-17 |
1997-07-30 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecules for treatment of stenotic conditions
|
|
US6235886B1
(en)
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
|
ATE227342T1
(de)
|
1993-09-02 |
2002-11-15 |
Ribozyme Pharm Inc |
Enzymatische nukleiksaüre die nicht-nukleotide enthaltet
|
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
|
US5624803A
(en)
|
1993-10-14 |
1997-04-29 |
The Regents Of The University Of California |
In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
|
|
ATE174600T1
(de)
|
1993-10-27 |
1999-01-15 |
Ribozyme Pharm Inc |
2'-amido-und 2'-peptido-modifizierte oligonukleotide
|
|
US6051256A
(en)
|
1994-03-07 |
2000-04-18 |
Inhale Therapeutic Systems |
Dispersible macromolecule compositions and methods for their preparation and use
|
|
ATE386131T1
(de)
|
1994-04-13 |
2008-03-15 |
Univ Rockefeller |
Aav-vermittelte überbringung von dna in zellen des nervensystems
|
|
CA2207593A1
(en)
|
1994-12-13 |
1996-06-20 |
John Gustofson |
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
DE19640092A1
(de)
|
1996-09-28 |
1998-04-16 |
Beiersdorf Ag |
Strukturen mit Lipid-Doppelmembranen, in deren lipophilen Bereich längerkettige Moleküle eintauchen oder durch hydrophobe Wechselwirkungen an solche Moleküle angedockt sind
|
|
DE19641672A1
(de)
|
1996-10-10 |
1998-04-16 |
Beiersdorf Ag |
Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6251666B1
(en)
|
1997-03-31 |
2001-06-26 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid catalysts comprising L-nucleotide analogs
|
|
AR013269A1
(es)
|
1997-08-04 |
2000-12-13 |
Scras |
Producto que contiene por lo menos un rna de doble filamento combinado con por lo menos un agente anti-viral, para la utilizacion terapeutica en eltratamiento de una enfermedad viral, en especial de la hepatitis viral
|
|
JP4236812B2
(ja)
|
1997-09-12 |
2009-03-11 |
エクシコン エ/エス |
オリゴヌクレオチド類似体
|
|
US6565885B1
(en)
|
1997-09-29 |
2003-05-20 |
Inhale Therapeutic Systems, Inc. |
Methods of spray drying pharmaceutical compositions
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
AR020078A1
(es)
|
1998-05-26 |
2002-04-10 |
Syngenta Participations Ag |
Metodo para alterar la expresion de un gen objetivo en una celula de planta
|
|
GB9827152D0
(en)
|
1998-07-03 |
1999-02-03 |
Devgen Nv |
Characterisation of gene function using double stranded rna inhibition
|
|
CA2361201A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
ES2234563T5
(es)
|
1999-02-12 |
2018-01-17 |
Daiichi Sankyo Company, Limited |
Nuevos análogos de nucleósidos y oligonucleótidos
|
|
HK1047109A1
(zh)
|
1999-10-15 |
2003-02-07 |
University Of Massachusetts |
作为指定基因干预工具的rna干预轨迹基因
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
US20020041898A1
(en)
|
2000-01-05 |
2002-04-11 |
Unger Evan C. |
Novel targeted delivery systems for bioactive agents
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
DE10012151A1
(de)
|
2000-03-13 |
2001-09-27 |
Gsf Forschungszentrum Umwelt |
Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
|
|
ES2336887T5
(es)
|
2000-03-30 |
2019-03-06 |
Whitehead Inst Biomedical Res |
Mediadores de interferencia por ARN específicos de secuencias de ARN
|
|
US20050209179A1
(en)
*
|
2000-08-30 |
2005-09-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
|
|
US20030130186A1
