JP2014516037A5 - - Google Patents
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- Publication number
- JP2014516037A5 JP2014516037A5 JP2014511554A JP2014511554A JP2014516037A5 JP 2014516037 A5 JP2014516037 A5 JP 2014516037A5 JP 2014511554 A JP2014511554 A JP 2014511554A JP 2014511554 A JP2014511554 A JP 2014511554A JP 2014516037 A5 JP2014516037 A5 JP 2014516037A5
- Authority
- JP
- Japan
- Prior art keywords
- aib
- exist
- ac5c
- ac4c
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 linker amino acid Chemical class 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 13
- 239000002253 acid Substances 0.000 claims 7
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
- 239000004094 surface-active agent Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 125000000923 (C1-C30) alkyl group Chemical group 0.000 claims 3
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 108010087791 pyroglutamylhistidine Proteins 0.000 claims 2
- SHCMCJLNUOZJOR-YXISZKLHSA-N (2s,3s,4s,5r,6r)-6-dodecyl-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical group CCCCCCCCCCCC[C@@]1(O)O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SHCMCJLNUOZJOR-YXISZKLHSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161487640P | 2011-05-18 | 2011-05-18 | |
| US61/487,640 | 2011-05-18 | ||
| US201161543716P | 2011-10-05 | 2011-10-05 | |
| US61/543,716 | 2011-10-05 | ||
| PCT/US2012/038434 WO2012158965A2 (en) | 2011-05-18 | 2012-05-17 | Improved peptide pharmaceuticals for insulin resistance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017028560A Division JP6684396B2 (ja) | 2011-05-18 | 2017-02-19 | インスリン抵抗性のための改善されたペプチドの調合薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516037A JP2014516037A (ja) | 2014-07-07 |
| JP2014516037A5 true JP2014516037A5 (cg-RX-API-DMAC7.html) | 2015-07-09 |
| JP6284471B2 JP6284471B2 (ja) | 2018-02-28 |
Family
ID=47177642
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511554A Active JP6284471B2 (ja) | 2011-05-18 | 2012-05-17 | インスリン抵抗性のための改善されたペプチドの調合薬 |
| JP2017028560A Active JP6684396B2 (ja) | 2011-05-18 | 2017-02-19 | インスリン抵抗性のための改善されたペプチドの調合薬 |
| JP2019192289A Active JP7015610B2 (ja) | 2011-05-18 | 2019-10-21 | インスリン抵抗性のための改善されたペプチドの調合薬 |
| JP2022005872A Active JP7389150B2 (ja) | 2011-05-18 | 2022-01-18 | インスリン抵抗性のための改善されたペプチドの調合薬 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017028560A Active JP6684396B2 (ja) | 2011-05-18 | 2017-02-19 | インスリン抵抗性のための改善されたペプチドの調合薬 |
| JP2019192289A Active JP7015610B2 (ja) | 2011-05-18 | 2019-10-21 | インスリン抵抗性のための改善されたペプチドの調合薬 |
| JP2022005872A Active JP7389150B2 (ja) | 2011-05-18 | 2022-01-18 | インスリン抵抗性のための改善されたペプチドの調合薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10471127B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2710031B9 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6284471B2 (cg-RX-API-DMAC7.html) |
| KR (5) | KR102011924B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103732617A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012255119B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013029409B1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3134906A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2710031T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL229373B (cg-RX-API-DMAC7.html) |
| MX (1) | MX344219B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2602801C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012158965A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295452A1 (en) | 2005-05-04 | 2011-03-16 | Zealand Pharma A/S | Glucagon-like-peptide-2 (GLP-2) analogues |
