JP2014519514A5 - - Google Patents
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- JP2014519514A5 JP2014519514A5 JP2014514581A JP2014514581A JP2014519514A5 JP 2014519514 A5 JP2014519514 A5 JP 2014519514A5 JP 2014514581 A JP2014514581 A JP 2014514581A JP 2014514581 A JP2014514581 A JP 2014514581A JP 2014519514 A5 JP2014519514 A5 JP 2014519514A5
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- 201000010099 disease Diseases 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims description 26
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims description 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 150000001413 amino acids Chemical group 0.000 claims description 18
- 230000000451 tissue damage Effects 0.000 claims description 18
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- 239000000203 mixture Substances 0.000 claims description 11
- 238000003745 diagnosis Methods 0.000 claims description 10
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 8
- 206010012601 diabetes mellitus Diseases 0.000 claims description 8
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 6
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 claims description 6
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims description 6
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 6
- 208000010125 myocardial infarction Diseases 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- 239000004474 valine Substances 0.000 claims description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 4
- LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 claims description 4
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims description 4
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims description 4
- 102000004173 Cathepsin G Human genes 0.000 claims description 4
- 108090000617 Cathepsin G Proteins 0.000 claims description 4
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims description 4
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 4
- 108010028275 Leukocyte Elastase Proteins 0.000 claims description 4
- 102000016799 Leukocyte elastase Human genes 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 230000031902 chemoattractant activity Effects 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 230000002779 inactivation Effects 0.000 claims description 4
- 125000000962 organic group Chemical group 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 3
- 208000037816 tissue injury Diseases 0.000 claims description 3
- 210000003462 vein Anatomy 0.000 claims description 3
- 206010007558 Cardiac failure chronic Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 210000005003 heart tissue Anatomy 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 238000001361 intraarterial administration Methods 0.000 claims description 2
- 201000002818 limb ischemia Diseases 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 230000008733 trauma Effects 0.000 claims description 2
- 230000000472 traumatic effect Effects 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 230000007998 vessel formation Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- 108010008951 Chemokine CXCL12 Proteins 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000025366 tissue development Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 33
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494079P | 2011-06-07 | 2011-06-07 | |
| US61/494,079 | 2011-06-07 | ||
| PCT/US2012/041054 WO2012170495A1 (en) | 2011-06-07 | 2012-06-06 | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017013060A Division JP2017114867A (ja) | 2011-06-07 | 2017-01-27 | ストロマ細胞由来因子−１のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014519514A JP2014519514A (ja) | 2014-08-14 |
| JP2014519514A5 true JP2014519514A5 (enExample) | 2015-04-02 |
| JP6145089B2 JP6145089B2 (ja) | 2017-06-07 |
Family
ID=47296407
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514581A Expired - Fee Related JP6145089B2 (ja) | 2011-06-07 | 2012-06-06 | ストロマ細胞由来因子−１のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 |
| JP2017013060A Pending JP2017114867A (ja) | 2011-06-07 | 2017-01-27 | ストロマ細胞由来因子−１のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017013060A Pending JP2017114867A (ja) | 2011-06-07 | 2017-01-27 | ストロマ細胞由来因子−１のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10662234B2 (enExample) |
| EP (1) | EP2717894B1 (enExample) |
| JP (2) | JP6145089B2 (enExample) |
| CN (1) | CN103747795A (enExample) |
| AU (2) | AU2012268078B2 (enExample) |
| CA (1) | CA2838155C (enExample) |
| IL (1) | IL229697A0 (enExample) |
| WO (1) | WO2012170495A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9308277B2 (en) | 2010-02-25 | 2016-04-12 | Mesoblast International Sàrl | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| US10662234B2 (en) | 2011-06-07 | 2020-05-26 | Mesoblast International Sàrl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
| CN106029086A (zh) * | 2013-12-13 | 2016-10-12 | 美索布拉斯特国际有限公司 | 使用基质细胞来源的因子-1的抗蛋白酶突变体修复组织损伤的方法 |
| KR101756131B1 (ko) | 2014-09-26 | 2017-07-12 | 주식회사 바이로메드 | 간세포 성장인자 및 기질세포 유발인자1알파를 이용한 말초동맥질환의 예방 또는 치료용 조성물 |
| CN114366806A (zh) * | 2021-12-16 | 2022-04-19 | 天津市泌尿外科研究所 | 一种纳米黑磷负载sdf-1的纳米药物复合体及其制备方法和应用 |
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| US5171680A (en) | 1988-06-14 | 1992-12-15 | Chiron Corporation | Superoxide dismutase analogs having novel binding properties |
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| US5670483A (en) | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| CA2117953C (en) | 1993-10-14 | 2001-12-11 | Tasuku Honjo | Human stromal derived factor 1 alpha and 1 beta and dnas encoding the same |
| US6100387A (en) | 1997-02-28 | 2000-08-08 | Genetics Institute, Inc. | Chimeric polypeptides containing chemokine domains |
| US6852508B1 (en) | 1997-02-28 | 2005-02-08 | Genetics Institute, Llc | Chemokine with amino-terminal modifications |
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| CA2305787A1 (en) | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
| CA2245224A1 (en) | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
| WO1999047158A2 (en) | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
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| US6440934B1 (en) * | 1998-10-13 | 2002-08-27 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
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| US7368425B2 (en) | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
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| DE10027383A1 (de) | 2000-06-02 | 2001-12-20 | Rhein Biotech Proz & Prod Gmbh | Nukleinsäure-Molekül umfassend eine für ein Chemokin, einen Neuropeptid-Präkursor oder mindestens ein Neuropeptid kodierende Nukleinsäuresequenz |
| CA2810249A1 (en) | 2000-06-05 | 2001-12-13 | The Trustees Of Columbia University In The City Of New York | Identification and use of human bone marrow-derived endothelial progenitor cell to improve myocardial function after ischemic injury |
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| US9308277B2 (en) | 2010-02-25 | 2016-04-12 | Mesoblast International Sàrl | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
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| JP5464276B2 (ja) * | 2010-08-27 | 2014-04-09 | 富士通株式会社 | 並列計算機、並列計算機のジョブ情報取得プログラム、並列計算機のジョブ情報取得方法、計算装置及び計算管理装置 |
| US10662234B2 (en) | 2011-06-07 | 2020-05-26 | Mesoblast International Sàrl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
| CN106029086A (zh) | 2013-12-13 | 2016-10-12 | 美索布拉斯特国际有限公司 | 使用基质细胞来源的因子-1的抗蛋白酶突变体修复组织损伤的方法 |
-
2012
- 2012-06-06 US US14/124,187 patent/US10662234B2/en not_active Expired - Fee Related
- 2012-06-06 WO PCT/US2012/041054 patent/WO2012170495A1/en not_active Ceased
- 2012-06-06 CA CA2838155A patent/CA2838155C/en active Active
- 2012-06-06 AU AU2012268078A patent/AU2012268078B2/en not_active Ceased
- 2012-06-06 EP EP12796309.8A patent/EP2717894B1/en not_active Not-in-force
- 2012-06-06 CN CN201280037907.4A patent/CN103747795A/zh active Pending
- 2012-06-06 JP JP2014514581A patent/JP6145089B2/ja not_active Expired - Fee Related
-
2013
- 2013-11-28 IL IL229697A patent/IL229697A0/en unknown
-
2017
- 2017-01-27 JP JP2017013060A patent/JP2017114867A/ja active Pending
- 2017-08-08 AU AU2017213440A patent/AU2017213440A1/en not_active Abandoned