JP2014518219A5 - - Google Patents

Download PDF

Info

Publication number
JP2014518219A5
JP2014518219A5 JP2014516091A JP2014516091A JP2014518219A5 JP 2014518219 A5 JP2014518219 A5 JP 2014518219A5 JP 2014516091 A JP2014516091 A JP 2014516091A JP 2014516091 A JP2014516091 A JP 2014516091A JP 2014518219 A5 JP2014518219 A5 JP 2014518219A5
Authority
JP
Japan
Prior art keywords
difluoro
difluorophenyl
tetrazol
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014516091A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014518219A (ja
JP6122846B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/043101 external-priority patent/WO2012177608A1/en
Publication of JP2014518219A publication Critical patent/JP2014518219A/ja
Publication of JP2014518219A5 publication Critical patent/JP2014518219A5/ja
Application granted granted Critical
Publication of JP6122846B2 publication Critical patent/JP6122846B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014516091A 2011-06-19 2012-06-19 金属酵素阻害剤化合物 Active JP6122846B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161498571P 2011-06-19 2011-06-19
US61/498,571 2011-06-19
US201161505949P 2011-07-08 2011-07-08
US61/505,949 2011-07-08
US201261611880P 2012-03-16 2012-03-16
US61/611,880 2012-03-16
PCT/US2012/043101 WO2012177608A1 (en) 2011-06-19 2012-06-19 Metalloenzyme inhibitor compounds

Publications (3)

Publication Number Publication Date
JP2014518219A JP2014518219A (ja) 2014-07-28
JP2014518219A5 true JP2014518219A5 (enExample) 2015-07-30
JP6122846B2 JP6122846B2 (ja) 2017-04-26

Family

ID=47391258

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014516090A Expired - Fee Related JP6159318B2 (ja) 2011-06-19 2012-06-19 金属酵素阻害化合物
JP2014516091A Active JP6122846B2 (ja) 2011-06-19 2012-06-19 金属酵素阻害剤化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2014516090A Expired - Fee Related JP6159318B2 (ja) 2011-06-19 2012-06-19 金属酵素阻害化合物

Country Status (20)