| BRPI0718566A2 (pt) | 2006-11-08 | 2014-03-11 | Zealand Pharma As | Peptídeo, análogo do mesmo, composição farmacêutica, usos de um análogo de peptídeo, e de uma molécula de ácido nucléico, de um vetor de expressão, ou de uma célula hospedeira, molécula de ácido nucléico, vetor de expressão, célula hospedeira, métodos para produzir o análogo de peptídeo-2 tipo-glucagon (glp-2), e, kit terapêutico. |
| EP4286400A3 (en) | 2011-05-18 | 2024-06-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| CA3134906A1 (en) | 2011-05-18 | 2012-11-22 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| CA2849673A1 (en) | 2011-09-23 | 2013-03-28 | Novo Nordisk A/S | Novel glucagon analogues |
| WO2013164484A1 (en) | 2012-05-03 | 2013-11-07 | Zealand Pharma A/S | Glucagon-like-peptide-2 (glp-2) analogues |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR102365582B1 (ko) * | 2012-11-20 | 2022-02-18 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
| ES2906975T3 (es) | 2012-11-20 | 2022-04-21 | Eumederis Pharmaceuticals Inc | Productos farmacéuticos de péptidos mejorados |
| RS57531B1 (sr) | 2012-12-21 | 2018-10-31 | Sanofi Sa | Derivati eksendina-4 kao dualni glp1/gip- ili trigonalni glp1/gip/glukagon agonisti |
| WO2014170496A1 (en) | 2013-04-18 | 2014-10-23 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| KR102542164B1 (ko) * | 2014-05-28 | 2023-06-12 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
| JP2017525656A (ja) | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー／エス | 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| PE20171154A1 (es) | 2014-12-30 | 2017-08-16 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon con estabilidad mejorada |
| CN107614565B (zh) * | 2015-04-21 | 2021-04-09 | Ran生物技术公司 | 氟化表面活性剂 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| KR102005456B1 (ko) | 2015-06-30 | 2019-07-30 | 한미약품 주식회사 | 신규 글루카곤 유도체 및 이의 지속형 결합체를 포함하는 조성물 |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| MX2018008128A (es) | 2015-12-31 | 2018-12-06 | Hanmi Pharm Ind Co Ltd | Conjugado persistente de triple activador que activa el receptor de glucagon, glp-1 y gip. |
| MX2019000019A (es) * | 2016-06-29 | 2019-05-06 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon, conjugado del mismo, composicion que comprende el mismo y uso terapeutico del mismo. |
| DK3551651T3 (da) | 2016-12-09 | 2024-05-13 | Zealand Pharma As | Acylerede glp-1/glp-2-dobbeltagonister |
| ES2989204T3 (es) | 2017-06-16 | 2024-11-25 | Zealand Pharma As | Pautas posológicas para la administración de análogos del péptido 2 similar al glucagón (GLP-2) |
| CN108054388B (zh) * | 2017-12-26 | 2020-02-21 | 吉林大学 | 以h6p2w18/l-3-(2-萘基)-丙氨酸复合水基黏合剂为电极涂层的化学电池 |
| CA3086918A1 (en) * | 2018-01-03 | 2019-07-11 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for treatment of nash and other disorders |
| CN117202924A (zh) | 2020-12-07 | 2023-12-08 | 斯皮特弗尔制药有限责任公司 | 使用glp-1r和gcgr平衡激动剂降低血糖和/或体重的治疗方案和方法 |
| WO2022241287A2 (en) | 2021-05-13 | 2022-11-17 | Carmot Therapeutics, Inc. | Modulators of g-protein coupled receptors |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5661130A (en) | 1993-06-24 | 1997-08-26 | The Uab Research Foundation | Absorption enhancers for drug administration |
| JPH1160598A (ja) | 1997-08-15 | 1999-03-02 | Asahi Glass Co Ltd | オピオイド様ペプチド |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| RU2181729C1 (ru) | 2000-09-20 | 2002-04-27 | Калюжин Олег Витальевич | Производные мурамовой кислоты |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US6864069B2 (en) | 2001-10-05 | 2005-03-08 | Bayer Pharmaceuticals Corporation | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use |
| DK2322229T3 (en) | 2001-10-10 | 2017-03-27 | Novo Nordisk As | Remodeling and Glycoconjugation of Factor IX |