(en)
|
2001-07-20 |
2003-07-10 |
Chandra Vargeese |
Conjugates and compositions for cellular delivery
|
|
US6586524B2
(en)
|
2001-07-19 |
2003-07-01 |
Expression Genetics, Inc. |
Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
|
|
ATE359829T1
(de)
|
2001-10-30 |
2007-05-15 |
Nektar Therapeutics Al Corp |
Wasserlösliche polymerkonjugate von retinoesäure
|
|
AUPR894201A0
(en)
|
2001-11-19 |
2001-12-13 |
Women's And Children's Hospital |
Respiratory delivery for gene therapy and lentiviral delivery particle
|
|
DE60310944T3
(de)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Weitere neue formen von interferierende rns moleküle
|
|
US20050106731A1
(en)
|
2002-08-05 |
2005-05-19 |
Davidson Beverly L. |
siRNA-mediated gene silencing with viral vectors
|
|
ATE443765T1
(de)
|
2003-03-21 |
2009-10-15 |
Santaris Pharma As |
Analoga kurzer interferierender rna (sirna)
|
|
JP2006522140A
(ja)
|
2003-03-31 |
2006-09-28 |
ベクトラメッド,インコーポレーテッド |
線維症の治療用ポリマー薬剤
|
|
US7407973B2
(en)
*
|
2003-10-24 |
2008-08-05 |
Intermune, Inc. |
Use of pirfenidone in therapeutic regimens
|
|
CA2559955C
(en)
|
2004-03-15 |
2016-02-16 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded rna
|
|
WO2006047842A2
(en)
|
2004-11-08 |
2006-05-11 |
K.U. Leuven Research And Development |
Modified nucleosides for rna interference
|
|
HUE056941T2
(hu)
*
|
2004-12-22 |
2022-04-28 |
Nitto Denko Corp |
Gyógyszerhordozó és gyógyszerhordozó kit fibrózis gátlására
|
|
JP2009221164A
(ja)
*
|
2008-03-17 |
2009-10-01 |
Nitto Denko Corp |
肺線維症処置剤
|
|
US20120269886A1
(en)
|
2004-12-22 |
2012-10-25 |
Nitto Denko Corporation |
Therapeutic agent for pulmonary fibrosis
|
|
US9393315B2
(en)
|
2011-06-08 |
2016-07-19 |
Nitto Denko Corporation |
Compounds for targeting drug delivery and enhancing siRNA activity
|
|
JP5342834B2
(ja)
*
|
2008-09-05 |
2013-11-13 |
日東電工株式会社 |
骨髄線維症処置剤
|
|
NZ571568A
(en)
*
|
2006-03-31 |
2010-11-26 |
Alnylam Pharmaceuticals Inc |
Double-stranded RNA molecule compositions and methods for inhibiting expression of Eg5 gene
|
|
DE202006005347U1
(de)
*
|
2006-04-03 |
2007-08-02 |
Efbe Elektrogeräte GmbH |
Infrarotleuchte
|
|
CA2666657A1
(en)
|
2006-10-18 |
2008-04-24 |
Nastech Pharmaceutical Company Inc. |
Nicked or gapped nucleic acid molecules and uses thereof
|
|
JP2010527914A
(ja)
|
2007-04-26 |
2010-08-19 |
クォーク ファーマシューティカルズ インコーポレーティッド |
呼吸器系への抑制性核酸分子の治療的送達
|
|
CN101970012A
(zh)
*
|
2007-09-14 |
2011-02-09 |
日东电工株式会社 |
药物载体
|
|
WO2009059450A1
(en)
|
2007-11-05 |
2009-05-14 |
Shanghai Jiaotong University |
Peptide ligand directed drug delivery
|
|
ES2657214T3
(es)
|
2008-07-30 |
2018-03-02 |
Nitto Denko Corporation |
Vehículos de fármacos
|
|
KR20160095209A
(ko)
|
2008-09-12 |
2016-08-10 |
닛토덴코 가부시키가이샤 |
섬유증 질환의 조영제
|
|
US20110294870A1
(en)
|
2008-12-04 |
2011-12-01 |
Opko Curna, Llc |
Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
|
|
WO2011072082A2
(en)
*
|
2009-12-09 |
2011-06-16 |
Nitto Denko Corporation |
Modulation of hsp47 expression
|
|
CA3102008A1
(en)
*
|
2010-06-02 |
2011-12-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
US9011903B2
(en)
|
2011-06-08 |
2015-04-21 |
Nitto Denko Corporation |
Cationic lipids for therapeutic agent delivery formulations
|
|
TWI658830B
(zh)
*
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|