JP2014500880A5 - - Google Patents
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- JP2014500880A5 JP2014500880A5 JP2013539257A JP2013539257A JP2014500880A5 JP 2014500880 A5 JP2014500880 A5 JP 2014500880A5 JP 2013539257 A JP2013539257 A JP 2013539257A JP 2013539257 A JP2013539257 A JP 2013539257A JP 2014500880 A5 JP2014500880 A5 JP 2014500880A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- fgf21
- pharmaceutical composition
- diabetes
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 25
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 208000035475 disorder Diseases 0.000 claims 15
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 7
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 6
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 5
- 230000006320 pegylation Effects 0.000 claims 5
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 201000001421 hyperglycemia Diseases 0.000 claims 4
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 4
- 201000008980 hyperinsulinism Diseases 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 208000032928 Dyslipidaemia Diseases 0.000 claims 3
- 208000002705 Glucose Intolerance Diseases 0.000 claims 3
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 3
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- 206010033645 Pancreatitis Diseases 0.000 claims 3
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 201000009104 prediabetes syndrome Diseases 0.000 claims 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41547610P | 2010-11-19 | 2010-11-19 | |
| US61/415,476 | 2010-11-19 | ||
| PCT/EP2011/070344 WO2012066075A1 (en) | 2010-11-19 | 2011-11-17 | Methods of treating fgf21-associated disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000935A Division JP2017110010A (ja) | 2010-11-19 | 2017-01-06 | Ｆｇｆ２１関連障害を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500880A JP2014500880A (ja) | 2014-01-16 |
| JP2014500880A5 true JP2014500880A5 (cg-RX-API-DMAC7.html) | 2015-01-08 |
| JP6110304B2 JP6110304B2 (ja) | 2017-04-05 |
Family
ID=44999776
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539257A Expired - Fee Related JP6110304B2 (ja) | 2010-11-19 | 2011-11-17 | Ｆｇｆ２１関連障害を処置する方法 |
| JP2017000935A Pending JP2017110010A (ja) | 2010-11-19 | 2017-01-06 | Ｆｇｆ２１関連障害を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000935A Pending JP2017110010A (ja) | 2010-11-19 | 2017-01-06 | Ｆｇｆ２１関連障害を処置する方法 |
Country Status (26)
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107501407B (zh) | 2007-03-30 | 2022-03-18 | Ambrx公司 | 经修饰fgf-21多肽和其用途 |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| JP5767314B2 (ja) | 2010-04-16 | 2015-08-19 | ソーク インスティチュート フォー バイオロジカル スタディーズ | Ｆｇｆを用いて代謝障害を処置するための方法 |
| US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
| TW201315742A (zh) | 2011-09-26 | 2013-04-16 | Novartis Ag | 治療代謝病症之雙功能蛋白質 |
| US9006400B2 (en) | 2011-09-26 | 2015-04-14 | Novartis Ag | Fibroblast growth factor-21-Fc fusion proteins |
| KR20220051197A (ko) | 2012-05-17 | 2022-04-26 | 익스텐드 바이오사이언시즈, 인크. | 개선된 약물 전달용 캐리어 |
| WO2014085365A2 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| DK2938740T3 (da) | 2012-12-27 | 2022-06-20 | Ngm Biopharmaceuticals Inc | Kimære fgf19-peptider til anvendelse til behandling af galdesyrelidelser |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| TWI696462B (zh) * | 2013-07-10 | 2020-06-21 | 日商興和股份有限公司 | 非酒精性脂肪性肝疾病治療劑 |