Country Link
US (4) US8901121B2 (enExample)
EP (2) EP2721021B1 (enExample)
JP (2) JP6159318B2 (enExample)
KR (2) KR20140040235A (enExample)
CN (2) CN103764646A (enExample)
AR (1) AR086988A1 (enExample)
AU (2) AU2012273166A1 (enExample)
BR (1) BR102012015199A2 (enExample)
CA (2) CA2839769A1 (enExample)
CL (1) CL2013003639A1 (enExample)
CO (1) CO6940433A2 (enExample)
CR (1) CR20140024A (enExample)
EA (2) EA201490038A1 (enExample)
EC (1) ECSP14013153A (enExample)
HK (1) HK1198651A1 (enExample)
IN (1) IN2014MN00093A (enExample)
MX (1) MX2013015160A (enExample)
PH (1) PH12013502624A1 (enExample)
UY (1) UY34146A (enExample)
WO (2) WO2012177603A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012177635A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20140040235A (ko) 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
JP2014523880A (ja) 2011-06-23 2014-09-18 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素化合物
HRP20180913T1 (hr) 2011-07-08 2018-07-27 H. Lundbeck A/S Pozitivni alosterni modulatori receptora nikotinskog acetilkolina
RS57248B1 (sr) 2011-12-11 2018-07-31 Viamet Pharmaceuticals Nc Inc Jedinjenja inhibitori metaloenzima
IN2014DN06792A (enExample) * 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
WO2013135674A1 (en) * 2012-03-12 2013-09-19 Syngenta Participations Ag Insecticidal 2-aryl-acetamide compounds
EP2894981B1 (en) * 2012-09-12 2019-12-04 Dow AgroSciences LLC Metalloenzyme inhibitor compounds
BR112015018547A2 (pt) * 2013-02-04 2017-07-18 Syngenta Participations Ag microbiocidas
WO2014167009A1 (en) 2013-04-12 2014-10-16 Bayer Cropscience Ag Novel triazole derivatives
MX2015014268A (es) * 2013-04-12 2016-06-02 Bayer Cropscience Ag Derivados de triazol novedosos.
EP2984080B1 (en) * 2013-04-12 2017-08-30 Bayer CropScience Aktiengesellschaft Novel triazolinthione derivatives
US9447073B2 (en) * 2013-05-28 2016-09-20 Viamet Pharmaceuticals, Inc. Fungicidal compositions
EP3008051A4 (en) 2013-06-12 2017-03-01 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP6572234B2 (ja) 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
US10196375B2 (en) 2014-03-19 2019-02-05 Mycovia Pharmaceuticals, Inc. Antifungal compound process
US10017494B2 (en) 2014-03-19 2018-07-10 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP2017507991A (ja) 2014-03-19 2017-03-23 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
WO2015143154A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US9914726B2 (en) 2014-03-19 2018-03-13 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
AU2015231270B2 (en) 2014-03-19 2019-03-07 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
JP2017509646A (ja) 2014-03-19 2017-04-06 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
CN109678791B (zh) * 2014-03-19 2022-07-01 美国陶氏益农公司 1-(2,4-二氟苯)-2,2-二氟-2-(5-取代吡啶-2-基)乙酮及制备方法
CA2942968C (en) * 2014-03-19 2022-03-15 William J. Hoekstra Antifungal compound process
CA2945674A1 (en) * 2014-04-15 2015-10-22 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
EP3164374A4 (en) 2014-07-02 2017-11-15 Ralco Nutrition, Inc. Agricultural compositions and applications utilizing essential oils
WO2016050769A1 (en) 2014-10-02 2016-04-07 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives useful as fungicides
CN107660203A (zh) * 2015-04-02 2018-02-02 拜耳作物科学股份公司 作为杀真菌剂的三唑衍生物
CA2986041C (en) 2015-05-18 2021-06-29 Viamet Pharmaceuticals, Inc. 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4,5-dihydro-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile compounds as antifungal agents
BR112018005194B1 (pt) 2015-09-18 2022-11-08 Vps-3, Inc Processo para preparar um composto antifúngico
AR106729A1 (es) 2015-11-17 2018-02-14 Viamet Pharmaceuticals Inc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación
BR112018009931A8 (pt) 2015-11-17 2019-02-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
WO2017172368A1 (en) 2016-03-31 2017-10-05 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
WO2018119440A1 (en) 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
CN106866575A (zh) * 2017-03-21 2017-06-20 苏州汉德创宏生化科技有限公司 2‑(1‑哌啶基)‑5‑溴噻唑的合成方法
CN107056690A (zh) * 2017-03-22 2017-08-18 上海康鹏科技有限公司 一种6‑溴吡啶‑3‑甲醛的制备方法
WO2019092086A1 (en) 2017-11-13 2019-05-16 Bayer Aktiengesellschaft Tetrazolylpropyl derivatives and their use as fungicides
CN108358871B (zh) * 2018-02-01 2020-05-22 浙江扬帆新材料股份有限公司 一种2-苄基-2-二甲基氨基-1-(4-吗啉苯基)丁酮的合成方法
AU2021361997A1 (en) * 2020-10-16 2023-06-15 Miralogx Llc Metalloenzyme inhibitors for treating cancers, alzheimer's disease, hemochromatosis, and other disorders
CN117069693A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含胺基结构化合物的制备方法及作为抗菌剂的应用
CN117069697A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含杂环结构化合物的制备方法及作为抗菌剂的应用
CN115007323B (zh) * 2022-06-17 2024-01-23 中南大学 一种抑制矿物中黄铁矿浮选的方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8301699D0 (en) * 1983-01-21 1983-02-23 Pfizer Ltd Antifungal agents
GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
DE3313073A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
DE3470881D1 (de) * 1983-12-20 1988-06-09 Ciba Geigy Ag Microbizides
GB8506619D0 (en) * 1985-03-14 1985-04-17 Pfizer Ltd Triazole antifungal agents
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5206364A (en) * 1988-08-13 1993-04-27 Pfizer Inc. Triazole antifungal agents
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
CA2031376A1 (en) 1989-12-04 1991-06-05 Bahram Farhadieh Single layer transdermal drug administration system
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
CA2123809A1 (en) 1991-12-18 1993-06-24 Debra L. Wilfong Multilayered barrier structures
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
GB9512961D0 (en) 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
CN1189162A (zh) 1995-06-26 1998-07-29 辉瑞研究开发公司 三唑抗真菌剂
FI102788B1 (fi) * 1995-09-14 1999-02-15 Nokia Telecommunications Oy Yhteisen levydatan hallinta kahdennetussa tietokoneyksikössä
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2000344744A (ja) 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
GB0227558D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
CN100422153C (zh) 2005-02-06 2008-10-01 沈阳化工研究院 N-(2-取代苯基)-n-甲氧基氨基甲酸酯类化合物及其制备与应用
BRPI0501146A (pt) * 2005-03-16 2006-10-31 Fmc Quimica Do Brasil Ltda composição fungicida/inseticida/herbicida/nematicida, uso de derivados de imidazóis e/ou trazóis no combate de pragas agrìcolas, método para preparação da referida composição, bem como método para controle de doenças/insetos/ácaros/nematóides e plantas daninhas, particularmente de doenças foliares e/ou de solos
EP2073741A4 (en) 2006-10-18 2013-07-24 Bnl Biotech Co Ltd ENDODONTIC INSTRUMENT FOR SHUTDOWN OF RADICULAR CHANNEL AND HEATED END SUITABLE FOR THIS INSTRUMENT
JP2010510248A (ja) * 2006-11-21 2010-04-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分をターゲティング部分と組み合わせて使用する金属酸化還元酵素阻害剤
WO2008124131A1 (en) * 2007-04-05 2008-10-16 The John Hopkins University Antifungal agents as neuroprotectants
US8221057B2 (en) 2008-06-25 2012-07-17 General Electric Company Method, system and controller for establishing a wheel space temperature alarm in a turbomachine
SI2563771T1 (sl) 2010-04-24 2016-05-31 Viamet Pharmaceuticals, Inc. Spojine inhibitorjev metaloencimov
WO2011134911A2 (en) 2010-04-28 2011-11-03 Bayer Cropscience Ag Fungicide hydroximoyl-tetrazole derivatives
EP2522683B1 (en) 2011-05-10 2013-12-11 Hüttenes-Albertus Chemische-Werke GmbH Silicic ester modified phenol/formaldehyde novolaks and their use for the production of resin coated substrates
WO2012177635A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20140040235A (ko) * 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
JP2014523880A (ja) * 2011-06-23 2014-09-18 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素化合物
RS57248B1 (sr) * 2011-12-11 2018-07-31 Viamet Pharmaceuticals Nc Inc Jedinjenja inhibitori metaloenzima
IN2014DN06792A (enExample) * 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
EP2894981B1 (en) * 2012-09-12 2019-12-04 Dow AgroSciences LLC Metalloenzyme inhibitor compounds

