JP2014507992A - 脳血液動態状態を監視するための装置および方法 - Google Patents
脳血液動態状態を監視するための装置および方法 Download PDFInfo
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Abstract
【選択図】なし
Description
本出願は、米国仮出願第61/441,248号(出願日:2011年2月9日)および米国仮出願第61/474,739号(出願日:2011年4月12日)の合衆国法典第 35 巻119条(e)項の下の優先権の利益を主張する。本明細書中、これらの文献双方の全体を参考のため援用する。
本開示の局面は、頭部生体インピーダンス測定を特徴付ける信号の検出、監視および/または分析、およびそのような分析に基づく生理学的脳状態の予測に関する。
Claims (30)
- 脳血液動態測定装置であって、
少なくとも1つのプロセッサであって、前記少なくとも1つのプロセッサは、
少なくとも1つの頭部生体インピーダンス測定値を特徴付ける少なくとも1つの信号を受信する、ことと、
前記少なくとも1つの信号と心臓波のタイミングとを相関させる、ことと、
前記心臓波により規定される時間的期間中の前記少なくとも1つの信号を分析することにより、前記時間的期間中における前記少なくとも1つの信号における少なくとも1つの予想特性の程度を確認する、ことと、
前記少なくとも1つの信号における前記少なくとも1つの予想特性の前記程度に基づいて生理学的脳状態を予測するための情報を出力する、ことと、
を行うよう構成される、プロセッサ、
を含む、脳血液動態測定装置。 - 前記少なくとも1つの信号は、それぞれが対象者の脳の異なる脳半球に関する少なくとも2つの生体インピーダンス信号を含み、前記少なくとも2つの生体インピーダンス信号は相互に対して同期される、請求項1記載の脳血液動態測定装置。
- 前記少なくとも1つの予想特性は生体インピーダンス信号におけるフィーチャの高さ、遅延、幅、およびタイミングのうちの少なくとも1つに関する、請求項1記載の脳血液動態測定装置。
- 前記少なくとも1つの予想特性は生体インピーダンス信号における第1のピーク、第2のピーク、および第3のピークのうちの少なくとも1つに関する、請求項1記載の脳血液動態測定装置。
- 前記少なくとも1つの信号は、対象者の脳の第1の脳半球に関する第1の信号と前記対象者の脳の第2の脳半球に関する第2の信号とを含み、前記プロセッサは、前記第1の信号の部分と前記第2の信号の部分との比較に少なくとも部分的に基づいて生理学的脳状態を予測するよう構成される、請求項1記載の脳血液動態測定装置。
- 前記プロセッサは、前記心臓波により規定される事前規定された対象時間的期間中の前記第1の信号および前記第2の信号のうちの少なくとも1つの部分を分析するようさらに構成される、請求項5記載の脳血液動態測定装置。
- 前記少なくとも1つの予想特性は、ピーク位置、最小値位置、予測されるピーク位置、および予測される最小値位置のうちの1つ以上を含む、請求項1記載の脳血液動態測定装置。
- 分析することは、前記少なくとも1つの信号を、前記少なくとも1つの予想特性と前記少なくとも1つの信号との間の相関程度に基づく予測に適合させることを含む、請求項1記載の脳血液動態測定装置。
- 前記プロセッサは、前記少なくとも1つの信号におけるフィーチャを脳血流画像情報で較正するようさらに構成される、請求項1記載の脳血液動態測定装置。
- 分析することは、表示された生理学的状態に基づいて、予想特性付近の時間的期間に注目することを含む、請求項4記載の脳血液動態測定装置。
- 相関させることは、前記少なくとも1つの信号と同時心臓周期のタイミングとを同期することを含む、請求項1記載の脳血液動態測定装置。
- 相関させることは、前記少なくとも1つの信号の部分と心臓周期に以前に相関された既知の信号とを比較することにより、前記少なくとも1つの信号と心臓周期とのタイミングの一致を検出することを含む、請求項1記載の脳血液動態測定装置。
- 前記心臓波はECGの任意の反復部分を含む、請求項1記載の脳血液動態測定装置。
- 前記心臓波はECGR波である、請求項1記載の脳血液動態測定装置。
- 前記心臓波により規定される前記時間的期間は心臓周期の少なくとも2つの反復を含む、請求項1記載の脳血液動態測定装置。
- 生理学的脳状態を予測するための方法であって、
少なくとも1つの頭部生体インピーダンス測定値を特徴付ける少なくとも1つの信号を受信することと、
前記少なくとも1つの信号と心臓波のタイミングとを相関させることと、
前記心臓波により規定される時間的期間中の前記少なくとも1つの信号を分析することにより、前記時間的期間中の前記少なくとも1つの信号における少なくとも1つの予想特性の程度を確認することと、
前記少なくとも1つの信号における前記少なくとも1つの予想特性の前記程度に基づいて生理学的脳状態を予測するための情報を出力することと、
を含む、方法。 - 前記少なくとも1つの信号は、それぞれが対象者の脳の異なる脳半球に関する生体インピーダンス測定値を特徴付ける少なくとも2つの信号を含み、前記少なくとも2つの信号を相互に対して同期することをさらに含む、請求項16記載の方法。
- 前記少なくとも1つの予想特性は生体インピーダンス信号におけるフィーチャの高さ、遅延、幅、およびタイミングのうちの少なくとも1つに関する、請求項16記載の方法。
- 前記少なくとも1つの予想特性は生体インピーダンス曲線における第1のピーク、第2のピーク、および第3のピークのうちの少なくとも1つに関する、請求項16記載の方法。
- 前記少なくとも1つの信号は、対象者の脳の第1の脳半球に関する第1の信号と前記対象者の脳の第2の脳半球に関する第2の信号とを含み、前記プロセッサは、前記第1の信号の部分と前記第2の信号の部分との比較に少なくとも部分的に基づいて生理学的脳状態を予測するよう構成される、請求項16記載の方法。
- 前記心臓波により規定される事前規定された対象時間的期間中の前記第1の信号または前記第2の信号の部分を分析することをさらに含む、請求項20記載の方法。
- 前記少なくとも1つの予想特性は、ピーク位置、最小値位置、予測されるピーク位置、および予測される最小値位置のうちの1つ以上を含む、請求項21記載の方法。
- 分析することは、前記少なくとも1つの信号を、前記少なくとも1つの予想特性と前記少なくとも1つの信号との間の相関程度に基づく予測に適合させることをさらに含む、請求項16記載の方法。