| WO2015057908A1 (en) | 2013-10-18 | 2015-04-23 | Novartis Ag | Methods of treating diabetes and related disorders |
| CN105828833A (zh) | 2013-10-21 | 2016-08-03 | 萨克生物研究学院 | 突变的成纤维细胞生长因子（fgf）1及使用方法 |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| WO2015065897A1 (en) | 2013-10-28 | 2015-05-07 | Ngm Biopharmaceuticals, Inc. | Cancer models and associated methods |
| CN106662577B (zh) | 2014-01-24 | 2020-07-21 | 恩格姆生物制药公司 | 结合蛋白及其使用方法 |
| JP6712230B2 (ja) * | 2014-03-11 | 2020-06-17 | ノバルティス アーゲー | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
| WO2015148708A1 (en) | 2014-03-25 | 2015-10-01 | Regeneron Pharmaceuticals, Inc. | Fgf21 receptor agonists and uses thereof |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016039339A1 (ja) | 2014-09-08 | 2016-03-17 | 国立大学法人大阪大学 | 脱髄疾患の予防又は治療剤 |
| WO2016048999A2 (en) * | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf21 truncations and mutants and uses thereof |
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| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065106A1 (en) | 2014-10-23 | 2016-04-28 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| UY36370A (es) * | 2014-10-24 | 2016-04-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Polipéptidos fgf-21 modificados y sus usos |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CN105802948B (zh) * | 2014-12-29 | 2020-06-09 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的门冬酰胺酶及其制备方法与应用 |
| KR20160088656A (ko) | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| TWI849231B (zh) | 2015-03-03 | 2024-07-21 | 香港商南沙生物科技（香港）有限公司 | 聚乙二醇化介白素-11之組合物及方法 |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| CA3002400A1 (en) | 2015-10-30 | 2017-05-04 | Salk Institute For Biological Studies | Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs |
| WO2017083276A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| KR101838687B1 (ko) | 2016-01-26 | 2018-03-15 | 한국생명공학연구원 | 나노포어를 이용한 단백질-단백질 상호작용 저해제 스크리닝 방법 |
| US11318186B2 (en) | 2016-05-25 | 2022-05-03 | Board Of Regents, The University Of Texas System | Use of FGF21 in methods of increasing exocrine pancreatic secretion |
| CN107759696A (zh) | 2016-08-19 | 2018-03-06 | 安源医药科技（上海）有限公司 | 人白介素7融合蛋白及其制备方法 |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CN106432509B (zh) * | 2016-09-13 | 2019-05-21 | 河南师范大学 | 一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用 |
| CN106220724B (zh) * | 2016-09-13 | 2019-10-11 | 河南师范大学 | 人成纤维细胞生长因子21重组蛋白及其制备方法和应用 |
| CN106397607A (zh) * | 2016-09-13 | 2017-02-15 | 河南师范大学 | 重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用 |
| BR112019009581A2 (pt) | 2016-11-10 | 2019-10-08 | Yuhan Corp | composição farmacêutica para evitar ou tratar hepatite, fibrose hepática, e cirrose hepática que compreende proteínas de fusão |
| WO2018166461A1 (en) | 2017-03-14 | 2018-09-20 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| CN107050429B (zh) * | 2017-04-01 | 2020-12-15 | 杭州生物医药创新研究中心 | 人成纤维生长因子21在制备用于治疗脑卒中药物中的应用 |
| MX2019012331A (es) | 2017-04-21 | 2020-01-23 | Yuhan Corp | Metodo para producir proteinas de doble funcion y sus derivados. |
| JP2020533304A (ja) | 2017-09-08 | 2020-11-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 改変型線維芽細胞成長因子２１（ｆｇｆ−２１）を用いる非アルコール性脂肪性肝炎（ｎａｓｈ）の処置方法 |
| US11752173B2 (en) | 2017-12-19 | 2023-09-12 | Beijing Jiyuan Biological Technology Co., Ltd. | FGF21 and GLP1 double gene-modified mesenchymal stem cell and use in treating a metabolic disease |
