|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US3885035A
(en)
|
1972-04-05 |
1975-05-20 |
Sandoz Ag |
Method for treating arrhythmia by using 1,4-bis(4 quinazolinyl) piperazines
|
|
US3956495A
(en)
|
1973-10-30 |
1976-05-11 |
Eli Lilly And Company |
2,4-Diaminoquinazolines as antithrombotic agents
|
|
US3966936A
(en)
|
1974-02-21 |
1976-06-29 |
Pfizer Inc. |
Piperazino quinazoline bronchodilators
|
|
US4060615A
(en)
|
1976-02-18 |
1977-11-29 |
Mead Johnson & Company |
2-Piperazinyl-6,7-dimethoxyquinazolines
|
|
JPS562968A
(en)
|
1979-06-21 |
1981-01-13 |
Mitsubishi Yuka Yakuhin Kk |
Novel pyrimidine derivative
|
|
JPS6270A
(ja)
|
1985-03-07 |
1987-01-06 |
Sankyo Co Ltd |
シクロペンタ〔ｄ〕ピリミジン誘導体
|
|
US5583024A
(en)
|
1985-12-02 |
1996-12-10 |
The Regents Of The University Of California |
Recombinant expression of Coleoptera luciferase
|
|
WO1987004928A1
(en)
|
1986-02-24 |
1987-08-27 |
Mitsui Petrochemical Industries, Ltd. |
Agents for treating neurophathy
|
|
US4871739A
(en)
|
1987-01-21 |
1989-10-03 |
Merck & Co., Inc. |
Substituted 6H-7,8-dihydrothiapyrano(3,2-D)-pyrimidines as hyopglycemic agents
|
|
US4889856A
(en)
|
1987-08-31 |
1989-12-26 |
Merck & Co., Inc. |
7,8-dihydro-4-(1-pierazinyl)-6H-thiopyrano-[3,2-d] pyrimidines as β-blockers
|
|
US4994464A
(en)
|
1987-08-31 |
1991-02-19 |
Merck & Co., Inc. |
Piperazinylpyrimidines as β-adrenergic receptor blockers
|
|
WO1990007926A1
(en)
|
1989-01-20 |
1990-07-26 |
Pfizer Inc. |
3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
|
|
DK0664291T3
(da)
|
1992-10-05 |
2000-10-30 |
Ube Industries |
Pyrimidinforbindelse
|
|
EP0710654A4
(en)
|
1993-07-23 |
1996-08-28 |
Green Cross Corp |
TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE
|
|
GB9416189D0
(en)
|
1994-08-10 |
1994-09-28 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
ES2201112T3
(es)
|
1994-08-13 |
2004-03-16 |
Yuhan Corporation |
Nuevos derivados de pirimidina y procedimientos para su preparacion.
|
|
US5543523A
(en)
|
1994-11-15 |
1996-08-06 |
Regents Of The University Of Minnesota |
Method and intermediates for the synthesis of korupensamines
|
|
US5525625A
(en)
|
1995-01-24 |
1996-06-11 |
Warner-Lambert Company |
2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
|
|
JPH08336393A
(ja)
|
1995-04-13 |
1996-12-24 |
Mitsubishi Chem Corp |
光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
|
|
US7067664B1
(en)
|
1995-06-06 |
2006-06-27 |
Pfizer Inc. |
Corticotropin releasing factor antagonists
|
|
ZA979961B
(en)
|
1996-11-15 |
1999-05-05 |
Lilly Co Eli |
5-HT1F agonists
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
EP0993437B1
(en)
|
1997-07-01 |
2006-11-08 |
Warner-Lambert Company Llc |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as mek inhibitors
|
|
US6506798B1
(en)
|
1997-07-01 |
2003-01-14 |
Warner-Lambert Company |
4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
|
|
US6821963B2
(en)
|
1997-07-01 |
2004-11-23 |
Warner-Lambert Company |
4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
|
|
WO1999001426A1
(en)
|
1997-07-01 |
1999-01-14 |
Warner-Lambert Company |
4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors
|
|
US6310060B1
(en)
|
1998-06-24 |
2001-10-30 |
Warner-Lambert Company |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
|
|
US6602677B1
(en)
|
1997-09-19 |
2003-08-05 |
Promega Corporation |
Thermostable luciferases and methods of production
|
|
EP1067123B1
(en)
|
1998-03-31 |
2011-01-19 |
Kyowa Hakko Kirin Co., Ltd. |
Nitrogenous heterocyclic compounds
|
|
DE19853278A1
(de)
|
1998-11-19 |
2000-05-25 |
Aventis Pharma Gmbh |
Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
|
|
HUP0104933A3
(en)
|
1999-01-07 |
2003-12-29 |
Warner Lambert Co |
Antiviral method using mek inhibitors
|
|
ATE292462T1
(de)
|
1999-01-07 |
2005-04-15 |
Warner Lambert Co |
Behandlung von asthma anhand von mek-inhibitoren
|
|
ES2252996T3
(es)
|
1999-01-13 |
2006-05-16 |
Warner-Lambert Company Llc |
Derivados de bencenosulfonamida y su uso como inhibidores de mek.
