JP2014505045A5 - - Google Patents
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- JP2014505045A5 JP2014505045A5 JP2013546193A JP2013546193A JP2014505045A5 JP 2014505045 A5 JP2014505045 A5 JP 2014505045A5 JP 2013546193 A JP2013546193 A JP 2013546193A JP 2013546193 A JP2013546193 A JP 2013546193A JP 2014505045 A5 JP2014505045 A5 JP 2014505045A5
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- 150000001875 compounds Chemical class 0.000 claims description 728
- 239000000203 mixture Substances 0.000 claims description 223
- 229940125904 compound 1 Drugs 0.000 claims description 127
- 229940126214 compound 3 Drugs 0.000 claims description 121
- 229940125782 compound 2 Drugs 0.000 claims description 99
- 229940125898 compound 5 Drugs 0.000 claims description 78
- 150000003839 salts Chemical class 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 20
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 16
- 241000282412 Homo Species 0.000 description 12
- 102000014150 Interferons Human genes 0.000 description 4
- 108010050904 Interferons Proteins 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 229940079322 interferon Drugs 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003443 antiviral agent Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 102100034343 Integrase Human genes 0.000 description 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000013160 medical therapy Methods 0.000 description 2
- 229960000329 ribavirin Drugs 0.000 description 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 101001023866 Arabidopsis thaliana Mannosyl-oligosaccharide glucosidase GCS1 Proteins 0.000 description 1
- VRTWBAAJJOHBQU-KMWAZVGDSA-N CC(C)[C@@H](C(N(CC1(CC1)C1)[C@@H]1c1ncc(-c(cc2C(c3c4)(F)F)ccc2-c3ccc4-c(cc2)cc3c2nc([C@H]([C@@H]2C[C@H]4CC2)N4C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CC1(CC1)C1)[C@@H]1c1ncc(-c(cc2C(c3c4)(F)F)ccc2-c3ccc4-c(cc2)cc3c2nc([C@H]([C@@H]2C[C@H]4CC2)N4C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[nH]1)=O)NC(OC)=O VRTWBAAJJOHBQU-KMWAZVGDSA-N 0.000 description 1
- 229940122806 Cyclophilin inhibitor Drugs 0.000 description 1
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 1
- 101150038760 Ns3 gene Proteins 0.000 description 1
- 238000009004 PCR Kit Methods 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 238000001190 Q-PCR Methods 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 229940124615 TLR 7 agonist Drugs 0.000 description 1
- -1 TLR-7 agonist Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000134 cyclophilin inhibitor Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061425194P | 2010-12-20 | 2010-12-20 | |
| US61/425,194 | 2010-12-20 | ||
| US201161495841P | 2011-06-10 | 2011-06-10 | |
| US61/495,841 | 2011-06-10 | ||
| PCT/US2011/064017 WO2012087596A1 (en) | 2010-12-20 | 2011-12-08 | Combinations for treating hcv |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015243341A Division JP6162206B2 (ja) | 2010-12-20 | 2015-12-14 | Ｈｃｖを処置するための組合せ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505045A JP2014505045A (ja) | 2014-02-27 |
| JP2014505045A5 true JP2014505045A5 (enExample) | 2015-01-29 |
| JP5891241B2 JP5891241B2 (ja) | 2016-03-22 |
Family
ID=45446195
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546193A Active JP5891241B2 (ja) | 2010-12-20 | 2011-12-08 | Ｈｃｖを処置するための組合せ |
| JP2015243341A Active JP6162206B2 (ja) | 2010-12-20 | 2015-12-14 | Ｈｃｖを処置するための組合せ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015243341A Active JP6162206B2 (ja) | 2010-12-20 | 2015-12-14 | Ｈｃｖを処置するための組合せ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20130273005A1 (enExample) |
| EP (1) | EP2654900A1 (enExample) |
| JP (2) | JP5891241B2 (enExample) |
| AR (1) | AR084237A1 (enExample) |
| AU (1) | AU2011349844B2 (enExample) |
| CA (1) | CA2822037A1 (enExample) |
| NZ (1) | NZ613370A (enExample) |
| TW (2) | TW201701876A (enExample) |
| UY (1) | UY33797A (enExample) |
| WO (1) | WO2012087596A1 (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CZ301182B6 (cs) | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| WO2004046331A2 (en) | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
| PE20120106A1 (es) | 2008-12-09 | 2012-02-20 | Gilead Sciences Inc | Moduladores de receptores tipo toll |
| MX363732B (es) * | 2009-05-13 | 2019-04-01 | Gilead Pharmasset Llc Star | Compuestos antivirales. |
| PE20130400A1 (es) | 2010-07-22 | 2013-04-10 | Gilead Sciences Inc | Metodos y compuestos para tratar infecciones virales por paramyxoviridae |
| TW201701876A (zh) | 2010-12-20 | 2017-01-16 | 吉李德科學股份有限公司 | 治療ｃ型肝炎病毒（ｈｃｖ）之方法 |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
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| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| US8759544B2 (en) * | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
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| EP2909222B1 (en) | 2012-10-22 | 2021-05-26 | Idenix Pharmaceuticals LLC | 2',4'-bridged nucleosides for hcv infection |
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| PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
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| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
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2011
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- 2011-12-08 WO PCT/US2011/064017 patent/WO2012087596A1/en not_active Ceased
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