Similar Documents

Publication Publication Date Title
JP2014518220A5 (enExample)
JP2014523880A5 (enExample)
JP2015505538A5 (enExample)
AU2021288898A1 (en) Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b protein conferring resistance to Qo inhibitors V
US20200008426A1 (en) Active compound combinations
HRP20160172T1 (hr) Spojevi koji su inhibitori metaloenzima
US8598176B2 (en) Pyridazine compound and use thereof
JP2014514299A5 (enExample)
JP2017501198A5 (enExample)
AR118840A2 (es) Combinaciones de compuestos activos que comprenden un derivado de (tio)carboxamida y un compuesto fungicida
JP2016512259A5 (enExample)
JP2017508719A5 (enExample)
NZ625074A (en) Synergistic fungicidal mixtures for fungal control in cereals
RU2017131549A (ru) Замещенные 2-тиоимидазолил-карбоксамиды в качестве средств для борьбы с вредителями
LV10714B (en) Triazole compounds
US20190233444A1 (en) Trisubstitutedsilylphenoxyheterocycles and analogues
JP2017502049A5 (enExample)
RU2015100942A (ru) Производное пиперидинилпиразолпиридина
US20210009575A1 (en) Hydroxyisoxazolines and derivatives thereof
JP2023527036A5 (enExample)
WO2020254494A1 (en) Fungicidal oxadiazoles
JP2020513413A (ja) フェニルアミジン類及びそれの殺菌剤としての使用
US20100029668A1 (en) Novel pyridazine derivatives
EP3708565A1 (en) Pyrimidinyloxyphenylamidines and the use thereof as fungicides
WO2018145934A1 (en) Novel triazole derivatives