JP2014509853A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014509853A5 JP2014509853A5 JP2013557906A JP2013557906A JP2014509853A5 JP 2014509853 A5 JP2014509853 A5 JP 2014509853A5 JP 2013557906 A JP2013557906 A JP 2013557906A JP 2013557906 A JP2013557906 A JP 2013557906A JP 2014509853 A5 JP2014509853 A5 JP 2014509853A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- antigen
- acid sequence
- variable region
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108060003951 Immunoglobulin Proteins 0.000 claims 55
- 102000018358 immunoglobulin Human genes 0.000 claims 55
- 239000000427 antigen Substances 0.000 claims 44
- 108091007433 antigens Proteins 0.000 claims 44
- 102000036639 antigens Human genes 0.000 claims 44
- 238000000034 method Methods 0.000 claims 32
- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 150000007523 nucleic acids Chemical group 0.000 claims 24
- 241001465754 Metazoa Species 0.000 claims 21
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 18
- 102000007079 Peptide Fragments Human genes 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 108010033276 Peptide Fragments Proteins 0.000 claims 15
- 230000003595 spectral effect Effects 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 238000003556 assay Methods 0.000 claims 7
- 229940072221 immunoglobulins Drugs 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 238000001819 mass spectrum Methods 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000282414 Homo sapiens Species 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 3
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 3
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000007026 protein scission Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010039101 Rhinorrhoea Diseases 0.000 claims 1
- 101710120037 Toxin CcdB Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000003567 ascitic fluid Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 238000001114 immunoprecipitation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 208000010753 nasal discharge Diseases 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 238000000730 protein immunoprecipitation Methods 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450922P | 2011-03-09 | 2011-03-09 | |
| US61/450,922 | 2011-03-09 | ||
| US201161560006P | 2011-11-15 | 2011-11-15 | |
| US61/560,006 | 2011-11-15 | ||
| US201161566876P | 2011-12-05 | 2011-12-05 | |
| US61/566,876 | 2011-12-05 | ||
| US201261594729P | 2012-02-03 | 2012-02-03 | |
| US61/594,729 | 2012-02-03 | ||
| PCT/US2012/028501 WO2012122484A1 (en) | 2011-03-09 | 2012-03-09 | Methods and reagents for creating monoclonal antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017175320A Division JP6557709B2 (ja) | 2011-03-09 | 2017-09-13 | モノクローナル抗体を作製するための方法および試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509853A JP2014509853A (ja) | 2014-04-24 |
| JP2014509853A5 true JP2014509853A5 (cg-RX-API-DMAC7.html) | 2015-04-09 |
| JP6211931B2 JP6211931B2 (ja) | 2017-10-11 |
Family
ID=45922811
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557906A Active JP6211931B2 (ja) | 2011-03-09 | 2012-03-09 | モノクローナル抗体を作製するための方法および試薬 |
| JP2017175320A Expired - Fee Related JP6557709B2 (ja) | 2011-03-09 | 2017-09-13 | モノクローナル抗体を作製するための方法および試薬 |
