JP2014518849A5 - - Google Patents

Info

Publication number

JP2014518849A5

JP2014518849A5 JP2014506576A JP2014506576A JP2014518849A5 JP 2014518849 A5 JP2014518849 A5 JP 2014518849A5 JP 2014506576 A JP2014506576 A JP 2014506576A JP 2014506576 A JP2014506576 A JP 2014506576A JP 2014518849 A5 JP2014518849 A5 JP 2014518849A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

composition

amino acid

effective

Prior art date

2012-04-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 229920001184 polypeptide Polymers 0.000 claims description 128
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 128
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 128
• 239000000203 mixture Substances 0.000 claims description 80
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 62
• 239000004472 Lysine Substances 0.000 claims description 62
• 241000192125 Firmicutes Species 0.000 claims description 58
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 48
• 238000000034 method Methods 0.000 claims description 29
• 241000894006 Bacteria Species 0.000 claims description 23
• 241000191967 Staphylococcus aureus Species 0.000 claims description 23
• 241000194017 Streptococcus Species 0.000 claims description 23
• 241000186781 Listeria Species 0.000 claims description 20
• 230000002147 killing effect Effects 0.000 claims description 20
• 241000191940 Staphylococcus Species 0.000 claims description 18
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 16
• 241000194033 Enterococcus Species 0.000 claims description 14
• 208000015181 infectious disease Diseases 0.000 claims description 12
• 108010059993 Vancomycin Proteins 0.000 claims description 8
• 239000008194 pharmaceutical composition Substances 0.000 claims description 8
• 229960003165 vancomycin Drugs 0.000 claims description 8
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 8
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 8
• 102000053602 DNA Human genes 0.000 claims description 6
• 241000194032 Enterococcus faecalis Species 0.000 claims description 6
• 108020004511 Recombinant DNA Proteins 0.000 claims description 6
• 108010039491 Ricin Proteins 0.000 claims description 6
• 241000193998 Streptococcus pneumoniae Species 0.000 claims description 6
• 241000193996 Streptococcus pyogenes Species 0.000 claims description 6
• 239000003242 anti bacterial agent Substances 0.000 claims description 6
• 238000011109 contamination Methods 0.000 claims description 6
• 229940032049 enterococcus faecalis Drugs 0.000 claims description 6
• 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 6
• 241000282412 Homo Species 0.000 claims description 5
• 102000002268 Hexosaminidases Human genes 0.000 claims description 4
• 108010000540 Hexosaminidases Proteins 0.000 claims description 4
• 241000186779 Listeria monocytogenes Species 0.000 claims description 4
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 4
• 241000191963 Staphylococcus epidermidis Species 0.000 claims description 4
• 241000191978 Staphylococcus simulans Species 0.000 claims description 4
• 241000193985 Streptococcus agalactiae Species 0.000 claims description 4
• 241000194042 Streptococcus dysgalactiae Species 0.000 claims description 4
• 241000194048 Streptococcus equi Species 0.000 claims description 4
• 241000194026 Streptococcus gordonii Species 0.000 claims description 4
• 241000194023 Streptococcus sanguinis Species 0.000 claims description 4
• 241000194021 Streptococcus suis Species 0.000 claims description 4
• 230000003115 biocidal effect Effects 0.000 claims description 4
• 229960003085 meticillin Drugs 0.000 claims description 4
• 108020004707 nucleic acids Proteins 0.000 claims description 4
• 102000039446 nucleic acids Human genes 0.000 claims description 4
• 150000007523 nucleic acids Chemical class 0.000 claims description 4
• 229940037648 staphylococcus simulans Drugs 0.000 claims description 4
• 229940115920 streptococcus dysgalactiae Drugs 0.000 claims description 4
• 230000000699 topical effect Effects 0.000 claims description 4
• 206010041925 Staphylococcal infections Diseases 0.000 claims description 3
• 102000005593 Endopeptidases Human genes 0.000 claims description 2
• 108010059378 Endopeptidases Proteins 0.000 claims description 2
• 241000193990 Streptococcus sp. 'group B' Species 0.000 claims description 2
• 229940088710 antibiotic agent Drugs 0.000 claims description 2
• 230000003197 catalytic effect Effects 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• 238000009396 hybridization Methods 0.000 claims description 2
• 238000012986 modification Methods 0.000 claims description 2
• 230000004048 modification Effects 0.000 claims description 2
• 239000002773 nucleotide Substances 0.000 claims description 2
• 125000003729 nucleotide group Chemical group 0.000 claims description 2
• 238000007911 parenteral administration Methods 0.000 claims description 2
• 230000001717 pathogenic effect Effects 0.000 claims description 2
• 241000894007 species Species 0.000 claims description 2
• 208000024891 symptom Diseases 0.000 claims description 2
• 150000001413 amino acids Chemical group 0.000 claims 34
• 241000186660 Lactobacillus Species 0.000 claims 1
• 101001057111 Staphylococcus aureus Enterotoxin type E Proteins 0.000 claims 1
• 208000027136 gram-positive bacterial infections Diseases 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 description 34
• 208000035143 Bacterial infection Diseases 0.000 description 2
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 230000036576 dermal application Effects 0.000 description 1