JP2014501784A - 経口投与用の鉄の医薬組成物 - Google Patents

経口投与用の鉄の医薬組成物 Download PDF

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Publication number
JP2014501784A
JP2014501784A JP2013548578A JP2013548578A JP2014501784A JP 2014501784 A JP2014501784 A JP 2014501784A JP 2013548578 A JP2013548578 A JP 2013548578A JP 2013548578 A JP2013548578 A JP 2013548578A JP 2014501784 A JP2014501784 A JP 2014501784A
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JP
Japan
Prior art keywords
iron
dosage form
pharmaceutical composition
oral dosage
subject
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2013548578A
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English (en)
Japanese (ja)
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JP2014501784A5 (enExample
Inventor
カレン，アラン
オトゥール，エデル
コフラン，デイヴィッド・シー
チャラサニ，キショール・バブ
レナード，トーマス・ダブリュー
Original Assignee
メリオン・リサーチ・Ｉｉｉ・リミテッド
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Application filed by メリオン・リサーチ・Ｉｉｉ・リミテッド filed Critical メリオン・リサーチ・Ｉｉｉ・リミテッド
Publication of JP2014501784A publication Critical patent/JP2014501784A/ja
Publication of JP2014501784A5 publication Critical patent/JP2014501784A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013548578A 2011-01-07 2012-01-06 経口投与用の鉄の医薬組成物 Pending JP2014501784A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430575P 2011-01-07 2011-01-07
US61/430,575 2011-01-07
PCT/US2012/020487 WO2012094598A2 (en) 2011-01-07 2012-01-06 Pharmaceutical compositions of iron for oral administration

Publications (2)

Publication Number Publication Date
JP2014501784A true JP2014501784A (ja) 2014-01-23
JP2014501784A5 JP2014501784A5 (enExample) 2015-02-26

Family

ID=46457982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013548578A Pending JP2014501784A (ja) 2011-01-07 2012-01-06 経口投与用の鉄の医薬組成物

Country Status (9)

Country Link
US (1) US8802114B2 (enExample)
EP (1) EP2661273A4 (enExample)
JP (1) JP2014501784A (enExample)
KR (1) KR20140026354A (enExample)
CN (1) CN103476419A (enExample)
AU (1) AU2012204213A1 (enExample)
BR (1) BR112013017169A2 (enExample)
CA (1) CA2819234A1 (enExample)
WO (1) WO2012094598A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2018533618A (ja) * 2015-08-28 2018-11-15 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ウロリチン化合物を含む組成物

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US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
CN102046192B (zh) * 2008-05-07 2014-11-19 默里昂研究Ⅲ有限公司 GnRH相关化合物的组合物及制备方法
WO2010099255A1 (en) * 2009-02-25 2010-09-02 Merrion Research Iii Limited Composition and drug delivery of bisphosphonates
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
WO2011156563A2 (en) * 2010-06-09 2011-12-15 Emisphere Technologies, Inc. Oral iron deficiency therapy
BR112015018549A8 (pt) * 2013-02-01 2018-01-30 Charak Llc métodos de tratamento de deficiência de ferro
BR112016004231B1 (pt) * 2013-08-28 2021-07-06 Dsm Ip Assets B.V. concentrado de caldo, processo para preparar o mesmo e composição alimentar pronta para comer compreendendo o referido concentrado de caldo
KR102339148B1 (ko) * 2013-08-28 2021-12-15 디에스엠 아이피 어셋츠 비.브이. 부용 농축물의 철 보충
KR20160091918A (ko) * 2013-11-05 2016-08-03 락웰 메디컬, 인코포레이티드 저반응성 환자에서 에리스로포이에틴 자극제의 용량을 감소시키는 방법
US9492421B1 (en) * 2013-11-14 2016-11-15 Argent Development Group, Llc Nutritional supplements for treatment of iron deficiency anemia
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
CN106344534B (zh) * 2016-09-30 2019-07-19 广西科技大学 硫酸亚铁肠溶滴丸的制备方法
DK3684344T3 (da) 2017-10-25 2025-08-04 Chiesi Farm Spa Deferipron-tabletter med forsinket frigivelse og fremgangsmåder til anvendelse deraf
KR102084489B1 (ko) * 2018-05-18 2020-03-04 강원대학교산학협력단 열용융압출법을 이용하여 제조된 철 나노콜로이드 분산체 및 이의 용도
SG11202101625RA (en) * 2018-09-05 2021-03-30 Renapharma AB An iron containing composition and use thereof
TWI717139B (zh) * 2018-12-20 2021-01-21 普惠德生技股份有限公司 含有亞鐵胺基酸螯合物粒子的組合物用於製備治療或減緩自體免疫相關疾病的醫藥品的用途
AU2020275505A1 (en) * 2019-05-14 2021-12-23 Nokha Trading Llp Ferrous sulphate oral compositions
CN111714470B (zh) * 2020-05-27 2022-04-08 天津瑞益瑞美生物技术有限公司 一种兽用肠溶乙二胺四乙酸铁钠预混剂及其制备方法
MX2024001246A (es) * 2021-08-16 2024-02-13 Thermolife Int Llc Composiciones de suplemento de hierro y metodos de uso de las mismas.
US12016850B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone
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