| JP2019128863A Pending JP2019195335A (ja) | 2011-03-09 | 2019-07-11 | モノクローナル抗体を作製するための方法および試薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017175320A Expired - Fee Related JP6557709B2 (ja) | 2011-03-09 | 2017-09-13 | モノクローナル抗体を作製するための方法および試薬 |
| JP2019128863A Pending JP2019195335A (ja) | 2011-03-09 | 2019-07-11 | モノクローナル抗体を作製するための方法および試薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9920110B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2683736B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6211931B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20190107761A (cg-RX-API-DMAC7.html) |
| CN (2) | CN108220297A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2012225310B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2829606C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2683736T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2666301T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1256304A1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE037095T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012122484A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| EP2783214A2 (en) | 2011-11-23 | 2014-10-01 | The Board of Regents of The University of Texas System | Proteomic identification of antibodies |
| EP2823060B1 (en) | 2012-03-05 | 2018-02-14 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
| BR112014027309A2 (pt) | 2012-05-08 | 2017-07-11 | Adaptive Biotechnologies Corp | composições e métodos para medir e calibrar a tendên-cia de amplificação em reações de pcr multiplexadas |
| CN104619862B (zh) | 2012-06-15 | 2017-10-31 | 得克萨斯系统大学董事会 | 单细胞的多转录物的高通量测序 |
| CA2906218A1 (en) * | 2013-03-15 | 2014-09-18 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| EP3023777B1 (en) * | 2013-09-09 | 2017-11-15 | Shimadzu Corporation | Method for preparing peptide fragments, kit for preparing peptide fragments to be used therein, and analysis method |
| GB201316644D0 (en) * | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
| EP3161166A4 (en) * | 2014-06-25 | 2017-11-29 | The Rockefeller University | Compositions and methods for rapid production of versatile nanobody repertoires |
| CN105277638A (zh) * | 2014-07-22 | 2016-01-27 | 沈鹤霄 | 一种单克隆抗体IgG质谱测序方法 |
| US10392663B2 (en) | 2014-10-29 | 2019-08-27 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CN104560980B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠BCR轻链Lamda文库的多重PCR引物和方法 |
| CN104560979B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠bcr重链文库的多重pcr引物和方法 |
| ES2858306T3 (es) | 2015-02-24 | 2021-09-30 | Adaptive Biotechnologies Corp | Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario |
| WO2016142674A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Cell population analysis |
| EP3570315B1 (en) * | 2015-03-06 | 2024-01-31 | Micromass UK Limited | Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples |
| EP3265823B1 (en) | 2015-03-06 | 2020-05-06 | Micromass UK Limited | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| EP4365928A3 (en) | 2015-03-06 | 2024-07-24 | Micromass UK Limited | Spectrometric analysis of microbes |
| US11289320B2 (en) | 2015-03-06 | 2022-03-29 | Micromass Uk Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| US10777398B2 (en) | 2015-03-06 | 2020-09-15 | Micromass Uk Limited | Spectrometric analysis |
| JP6783240B2 (ja) | 2015-03-06 | 2020-11-11 | マイクロマス ユーケー リミテッド | 生体内内視鏡的組織同定機器 |
| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| AU2016321333A1 (en) * | 2015-09-09 | 2018-04-26 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with cerebro-craniofacial health |
| EP3443354B1 (en) | 2016-04-14 | 2025-08-20 | Micromass UK Limited | Spectrometric analysis of plants |
| CN106047857B (zh) * | 2016-06-01 | 2020-04-03 | 苏州金唯智生物科技有限公司 | 一种发掘特异性功能抗体的方法 |
| CN107525934A (zh) * | 2016-06-21 | 2017-12-29 | 张效龙 | 一种测定血液中抗体氨基酸序列的方法 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| WO2018162376A1 (en) * | 2017-03-07 | 2018-09-13 | F. Hoffmann-La Roche Ag | Method for discovery of alternative antigen specific antibody variants |
| AU2018303254B2 (en) * | 2017-07-21 | 2025-05-29 | Novimmune Sa | Generating multispecific antibody mixtures and methods of uses thereof |
| CN109425662A (zh) * | 2017-08-23 | 2019-03-05 | 深圳华大基因研究院 | 一种鉴定蛋白的方法及系统 |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| WO2019183334A1 (en) | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| WO2019183882A1 (zh) * | 2018-03-29 | 2019-10-03 | 深圳达闼科技控股有限公司 | 物质检测方法、装置、电子设备及计算机可读存储介质 |
| CN108530533B (zh) * | 2018-04-13 | 2020-09-04 | 吉林大学 | 猪瘟病毒单克隆抗体hk24及医用用途 |
| US20220034902A1 (en) * | 2018-12-11 | 2022-02-03 | Merck Sharp & Dohme Corp. | Method for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of b-cell and hybridoma libraries |
| US20220253669A1 (en) * | 2019-06-07 | 2022-08-11 | Chugai Seiyaku Kabushiki Kaisha | Information processing system, information processing method, program, and method for producing antigen-binding molecule or protein |
| CN110452296A (zh) * | 2019-07-16 | 2019-11-15 | 福州精锐生物技术有限公司 | 一种兔单克隆抗体制备方法 |
| CA3154609A1 (en) | 2019-09-16 | 2021-03-25 | Regeneron Pharmaceuticals, Inc. | Lc-ms methods for antibody isotyping and quantification |
| US20230073007A1 (en) * | 2019-12-09 | 2023-03-09 | Optolane Technologies Inc. | Switching binder, preparation method therefor, and pharmaceutical composition, assay kit, and antigen and antibody assay method, each using same |
| EP4143582A4 (en) * | 2020-05-01 | 2024-09-25 | University of Pittsburgh - of the Commonwealth System of Higher Education | COMPOSITIONS AND METHODS FOR IDENTIFYING NANOBODIES AND NANOBODY AFFINITIES |
| CA3214755A1 (en) * | 2021-04-09 | 2022-10-13 | Natalie CASTELLANA | Method for antibody identification from protein mixtures |
| IT202100019334A1 (it) * | 2021-07-21 | 2023-01-21 | Univ Degli Studi Di Pavia | Metodo per l’identificazione dell’intera sequenza della regione variabile delle catene pesanti e leggere di immunoglobuline |
| CN115894687B (zh) * | 2022-03-31 | 2024-06-07 | 台州恩泽医疗中心(集团) | 一种抗hla-g1，-g2，-g5及hla-g6异构体分子的单克隆抗体及其用途 |
| CN116779037B (zh) * | 2022-07-27 | 2025-08-05 | 北京理工大学 | 一种基于从头测序和同源标签图论的抗体序列鉴定方法 |
| CN117849159B (zh) * | 2024-01-09 | 2025-01-07 | 融智生物科技（青岛）有限公司 | M蛋白的检测方法、电子设备及存储介质 |
| CN120214310B (zh) * | 2025-05-20 | 2025-08-19 | 中国农业大学 | 一种禽白血病抗原检测试剂盒及其制备方法 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| SG44845A1 (en) | 1993-01-12 | 1997-12-19 | Biogen Inc | Recombitant anti-vla4 antibody molecules |
| US6436908B1 (en) | 1995-05-30 | 2002-08-20 | Duke University | Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
| US6376471B1 (en) | 1997-10-10 | 2002-04-23 | Johns Hopkins University | Gene delivery compositions and methods |