|
|
YU49401A
(sh)
|
1999-01-13 |
2004-07-15 |
Warner-Lambert Company |
Benzoheterocikli i njihova upotreba kao inhibitori mek
|
|
JP2002534446A
(ja)
|
1999-01-13 |
2002-10-15 |
ワーナー−ランバート・カンパニー |
４′ヘテロアリールジアリールアミン
|
|
ATE311363T1
(de)
|
1999-01-13 |
2005-12-15 |
Warner Lambert Co |
Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
|
|
CA2348236A1
(en)
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
|
|
SK9822001A3
(en)
|
1999-01-13 |
2002-08-06 |
Warner Lambert Co |
1-heterocycle substituted diarylamines, pharmaceutical compositions based thereon and their use in therapy
|
|
GB9910577D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
HUP0202623A3
(en)
|
1999-07-16 |
2003-03-28 |
Warner Lambert Co |
Method for treating chronic pain using mek inhibitors
|
|
WO2001005393A2
(en)
|
1999-07-16 |
2001-01-25 |
Warner-Lambert Company |
Method for treating chronic pain using mek inhibitors
|
|
WO2001005390A2
(en)
|
1999-07-16 |
2001-01-25 |
Warner-Lambert Company |
Method for treating chronic pain using mek inhibitors
|
|
AU5785900A
(en)
|
1999-07-16 |
2001-02-05 |
Warner-Lambert Company |
Method for treating chronic pain using mek inhibitors
|
|
CA2403017A1
(en)
|
2000-03-15 |
2001-09-20 |
Warner-Lambert Company |
5-amide substituted diarylamines as mex inhibitors
|
|
GEP20053496B
(en)
|
2000-07-19 |
2005-04-25 |
Warner Lambert Co |
Oxygenated Esters of 4-Iodo Phenylamino Benzhydroxamic Acids
|
|
SK2072003A3
(en)
|
2000-08-25 |
2004-01-08 |
Warner Lambert Co |
Process for making N-aryl-anthranilic acids and their derivatives
|
|
HUP0302173A2
(hu)
|
2000-09-15 |
2003-09-29 |
Vertex Pharmaceuticals Incorporated |
Protein kináz inhibitorokként alkalmazható pirazolvegyületek
|
|
AU2002210714A1
(en)
|
2000-11-02 |
2002-06-11 |
Astrazeneca Ab |
Substituted quinolines as antitumor agents
|
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
ES2301633T3
(es)
|
2001-04-30 |
2008-07-01 |
Glaxo Group Limited |
Pirimidinas condensadas como antagonistas del factor de liberacion de corticotropina (crf).
