JP2014501780A5 - - Google Patents
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- Publication number
- JP2014501780A5 JP2014501780A5 JP2013548455A JP2013548455A JP2014501780A5 JP 2014501780 A5 JP2014501780 A5 JP 2014501780A5 JP 2013548455 A JP2013548455 A JP 2013548455A JP 2013548455 A JP2013548455 A JP 2013548455A JP 2014501780 A5 JP2014501780 A5 JP 2014501780A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- dosage form
- api
- solid dosage
- ethoxybenzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000007909 solid dosage form Substances 0.000 claims 10
- 239000008186 active pharmaceutical agent Substances 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 239000008187 granular material Substances 0.000 claims 5
- 239000003472 antidiabetic agent Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- -1 4-chloro-3- (4-ethoxybenzyl) phenyl Chemical group 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000000883 anti-obesity agent Substances 0.000 claims 2
- 229940125708 antidiabetic agent Drugs 0.000 claims 2
- 239000002220 antihypertensive agent Substances 0.000 claims 2
- 229940030600 antihypertensive agent Drugs 0.000 claims 2
- 239000003524 antilipemic agent Substances 0.000 claims 2
- 229940125710 antiobesity agent Drugs 0.000 claims 2
- 239000002830 appetite depressant Substances 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical group OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 claims 2
- QKDRXGFQVGOQKS-CRSSMBPESA-N (2s,3r,4r,5s,6r)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol Chemical group C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](SC)O2)O)=CC=C1Cl QKDRXGFQVGOQKS-CRSSMBPESA-N 0.000 claims 1
- 229940123208 Biguanide Drugs 0.000 claims 1
- DVJAMEIQRSHVKC-BDAKNGLRSA-N Dutogliptin Chemical compound OB(O)[C@@H]1CCCN1C(=O)CN[C@H]1CNCC1 DVJAMEIQRSHVKC-BDAKNGLRSA-N 0.000 claims 1
- 150000004283 biguanides Chemical group 0.000 claims 1
- 230000036996 cardiovascular health Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 claims 1
- 229950003693 dutogliptin Drugs 0.000 claims 1
- 230000010034 metabolic health Effects 0.000 claims 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 claims 1
- 229960003243 phenformin Drugs 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229960004034 sitagliptin Drugs 0.000 claims 1
- MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430027P | 2011-01-05 | 2011-01-05 | |
| US61/430,027 | 2011-01-05 | ||
| PCT/US2012/020042 WO2012094293A1 (en) | 2011-01-05 | 2012-01-03 | Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019445A Division JP6682460B2 (ja) | 2011-01-05 | 2017-02-06 | ナトリウム−グルコース共輸送体１及びナトリウム−グルコース共輸送体２の阻害剤を含む組成物、並びに該阻害剤を使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014501780A JP2014501780A (ja) | 2014-01-23 |
| JP2014501780A5 true JP2014501780A5 (OSRAM) | 2015-02-19 |
Family
ID=45507917
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548455A Pending JP2014501780A (ja) | 2011-01-05 | 2012-01-03 | ナトリウム−グルコース共輸送体１及びナトリウム−グルコース共輸送体２の阻害剤を含む組成物、並びに該阻害剤を使用する方法 |
| JP2017019445A Active JP6682460B2 (ja) | 2011-01-05 | 2017-02-06 | ナトリウム−グルコース共輸送体１及びナトリウム−グルコース共輸送体２の阻害剤を含む組成物、並びに該阻害剤を使用する方法 |
| JP2018218925A Pending JP2019048866A (ja) | 2011-01-05 | 2018-11-22 | ナトリウム−グルコース共輸送体１及びナトリウム−グルコース共輸送体２の阻害剤を含む組成物、並びに該阻害剤を使用する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019445A Active JP6682460B2 (ja) | 2011-01-05 | 2017-02-06 | ナトリウム−グルコース共輸送体１及びナトリウム−グルコース共輸送体２の阻害剤を含む組成物、並びに該阻害剤を使用する方法 |
| JP2018218925A Pending JP2019048866A (ja) | 2011-01-05 | 2018-11-22 | ナトリウム−グルコース共輸送体１及びナトリウム−グルコース共輸送体２の阻害剤を含む組成物、並びに該阻害剤を使用する方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US20120172320A1 (OSRAM) |
| EP (1) | EP2661256B1 (OSRAM) |
| JP (3) | JP2014501780A (OSRAM) |
| KR (1) | KR102024204B1 (OSRAM) |
| CN (1) | CN103458875A (OSRAM) |
| AR (1) | AR084781A1 (OSRAM) |
| AU (1) | AU2012204567B9 (OSRAM) |
| BR (1) | BR112013017314B1 (OSRAM) |
| CA (1) | CA2823736C (OSRAM) |
| DK (1) | DK2661256T3 (OSRAM) |
| ES (1) | ES2710341T3 (OSRAM) |
| HU (1) | HUE041364T2 (OSRAM) |
| IL (1) | IL295438A (OSRAM) |
| MX (1) | MX360554B (OSRAM) |
| PL (1) | PL2661256T3 (OSRAM) |