- 前記少なくとも1つの信号におけるフィーチャを脳血流画像情報で較正することをさらに含む、請求項16記載の方法。
- 分析することは、表示された生理学的状態に基づいて、予想特性付近の少なくとも1つの時間的期間に注目することを含む、請求項16記載の方法。
- 相関させることは、前記少なくとも1つの信号と同時心臓周期のタイミングとを同期することを含む、請求項16記載の方法。
- 相関させることは、前記少なくとも1つの信号の部分と心臓周期に以前に相関された既知の信号とを比較することにより、前記少なくとも1つの信号と心臓周期とのタイミングの一致を検出することをさらに含む、請求項16記載の方法。
- 前記心臓波はECGの任意の反復部分を含む、請求項16記載の方法。
- 前記心臓波はECGR波である、請求項16記載の方法。
- 前記心臓波により規定される前記時間的期間は心臓周期の少なくとも2つの反復を含む、請求項16記載の方法。
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US13/252,191 US9307918B2 (en) | 2011-02-09 | 2011-10-03 | Devices and methods for monitoring cerebral hemodynamic conditions |
US13/252,191 | 2011-10-03 | ||
PCT/IB2012/000846 WO2012107843A2 (en) | 2011-02-09 | 2012-02-08 | Devices and methods for monitoring cerebral hemodynamic conditions |
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US20120203121A1 (en) | 2011-02-09 | 2012-08-09 | Opher Kinrot | Devices and methods for monitoring cerebral hemodynamic characteristics |
US9456757B1 (en) * | 2011-10-03 | 2016-10-04 | Yi Zheng | Noninvasive monitoring hydrocephalus, cerebral edema, and intracranial bleeding using electromagnetic wave propagation properties |
US8870783B2 (en) * | 2011-11-30 | 2014-10-28 | Covidien Lp | Pulse rate determination using Gaussian kernel smoothing of multiple inter-fiducial pulse periods |
US10743815B2 (en) | 2012-01-19 | 2020-08-18 | Cerebrotech Medical Systems, Inc. | Detection and analysis of spatially varying fluid levels using magnetic signals |
US11357417B2 (en) | 2012-01-19 | 2022-06-14 | Cerebrotech Medical Systems, Inc. | Continuous autoregulation system |
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2012
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- 2012-02-07 JP JP2013553046A patent/JP5981945B2/ja not_active Expired - Fee Related
- 2012-02-07 CN CN201280017468.0A patent/CN103517670B/zh not_active Expired - Fee Related
- 2012-02-08 CN CN201280014244.4A patent/CN103635132A/zh active Pending
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CN103517670A (zh) | 2014-01-15 |
EP2672883A2 (en) | 2013-12-18 |
EP2672886A2 (en) | 2013-12-18 |
CN104023623A (zh) | 2014-09-03 |
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WO2012107843A2 (en) | 2012-08-16 |
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US9307918B2 (en) | 2016-04-12 |
WO2012107836A3 (en) | 2012-11-01 |
JP2014504936A (ja) | 2014-02-27 |
WO2012107842A3 (en) | 2015-08-06 |
EP2672885A2 (en) | 2013-12-18 |
JP2014516593A (ja) | 2014-07-17 |
JP2014507991A (ja) | 2014-04-03 |
WO2012107840A2 (en) | 2012-08-16 |
CN103517670B (zh) | 2016-02-03 |
JP5981944B2 (ja) | 2016-08-31 |
JP5981945B2 (ja) | 2016-08-31 |
US20120203134A1 (en) | 2012-08-09 |
CN104039219A (zh) | 2014-09-10 |
EP2672887A2 (en) | 2013-12-18 |
WO2012107840A3 (en) | 2012-11-22 |
US20120203122A1 (en) | 2012-08-09 |
WO2012107842A2 (en) | 2012-08-16 |
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