|
|
AU2002336462A1
(en)
|
2001-09-06 |
2003-03-24 |
Millennium Pharmaceuticals, Inc. |
Piperazine and homopiperazine compounds
|
|
WO2003049678A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
|
JP4469179B2
(ja)
|
2002-01-23 |
2010-05-26 |
バイエル ファーマセチカル コーポレーション |
Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体
|
|
TW200306819A
(en)
|
2002-01-25 |
2003-12-01 |
Vertex Pharma |
Indazole compounds useful as protein kinase inhibitors
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
NZ535158A
(en)
|
2002-03-13 |
2007-06-29 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
AU2003220202A1
(en)
|
2002-03-13 |
2003-09-29 |
Array Biopharma, Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
EP1496896A4
(en)
|
2002-04-08 |
2007-10-31 |
Merck & Co Inc |
AKT INHIBITORS EFFECT
|
|
AU2003226250B2
(en)
|
2002-04-08 |
2007-08-16 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
|
CA2480880C
(en)
|
2002-04-08 |
2011-03-22 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
JP4394961B2
(ja)
|
2002-04-08 |
2010-01-06 |
メルク エンド カムパニー インコーポレーテッド |
Ａｋｔ活性の阻害剤としての融合キノキサリン誘導体
|
|
CA2484968A1
(en)
|
2002-05-10 |
2003-11-20 |
Neurocrine Biosciences, Inc. |
Substituted piperazine as melanocortin receptors ligands
|
|
CA2501365C
(en)
|
2002-10-30 |
2011-05-31 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
US20040102360A1
(en)
|
2002-10-30 |
2004-05-27 |
Barnett Stanley F. |
Combination therapy
|
|
CA2502970A1
(en)
|
2002-11-28 |
2004-06-10 |
Schering Aktiengesellschaft |
Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
|
|
GB0308208D0
(en)
|
2003-04-09 |
2003-05-14 |
Glaxo Group Ltd |
Chemical compounds
|
|
WO2004096130A2
(en)
|
2003-04-24 |
2004-11-11 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
EP1646615B1
(en)
|
2003-06-06 |
2009-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrimidine derivatives as modulators of atp-binding cassette transporters
|
|
PE20050355A1
(es)
|
2003-08-05 |
2005-05-16 |
Vertex Pharma |
Composiciones referidas a inhibidores de canales ionicos regulados por voltaje
|
|
ES2293317T3
(es)
|
2003-08-12 |
2008-03-16 |
F. Hoffmann-La Roche Ag |
Derivados de tetrahidroquinazolina com antagonistas de cfr.
|
|
BRPI0414238A
(pt)
|
2003-09-09 |
2006-10-31 |
Ono Pharmaceutical Co |
antagonistas de crf e compostos heterobicìclicos
|
|
WO2005039564A1
(en)
|
2003-10-02 |
2005-05-06 |
Vertex Pharmaceuticals Incorporated |
Phthalimide compounds useful as protein kinase inhibitors
|
|
AU2004283148A1
(en)
*
|
2003-10-21 |
2005-05-06 |
Warner-Lambert Company Llc |
Polymorphic form of N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
|
|
CN1882347A
(zh)
|
2003-11-21 |
2006-12-20 |
阿雷生物药品公司 |
Akt蛋白激酶抑制剂
|
|
CA2563699C
(en)
|
2004-04-23 |
2014-03-25 |
Exelixis, Inc. |
Kinase modulators and method of use
|
|
ATE464303T1
(de)
|
2004-04-28 |
2010-04-15 |
Vertex Pharma |
Als inhibitoren von rock und anderen proteinkinasen geeignete zusammensetzungen
|
|
ATE434614T1
(de)
|
2004-06-28 |
2009-07-15 |
Bayer Schering Pharma Ag |
4,6-disubstitutierte pyrimidine und deren verwendung als proteinkinase-hemmer
|
|
US20060025074A1
(en)
|
2004-07-30 |
2006-02-02 |
Chih-Ming Liang |
Bluetooth-based headset
|
|
TWM266655U
(en)
|
2004-09-23 |
2005-06-01 |
Blueexpert Technology Corp |
Bluetooth earphone device capable of wirelessly receiving and transmitting stereo sound signal and digital information signal
|
|
TW200621257A
(en)
|
2004-10-20 |
2006-07-01 |
Astellas Pharma Inc |
Pyrimidine derivative fused with nonaromatic ring
|
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
|
US7994172B2
(en)
|
2004-12-28 |
2011-08-09 |
Exelixis, Inc. |
[1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
|
|
JP2008531542A
(ja)
|
2005-02-24 |
2008-08-14 |
ファイザー・プロダクツ・インク |
抗癌剤として有用な二環式複素芳香族誘導体
|
|
WO2006094230A2
(en)
|
2005-03-03 |
2006-09-08 |
The Burnham Institute For Medical Research |
Screening methods for protein kinase b inhibitors employing virtual docking approaches and compounds and compositions discovered thereby
|
|
MX2007014619A
(es)
|
2005-05-20 |
2009-02-13 |
Vertex Pharma |
Pirrolopiridinas de utilidad como inhibidores de proteina quinasa.
