JP6145089B2 - ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 - Google Patents

ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 Download PDF

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JP6145089B2
JP6145089B2 JP2014514581A JP2014514581A JP6145089B2 JP 6145089 B2 JP6145089 B2 JP 6145089B2 JP 2014514581 A JP2014514581 A JP 2014514581A JP 2014514581 A JP2014514581 A JP 2014514581A JP 6145089 B2 JP6145089 B2 JP 6145089B2
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JP2014519514A (ja
JP2014519514A5 (enExample
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アンソニー サンドラサグラ
アンソニー サンドラサグラ
ウェイタオ ウー
ウェイタオ ウー
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メソブラスト インターナショナル エスエイアールエル
メソブラスト インターナショナル エスエイアールエル
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2014514581A 2011-06-07 2012-06-06 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 Expired - Fee Related JP6145089B2 (ja)

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US201161494079P 2011-06-07 2011-06-07
US61/494,079 2011-06-07
PCT/US2012/041054 WO2012170495A1 (en) 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1

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JP2017013060A Division JP2017114867A (ja) 2011-06-07 2017-01-27 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法

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JP2014519514A5 JP2014519514A5 (enExample) 2015-04-02
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JP2017013060A Pending JP2017114867A (ja) 2011-06-07 2017-01-27 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法

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US (1) US10662234B2 (enExample)
EP (1) EP2717894B1 (enExample)
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CN (1) CN103747795A (enExample)
AU (2) AU2012268078B2 (enExample)
CA (1) CA2838155C (enExample)
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WO2011106234A1 (en) 2010-02-25 2011-09-01 Provasculon, Inc. Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JP6145089B2 (ja) 2011-06-07 2017-06-07 メソブラスト インターナショナル エスエイアールエル ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
AU2014362198A1 (en) * 2013-12-13 2016-07-07 Mesoblast International Sarl Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
ES2822924T3 (es) * 2014-09-26 2021-05-05 Helixmith Co Ltd Composición para prevenir o tratar una enfermedad arterial periférica utilizando el factor de crecimiento de hepatocitos y el factor 1a derivado de células del estroma
CN114366806A (zh) * 2021-12-16 2022-04-19 天津市泌尿外科研究所 一种纳米黑磷负载sdf-1的纳米药物复合体及其制备方法和应用
CN122297638A (zh) * 2026-06-02 2026-06-30 中国人民解放军陆军特色医学中心 多肽srd在制备治疗急性肺损伤药物中的应用

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JP6145089B2 (ja) 2011-06-07 2017-06-07 メソブラスト インターナショナル エスエイアールエル ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
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EP2717894A1 (en) 2014-04-16
CA2838155A1 (en) 2012-12-13
IL229697A0 (en) 2014-01-30
AU2012268078B2 (en) 2017-06-01
US20140199304A1 (en) 2014-07-17
WO2012170495A1 (en) 2012-12-13
CA2838155C (en) 2021-10-19
US10662234B2 (en) 2020-05-26
AU2017213440A1 (en) 2017-08-24
JP2014519514A (ja) 2014-08-14
EP2717894B1 (en) 2018-01-24
CN103747795A (zh) 2014-04-23
JP2017114867A (ja) 2017-06-29
AU2012268078A1 (en) 2013-12-19
EP2717894A4 (en) 2015-02-25

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