JP2014501526A5 - - Google Patents
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- Publication number
- JP2014501526A5 JP2014501526A5 JP2013545486A JP2013545486A JP2014501526A5 JP 2014501526 A5 JP2014501526 A5 JP 2014501526A5 JP 2013545486 A JP2013545486 A JP 2013545486A JP 2013545486 A JP2013545486 A JP 2013545486A JP 2014501526 A5 JP2014501526 A5 JP 2014501526A5
- Authority
- JP
- Japan
- Prior art keywords
- assay
- assay method
- haptoglobin
- reagent
- hydrogen peroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003556 assay Methods 0.000 claims 44
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 16
- 239000003153 chemical reaction reagent Substances 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 claims 6
- FWEOQOXTVHGIFQ-UHFFFAOYSA-N 8-anilinonaphthalene-1-sulfonic acid Chemical compound C=12C(S(=O)(=O)O)=CC=CC2=CC=CC=1NC1=CC=CC=C1 FWEOQOXTVHGIFQ-UHFFFAOYSA-N 0.000 claims 6
- 102000014702 Haptoglobin Human genes 0.000 claims 6
- 108050005077 Haptoglobin Proteins 0.000 claims 6
- 108010071602 haptoglobin-hemoglobin complex Proteins 0.000 claims 5
- 102000013415 peroxidase activity proteins Human genes 0.000 claims 5
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 108010054147 Hemoglobins Proteins 0.000 claims 4
- 102000001554 Hemoglobins Human genes 0.000 claims 4
- 229940088598 enzyme Drugs 0.000 claims 4
- 239000011541 reaction mixture Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- YXIWHUQXZSMYRE-UHFFFAOYSA-N 1,3-benzothiazole-2-thiol Chemical compound C1=CC=C2SC(S)=NC2=C1 YXIWHUQXZSMYRE-UHFFFAOYSA-N 0.000 claims 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000003196 chaotropic effect Effects 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- BYMZHAPPSICVQH-UHFFFAOYSA-N 2-amino-4-hydroxybenzenesulfonic acid Chemical compound NC1=CC(O)=CC=C1S(O)(=O)=O BYMZHAPPSICVQH-UHFFFAOYSA-N 0.000 claims 1
- SLAMLWHELXOEJZ-UHFFFAOYSA-N 2-nitrobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1[N+]([O-])=O SLAMLWHELXOEJZ-UHFFFAOYSA-N 0.000 claims 1
- JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 claims 1
- -1 3-aminophenozone Chemical compound 0.000 claims 1
- HQFLTUZKIRYQSP-UHFFFAOYSA-N 3-ethyl-2h-1,3-benzothiazole-6-sulfonic acid Chemical compound OS(=O)(=O)C1=CC=C2N(CC)CSC2=C1 HQFLTUZKIRYQSP-UHFFFAOYSA-N 0.000 claims 1
- UHBAPGWWRFVTFS-UHFFFAOYSA-N 4,4'-dipyridyl disulfide Chemical compound C=1C=NC=CC=1SSC1=CC=NC=C1 UHBAPGWWRFVTFS-UHFFFAOYSA-N 0.000 claims 1
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 claims 1
- VSMDINRNYYEDRN-UHFFFAOYSA-N 4-iodophenol Chemical compound OC1=CC=C(I)C=C1 VSMDINRNYYEDRN-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- RIIWUGSYXOBDMC-UHFFFAOYSA-N benzene-1,2-diamine;hydron;dichloride Chemical compound Cl.Cl.NC1=CC=CC=C1N RIIWUGSYXOBDMC-UHFFFAOYSA-N 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 claims 1
- 229960001912 dicoumarol Drugs 0.000 claims 1
- VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 claims 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical group SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 229960000789 guanidine hydrochloride Drugs 0.000 claims 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 claims 1
- 229940116357 potassium thiocyanate Drugs 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000012207 quantitative assay Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
- NMWCVZCSJHJYFW-UHFFFAOYSA-M sodium;3,5-dichloro-2-hydroxybenzenesulfonate Chemical compound [Na+].OC1=C(Cl)C=C(Cl)C=C1S([O-])(=O)=O NMWCVZCSJHJYFW-UHFFFAOYSA-M 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- AWDRATDZQPNJFN-VAYUFCLWSA-N taurodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 AWDRATDZQPNJFN-VAYUFCLWSA-N 0.000 claims 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1021509.3 | 2010-12-20 | ||
| GBGB1021509.3A GB201021509D0 (en) | 2010-12-20 | 2010-12-20 | Assay method |
