JP2014240385A5 - - Google Patents

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JP2014240385A5
JP2014240385A5 JP2014115617A JP2014115617A JP2014240385A5 JP 2014240385 A5 JP2014240385 A5 JP 2014240385A5 JP 2014115617 A JP2014115617 A JP 2014115617A JP 2014115617 A JP2014115617 A JP 2014115617A JP 2014240385 A5 JP2014240385 A5 JP 2014240385A5
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JP
Japan
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mab
fgfr2iiic
inhibits
fgfr2iiib
binds
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JP2014115617A
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Japanese (ja)
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JP6342223B2 (ja
JP2014240385A (ja
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JP2014115617A 2008-11-07 2014-06-04 線維芽増殖因子受容体2に対するモノクローナル抗体 Active JP6342223B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11268608P 2008-11-07 2008-11-07
US61/112,686 2008-11-07
US16487009P 2009-03-30 2009-03-30
US61/164,870 2009-03-30

Related Parent Applications (1)

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JP2011534932A Division JP5627591B2 (ja) 2008-11-07 2009-11-06 線維芽増殖因子受容体2に対するモノクローナル抗体

Related Child Applications (1)

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JP2016152670A Division JP6445496B2 (ja) 2008-11-07 2016-08-03 線維芽増殖因子受容体2に対するモノクローナル抗体

Publications (3)

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JP2014240385A JP2014240385A (ja) 2014-12-25
JP2014240385A5 true JP2014240385A5 (enExample) 2015-02-12
JP6342223B2 JP6342223B2 (ja) 2018-06-13

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Application Number Title Priority Date Filing Date
JP2011534932A Active JP5627591B2 (ja) 2008-11-07 2009-11-06 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2014115617A Active JP6342223B2 (ja) 2008-11-07 2014-06-04 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2016152670A Active JP6445496B2 (ja) 2008-11-07 2016-08-03 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2018223183A Active JP6661734B2 (ja) 2008-11-07 2018-11-29 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2020018719A Active JP6960485B2 (ja) 2008-11-07 2020-02-06 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2021166672A Active JP7301106B2 (ja) 2008-11-07 2021-10-11 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2023100475A Pending JP2023116746A (ja) 2008-11-07 2023-06-20 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2024193584A Pending JP2025032085A (ja) 2008-11-07 2024-11-05 線維芽増殖因子受容体2に対するモノクローナル抗体

Family Applications Before (1)

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JP2011534932A Active JP5627591B2 (ja) 2008-11-07 2009-11-06 線維芽増殖因子受容体2に対するモノクローナル抗体

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2016152670A Active JP6445496B2 (ja) 2008-11-07 2016-08-03 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2018223183A Active JP6661734B2 (ja) 2008-11-07 2018-11-29 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2020018719A Active JP6960485B2 (ja) 2008-11-07 2020-02-06 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2021166672A Active JP7301106B2 (ja) 2008-11-07 2021-10-11 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2023100475A Pending JP2023116746A (ja) 2008-11-07 2023-06-20 線維芽増殖因子受容体2に対するモノクローナル抗体
JP2024193584A Pending JP2025032085A (ja) 2008-11-07 2024-11-05 線維芽増殖因子受容体2に対するモノクローナル抗体

Country Status (20)

