JP2014515921A5 - - Google Patents
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- JP2014515921A5 JP2014515921A5 JP2014509467A JP2014509467A JP2014515921A5 JP 2014515921 A5 JP2014515921 A5 JP 2014515921A5 JP 2014509467 A JP2014509467 A JP 2014509467A JP 2014509467 A JP2014509467 A JP 2014509467A JP 2014515921 A5 JP2014515921 A5 JP 2014515921A5
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- Japan
- Prior art keywords
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- amino acid
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483531P | 2011-05-06 | 2011-05-06 | |
| US61/483,531 | 2011-05-06 | ||
| PCT/US2012/036456 WO2012154530A1 (en) | 2011-05-06 | 2012-05-04 | Recombinant immunotoxin targeting mesothelin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017043879A Division JP2017140029A (ja) | 2011-05-06 | 2017-03-08 | メソテリンを標的とする組換え免疫毒素 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515921A JP2014515921A (ja) | 2014-07-07 |
| JP2014515921A5 true JP2014515921A5 (https=) | 2015-06-25 |
| JP6169561B2 JP6169561B2 (ja) | 2017-07-26 |
Family
ID=46147033
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509467A Active JP6169561B2 (ja) | 2011-05-06 | 2012-05-04 | メソテリンを標的とする組換え免疫毒素 |
| JP2017043879A Pending JP2017140029A (ja) | 2011-05-06 | 2017-03-08 | メソテリンを標的とする組換え免疫毒素 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017043879A Pending JP2017140029A (ja) | 2011-05-06 | 2017-03-08 | メソテリンを標的とする組換え免疫毒素 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10683362B2 (https=) |
| EP (1) | EP2704739B1 (https=) |
| JP (2) | JP6169561B2 (https=) |
| KR (1) | KR20140036216A (https=) |
| CN (1) | CN103648525B (https=) |
| AU (1) | AU2012253896B2 (https=) |
| BR (1) | BR112013028537A2 (https=) |
| CA (1) | CA2835070C (https=) |
| CL (1) | CL2013003182A1 (https=) |
| CO (1) | CO6862104A2 (https=) |
| CR (1) | CR20130571A (https=) |
| EC (1) | ECSP13013067A (https=) |
| ES (1) | ES2641877T3 (https=) |
| IL (1) | IL229198A0 (https=) |
| MA (1) | MA35244B1 (https=) |
| MX (1) | MX2013012905A (https=) |
| PE (1) | PE20141454A1 (https=) |
| PH (1) | PH12013502264A1 (https=) |
| RU (1) | RU2600067C2 (https=) |
| SG (1) | SG194787A1 (https=) |
| WO (1) | WO2012154530A1 (https=) |
| ZA (1) | ZA201308270B (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG194787A1 (en) | 2011-05-06 | 2013-12-30 | Us Gov Health & Human Serv | Recombinant immunotoxin targeting mesothelin |
| US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
| EP3666795A1 (en) | 2013-03-12 | 2020-06-17 | Molecular Templates, Inc. | Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types |
| WO2014182532A1 (en) * | 2013-05-07 | 2014-11-13 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Mesothelin-specific immunocytokine and use thereof |
| WO2015051199A2 (en) * | 2013-10-06 | 2015-04-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified pseudomonas exotoxin a |
| CN112851769A (zh) | 2014-01-27 | 2021-05-28 | 分子模板公司 | 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽 |
| WO2015120058A2 (en) | 2014-02-05 | 2015-08-13 | Molecular Templates, Inc. | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| CN106604934A (zh) | 2014-06-11 | 2017-04-26 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| EP3253799B1 (en) | 2015-02-05 | 2020-12-02 | Molecular Templates, Inc. | Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof |
| WO2016146833A1 (en) | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance |
| EP3303373B1 (en) | 2015-05-30 | 2020-04-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| JP2018536389A (ja) * | 2015-10-02 | 2018-12-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | メソテリンとｃｄ３に結合する二重特異性細胞活性化抗原結合分子 |
