JP2014508720A5 - - Google Patents

Download PDF

Info

Publication number
JP2014508720A5
JP2014508720A5 JP2013543275A JP2013543275A JP2014508720A5 JP 2014508720 A5 JP2014508720 A5 JP 2014508720A5 JP 2013543275 A JP2013543275 A JP 2013543275A JP 2013543275 A JP2013543275 A JP 2013543275A JP 2014508720 A5 JP2014508720 A5 JP 2014508720A5
Authority
JP
Japan
Prior art keywords
substituted
alkyl
group
formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013543275A
Other languages
English (en)
Japanese (ja)
Other versions
JP6076913B2 (ja
JP2014508720A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/063533 external-priority patent/WO2012078633A2/en
Publication of JP2014508720A publication Critical patent/JP2014508720A/ja
Publication of JP2014508720A5 publication Critical patent/JP2014508720A5/ja
Application granted granted Critical
Publication of JP6076913B2 publication Critical patent/JP6076913B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013543275A 2010-12-07 2011-12-06 癌からの転移を阻害する方法 Expired - Fee Related JP6076913B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42064010P 2010-12-07 2010-12-07
US61/420,640 2010-12-07
PCT/US2011/063533 WO2012078633A2 (en) 2010-12-07 2011-12-06 Methods of inhibiting metastasis from cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017002396A Division JP2017122085A (ja) 2010-12-07 2017-01-11 癌からの転移を阻害する方法

Publications (3)

Publication Number Publication Date
JP2014508720A JP2014508720A (ja) 2014-04-10
JP2014508720A5 true JP2014508720A5 (enExample) 2015-01-29
JP6076913B2 JP6076913B2 (ja) 2017-02-08

Family

ID=46162450

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013543275A Expired - Fee Related JP6076913B2 (ja) 2010-12-07 2011-12-06 癌からの転移を阻害する方法
JP2017002396A Pending JP2017122085A (ja) 2010-12-07 2017-01-11 癌からの転移を阻害する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017002396A Pending JP2017122085A (ja) 2010-12-07 2017-01-11 癌からの転移を阻害する方法

Country Status (4)

Country Link
US (4) US8435993B2 (enExample)
EP (1) EP2648754A4 (enExample)
JP (2) JP6076913B2 (enExample)
WO (1) WO2012078633A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2648754A4 (en) * 2010-12-07 2016-02-24 Philadelphia Health & Educatio METHOD OF INHIBITING CANCER METASTASES
US8883989B2 (en) * 2011-10-18 2014-11-11 Regents Of The University Of Minnesota Fractalkine binding polynucleotides and methods of use
CN108610421B (zh) * 2012-02-27 2022-08-19 阿布林克斯有限公司 Cx3cr1结合多肽
US9637542B2 (en) * 2013-08-21 2017-05-02 Boehringer Ingelheim International Gmbh CX3CR1-targeting imaging agents and their use in the diagnosis and treatment of disease
WO2016024096A1 (en) * 2014-08-11 2016-02-18 Redx Pharma Plc Antibacterial compounds
CN109069486A (zh) 2015-12-14 2018-12-21 X4 制药有限公司 治疗癌症的方法
CN109069426B (zh) 2015-12-14 2021-10-29 X4 制药有限公司 治疗癌症的方法
US10610527B2 (en) 2015-12-22 2020-04-07 X4 Pharmaceuticals, Inc. Methods for treating immunodeficiency disease
US11337969B2 (en) 2016-04-08 2022-05-24 X4 Pharmaceuticals, Inc. Methods for treating cancer
EP3808748B1 (en) * 2016-06-21 2026-05-20 X4 Pharmaceuticals, Inc. Substituted piperidines as cxcr4-inhibitors
US10988465B2 (en) 2016-06-21 2021-04-27 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
JP6994767B2 (ja) 2016-06-21 2022-01-14 エックス4 ファーマシューティカルズ, インコーポレイテッド Cxcr4阻害剤およびその使用
US11267817B2 (en) 2017-05-02 2022-03-08 Drexel University Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
US11279765B2 (en) 2017-07-08 2022-03-22 The General Hospital Corporation Compositions and methods to improve anti-angiogenic therapy and immunotherapy
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
AU2020316080A1 (en) 2019-07-23 2022-03-03 Axxam S.P.A. Bicyclic CX3CR1 receptor agonists
CN115515585A (zh) 2020-03-10 2022-12-23 X4 制药有限公司 用于治疗中性粒细胞减少症的方法
IL298941A (en) 2020-06-11 2023-02-01 Chdi Foundation Inc Heterocyclic compounds and imaging agents for the imaging of huntingtin protein
US12667578B2 (en) 2024-07-25 2026-06-30 Visionary Assets, Llc Cryogenic process for making cannabinoid nanoparticles and compositions made thereby
US12605394B2 (en) 2024-07-25 2026-04-21 Visionary Assets, Llc Compositions containing cannabinoid nanoparticles