| PCT/GB2011/001731 WO2012085497A1 (en) | 2010-12-20 | 2011-12-19 | Assay method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014501526A JP2014501526A (ja) | 2014-01-23 |
| JP2014501526A5 true JP2014501526A5 (enExample) | 2015-02-12 |
Family
ID=43598612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545486A Pending JP2014501526A (ja) | 2010-12-20 | 2011-12-19 | アッセイ法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130337481A1 (enExample) |
| EP (1) | EP2656082A1 (enExample) |
| JP (1) | JP2014501526A (enExample) |
| CN (1) | CN103492881A (enExample) |
| GB (1) | GB201021509D0 (enExample) |
| WO (1) | WO2012085497A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3031593B1 (fr) * | 2015-01-13 | 2019-05-03 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Analyse du phenol en phase liquide |
| CN104749153A (zh) * | 2015-04-16 | 2015-07-01 | 安徽农业大学 | 一种利用血清氧化巯基的性质诊断肝病的方法和试剂盒 |
| CN105498874B (zh) * | 2016-01-29 | 2017-05-24 | 中国农业大学 | 检测过氧化物酶浓度的芯片、系统、方法及芯片制作方法 |
| CN107966567B (zh) * | 2017-11-21 | 2018-12-18 | 浙江夸克生物科技有限公司 | 一种触珠蛋白测定试剂盒 |
| CN110779914B (zh) * | 2019-11-05 | 2022-05-20 | 湖南科技大学 | 基于血红蛋白与四碳或五碳二元酸复合物试剂盒制备方法 |
| CN112903627B (zh) * | 2021-03-06 | 2023-01-24 | 中国烟草总公司郑州烟草研究院 | 一种在线判定烟草加工过程生物酶活性的方法 |
| CN113372253B (zh) * | 2021-06-11 | 2024-12-06 | 吉林基蛋生物科技有限公司 | 一种胆红素的提取方法及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5954962A (ja) * | 1982-09-22 | 1984-03-29 | Fuji Photo Film Co Ltd | 多層分析材料 |
| DE3314308A1 (de) | 1983-04-20 | 1984-10-25 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmung des haemoglobin-haptoglobin komplexes in gegenwart von freiem haemoglobin |
| JPH0814582B2 (ja) * | 1986-02-20 | 1996-02-14 | 富士写真フイルム株式会社 | 免疫反応物定量用多層分析要素 |
| JPH02208568A (ja) | 1989-02-09 | 1990-08-20 | Green Cross Corp:The | ハプトグロビン定量試薬キット及びそれを用いるハプトグロビン定量方法 |
| US5552298A (en) * | 1992-10-23 | 1996-09-03 | Lumigen, Inc. | Enzyme-catalyzed chemiluminescence from hydroxyaryl cyclic diacylhydrazide compounds |
| US5416003A (en) * | 1993-04-14 | 1995-05-16 | Litmus Concepts, Inc. | Reporter enzyme release technology: methods of assaying for the presence of aspartic proteases and other hydrolytic enzyme activities |
| US5354654A (en) * | 1993-07-16 | 1994-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Lyophilized ligand-receptor complexes for assays and sensors |
| GB9723773D0 (en) * | 1997-11-12 | 1998-01-07 | Univ Glasgow | Haptoglobin assay |
| EP1254252A4 (en) * | 2000-01-28 | 2006-06-07 | Brij P Giri | NEW STABILIZED FORMULATIONS FOR CHEMILUMINESCENCE ASSAYS |
| US7223552B2 (en) * | 2001-01-02 | 2007-05-29 | The Cleveland Clinic Foundation | Myeloperoxidase, a risk indicator for cardiovascular disease |
| EP1766408A2 (en) * | 2004-07-09 | 2007-03-28 | Tripath Imaging, Inc. | Methods and compositions for the detection of ovarian cancer |
| CA2574727A1 (en) * | 2004-07-19 | 2006-02-23 | University Of Rochester | Biomarkers of neurodegenerative disease |
| SG140505A1 (en) * | 2006-09-05 | 2008-03-28 | Univ Singapore | Diagnostic biomolecule(s) |
| US20090053747A1 (en) * | 2007-08-21 | 2009-02-26 | Mattingly Phillip G | Measurement of Haloperoxidase Activity With Chemiluminescent Detection |
| ATE521894T1 (de) * | 2007-11-20 | 2011-09-15 | Hoffmann La Roche | Verfahren zur beurteilung von kolorektalem krebs anhand einer stuhlprobe durch verwendung einer marker-kombination aus calprotectin und einem hämoglobin/haptoglobin-komplex |
-
2010
- 2010-12-20 GB GBGB1021509.3A patent/GB201021509D0/en not_active Ceased
-
2011
- 2011-12-19 US US13/995,894 patent/US20130337481A1/en not_active Abandoned
- 2011-12-19 WO PCT/GB2011/001731 patent/WO2012085497A1/en not_active Ceased
- 2011-12-19 EP EP11811109.5A patent/EP2656082A1/en not_active Withdrawn
- 2011-12-19 JP JP2013545486A patent/JP2014501526A/ja active Pending
- 2011-12-19 CN CN201180067993.9A patent/CN103492881A/zh active Pending
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