| PE20180484A1 (es) * | 2015-10-02 | 2018-03-07 | Hoffmann La Roche | Moleculas biespecificas de union a antigeno activadoras de celulas t |
| EP3184547A1 (en) | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anti-tpbg antibodies and methods of use |
| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| WO2017196847A1 (en) | 2016-05-10 | 2017-11-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens |
| US11827688B2 (en) | 2016-06-02 | 2023-11-28 | Immunocore Limited | Dosing regimen for GP100-specific TCR—anti-CD3 SCFV fusion protein |
| TW201809013A (zh) * | 2016-06-06 | 2018-03-16 | 艾斯克立必恩股份有限公司 | 用於藥物遞送之抗體融合蛋白 |
| WO2017214182A1 (en) | 2016-06-07 | 2017-12-14 | The United States Of America. As Represented By The Secretary, Department Of Health & Human Services | Fully human antibody targeting pdi for cancer immunotherapy |
| EP3494135A1 (en) | 2016-08-02 | 2019-06-12 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Monoclonal antibodies targeting glypican-2 (gpc2) and use thereof |
| WO2018106895A1 (en) | 2016-12-07 | 2018-06-14 | Molecular Templates, Inc. | Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
| AU2017382883B2 (en) | 2016-12-21 | 2024-07-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for FLT3 and uses thereof |
| MX2019008840A (es) | 2017-01-25 | 2019-09-09 | Molecular Templates Inc | Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+. |
| CN108624607B (zh) * | 2017-03-16 | 2021-11-16 | 上海恒润达生生物科技股份有限公司 | 靶向mesothelin的嵌合抗原受体并对其双重修饰的方法和用途 |
| CN108624608B (zh) * | 2017-03-17 | 2021-11-16 | 上海恒润达生生物科技股份有限公司 | 靶向mesothelin的第四代嵌合抗原受体的制备方法和用途 |
| EP3600590B1 (en) | 2017-03-27 | 2025-10-01 | Cidra Corporate Services LLC | Removal of hydrophobic particles using carbon dioxide |
| CN108728458B (zh) * | 2017-04-21 | 2021-11-16 | 上海恒润达生生物科技股份有限公司 | 靶向mesothelin的嵌合抗原受体并联合表达IL-15的方法和用途 |
| WO2018213612A1 (en) | 2017-05-18 | 2018-11-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin polypeptides and proteins |
| WO2018213064A1 (en) | 2017-05-19 | 2018-11-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibody targeting tnfer2 for cancer immunotherapy |
| CN109134660B (zh) * | 2017-06-16 | 2022-07-01 | 上海恒润达生生物科技股份有限公司 | 靶向Mesothelin的嵌合抗原受体并联合表达抗PD1抗体的方法及其用途 |
| WO2019005208A1 (en) | 2017-06-30 | 2019-01-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | ANTIBODIES TO HUMAN MESOTHELIN AND USES IN ANTICANCER THERAPY |
| US11795235B2 (en) * | 2017-09-18 | 2023-10-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotoxins with albumin binding domain |
| WO2019118760A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
| CN110612117B (zh) | 2018-04-17 | 2024-04-12 | 分子模板公司 | 包含去免疫化的志贺毒素a亚基支架的her2靶向分子 |
| US11939377B2 (en) | 2018-07-12 | 2024-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Affinity matured CD22-specific monoclonal antibody and uses thereof |
| EP3833684A1 (en) | 2018-08-08 | 2021-06-16 | The United States of America, as represented by the Secretary, Department of Health and Human Services | High affinity monoclonal antibodies targeting glypican-2 and uses thereof |
| CA3125484A1 (en) | 2019-01-08 | 2020-07-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cross-species single domain antibodies targeting mesothelin for treating solid tumors |
| US12122843B2 (en) | 2019-01-22 | 2024-10-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity monoclonal antibodies targeting glypican-1 and methods of use |
| CA3156761A1 (en) | 2019-10-22 | 2021-04-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity nanobodies targeting b7h3 (cd276) for treating multiple solid tumors |
| CN112210008A (zh) * | 2020-07-16 | 2021-01-12 | 上海恒润达生生物科技有限公司 | 一种新型抗人msln抗体及其用途 |
| EP4192874A1 (en) | 2020-08-05 | 2023-06-14 | Dragonfly Therapeutics, Inc. | Antibodies targeting egfr and use thereof |
