JP2014518220A5 - - Google Patents

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Publication number
JP2014518220A5
JP2014518220A5 JP2014516092A JP2014516092A JP2014518220A5 JP 2014518220 A5 JP2014518220 A5 JP 2014518220A5 JP 2014516092 A JP2014516092 A JP 2014516092A JP 2014516092 A JP2014516092 A JP 2014516092A JP 2014518220 A5 JP2014518220 A5 JP 2014518220A5
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JP
Japan
Prior art keywords
difluoro
pyridin
difluorophenyl
tetrazol
oxy
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JP2014516092A
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English (en)
Japanese (ja)
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JP6247632B2 (ja
JP2014518220A (ja
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Priority claimed from PCT/US2012/043147 external-priority patent/WO2012177638A1/en
Publication of JP2014518220A publication Critical patent/JP2014518220A/ja
Publication of JP2014518220A5 publication Critical patent/JP2014518220A5/ja
Application granted granted Critical
Publication of JP6247632B2 publication Critical patent/JP6247632B2/ja
Expired - Fee Related legal-status Critical Current
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JP2014516092A 2011-06-19 2012-06-19 メタロ酵素阻害剤化合物 Expired - Fee Related JP6247632B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161498570P 2011-06-19 2011-06-19
US61/498,570 2011-06-19
US201261611897P 2012-03-16 2012-03-16
US61/611,897 2012-03-16
PCT/US2012/043147 WO2012177638A1 (en) 2011-06-19 2012-06-19 Metalloenzyme inhibitor compounds

Publications (3)

Publication Number Publication Date
JP2014518220A JP2014518220A (ja) 2014-07-28
JP2014518220A5 true JP2014518220A5 (enExample) 2015-07-30
JP6247632B2 JP6247632B2 (ja) 2017-12-13

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ID=47362418

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014516092A Expired - Fee Related JP6247632B2 (ja) 2011-06-19 2012-06-19 メタロ酵素阻害剤化合物
JP2014517090A Expired - Fee Related JP6158797B2 (ja) 2011-06-19 2012-06-19 金属酵素阻害剤化合物
JP2017019006A Pending JP2017132766A (ja) 2011-06-19 2017-02-03 金属酵素阻害剤化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014517090A Expired - Fee Related JP6158797B2 (ja) 2011-06-19 2012-06-19 金属酵素阻害剤化合物
JP2017019006A Pending JP2017132766A (ja) 2011-06-19 2017-02-03 金属酵素阻害剤化合物

Country Status (23)

