RU2013136384A - Композиция, содержащая ингибиторы котранспортеров натрия-глюкозы 1 и 2, и способы их применения - Google Patents
Композиция, содержащая ингибиторы котранспортеров натрия-глюкозы 1 и 2, и способы их применения Download PDFInfo
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- RU2013136384A RU2013136384A RU2013136384/15A RU2013136384A RU2013136384A RU 2013136384 A RU2013136384 A RU 2013136384A RU 2013136384/15 A RU2013136384/15 A RU 2013136384/15A RU 2013136384 A RU2013136384 A RU 2013136384A RU 2013136384 A RU2013136384 A RU 2013136384A
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- 239000003112 inhibitor Substances 0.000 title 2
- YKXCWZVUWWQSAV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O YKXCWZVUWWQSAV-BTVCFUMJSA-N 0.000 title 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims abstract 17
- 239000007909 solid dosage form Substances 0.000 claims abstract 16
- QKDRXGFQVGOQKS-CRSSMBPESA-N (2s,3r,4r,5s,6r)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](SC)O2)O)=CC=C1Cl QKDRXGFQVGOQKS-CRSSMBPESA-N 0.000 claims abstract 10
- 239000003814 drug Substances 0.000 claims abstract 9
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000003472 antidiabetic agent Substances 0.000 claims abstract 6
- 239000008187 granular material Substances 0.000 claims abstract 5
- 229920002785 Croscarmellose sodium Polymers 0.000 claims abstract 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract 4
- 239000000883 anti-obesity agent Substances 0.000 claims abstract 3
- 229940125708 antidiabetic agent Drugs 0.000 claims abstract 3
- 239000002220 antihypertensive agent Substances 0.000 claims abstract 3
- 229940030600 antihypertensive agent Drugs 0.000 claims abstract 3
- 239000003524 antilipemic agent Substances 0.000 claims abstract 3
- 229940125710 antiobesity agent Drugs 0.000 claims abstract 3
- DVJAMEIQRSHVKC-BDAKNGLRSA-N Dutogliptin Chemical compound OB(O)[C@@H]1CCCN1C(=O)CN[C@H]1CNCC1 DVJAMEIQRSHVKC-BDAKNGLRSA-N 0.000 claims abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims abstract 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims abstract 2
- 229960005168 croscarmellose Drugs 0.000 claims abstract 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims abstract 2
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims abstract 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims abstract 2
- 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 claims abstract 2
- 229950003693 dutogliptin Drugs 0.000 claims abstract 2
- 239000000377 silicon dioxide Substances 0.000 claims abstract 2
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract 2
- 229960004034 sitagliptin Drugs 0.000 claims abstract 2
- MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 claims abstract 2
- 229910052708 sodium Inorganic materials 0.000 claims abstract 2
- 239000011734 sodium Substances 0.000 claims abstract 2
- 230000036528 appetite Effects 0.000 claims 2
- 235000019789 appetite Nutrition 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 229940123208 Biguanide Drugs 0.000 claims 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 1
- 229960003243 phenformin Drugs 0.000 claims 1
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 claims 1
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Abstract
1. Твердая дозированная форма, содержащая API и по меньшей мере одно из натриевой соли кроскармеллозы или микрокристаллической целлюлозы, где API представляет кристаллический безводный (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триол.2. Твердая дозированная форма по п.1, где API представляет кристаллическую безводную форму 1 (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триола.3. Твердая дозированная форма по п.1, где API представляет кристаллическую безводную форму 2 (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триола.4. Твердая дозированная форма по п.1, где API находится в количестве 300 мг или ниже.5. Твердая дозированная форма по п.1, которая дополнительно содержит диоксид кремния.6. Твердая дозированная форма по п.1, которая представляет таблетку.7. Твердая дозированная форма по пп.1-6, которая дополнительно содержит второй терапевтический агент, где второй терапевтический агент представляет антидиабетический агент, антигипергликемический агент, гиполипидемический/снижающий уровень липидов агент, агенты против ожирения, антигипертензивный агент или агент, снижающий аппетит.8. Твердая дозированная форма по п.7, где второй терапевтический агент представляет ингибитор DPP-4 (например, ситаглиптин, дутоглиптин).9. Гранула, содержащая API и по меньшей мере одно из натриевой соли кроскармеллозы, коллоидного диоксида кремния и микрокристаллической целлюлозы, где API представляет (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триол.10. Гранула по п.9, где API представляет кристаллическую безводную форму 1 (2S,3R,4R,5S,6R)-2-(4-хлор-3-
Claims (15)
1. Твердая дозированная форма, содержащая API и по меньшей мере одно из натриевой соли кроскармеллозы или микрокристаллической целлюлозы, где API представляет кристаллический безводный (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триол.
