JP2014526254A5 - - Google Patents
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- Publication number
- JP2014526254A5 JP2014526254A5 JP2014529994A JP2014529994A JP2014526254A5 JP 2014526254 A5 JP2014526254 A5 JP 2014526254A5 JP 2014529994 A JP2014529994 A JP 2014529994A JP 2014529994 A JP2014529994 A JP 2014529994A JP 2014526254 A5 JP2014526254 A5 JP 2014526254A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- glp
- xten
- fusion protein
- nmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161573748P | 2011-09-12 | 2011-09-12 | |
| US61/573,748 | 2011-09-12 | ||
| PCT/US2012/054941 WO2013040093A2 (en) | 2011-09-12 | 2012-09-12 | Glucagon-like peptide-2 compositions and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017137310A Division JP2017186374A (ja) | 2011-09-12 | 2017-07-13 | グルカゴン様ペプチド−２組成物およびその作製法および使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526254A JP2014526254A (ja) | 2014-10-06 |
| JP2014526254A5 true JP2014526254A5 (enExample) | 2015-11-05 |
| JP6206972B2 JP6206972B2 (ja) | 2017-10-04 |
Family
ID=47883955
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529994A Expired - Fee Related JP6206972B2 (ja) | 2011-09-12 | 2012-09-12 | グルカゴン様ペプチド−２組成物およびその作製法および使用法 |
| JP2017137310A Pending JP2017186374A (ja) | 2011-09-12 | 2017-07-13 | グルカゴン様ペプチド−２組成物およびその作製法および使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017137310A Pending JP2017186374A (ja) | 2011-09-12 | 2017-07-13 | グルカゴン様ペプチド−２組成物およびその作製法および使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20160137711A1 (enExample) |
| EP (2) | EP2755675B1 (enExample) |
| JP (2) | JP6206972B2 (enExample) |
| KR (1) | KR102007054B1 (enExample) |
| CN (1) | CN103945861B (enExample) |
| AU (2) | AU2012308636B2 (enExample) |
| BR (1) | BR112014005744B1 (enExample) |
| CA (1) | CA2848204C (enExample) |
| DK (1) | DK2755675T3 (enExample) |
| ES (1) | ES2687651T3 (enExample) |
| PT (1) | PT2755675T (enExample) |
| WO (1) | WO2013040093A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104302408B (zh) | 2012-02-27 | 2016-12-14 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| MX349035B (es) | 2012-05-17 | 2017-07-07 | Extend Biosciences Inc | Portadores para el suministro mejorado de farmaco. |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| CN105602877B (zh) * | 2016-01-25 | 2019-02-01 | 广州沃德生物技术有限公司 | 一种定点改造的猪源glp-2重组植物乳杆菌及其制备方法和应用 |
| US10774127B2 (en) | 2016-10-12 | 2020-09-15 | University Of Copenhagen | Peptide dual agonists of GIPR and GLP2R |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL271245B2 (en) * | 2017-06-16 | 2023-10-01 | Zealand Pharma As | Dosing regimen for administration of glucagon-like peptide analog (GLP-2) 2 |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| AU2018321841A1 (en) * | 2017-08-22 | 2020-02-20 | Shire-Nps Pharmaceuticals, Inc. | GLP-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions |
| EP3684816B1 (en) | 2017-09-22 | 2024-05-29 | Kite Pharma, Inc. | Chimeric polypeptides and uses thereof |
| AR113258A1 (es) * | 2017-09-28 | 2020-03-11 | Hanmi Pharm Ind Co Ltd | Conjugados persistentes de derivados del péptido 2 similar al glucagón (glp-2) |
| CN111629745A (zh) | 2017-11-06 | 2020-09-04 | 夏尔-Nps医药品有限公司 | 用于在手术前、期间或之后投与的glp-2类似物和肽体(peptibodies) |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| KR20260039804A (ko) | 2017-12-21 | 2026-03-20 | 아뮤닉스 파마슈티컬스, 인크. | 유리 세그먼트 및 이것을 포함하는 결합 조성물 |
| JP2021511785A (ja) * | 2018-01-19 | 2021-05-13 | ペプジーン インコーポレーテッドＰｅｐｇｅｎｅ Ｉｎｃ． | 組換えポリペプチド生産用ｎ末端融合パートナーおよびこれを用いた組換えポリペプチドの生産方法 |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110305223B (zh) | 2019-06-26 | 2022-05-13 | 重庆派金生物科技有限公司 | 重组串联融合蛋白制备目标多肽的方法 |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021136223A1 (en) | 2019-12-31 | 2021-07-08 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| CN113728013B (zh) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| CA3182260A1 (en) * | 2020-06-09 | 2021-12-16 | Gleb Feldman | Manufacture, formulation and dosing of apraglutide |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| CA3193453A1 (en) | 2020-09-30 | 2022-04-07 | Beijing Ql Biopharmaceutical Co., Ltd. | Polypeptide conjugates and methods of uses |
