JP2015529234A5 - - Google Patents
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- Publication number
- JP2015529234A5 JP2015529234A5 JP2015532437A JP2015532437A JP2015529234A5 JP 2015529234 A5 JP2015529234 A5 JP 2015529234A5 JP 2015532437 A JP2015532437 A JP 2015532437A JP 2015532437 A JP2015532437 A JP 2015532437A JP 2015529234 A5 JP2015529234 A5 JP 2015529234A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- compound
- regorafenib
- acetylsalicylic acid
- metabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000002138 L01XE21 - Regorafenib Substances 0.000 claims 5
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 5
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 claims 5
- 229960004836 regorafenib Drugs 0.000 claims 5
- 230000003463 hyperproliferative Effects 0.000 claims 4
- 239000002207 metabolite Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 210000004556 Brain Anatomy 0.000 claims 1
- 210000000481 Breast Anatomy 0.000 claims 1
- 210000001508 Eye Anatomy 0.000 claims 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 1
- 210000004392 Genitalia Anatomy 0.000 claims 1
- 210000003128 Head Anatomy 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 206010027476 Metastasis Diseases 0.000 claims 1
- 210000003739 Neck Anatomy 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 210000001685 Thyroid Gland Anatomy 0.000 claims 1
- 210000001635 Urinary Tract Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000849 parathyroid Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12185852 | 2012-09-25 | ||
| EP12185852.6 | 2012-09-25 | ||
| PCT/EP2013/069735 WO2014048881A1 (en) | 2012-09-25 | 2013-09-23 | Combination of regorafenib and acetylsalicylic acid for treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529234A JP2015529234A (ja) | 2015-10-05 |
| JP2015529234A5 true JP2015529234A5 (pt-PT) | 2016-11-10 |
| JP6294888B2 JP6294888B2 (ja) | 2018-03-14 |
Family
ID=46963566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532437A Active JP6294888B2 (ja) | 2012-09-25 | 2013-09-23 | 癌を治療するためのレゴラフェニブおよびアセチルサリチル酸の組み合わせ |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US10898500B2 (pt-PT) |
| EP (1) | EP2900269B1 (pt-PT) |
| JP (1) | JP6294888B2 (pt-PT) |
| KR (1) | KR102210575B1 (pt-PT) |
| CN (1) | CN104994876A (pt-PT) |
| AU (1) | AU2013322854B2 (pt-PT) |
| BR (1) | BR112015006686B1 (pt-PT) |
| CA (1) | CA2885688C (pt-PT) |
| CL (1) | CL2015000744A1 (pt-PT) |
| CY (1) | CY1120939T1 (pt-PT) |
| DK (1) | DK2900269T3 (pt-PT) |
| EA (1) | EA032023B1 (pt-PT) |
| ES (1) | ES2687985T3 (pt-PT) |
| HK (1) | HK1214169A1 (pt-PT) |
| HR (1) | HRP20181462T1 (pt-PT) |
| HU (1) | HUE039878T2 (pt-PT) |
| IL (1) | IL237690B (pt-PT) |
| LT (1) | LT2900269T (pt-PT) |
| MX (1) | MX357035B (pt-PT) |
| MY (1) | MY183969A (pt-PT) |
| NZ (1) | NZ705860A (pt-PT) |
| PH (1) | PH12015500587A1 (pt-PT) |
| PL (1) | PL2900269T3 (pt-PT) |
| PT (1) | PT2900269T (pt-PT) |
| RS (1) | RS57875B1 (pt-PT) |
| SG (2) | SG11201501963RA (pt-PT) |
| SI (1) | SI2900269T1 (pt-PT) |
| WO (1) | WO2014048881A1 (pt-PT) |
| ZA (1) | ZA201502840B (pt-PT) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013276617B9 (en) | 2012-06-13 | 2018-03-29 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
| SI2900669T1 (sl) | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| MY187449A (en) | 2013-11-26 | 2021-09-22 | Hoffmann La Roche | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
| PE20161223A1 (es) | 2014-03-26 | 2016-11-12 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa) |
| DK3122750T3 (da) | 2014-03-26 | 2019-11-04 | Hoffmann La Roche | Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere |
| CN103923001B (zh) * | 2014-04-30 | 2016-02-10 | 药源药物化学（上海）有限公司 | 瑞戈非尼盐及其晶型、制备方法 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| JP6886967B2 (ja) | 2015-09-04 | 2021-06-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | フェノキシメチル誘導体 |