| US6881829B2 (en) | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
| US20110257096A1 (en) | 2004-08-25 | 2011-10-20 | Aegis Therapeutics, Inc. | Compositions for drug administration |
| US20060046962A1 (en) * | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
| ITRM20040607A1 (it) | 2004-12-15 | 2005-03-15 | Biogen S R L | Analoghi della dermorfina ad attivita' analgesica. |
| WO2006096426A2 (en) | 2005-03-03 | 2006-09-14 | The Board Of Trustees Of The University Of Illinois | Targeted drug delivery of pain and addiction therapies using opioid receptor-mediated internalization |
| JP2008539735A (ja) * | 2005-05-06 | 2008-11-20 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | グルカゴン様ペプチド１（ｇｌｐ−１）受容体アンタゴニストおよびそれらの薬理学的使用方法 |
| WO2007002465A2 (en) | 2005-06-23 | 2007-01-04 | Rapid Pharmaceuticals, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| WO2007060692A2 (en) | 2005-11-24 | 2007-05-31 | Brain N' Beyond Biotech Pvt. Ltd. | Compositions for increasing bioavailability of peptides or proteins and method thereof |
| US7998927B2 (en) | 2006-06-23 | 2011-08-16 | Aegis Therapeutics, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| US8173594B2 (en) | 2006-06-23 | 2012-05-08 | Aegis Therapeutics, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| HUE036502T2 (hu) * | 2006-10-04 | 2018-07-30 | Novo Nordisk As | Glicerinhez kapcsolódó pegilált cukrok és glükopeptidek |
| JP5775450B2 (ja) * | 2008-06-17 | 2015-09-09 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | グルカゴン／ｇｌｐ−１受容体コアゴニスト |
| US8221753B2 (en) | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
| EP4286400A3 (en) | 2011-05-18 | 2024-06-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| CA3134906A1 (en) | 2011-05-18 | 2012-11-22 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| KR102365582B1 (ko) | 2012-11-20 | 2022-02-18 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
| ES2906975T3 (es) | 2012-11-20 | 2022-04-21 | Eumederis Pharmaceuticals Inc | Productos farmacéuticos de péptidos mejorados |
| KR102542164B1 (ko) | 2014-05-28 | 2023-06-12 | 메더리스 다이어비티즈, 엘엘씨 | 인슐린 저항성에 대한 개선된 펩티드 약제 |
-
2012
- 2012-05-17 CA CA3134906A patent/CA3134906A1/en active Pending
- 2012-05-17 KR KR1020137033668A patent/KR102011924B1/ko active Active
- 2012-05-17 JP JP2014511554A patent/JP6284471B2/ja active Active
- 2012-05-17 RU RU2013154047/04A patent/RU2602801C2/ru active
- 2012-05-17 MX MX2013013395A patent/MX344219B/es active IP Right Grant
- 2012-05-17 WO PCT/US2012/038434 patent/WO2012158965A2/en not_active Ceased
- 2012-05-17 EP EP12785861.1A patent/EP2710031B9/en active Active
- 2012-05-17 KR KR1020217014931A patent/KR102497726B1/ko active Active
- 2012-05-17 BR BR112013029409-4A patent/BR112013029409B1/pt active IP Right Grant
- 2012-05-17 KR KR1020247021588A patent/KR20240110072A/ko active Pending
- 2012-05-17 US US14/118,545 patent/US10471127B2/en active Active
- 2012-05-17 CN CN201280035629.9A patent/CN103732617A/zh active Pending
- 2012-05-17 CA CA2836574A patent/CA2836574C/en active Active
- 2012-05-17 KR KR1020237004115A patent/KR20230023059A/ko not_active Ceased
- 2012-05-17 AU AU2012255119A patent/AU2012255119B2/en active Active
- 2012-05-17 DK DK12785861.1T patent/DK2710031T3/en active
- 2012-05-17 CN CN202010611969.8A patent/CN111701028A/zh active Pending
- 2012-05-17 KR KR1020197023482A patent/KR102255479B1/ko active Active
-
2013
- 2013-11-11 IL IL229373A patent/IL229373B/en active IP Right Grant
-
2017
- 2017-02-19 JP JP2017028560A patent/JP6684396B2/ja active Active
-
2019
- 2019-10-21 JP JP2019192289A patent/JP7015610B2/ja active Active
-
2022
- 2022-01-18 JP JP2022005872A patent/JP7389150B2/ja active Active
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