| PT (1) | PT2661256T (OSRAM) |
| RU (1) | RU2669921C2 (OSRAM) |
| SG (2) | SG191865A1 (OSRAM) |
| TR (1) | TR201901262T4 (OSRAM) |
| TW (1) | TWI631963B (OSRAM) |
| WO (1) | WO2012094293A1 (OSRAM) |
| ZA (1) | ZA201304694B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015123738A (ru) * | 2012-11-20 | 2017-01-10 | Лексикон Фармасьютикалз, Инк. | Ингибиторы котранспортера натрий-глюкозы 1 |
| CN109195980B (zh) * | 2016-05-25 | 2022-05-17 | 苏州科睿思制药有限公司 | 一种钠-葡萄糖协同转运蛋白抑制剂药物的新晶型及其制备方法和用途 |
| US11723929B2 (en) | 2017-06-13 | 2023-08-15 | The Regents Of The University Of California | Methods of improving cell-based therapy |
| CN107540685B (zh) * | 2017-09-04 | 2020-05-05 | 杭州科巢生物科技有限公司 | 一种Sotagliflozin的制备方法及其中间体 |
| EP3456320A1 (de) * | 2017-09-15 | 2019-03-20 | Stada Arzneimittel Ag | Dpp-4-inhibitor-mono-zusammensetzung |
| JP6917527B2 (ja) * | 2018-01-05 | 2021-08-11 | シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | Ｓｇｌｔ阻害剤及びその応用 |
| CN110117304A (zh) * | 2018-04-23 | 2019-08-13 | 中国科学院成都生物研究所 | 一种钠-葡萄糖协同转运蛋白1和2抑制剂的药物用途 |
| CN110818722B (zh) * | 2018-08-14 | 2022-12-02 | 苏州鹏旭医药科技有限公司 | 三种化合物及其制备方法和在合成索格列净中的用途 |
| JP7273997B2 (ja) | 2019-07-05 | 2023-05-15 | 山東丹紅制薬有限公司 | Ｓｇｌｔ阻害剤の結晶形及びその使用 |
| MX2022001044A (es) * | 2019-07-26 | 2022-04-06 | Medshine Discovery Inc | Inhibidor de sglt2/dpp4 y su aplicacion. |
| CN114585358B (zh) | 2019-07-26 | 2023-11-10 | 东宝紫星(杭州)生物医药有限公司 | 一种SGLTs/DPP4抑制剂及其应用 |
| EP3771480A1 (en) * | 2019-08-01 | 2021-02-03 | Lexicon Pharmaceuticals, Inc. | Continuous process for preparing the crystalline form ii of sotagliflozin |
| JP2022554344A (ja) * | 2019-11-07 | 2022-12-28 | インクレベット，インコーポレイティド | コンパニオンアニマルにおける慢性腎疾患、高血圧、及び心不全の管理のためのナトリウム－グルコース共輸送体阻害剤 |
| US20240100013A1 (en) | 2021-01-04 | 2024-03-28 | Lexicon Pharmaceuticals, Inc. | Sotagliflozin for improving left atrial function |
| US20220370485A1 (en) | 2021-01-14 | 2022-11-24 | Lexicon Pharmaceuticals, Inc. | Compounds and methods for treating or preventing cardiovascular diseases and conditions |
| WO2025072413A1 (en) | 2023-09-28 | 2025-04-03 | Lexicon Pharmaceuticals, Inc. | Methods of treating type 1 diabetes and kidney disease |
| US20250114323A1 (en) | 2023-10-06 | 2025-04-10 | Lexicon Pharmaceuticals, Inc. | Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy |
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| US7846945B2 (en) | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
| PE20090185A1 (es) * | 2007-03-22 | 2009-02-28 | Bristol Myers Squibb Co | Formulaciones farmaceuticas que contienen un inhibidor sglt2 |
| CL2008003653A1 (es) * | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
| TWI472521B (zh) * | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法 |
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| WO2011060256A2 (en) * | 2009-11-13 | 2011-05-19 | Bristol-Myers Squibb Company | Bilayer tablet formulations |
| TWI562775B (en) * | 2010-03-02 | 2016-12-21 | Lexicon Pharmaceuticals Inc | Methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
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2012
- 2012-01-02 TW TW101100085A patent/TWI631963B/zh active
- 2012-01-03 PT PT12700583T patent/PT2661256T/pt unknown
- 2012-01-03 WO PCT/US2012/020042 patent/WO2012094293A1/en not_active Ceased
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- 2012-01-03 JP JP2013548455A patent/JP2014501780A/ja active Pending
- 2012-01-03 DK DK12700583.3T patent/DK2661256T3/en active
- 2012-01-03 TR TR2019/01262T patent/TR201901262T4/tr unknown
- 2012-01-03 AU AU2012204567A patent/AU2012204567B9/en active Active
- 2012-01-03 EP EP12700583.3A patent/EP2661256B1/en active Active
- 2012-01-03 KR KR1020137020505A patent/KR102024204B1/ko active Active
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- 2012-01-03 CA CA2823736A patent/CA2823736C/en active Active
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- 2014-05-30 US US14/291,804 patent/US20150111840A1/en not_active Abandoned
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- 2015-11-19 US US14/945,977 patent/US20160296547A1/en not_active Abandoned
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