| CN105267167A (zh) * | 2015-09-11 | 2016-01-27 | 江苏嘉逸医药有限公司 | 一种瑞戈非尼口服固体药物组合物的制备方法 |
| MA42923A (fr) | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
| CN107614505B (zh) | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | 作为双重atx/ca抑制剂的新型二环化合物 |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| BR112018006024A2 (pt) | 2015-09-24 | 2020-05-12 | F. Hoffmann-La Roche Ag | Compostos bicíclicos como inibidores de atx |
| KR102397334B1 (ko) * | 2016-06-28 | 2022-05-11 | 아사메딕 에이에스 | 2성분 조성물 |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| PT3630112T (pt) | 2017-06-02 | 2024-04-23 | Bayer Healthcare Llc | Combinação de regorafenib e nivolumab para tratamento de cancro |
| EP3501522A1 (en) | 2017-12-22 | 2019-06-26 | Asamedic AS | Compositions comprising acetylsalicylic acid and a phosphate salt |
| EP3501523A1 (en) | 2017-12-22 | 2019-06-26 | Asamedic AS | Two-component compositions comprising acetyl salicylic acid and a carbonate salt |
| KR20210156389A (ko) | 2020-06-17 | 2021-12-27 | 재단법인대구경북과학기술원 | 레고라페닙을 유효성분으로 포함하는 염증질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1197228A4 (en) * | 1999-07-02 | 2004-03-10 | Hisamitsu Pharmaceutical Co | DRUG COMPOSITIONS FOR THE TREATMENT OF COLORECTAL CANCER |
| US20040121004A1 (en) | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| DK1663978T3 (da) * | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
| CA2628881A1 (en) * | 2005-11-10 | 2007-05-18 | Bayer Healthcare Ag | Diaryl urea for treating diabetic neuropathy |
| AR062927A1 (es) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
| GB201002530D0 (en) * | 2010-02-15 | 2010-03-31 | Univ Wolverhampton The | Di-aspirin derivatives |
| AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
-
2013
- 2013-09-23 SG SG11201501963RA patent/SG11201501963RA/en unknown
- 2013-09-23 ES ES13770659.4T patent/ES2687985T3/es active Active
- 2013-09-23 KR KR1020157010519A patent/KR102210575B1/ko active IP Right Grant
- 2013-09-23 AU AU2013322854A patent/AU2013322854B2/en active Active
- 2013-09-23 MY MYPI2015700911A patent/MY183969A/en unknown
- 2013-09-23 PL PL13770659T patent/PL2900269T3/pl unknown
- 2013-09-23 JP JP2015532437A patent/JP6294888B2/ja active Active
- 2013-09-23 SG SG10201702356VA patent/SG10201702356VA/en unknown
- 2013-09-23 PT PT13770659T patent/PT2900269T/pt unknown
- 2013-09-23 EA EA201500365A patent/EA032023B1/ru not_active IP Right Cessation
- 2013-09-23 SI SI201331181T patent/SI2900269T1/sl unknown
- 2013-09-23 BR BR112015006686-0A patent/BR112015006686B1/pt active IP Right Grant
- 2013-09-23 CN CN201380050150.7A patent/CN104994876A/zh active Pending
- 2013-09-23 MX MX2015003728A patent/MX357035B/es active IP Right Grant
- 2013-09-23 HU HUE13770659A patent/HUE039878T2/hu unknown
- 2013-09-23 NZ NZ705860A patent/NZ705860A/en unknown
- 2013-09-23 DK DK13770659.4T patent/DK2900269T3/en active
- 2013-09-23 US US14/431,119 patent/US10898500B2/en active Active
- 2013-09-23 CA CA2885688A patent/CA2885688C/en active Active
- 2013-09-23 RS RS20181015A patent/RS57875B1/sr unknown
- 2013-09-23 EP EP13770659.4A patent/EP2900269B1/en active Active
- 2013-09-23 WO PCT/EP2013/069735 patent/WO2014048881A1/en active Application Filing
- 2013-09-23 LT LTEP13770659.4T patent/LT2900269T/lt unknown
-
2015
- 2015-03-12 IL IL237690A patent/IL237690B/en active IP Right Grant
- 2015-03-17 PH PH12015500587A patent/PH12015500587A1/en unknown
- 2015-03-24 CL CL2015000744A patent/CL2015000744A1/es unknown
- 2015-04-24 ZA ZA2015/02840A patent/ZA201502840B/en unknown
-
2016
- 2016-03-01 HK HK16102326.3A patent/HK1214169A1/zh unknown
-
2018
- 2018-09-12 HR HRP20181462TT patent/HRP20181462T1/hr unknown
- 2018-09-20 CY CY181100976T patent/CY1120939T1/el unknown
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