| JP3813818B2 (ja) | 1998-05-01 | 2006-08-23 | アリゾナ ボード オブ リージェンツ | オリゴヌクレオチドおよびｄｎａ分子のヌクレオチド配列の決定方法 |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US7300753B2 (en) | 1998-09-04 | 2007-11-27 | John Rush | Immunoaffinity isolation of modified peptides from complex mixtures |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| WO2003016861A2 (en) | 2001-08-14 | 2003-02-27 | President And Fellows Of Harvard College | Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry |
| CN1302006C (zh) * | 2001-12-14 | 2007-02-28 | 伊莱利利公司 | 重组牛凝血酶 |
| GB0130267D0 (en) | 2001-12-19 | 2002-02-06 | Neutec Pharma Plc | Focussed antibody technology |
| JP4644663B2 (ja) | 2003-06-03 | 2011-03-02 | セル ジェネシス インコーポレイテッド | ペプチド開裂部位を用いた単一ベクターからの組換えポリペプチドの高められた発現のための構成と方法 |
| US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| WO2005077106A2 (en) | 2004-02-09 | 2005-08-25 | Northeastern University | Monoclonal antibody based biomarker discovery and development platform |
| CA2557841A1 (en) | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
| US20070161001A1 (en) | 2004-03-04 | 2007-07-12 | Dena Leshkowitz | Quantifying and profiling antibody and t cell receptor gene expression |
| PA8672101A1 (es) | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| RS52273B (sr) * | 2005-06-10 | 2012-10-31 | Ares Trading S.A. | Proces za purifikaciju il-18 vezujućeg proteina |
| AU2007254005B2 (en) | 2006-02-10 | 2012-11-29 | Genentech, Inc. | Anti-FGF19 antibodies and methods using same |
| GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
| US20090209737A1 (en) * | 2006-07-07 | 2009-08-20 | Pall Corporation | Use of denaturing agents during affinity capture |
| ATE529752T1 (de) | 2006-12-21 | 2011-11-15 | Novartis Ag | Antikörperquantifizierung |
| DK2132229T3 (en) | 2007-03-01 | 2016-06-20 | Symphogen As | Recombinant anti-epidermal growth factor receptor-ANTIBODY COMPOSITIONS |
| WO2008106980A2 (en) * | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
| ME00832B (me) | 2007-03-22 | 2012-03-20 | Ucb Biopharma Sprl | Vezivni proteini uključujući antitjela, derivate antitjela i fragmente antitjela, koji specifično vezuju cd154 i njihova upotreba |
| PT2336329E (pt) | 2007-06-01 | 2012-12-24 | Omt Inc | Composições e métodos para inibição de genes de imunoglobulina endógena e produção de anticorpos transgénicos humanos idiotípicos |
| US7887801B2 (en) | 2007-07-13 | 2011-02-15 | Topotarget Germany Ag | Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins |
| PT2220116E (pt) * | 2007-11-12 | 2012-12-07 | Theraclone Sciences Inc | Composições e métodos para a terapia e o diagnóstico da gripe |
| JP2011522213A (ja) | 2007-11-22 | 2011-07-28 | シムフォゲン・アクティーゼルスカブ | 組み換えポリクローナルタンパク質の特徴づけに関する方法 |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| US20110151494A1 (en) | 2008-06-30 | 2011-06-23 | H. Lee Moffit Cancer & Research Institute | Methods and materials for monitoring myeloma using quantitative mass spectrometry |
| KR102362774B1 (ko) | 2008-09-30 | 2022-02-15 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
| US20110314563A1 (en) | 2008-12-18 | 2011-12-22 | Kingdon Craig R | Antibody production |
| EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| WO2010097435A1 (en) | 2009-02-25 | 2010-09-02 | Ucb Pharma, S.A. | Method for producing antibodies |
| NO2792236T3 (cg-RX-API-DMAC7.html) | 2009-07-08 | 2018-04-14 | ||
| US20110045534A1 (en) | 2009-08-20 | 2011-02-24 | Cell Signaling Technology, Inc. | Nucleic Acid Cassette For Producing Recombinant Antibodies |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| ES2641920T3 (es) | 2010-03-31 | 2017-11-14 | Ablexis, Llc | Ingeniería genética de animales no humanos para la producción de anticuerpos quiméricos |
