AU2012308636B2 - Glucagon-like peptide-2 compositions and methods of making and using same - Google Patents

Glucagon-like peptide-2 compositions and methods of making and using same Download PDF

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Publication number
AU2012308636B2
AU2012308636B2 AU2012308636A AU2012308636A AU2012308636B2 AU 2012308636 B2 AU2012308636 B2 AU 2012308636B2 AU 2012308636 A AU2012308636 A AU 2012308636A AU 2012308636 A AU2012308636 A AU 2012308636A AU 2012308636 B2 AU2012308636 B2 AU 2012308636B2
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AU
Australia
Prior art keywords
xten
glp
sequence
fusion protein
composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2012308636A
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English (en)
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AU2012308636A1 (en
Inventor
Nathan Geething
Volker Schellenberger
Joshua Silverman
Benjamin Spink
Willem P. Stemmer
Chia-Wei Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amunix Pharmaceuticals Inc
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Amunix Operating Inc
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Filing date
Publication date
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Publication of AU2012308636A1 publication Critical patent/AU2012308636A1/en
Application granted granted Critical
Publication of AU2012308636B2 publication Critical patent/AU2012308636B2/en
Priority to AU2017268558A priority Critical patent/AU2017268558A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012308636A 2011-09-12 2012-09-12 Glucagon-like peptide-2 compositions and methods of making and using same Ceased AU2012308636B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017268558A AU2017268558A1 (en) 2011-09-12 2017-11-29 Glucagon-like peptide-2 compositions and methods of making and using same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161573748P 2011-09-12 2011-09-12
US61/573,748 2011-09-12
PCT/US2012/054941 WO2013040093A2 (en) 2011-09-12 2012-09-12 Glucagon-like peptide-2 compositions and methods of making and using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017268558A Division AU2017268558A1 (en) 2011-09-12 2017-11-29 Glucagon-like peptide-2 compositions and methods of making and using same

Publications (2)

Publication Number Publication Date
AU2012308636A1 AU2012308636A1 (en) 2014-03-27
AU2012308636B2 true AU2012308636B2 (en) 2017-08-31

Family

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AU2012308636A Ceased AU2012308636B2 (en) 2011-09-12 2012-09-12 Glucagon-like peptide-2 compositions and methods of making and using same
AU2017268558A Abandoned AU2017268558A1 (en) 2011-09-12 2017-11-29 Glucagon-like peptide-2 compositions and methods of making and using same

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Country Link
US (4) US20160137711A1 (enExample)
EP (2) EP2755675B1 (enExample)
JP (2) JP6206972B2 (enExample)
KR (1) KR102007054B1 (enExample)
CN (1) CN103945861B (enExample)
AU (2) AU2012308636B2 (enExample)
BR (1) BR112014005744B1 (enExample)
CA (1) CA2848204C (enExample)
DK (1) DK2755675T3 (enExample)
ES (1) ES2687651T3 (enExample)
PT (1) PT2755675T (enExample)
WO (1) WO2013040093A2 (enExample)

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US10774127B2 (en) 2016-10-12 2020-09-15 University Of Copenhagen Peptide dual agonists of GIPR and GLP2R
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Also Published As

Publication number Publication date
BR112014005744A2 (pt) 2017-03-28
US20200392195A1 (en) 2020-12-17
US20250388643A1 (en) 2025-12-25
AU2017268558A1 (en) 2017-12-21
NZ622174A (en) 2015-12-24
BR112014005744B1 (pt) 2020-11-17
CA2848204A1 (en) 2013-03-21
CN103945861A (zh) 2014-07-23
EP3431098A1 (en) 2019-01-23
CN103945861B (zh) 2018-06-05
JP2014526254A (ja) 2014-10-06
PT2755675T (pt) 2018-10-11
JP2017186374A (ja) 2017-10-12
CA2848204C (en) 2023-04-04
US20240067695A1 (en) 2024-02-29
KR102007054B1 (ko) 2019-08-02
KR20140069131A (ko) 2014-06-09
WO2013040093A3 (en) 2014-05-08
EP2755675A4 (en) 2015-07-08
AU2012308636A1 (en) 2014-03-27
JP6206972B2 (ja) 2017-10-04
EP2755675B1 (en) 2018-06-06
US20160137711A1 (en) 2016-05-19
WO2013040093A2 (en) 2013-03-21
ES2687651T3 (es) 2018-10-26
EP2755675A2 (en) 2014-07-23
DK2755675T3 (en) 2018-08-06

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