Country Link
US (3) US8796001B2 (enExample)
EP (4) EP3067350B1 (enExample)
JP (3) JP6247632B2 (enExample)
KR (4) KR20180095108A (enExample)
CN (3) CN103764647B (enExample)
AR (1) AR088130A1 (enExample)
AU (2) AU2012273103B2 (enExample)
BR (2) BR102012015179B1 (enExample)
CA (2) CA2839691A1 (enExample)
CL (1) CL2013003638A1 (enExample)
CO (1) CO6930356A2 (enExample)
CR (1) CR20140020A (enExample)
EA (2) EA025406B1 (enExample)
EC (2) ECSP14013152A (enExample)
ES (1) ES2700250T3 (enExample)
IL (1) IL229965A (enExample)
IN (1) IN2014DN00288A (enExample)
MX (1) MX351943B (enExample)
PH (1) PH12013502623A1 (enExample)
UA (1) UA114090C2 (enExample)
UY (2) UY39413A (enExample)
WO (2) WO2012177635A1 (enExample)
ZA (1) ZA201400232B (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012177635A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20140040235A (ko) 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
JP2014523880A (ja) 2011-06-23 2014-09-18 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 金属酵素化合物
IN2014DN06792A (enExample) * 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
AU2014209107B2 (en) 2013-01-28 2018-04-12 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
MX2015014268A (es) * 2013-04-12 2016-06-02 Bayer Cropscience Ag Derivados de triazol novedosos.
WO2014167009A1 (en) 2013-04-12 2014-10-16 Bayer Cropscience Ag Novel triazole derivatives
EP2984080B1 (en) * 2013-04-12 2017-08-30 Bayer CropScience Aktiengesellschaft Novel triazolinthione derivatives
US9447073B2 (en) 2013-05-28 2016-09-20 Viamet Pharmaceuticals, Inc. Fungicidal compositions
EP3008051A4 (en) 2013-06-12 2017-03-01 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR101885219B1 (ko) * 2013-08-27 2018-08-14 시노켐 코포레이션 치환체 벤질옥시 그룹 함유 에테르 화합물을 포함하는 항종양제.
US10017494B2 (en) 2014-03-19 2018-07-10 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942968C (en) * 2014-03-19 2022-03-15 William J. Hoekstra Antifungal compound process
JP2017507991A (ja) 2014-03-19 2017-03-23 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 抗真菌化合物の調製方法
WO2015143154A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US9914726B2 (en) 2014-03-19 2018-03-13 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
JP2017509646A (ja) 2014-03-19 2017-04-06 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 抗真菌化合物の調製方法
CN109678791B (zh) * 2014-03-19 2022-07-01 美国陶氏益农公司 1-(2,4-二氟苯)-2,2-二氟-2-(5-取代吡啶-2-基)乙酮及制备方法
JP6572234B2 (ja) * 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ(エヌシー),インコーポレイテッド 抗真菌化合物の調製方法
AU2015231270B2 (en) 2014-03-19 2019-03-07 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
US10196375B2 (en) 2014-03-19 2019-02-05 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP6623015B2 (ja) * 2014-09-29 2019-12-18 国立研究開発法人理化学研究所 植物の耐塩性向上剤
WO2016050769A1 (en) 2014-10-02 2016-04-07 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives useful as fungicides
CN107660203A (zh) 2015-04-02 2018-02-02 拜耳作物科学股份公司 作为杀真菌剂的三唑衍生物
CA2986041C (en) 2015-05-18 2021-06-29 Viamet Pharmaceuticals, Inc. 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4,5-dihydro-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile compounds as antifungal agents
BR112018005194B1 (pt) * 2015-09-18 2022-11-08 Vps-3, Inc Processo para preparar um composto antifúngico
EP3374350B1 (en) 2015-11-09 2022-01-05 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
US10611747B2 (en) 2015-11-09 2020-04-07 Forge Therapeutics, Inc. Pyrone based compounds for treating bacterial infections
BR112018009931A8 (pt) * 2015-11-17 2019-02-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
AR106729A1 (es) * 2015-11-17 2018-02-14 Viamet Pharmaceuticals Inc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación
AR106731A1 (es) * 2015-11-17 2018-02-14 Viamet Pharmaceuticals Inc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación
CN108473463A (zh) * 2015-11-17 2018-08-31 美国陶氏益农公司 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈以及制备方法
CN113912586B (zh) 2016-08-31 2023-04-07 江苏恒瑞医药股份有限公司 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用
JP2018048090A (ja) * 2016-09-21 2018-03-29 大阪ガスケミカル株式会社 工業用保存剤
EP3541799A4 (en) * 2016-11-18 2020-04-01 Dow Agrosciences Llc PROCESSES FOR THE PREPARATION OF 4 - ((6- (2- (2,4-DIFLUOROPHENYL) -1,1-DIFLUORO-2-HYDROXY-3- (5-MERCAPTO-1H-1,2,4-TRIAZOL-1- YL) PROPYL) PYRIDIN-3-YL) OXY) BENZONITRILE