| RS65720B1 (sr) * | 2017-12-22 | 2024-08-30 | Novartis Ag | Tretiranje metaboličkih poremećaja pomoću fgf21 varijanti |
| BR112020026512A2 (pt) | 2018-07-03 | 2021-04-06 | Bristol-Myers Squibb Company | Formulações de fgf-21 |
| EP3955954A4 (en) * | 2019-04-17 | 2023-05-17 | NGM Biopharmaceuticals, Inc. | COMBINATION THERAPY FOR MODULATION OF BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES |
| US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
| CN115243725A (zh) | 2020-01-08 | 2022-10-25 | 百时美施贵宝公司 | Fgf-21缀合物配制品 |
| WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| EP4192495A1 (en) | 2020-08-07 | 2023-06-14 | Bristol-Myers Squibb Company | Fgf21 combined with ccr2/5 antagonists for the treatment of fibrosis |
| KR20220021207A (ko) | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
| US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
| CN117586423A (zh) | 2021-07-14 | 2024-02-23 | 北京质肽生物医药科技有限公司 | 用于代谢病症的融合多肽 |
| CN113717269B (zh) * | 2021-08-31 | 2022-04-19 | 赣江中药创新中心 | 一种重组的变体fgf21蛋白及其制备方法和应用 |
| CN114699509A (zh) * | 2021-09-23 | 2022-07-05 | 中南大学湘雅三医院 | Fgf21调控糖尿病缺血创面细胞焦亡的机制的应用 |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
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-
2011
- 2011-11-15 US US13/296,343 patent/US9023791B2/en active Active
- 2011-11-17 MX MX2013005639A patent/MX2013005639A/es not_active Application Discontinuation
- 2011-11-17 PH PH1/2013/501010A patent/PH12013501010A1/en unknown
- 2011-11-17 AU AU2011331166A patent/AU2011331166A1/en not_active Abandoned
- 2011-11-17 EP EP11785007.3A patent/EP2640741A1/en not_active Withdrawn
- 2011-11-17 JP JP2013539257A patent/JP6110304B2/ja not_active Expired - Fee Related
- 2011-11-17 CU CU20130073A patent/CU24115B1/es active IP Right Grant
- 2011-11-17 NZ NZ611108A patent/NZ611108A/en not_active IP Right Cessation
- 2011-11-17 CA CA2817786A patent/CA2817786A1/en not_active Abandoned
- 2011-11-17 EP EP16151097.9A patent/EP3067364A3/en not_active Withdrawn
- 2011-11-17 CN CN201180065381.6A patent/CN103328502B/zh not_active Expired - Fee Related
- 2011-11-17 CN CN201610319790.9A patent/CN105837680A/zh active Pending
- 2011-11-17 PE PE2013001217A patent/PE20140574A1/es not_active Application Discontinuation
- 2011-11-17 WO PCT/EP2011/070344 patent/WO2012066075A1/en not_active Ceased
- 2011-11-17 AP AP2013006871A patent/AP2013006871A0/xx unknown
- 2011-11-17 KR KR20137015741A patent/KR20130115305A/ko not_active Withdrawn
- 2011-11-17 SG SG2013038195A patent/SG190324A1/en unknown
- 2011-11-17 UY UY33739A patent/UY33739A/es not_active Application Discontinuation
- 2011-11-17 EA EA201390739A patent/EA201390739A1/ru unknown
- 2011-11-18 TW TW100142397A patent/TW201302782A/zh unknown
- 2011-11-18 AR ARP110104305 patent/AR083920A1/es unknown
-
2013
- 2013-05-14 ZA ZA2013/03498A patent/ZA201303498B/en unknown
- 2013-05-16 IL IL226401A patent/IL226401A0/en unknown
- 2013-05-17 GT GT201300131A patent/GT201300131A/es unknown
- 2013-05-17 CL CL2013001410A patent/CL2013001410A1/es unknown
- 2013-05-20 CR CR20130234A patent/CR20130234A/es unknown
- 2013-05-24 CO CO13128283A patent/CO6791605A2/es unknown
- 2013-06-05 MA MA35962A patent/MA34710B1/fr unknown
-
2015
- 2015-04-02 US US14/676,863 patent/US20160051628A1/en not_active Abandoned
-
2017
- 2017-01-06 JP JP2017000935A patent/JP2017110010A/ja active Pending
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