|
|
UY29610A1
(es)
|
2005-06-21 |
2007-01-31 |
Cancer Rec Tech Ltd |
Aril-alquilaminas y heteroaril-alquilaminas como inhibidores de la quinasa proteínica
|
|
JP5129143B2
(ja)
|
2005-10-07 |
2013-01-23 |
エグゼリクシス， インコーポレイテッド |
Ｍｅｋインヒビターおよびその使用方法
|
|
US20080004295A1
(en)
|
2005-10-13 |
2008-01-03 |
Gore Paul M |
Novel compounds
|
|
WO2007077961A2
(en)
|
2005-12-28 |
2007-07-12 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic compounds and their use as mineralocorticoid receptor ligands
|
|
EP2013206A1
(en)
|
2006-04-25 |
2009-01-14 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
|
KR20090024834A
(ko)
|
2006-07-05 |
2009-03-09 |
인터뮨, 인크. |
Ｃ형 간염 바이러스 복제의 신규 억제제
|
|
UA95641C2
(en)
*
|
2006-07-06 |
2011-08-25 |
Эррей Биофарма Инк. |
Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
|
|
TW200808325A
(en)
|
2006-07-06 |
2008-02-16 |
Astrazeneca Ab |
Novel compounds
|
|
EA016076B1
(ru)
|
2006-07-06 |
2012-01-30 |
Глэксо Груп Лимитед |
Замещенные n-фенилметил-5-оксопролин-2-амиды в качестве антагонистов р2х7-рецептора и способы их применения
|
|
US7910747B2
(en)
|
2006-07-06 |
2011-03-22 |
Bristol-Myers Squibb Company |
Phosphonate and phosphinate pyrazolylamide glucokinase activators
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
GB0613518D0
(en)
|
2006-07-06 |
2006-08-16 |
Phytopharm Plc |
Chemical compounds
|
|
CA2656618C
(en)
|
2006-07-06 |
2014-08-26 |
Array Biopharma Inc. |
Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
|
|
EP2054418B1
(en)
|
2006-07-06 |
2011-11-09 |
Array Biopharma Inc. |
Dihydrothieno pyrimidines as akt protein kinase inhibitors
|
|
WO2008012635A2
(en)
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
|
CN101605540A
(zh)
*
|
2006-12-14 |
2009-12-16 |
埃克塞利希斯股份有限公司 |
使用mek抑制剂的方法
|
|
AU2008298948B2
(en)
*
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
MX2011000440A
(es)
|
2008-07-11 |
2011-02-24 |
Novartis Ag |
Combinacion de (a) un inhibidor de fosfoinositido 3-cinasa y (b) un modulador de la ruta de ras/raf/mek.
|
|
RU2473549C2
(ru)
|
2008-07-31 |
2013-01-27 |
Дженентек, Инк. |
Пиримидиновые соединения, композиции и способы применения
|
|
MX2012003546A
(es)
*
|
2009-09-23 |
2012-09-07 |
Glaxosmithkline Llc |
Combinacion.
|