JP2014506259A5 - - Google Patents
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- Publication number
- JP2014506259A5 JP2014506259A5 JP2013548861A JP2013548861A JP2014506259A5 JP 2014506259 A5 JP2014506259 A5 JP 2014506259A5 JP 2013548861 A JP2013548861 A JP 2013548861A JP 2013548861 A JP2013548861 A JP 2013548861A JP 2014506259 A5 JP2014506259 A5 JP 2014506259A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr
- ligand
- antibody
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 19
- 239000003446 ligand Substances 0.000 claims 18
- 108010074108 interleukin-21 Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 101001010621 Homo sapiens Interleukin-21 Proteins 0.000 claims 2
- 102220522291 THAP domain-containing protein 1_S31A_mutation Human genes 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102220534368 OX-2 membrane glycoprotein_S54A_mutation Human genes 0.000 claims 1
- 102220534375 OX-2 membrane glycoprotein_Y53F_mutation Human genes 0.000 claims 1
- 102220638483 Protein PML_K65R_mutation Human genes 0.000 claims 1
- 102220536512 THAP domain-containing protein 1_S52A_mutation Human genes 0.000 claims 1
- 102220524532 Tumor necrosis factor receptor superfamily member 19_S31T_mutation Human genes 0.000 claims 1
- 102220482677 Uncharacterized protein EXOC3-AS1_A61S_mutation Human genes 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 102000008640 interleukin-21 receptor activity proteins Human genes 0.000 claims 1
- 108040002099 interleukin-21 receptor activity proteins Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102200058925 rs121909538 Human genes 0.000 claims 1
- 102220037457 rs201443058 Human genes 0.000 claims 1
- 102220036189 rs273585616 Human genes 0.000 claims 1
- 102220040126 rs371657037 Human genes 0.000 claims 1
- 102220316120 rs763702846 Human genes 0.000 claims 1
- 102220088977 rs869312698 Human genes 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151073 | 2011-01-17 | ||
| EP11151073.1 | 2011-01-17 | ||
| US201161434989P | 2011-01-21 | 2011-01-21 | |
| US61/434,989 | 2011-01-21 | ||
| EP11168328 | 2011-05-31 | ||
| EP11168328.0 | 2011-05-31 | ||
| US201161493002P | 2011-06-03 | 2011-06-03 | |
| US61/493,002 | 2011-06-03 | ||
| EP11187212.3 | 2011-10-31 | ||
| EP11187212 | 2011-10-31 | ||
| PCT/EP2012/050633 WO2012098113A1 (en) | 2011-01-17 | 2012-01-17 | Il-21 ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014506259A JP2014506259A (ja) | 2014-03-13 |
| JP2014506259A5 true JP2014506259A5 (enExample) | 2015-03-05 |
Family
ID=46515179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548861A Withdrawn JP2014506259A (ja) | 2011-01-17 | 2012-01-17 | Ｉｌ−２１リガンド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20130323259A1 (enExample) |
| EP (1) | EP2665750A1 (enExample) |
| JP (1) | JP2014506259A (enExample) |
| CN (1) | CN103443124A (enExample) |
| WO (1) | WO2012098113A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1963369B1 (en) | 2005-11-28 | 2013-05-15 | Zymogenetics, Inc. | Il-21 antagonists |
| EP2746292A1 (en) | 2012-12-21 | 2014-06-25 | Novo Nordisk A/S | Anti-IL21 antibodies for use in the treatment of nephropathies |
| EP2746293A1 (en) | 2012-12-21 | 2014-06-25 | Novo Nordisk A/S | Anti-IL21 antibodies for use in the treatment of cardiovascular diseases |
| JP2017507132A (ja) * | 2014-02-07 | 2017-03-16 | ノヴォ ノルディスク アー／エス | 抗体プロセス |
| AR099625A1 (es) | 2014-03-21 | 2016-08-03 | Lilly Co Eli | Anticuerpos de il-21 |
| JP6672175B2 (ja) * | 2014-05-07 | 2020-03-25 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１及び抗ｉｌ−２１を使用した１型糖尿病の治療 |
| SMT201900668T1 (it) | 2014-06-06 | 2020-01-14 | Bristol Myers Squibb Co | Anticorpi contro il recettore per il fattore di necrosi tumorale indotto da glucocorticoidi(gitr)e loro usi |
| EP3304079B1 (en) | 2015-06-03 | 2020-06-03 | Bristol-Myers Squibb Company | Anti-gitr antibodies for cancer diagnostics |
| KR20180082563A (ko) | 2015-11-19 | 2018-07-18 | 브리스톨-마이어스 스큅 컴퍼니 | 글루코코르티코이드-유도된 종양 괴사 인자 수용체 (gitr)에 대한 항체 및 그의 용도 |
| CN110869392A (zh) | 2017-05-16 | 2020-03-06 | 百时美施贵宝公司 | 用抗gitr激动性抗体治疗癌症 |
| EP4309722A3 (en) | 2019-12-13 | 2024-08-07 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2380958T3 (es) | 1999-12-23 | 2012-05-21 | Genentech, Inc. | Polipéptidos homólogos IL-17 y utilizaciones terapéuticas de los mismos |
| SG177012A1 (en) * | 2002-05-20 | 2012-01-30 | Abmaxis Inc | Generation and selection of protein library in silico |
| CN101014364B (zh) * | 2002-12-24 | 2012-01-18 | 里纳特神经系统学公司 | 抗ngf抗体及其使用方法 |
| ITRM20040586A1 (it) * | 2004-11-29 | 2005-02-28 | Giuliani Spa | Epitopi antigenici dell'interleuchina-21, anticorpi relativi e loro uso in campo medico. |
| EP1963369B1 (en) * | 2005-11-28 | 2013-05-15 | Zymogenetics, Inc. | Il-21 antagonists |
| CA2633138A1 (en) * | 2005-12-23 | 2007-06-28 | Viventia Biotech Inc. | Methods for generating and screening fusion protein libraries and uses thereof |
| WO2009047360A1 (en) * | 2007-10-11 | 2009-04-16 | Novo Nordisk A/S | Il-21 antibodies |
| BRPI0821168B8 (pt) * | 2007-12-07 | 2021-05-25 | Zymogenetics Inc | anticorpo isolado que se liga ao il-21 humano, ou um fragmento deste, usos de dito anticorpo ou fragmento, e, hibridoma |
| WO2009132821A1 (en) * | 2008-04-28 | 2009-11-05 | Giuliani International Limited | Interleukin (il-21) binding proteins and methods of making and using same |
| WO2010027981A1 (en) * | 2008-09-03 | 2010-03-11 | Genentech, Inc. | Multispecific antibodies |
| SG175396A1 (en) * | 2009-04-29 | 2011-12-29 | Centocor Ortho Biotech Inc | Toll-like receptor 3 antagonists |
-
2012
- 2012-01-17 EP EP12708706.2A patent/EP2665750A1/en not_active Withdrawn
- 2012-01-17 US US13/979,430 patent/US20130323259A1/en not_active Abandoned
- 2012-01-17 CN CN2012800138627A patent/CN103443124A/zh active Pending
- 2012-01-17 JP JP2013548861A patent/JP2014506259A/ja not_active Withdrawn
- 2012-01-17 WO PCT/EP2012/050633 patent/WO2012098113A1/en not_active Ceased