| US9234240B2 (en) | 2010-05-07 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| KR20130135028A (ko) | 2010-05-17 | 2013-12-10 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 동물로부터 단일클론 항체의 고속 분리 |
| CN105695415A (zh) | 2010-06-17 | 2016-06-22 | 科马布有限公司 | 动物模型及治疗分子 |
-
2012
- 2012-03-09 CN CN201810154961.6A patent/CN108220297A/zh active Pending
- 2012-03-09 WO PCT/US2012/028501 patent/WO2012122484A1/en not_active Ceased
- 2012-03-09 CN CN201280021326.1A patent/CN103842379A/zh active Pending
- 2012-03-09 AU AU2012225310A patent/AU2012225310B2/en active Active
- 2012-03-09 KR KR1020197026655A patent/KR20190107761A/ko not_active Ceased
- 2012-03-09 HU HUE12711501A patent/HUE037095T2/hu unknown
- 2012-03-09 US US13/416,582 patent/US9920110B2/en active Active
- 2012-03-09 DK DK12711501.2T patent/DK2683736T3/en active
- 2012-03-09 EP EP12711501.2A patent/EP2683736B1/en active Active
- 2012-03-09 KR KR1020197000660A patent/KR20190006083A/ko not_active Ceased
- 2012-03-09 CA CA2829606A patent/CA2829606C/en active Active
- 2012-03-09 JP JP2013557906A patent/JP6211931B2/ja active Active
- 2012-03-09 ES ES12711501.2T patent/ES2666301T3/es active Active
- 2012-03-09 EP EP17196465.3A patent/EP3345922A1/en not_active Withdrawn
- 2012-03-09 KR KR1020137026647A patent/KR101938343B1/ko active Active
-
2017
- 2017-09-13 JP JP2017175320A patent/JP6557709B2/ja not_active Expired - Fee Related
- 2017-10-12 AU AU2017245395A patent/AU2017245395B2/en active Active
-
2018
- 2018-01-19 US US15/875,615 patent/US20190002532A1/en not_active Abandoned
- 2018-11-30 HK HK18115369.1A patent/HK1256304A1/en unknown
-
2019
- 2019-07-11 JP JP2019128863A patent/JP2019195335A/ja active Pending
- 2019-08-14 AU AU2019216660A patent/AU2019216660A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014509853A5 (cg-RX-API-DMAC7.html) | ||
| JP2019195335A5 (cg-RX-API-DMAC7.html) | ||
| He et al. | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq | |
| US11046745B2 (en) | Peptide mimotopes of the CD3 T-cell co-receptor epsilon chain and uses thereof | |
| KR20130135028A (ko) | 동물로부터 단일클론 항체의 고속 분리 | |
| CN112225806B (zh) | 一种人源抗新型冠状病毒（SARS-CoV-2）的中和活性单克隆抗体 | |
| CN113354729A (zh) | 一种抗新型冠状病毒的单克隆抗体及其应用 | |
| JP2009039107A5 (cg-RX-API-DMAC7.html) | ||
| CN112500481B (zh) | 一种人源抗新型冠状病毒的中和活性单克隆抗体 | |
| Jia et al. | A novel method of multiplexed competitive antibody binning for the characterization of monoclonal antibodies | |
| JP2018148915A5 (cg-RX-API-DMAC7.html) | ||
| CN104379821A (zh) | 肽和抗体文库及其应用 | |
| JP2008538182A5 (cg-RX-API-DMAC7.html) | ||
| JP5821198B2 (ja) | 抗ｉｌ２８ｂ抗体及びこれを用いたｉｌ２８ｂの測定方法 | |
| JP2008500833A5 (cg-RX-API-DMAC7.html) | ||
| CN115485392A (zh) | 用于鉴别配体阻断性抗体及用于确定抗体效价的方法 | |
| CN117820471B (zh) | Gfap特异性抗体及其在检测gfap试剂盒中的应用 | |
| CN117069840B (zh) | 特异性检测il-21的抗体及应用 | |
| CN118440188B (zh) | 抗新型冠状病毒或其n蛋白抗体、检测新型冠状病毒或其n蛋白的试剂和试剂盒 | |
| KR20230124280A (ko) | 메르스 코로나 바이러스의 뉴클레오캡시드 단백질에 특이적인 진단용 항체 및 이의 용도 | |
| CN117886929A (zh) | 抗新型冠状病毒的抗体、检测新型冠状病毒的试剂和试剂盒 | |
| TWI698643B (zh) | 用於檢測米田堡血型抗原的抗體及其片段、試劑盒及方法 | |
| US20070015211A1 (en) | Conformer-specific antibodies and method of use, thereof | |
| JP2008509659A5 (cg-RX-API-DMAC7.html) | ||
| CN118255889B (zh) | 抗ca153抗体和检测试剂盒 |