| CN114213524A (zh) * | 2021-11-08 | 2022-03-22 | 苏州博领干细胞再生医学有限公司 | 用于胰高血糖素样肽-2抗体检测的包被抗原及纯化方法、重组工程菌及培养方法 |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| IT202200015204A1 (it) * | 2022-07-20 | 2024-01-20 | Bioinnova S R L S | Microalghe esprimenti glp-2 e usi relativi |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| WO2026024863A2 (en) * | 2024-07-24 | 2026-01-29 | Amunix Pharmaceuticals, Inc. | Compositions targeting prostate-specific membrane antigen (psma) in combination with androgen receptor antagonists |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| US4885249A (en) | 1984-12-05 | 1989-12-05 | Allelix, Inc. | Aspergillus niger transformation system |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| AT387234B (de) | 1987-03-05 | 1988-12-27 | Vogelbusch Gmbh | Vorrichtung zur zuechtung von dauerformen insbesondere filamentoeser mikroorganismen |
| US5834428A (en) | 1995-04-14 | 1998-11-10 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| US6184201B1 (en) | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
| US5990077A (en) | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| US5789379A (en) * | 1995-04-14 | 1998-08-04 | Allelix Biopharmaceutical Inc. | Glucagon-like peptide-2 analogs |
| US5994500A (en) | 1996-07-19 | 1999-11-30 | 1149336 Ontario Inc. | Antagonists of intestinotrophic GLP-2 peptides |
| US20020025933A1 (en) | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
| US7186683B2 (en) | 2000-09-18 | 2007-03-06 | Sanos Bioscience A/S | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders |
| US20030228309A1 (en) | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| EP1608680A2 (en) * | 2003-03-24 | 2005-12-28 | Novo Nordisk A/S | Glp-2 derivatives |
| DE602006020123D1 (de) | 2005-05-04 | 2011-03-31 | Zealand Pharma As | Glucagon-like-peptide-2- (glp-2-) analoga |
| CN101341254A (zh) * | 2005-12-24 | 2009-01-07 | 蒂加斯克乳制品研究中心 | 反-10，顺-12十八碳二烯酸的生产方法 |
| US20090028832A1 (en) * | 2006-08-10 | 2009-01-29 | Chung Leland F | Compositions and methods for targeted tumor therapy |
| DK3178835T3 (da) * | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| CA2771999A1 (en) * | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
| US20110312881A1 (en) * | 2009-12-21 | 2011-12-22 | Amunix, Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
| JP2013533217A (ja) * | 2010-05-17 | 2013-08-22 | セビックス・インコーポレイテッド | Ｐｅｇ化ｃ−ペプチド |
-
2012
- 2012-09-12 ES ES12831010T patent/ES2687651T3/es active Active
- 2012-09-12 WO PCT/US2012/054941 patent/WO2013040093A2/en not_active Ceased
- 2012-09-12 DK DK12831010.9T patent/DK2755675T3/en active
- 2012-09-12 KR KR1020147009519A patent/KR102007054B1/ko active Active
- 2012-09-12 CN CN201280055552.1A patent/CN103945861B/zh active Active
- 2012-09-12 JP JP2014529994A patent/JP6206972B2/ja not_active Expired - Fee Related
- 2012-09-12 EP EP12831010.9A patent/EP2755675B1/en active Active
- 2012-09-12 EP EP18176085.1A patent/EP3431098A1/en not_active Withdrawn
- 2012-09-12 AU AU2012308636A patent/AU2012308636B2/en not_active Ceased
- 2012-09-12 PT PT12831010T patent/PT2755675T/pt unknown
- 2012-09-12 BR BR112014005744-3A patent/BR112014005744B1/pt not_active IP Right Cessation
- 2012-09-12 US US14/343,111 patent/US20160137711A1/en not_active Abandoned
- 2012-09-12 CA CA2848204A patent/CA2848204C/en active Active
-
2017
- 2017-07-13 JP JP2017137310A patent/JP2017186374A/ja active Pending
- 2017-11-29 AU AU2017268558A patent/AU2017268558A1/en not_active Abandoned
-
2020
- 2020-01-30 US US16/777,125 patent/US20200392195A1/en not_active Abandoned
-
2023
- 2023-06-06 US US18/330,032 patent/US20240067695A1/en not_active Abandoned
-
2025
- 2025-01-16 US US19/025,005 patent/US20250388643A1/en active Pending
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