2. Твердая дозированная форма по п.1, где API представляет кристаллическую безводную форму 1 (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триола.
3. Твердая дозированная форма по п.1, где API представляет кристаллическую безводную форму 2 (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триола.
4. Твердая дозированная форма по п.1, где API находится в количестве 300 мг или ниже.
5. Твердая дозированная форма по п.1, которая дополнительно содержит диоксид кремния.
6. Твердая дозированная форма по п.1, которая представляет таблетку.
7. Твердая дозированная форма по пп.1-6, которая дополнительно содержит второй терапевтический агент, где второй терапевтический агент представляет антидиабетический агент, антигипергликемический агент, гиполипидемический/снижающий уровень липидов агент, агенты против ожирения, антигипертензивный агент или агент, снижающий аппетит.
8. Твердая дозированная форма по п.7, где второй терапевтический агент представляет ингибитор DPP-4 (например, ситаглиптин, дутоглиптин).
9. Гранула, содержащая API и по меньшей мере одно из натриевой соли кроскармеллозы, коллоидного диоксида кремния и микрокристаллической целлюлозы, где API представляет (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триол.
10. Гранула по п.9, где API представляет кристаллическую безводную форму 1 (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триола.
11. Гранула по п.9, где API представляет кристаллическую безводную форму 2 (2S,3R,4R,5S,6R)-2-(4-хлор-3-(4-этоксибензил)фенил)-6-(метилтио)тетрагидро-2Н-пиран-3,4,5-триола.
12. Применение лекарственной формы по любому из пп.1-8 для улучшения состояния сердечно-сосудистой системы и обмена веществ у пациента.
13. Применение лекарственной формы по любому из пп.1-8 для лечения диабета у пациента.
14. Применение по п.13, где пациент принял или принимает в настоящее время второй терапевтический агент, где второй терапевтический агент представляет антидиабетический агент, антигипергликемический агент, гиполипидемический/снижающий уровень липидов агент, агенты против ожирения, антигипертензивный агент или агент, снижающий аппетит.
15. Применение по п.14, где второе лекарственное средство представляет бигуанид, например метформин, фенформин.
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WO2018231702A1 (en) | 2017-06-13 | 2018-12-20 | The Regents Of The University Of California | Methods of improving cell-based therapy |
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EP3456320A1 (de) | 2017-09-15 | 2019-03-20 | Stada Arzneimittel Ag | Dpp-4-inhibitor-mono-zusammensetzung |
KR102283677B1 (ko) * | 2018-01-05 | 2021-07-29 | 산동 단홍 파머수티컬 컴퍼니., 리미티드. | Sglt 억제제 및 그 응용 |
CN110117304A (zh) * | 2018-04-23 | 2019-08-13 | 中国科学院成都生物研究所 | 一种钠-葡萄糖协同转运蛋白1和2抑制剂的药物用途 |
CN110818722B (zh) * | 2018-08-14 | 2022-12-02 | 苏州鹏旭医药科技有限公司 | 三种化合物及其制备方法和在合成索格列净中的用途 |
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