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939159A (en) * 1974-05-29 1976-02-17 American Hoechst Corporation Spiro(pyrrolo (1,2-A)quinoxalines)
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
DE3689123T2 (de) 1985-11-01 1994-03-03 Xoma Corp Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
CA2132012C (en) 1992-03-25 2003-04-22 John W. Shell Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
US5582837A (en) 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
AU3290397A (en) 1996-06-10 1998-01-07 Depomed, Inc. Gastric-retentive oral controlled drug delivery system with enhanced retention properties
US5972389A (en) 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
ATE302597T1 (de) 1997-06-06 2005-09-15 Depomed Inc Im magen verweilende orale dosierungsformen von wasserlöslichen arzneistoffen mit kontrollierter freisetzung
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
NZ518739A (en) 1999-11-02 2004-12-24 Depomed Inc Pharmacological inducement of the fed mode for enhanced drug administration to the stomach
MXPA02007254A (es) 2000-02-04 2002-12-09 Depomed Inc Forma de dosis de cubierta-y-nucleo que se aproxima a liberacion de droga de orden cero.
AU2000273378A1 (en) 2000-02-18 2001-08-27 Millennium Pharmaceuticals, Inc. Therapeutic methods that target fractalkine or cx3cr1
US20020010125A1 (en) 2000-03-16 2002-01-24 Carson Dennis A. Assay for agents that induce chemokinesis
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6451808B1 (en) 2000-10-17 2002-09-17 Depomed, Inc. Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists
WO2002096404A1 (en) 2001-05-29 2002-12-05 Depomed Development Ltd Method of treating gastroesophageal reflux disease and nocturnal acid breakthrough
JP2005508358A (ja) 2001-10-25 2005-03-31 デポメド・インコーポレイテッド 胃滞留型ロサルタン投与量を用いる治療方法
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US20030091630A1 (en) 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
US7491530B2 (en) 2001-12-18 2009-02-17 Whitehead Institute For Biomedical Research Fusion partner cells and uses thereof
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
US7919083B2 (en) 2002-11-15 2011-04-05 Morehouse School Of Medicine Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms
WO2005033115A1 (en) * 2003-10-07 2005-04-14 Astrazeneca Ab New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1
US20060003020A1 (en) 2004-03-11 2006-01-05 The Regents Of The University Of Michigan Anti-metastatic ability of mibefradil and gadolinium
US20060115834A1 (en) * 2004-10-19 2006-06-01 University Of Iowa Research Foundation Methods of identifying metastatic potential in cancer
UA90707C2 (en) 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
CN101522693B (zh) 2006-09-29 2012-01-04 阿斯利康(瑞典)有限公司 5,7-二取代的[1,3]噻唑并[4,5-d]嘧啶-2(3h)-胺衍生物和它们在治疗中的用途
WO2009027820A2 (en) * 2007-08-31 2009-03-05 Purdue Pharma L.P. Substituted-quinoxaline-type-piperidine compounds and the uses thereof
MX2010009625A (es) * 2008-03-07 2010-09-28 Acraf Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
AR071036A1 (es) 2008-03-26 2010-05-19 Astrazeneca Ab Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1.
AU2009248774B2 (en) * 2008-05-23 2012-05-31 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
CN102159213B (zh) * 2008-09-11 2015-05-27 凯莫森特里克斯股份有限公司 4-氨基-3-(咪唑基)-吡唑并[3,4-b]嘧啶
JP2011127042A (ja) 2009-12-18 2011-06-30 Fujifilm Corp アゾ顔料、アゾ顔料の製造方法、アゾ顔料を含む分散物、及び着色組成物
WO2011127333A2 (en) * 2010-04-09 2011-10-13 University Of Louisville Research Foundation, Inc. Compounds for treating disease, for administering, and for pharmaceutical compositions
EP2648754A4 (en) 2010-12-07 2016-02-24 Philadelphia Health & Educatio METHOD OF INHIBITING CANCER METASTASES

Similar Documents

Publication Publication Date Title
JP2023514872A5 (enExample)
RU2014105624A (ru) Соединения индазола, способ их применения и фармацевтическая композиция
RU2012116877A (ru) Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы
JP2020505356A5 (enExample)
JP2011509309A5 (enExample)
US20130150385A1 (en) Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
JP2010502751A5 (enExample)
JP2014528464A5 (enExample)
RU2015139590A (ru) ИНГИБИРУЮЩЕЕ Trk СОЕДИНЕНИЕ
JP2013518129A5 (enExample)
JP2009536620A5 (enExample)
JP2016510785A5 (enExample)
JP2015524472A5 (enExample)
JP2014500265A5 (enExample)
JP2005517006A5 (enExample)
JP2013523814A5 (enExample)
JP2026020169A (ja) Rho関連コイルドコイル含有プロテインキナーゼの阻害剤
JP7849141B2 (ja) がんの治療のためのnox阻害剤の使用
JP2019525948A5 (enExample)
JP2022535734A5 (enExample)
JP2010536821A5 (enExample)
JP2022500428A5 (enExample)
JP2021527693A5 (enExample)
JP2024507414A5 (enExample)
JP2016540811A5 (enExample)