| US20230391852A1 (en) | 2020-10-26 | 2023-12-07 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies targeting sars coronavirus spike protein and uses thereof |
| CN112574953A (zh) * | 2020-12-11 | 2021-03-30 | 南通大学 | 一种间皮素嵌合抗原受体外泌体、及其制备方法和应用 |
| WO2022232612A1 (en) | 2021-04-29 | 2022-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lassa virus-specific nanobodies and methods of their use |
| US20240270851A1 (en) | 2021-06-09 | 2024-08-15 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Cross species single domain antibodies targeting pd-l1 for treating solid tumors |
| CN116023501A (zh) * | 2021-10-25 | 2023-04-28 | 三生国健药业（上海）股份有限公司 | 一种抗her2的免疫毒素分子、及其制备方法与应用 |
| WO2023076881A1 (en) | 2021-10-26 | 2023-05-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies targeting the s2 subunit of sars-cov-2 spike protein |
| US20230220106A1 (en) | 2021-12-08 | 2023-07-13 | Dragonfly Therapeutics, Inc. | Antibodies targeting 5t4 and uses thereof |
| WO2023114980A1 (en) | 2021-12-17 | 2023-06-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin polypeptides, proteins, and chimeric antigen receptors |
| CN118510890A (zh) * | 2022-01-07 | 2024-08-16 | 原启生物科技(上海)有限责任公司 | 靶向cldn18.2和msln的嵌合抗原受体及其用途 |
| US20260070960A1 (en) | 2022-09-01 | 2026-03-12 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies targeting hpv e6/e7 oncogenic peptide/mhc complexes |
| WO2024104584A1 (en) | 2022-11-17 | 2024-05-23 | University Of Cape Town | Deimmunized pseudomonas exotoxin a |
| WO2024238346A1 (en) | 2023-05-12 | 2024-11-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that specifically bind the s2 subunit of sars-cov-2 spike protein and compositions and uses thereof |
| AU2024295016A1 (en) | 2023-07-20 | 2026-02-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment of solid tumors |
| WO2025171238A1 (en) | 2024-02-07 | 2025-08-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof |
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| SG194787A1 (en) | 2011-05-06 | 2013-12-30 | Us Gov Health & Human Serv | Recombinant immunotoxin targeting mesothelin |
-
2012
- 2012-05-04 SG SG2013081799A patent/SG194787A1/en unknown
- 2012-05-04 WO PCT/US2012/036456 patent/WO2012154530A1/en not_active Ceased
- 2012-05-04 CN CN201280033583.7A patent/CN103648525B/zh active Active
- 2012-05-04 PE PE2013002456A patent/PE20141454A1/es not_active Application Discontinuation
- 2012-05-04 US US14/115,131 patent/US10683362B2/en active Active
- 2012-05-04 BR BR112013028537A patent/BR112013028537A2/pt not_active IP Right Cessation
- 2012-05-04 EP EP12722586.0A patent/EP2704739B1/en active Active
- 2012-05-04 RU RU2013148919/10A patent/RU2600067C2/ru active
- 2012-05-04 KR KR1020137032247A patent/KR20140036216A/ko not_active Withdrawn
- 2012-05-04 MX MX2013012905A patent/MX2013012905A/es not_active Application Discontinuation
- 2012-05-04 PH PH1/2013/502264A patent/PH12013502264A1/en unknown
- 2012-05-04 ES ES12722586.0T patent/ES2641877T3/es active Active
- 2012-05-04 JP JP2014509467A patent/JP6169561B2/ja active Active
- 2012-05-04 CA CA2835070A patent/CA2835070C/en active Active
- 2012-05-04 AU AU2012253896A patent/AU2012253896B2/en active Active
-
2013
- 2013-10-31 IL IL229198A patent/IL229198A0/en unknown
- 2013-11-05 CR CR20130571A patent/CR20130571A/es unknown
- 2013-11-05 ZA ZA2013/08270A patent/ZA201308270B/en unknown
- 2013-11-06 CL CL2013003182A patent/CL2013003182A1/es unknown
- 2013-11-21 CO CO13274153A patent/CO6862104A2/es unknown
- 2013-12-04 EC ECSP13013067 patent/ECSP13013067A/es unknown
- 2013-12-06 MA MA36534A patent/MA35244B1/fr unknown
-
2017
- 2017-03-08 JP JP2017043879A patent/JP2017140029A/ja active Pending
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