BR112019009767A2 (pt) * 2016-11-18 2019-08-13 Dow Agrosciences Llc 4-((6-(2,4-difluorofenil)-1,1-difluoro-2-hidróxi-3(5-mercapto-1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
CN109983005A (zh) * 2016-11-18 2019-07-05 美国陶氏益农公司 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(5-巯基-1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈及制备方法
EP3541797A4 (en) * 2016-11-18 2020-04-29 Dow AgroSciences LLC 4 - ((6- (2- (2,4-DIFLUORPHENYL) -1,1-DIFLUOR-2-HYDROXY-3- (5-MERCAPTO-1H
US20190284161A1 (en) * 2016-11-18 2019-09-19 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
US20190284159A1 (en) * 2016-11-18 2019-09-19 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
ES2890228T3 (es) * 2016-11-18 2022-01-18 Corteva Agriscience Llc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidroxi-3-(5-mercapto-1H-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y procesos de preparación
BR112019009801A2 (pt) * 2016-11-18 2019-08-06 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidróxi-3-(5-mercapto-1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
EP3544431A4 (en) * 2016-11-22 2020-04-22 Dow AgroSciences LLC USE OF A DIFLUOR (2-HYDROXYPROPYL) PYRIDINE COMPOUND AS A FUNGICIDE FOR CONTROLLING PHYTOPATHOGENIC MUSHROOMS OF RICE
US20190274303A1 (en) * 2016-11-22 2019-09-12 Dow Agrosciences Llc Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of barley
WO2018098237A1 (en) * 2016-11-22 2018-05-31 Vps-3, Inc. Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of leaf spot of sugar beets
US20210282401A1 (en) * 2016-11-22 2021-09-16 Dow Agrosciences Llc Fungicidal compounds and mixtures for fungal control in cereals
US20210298305A1 (en) * 2016-11-22 2021-09-30 Dow Agrosciences Llc Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of wheat
JP2019535748A (ja) * 2016-11-22 2019-12-12 ダウ アグロサイエンシィズ エルエルシー 殺真菌組成物および穀類における真菌防除のための混合物
MA46076B1 (fr) * 2016-11-22 2022-01-31 Dow Agrosciences Llc Composés fongicides et mélanges de régulation des champignons dans les céréales
RU2759947C2 (ru) * 2016-11-22 2021-11-19 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Фунгицидные соединения и смеси для борьбы с грибковыми заболеваниями зерновых культур
CA3044386A1 (en) * 2016-11-22 2018-05-31 Dow Agrosciences Llc Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of corn
JP7084398B2 (ja) * 2016-11-22 2022-06-14 コルテバ アグリサイエンス エルエルシー 殺真菌組成物および穀類における真菌防除のための混合物
WO2018119440A1 (en) 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
EP3621962A4 (en) 2017-05-10 2020-12-09 Forge Therapeutics, Inc. ANTIBACTERIAL COMPOUNDS
WO2019092086A1 (en) 2017-11-13 2019-05-16 Bayer Aktiengesellschaft Tetrazolylpropyl derivatives and their use as fungicides
WO2020061375A1 (en) 2018-09-20 2020-03-26 Forge Therapeutics, Inc. Antibacterial compounds
EP4097119B1 (en) 2020-01-31 2025-05-07 The Johns Hopkins University Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
TW202144340A (zh) 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
CN113278409B (zh) * 2021-06-22 2022-04-29 西南石油大学 一种高温酸化缓蚀剂
AR127139A1 (es) 2021-09-28 2023-12-20 Forge Therapeutics Inc Inhibidores de lpxc y usos de estos
CN117069693A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含胺基结构化合物的制备方法及作为抗菌剂的应用
WO2024068656A1 (en) 2022-09-28 2024-04-04 Syngenta Crop Protection Ag Fungicidal compositions
WO2024068655A1 (en) 2022-09-28 2024-04-04 Syngenta Crop Protection Ag Fungicidal compositions
CN120843557B (zh) * 2025-07-08 2026-03-17 贵州大学 锌金属蛋白酶CsMep基因在调控高粱炭疽病菌致病力中的应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
DE3470881D1 (de) * 1983-12-20 1988-06-09 Ciba Geigy Ag Microbizides
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
GB8819308D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
CA2031376A1 (en) 1989-12-04 1991-06-05 Bahram Farhadieh Single layer transdermal drug administration system
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
CA2123809A1 (en) 1991-12-18 1993-06-24 Debra L. Wilfong Multilayered barrier structures
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2010510248A (ja) 2006-11-21 2010-04-02 ビアメト ファーマシューティカルズ,インク. 金属結合部分をターゲティング部分と組み合わせて使用する金属酸化還元酵素阻害剤
WO2008124131A1 (en) * 2007-04-05 2008-10-16 The John Hopkins University Antifungal agents as neuroprotectants
SI2563771T1 (sl) * 2010-04-24 2016-05-31 Viamet Pharmaceuticals, Inc. Spojine inhibitorjev metaloencimov
WO2012177635A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20140040235A (ko) * 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물

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