Country Link
US (8) US8101723B2 (enExample)
EP (4) EP2365828B1 (enExample)
JP (8) JP5627591B2 (enExample)
KR (1) KR101699432B1 (enExample)
CN (1) CN102131524B (enExample)
AU (1) AU2009313357B2 (enExample)
BR (1) BRPI0917315B8 (enExample)
CA (3) CA3287843A1 (enExample)
DK (3) DK3290052T3 (enExample)
ES (3) ES2770134T3 (enExample)
HR (2) HRP20171640T1 (enExample)
HU (1) HUE035700T2 (enExample)
LT (2) LT2842573T (enExample)
MX (1) MX2011000455A (enExample)
NO (1) NO2842573T3 (enExample)
PL (3) PL2842573T3 (enExample)
PT (3) PT2365828E (enExample)
RU (1) RU2546254C9 (enExample)
SI (2) SI2842573T1 (enExample)
WO (1) WO2010054265A2 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9260525B2 (en) 2008-02-04 2016-02-16 Xiao-Jia Chang Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
WO2009100105A2 (en) * 2008-02-04 2009-08-13 Attogen Inc. Inhibitors of oncogenic isoforms and uses thereof
HUE035700T2 (en) 2008-11-07 2018-05-28 Galaxy Biotech Llc Monoclonal antibodies to Fibroblast Growth Factor receptor 2
RU2012153241A (ru) * 2010-05-11 2014-06-20 Авео Фармасьютикалз, Инк. Антитела к fgfr2
EP2603521A4 (en) * 2010-08-12 2014-10-01 Attogen Inc ANTIBODY MOLECULARS FOR ONGOGEN FIBROBLAST GROWTH RECEPTOR 2 ISOFORMS AND ITS USES
WO2012158818A2 (en) 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
AR088941A1 (es) * 2011-11-23 2014-07-16 Bayer Ip Gmbh Anticuerpos anti-fgfr2 y sus usos
SG11201403085PA (en) * 2011-12-14 2014-10-30 Seattle Genetics Inc Fgfr antibody drug conjugates (adcs) and the use thereof
SG11201405226TA (en) 2012-03-08 2014-11-27 Crucell Holland Bv Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof
AU2013247645B2 (en) * 2012-04-09 2019-02-14 Daiichi Sankyo Company, Limited Anti-FGFR2 antibody
WO2014089193A1 (en) * 2012-12-04 2014-06-12 Aveo Pharmaceuticals, Inc. Anti-fgfr2 antibodies
HRP20190157T1 (hr) * 2012-12-21 2019-03-22 Janssen Biotech, Inc. Senzitivni višestruki imunotest za topljive receptore faktora rasta fibroblasta
CN103145843B (zh) * 2013-02-20 2014-10-29 暨南大学 抗成纤维细胞生长因子受体的单链抗体
MX2015011428A (es) 2013-03-06 2016-02-03 Genentech Inc Metodos para tratar y prevenir la resistencia a los farmacos para el cancer.
KR102516152B1 (ko) 2013-08-01 2023-03-31 파이브 프라임 테라퓨틱스, 인크. 비푸코실화된 항-fgfr2iiib 항체
TWI664977B (zh) * 2013-10-08 2019-07-11 第一三共股份有限公司 抗fgfr2抗體及其與其他藥劑之組合
CN103757026B (zh) * 2013-12-20 2017-04-05 广州圣露生物技术有限公司 FGFR2b胞外段的基因序列、多肽及其应用
CN107073121A (zh) 2014-06-13 2017-08-18 基因泰克公司 治疗及预防癌症药物抗性的方法
CN104231079A (zh) * 2014-09-12 2014-12-24 暨南大学 一种靶向bFGF高亲和力受体结合位点的抗体及其应用
JP6887944B2 (ja) * 2015-04-08 2021-06-16 第一三共株式会社 抗fgfr2抗体と他剤を含む組成物
JPWO2016171107A1 (ja) * 2015-04-20 2018-03-22 第一三共株式会社 Fgfr2の検出
RU2638457C2 (ru) * 2015-09-28 2017-12-13 Общество С Ограниченной Ответственностью "Онкомакс" Антитела, специфически связывающие рецептор 1 типа фактора роста фибробластов, применение антител для лечения онкологического заболевания, способ получения антител
MX2018006181A (es) * 2015-11-23 2018-09-24 Five Prime Therapeutics Inc Inhibidores de fgfr2 solos o en combinacion con agentes que estimulan el sistema inmunitario en el tratamiento contra el cancer.
EP3430058A4 (en) 2016-03-15 2019-10-23 Generon (Shanghai) Corporation Ltd. MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
PT3624837T (pt) 2017-05-16 2025-10-01 Five Prime Therapeutics Inc Anticorpos anti-fgfr2 em combinação com agentes quimioterapêuticos no tratamento do cancro
NZ759601A (en) 2017-06-02 2023-06-30 Merck Patent Gmbh Aggrecan binding immunoglobulins
WO2019084057A2 (en) 2017-10-24 2019-05-02 Magenta Therapeutics, Inc. COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS
WO2019084067A1 (en) * 2017-10-24 2019-05-02 Magenta Therapeutics, Inc. ANTI-CD117 ANTIBODIES AND METHODS OF USE
KR20200069364A (ko) 2017-10-24 2020-06-16 마젠타 테라퓨틱스 인코포레이티드 Cd117+ 세포의 고갈을 위한 조성물 및 방법
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
PE20211213A1 (es) 2018-10-05 2021-07-05 Five Prime Therapeutics Inc Formulaciones de anticuerpos anti-fgfr2
WO2020132810A1 (en) 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
JP7686000B2 (ja) * 2019-12-24 2025-05-30 ディザル(ジァンスー)ファーマシューティカル・カンパニー・リミテッド 新規抗FGFR2b抗体
KR20220119144A (ko) * 2019-12-24 2022-08-26 디잘 (지앙수) 파마슈티칼 씨오., 리미티드 신규한 항fgfr2b 항체
CA3185812A1 (en) * 2020-06-03 2021-12-09 The Broad Institute, Inc. Antagonistic biparatopic antibodies that specifically bind fibroblast growth factor receptor 2 and methods of using same
CA3190569A1 (en) 2020-10-22 2022-04-28 Christopher Daly Anti-fgfr2 antibodies and methods of use thereof
JP2024501565A (ja) * 2020-12-29 2024-01-12 深▲せん▼福沃薬業有限公司 抗fgfr2抗体およびその使用
WO2023056916A1 (zh) * 2021-10-08 2023-04-13 深圳福沃药业有限公司 Adcc增强型抗fgfr2抗体及其用途
TW202342527A (zh) 2022-02-25 2023-11-01 美商安進公司 鱗狀非小細胞肺癌之治療
CN120418288A (zh) * 2022-09-30 2025-08-01 思康睿奇(上海)药业有限公司 FGFR2b抗体及其用途
CN118852431A (zh) * 2023-04-28 2024-10-29 武汉人福创新药物研发中心有限公司 抗FGFR2b单抗
WO2024240107A1 (zh) * 2023-05-19 2024-11-28 广东东阳光药业股份有限公司 一种抗fgfr2抗体及其应用
CN119855835A (zh) * 2023-06-13 2025-04-18 南京维立志博生物科技股份有限公司 基于共同轻链产生双特异性抗体的方法
WO2025130905A1 (zh) * 2023-12-18 2025-06-26 山东先声生物制药有限公司 抗FGFR2b抗体-药物缀合物及其应用
WO2025218662A1 (zh) * 2024-04-16 2025-10-23 杭州中美华东制药有限公司 抗成纤维细胞生长因子受体2b的抗体及其用途
TW202547875A (zh) * 2024-05-09 2025-12-16 大陸商正大天晴藥業集團股份有限公司 靶向成纖維細胞生長因子受體2IIIb的抗體及其應用
WO2026007196A1 (zh) * 2024-07-02 2026-01-08 安博泰克药业有限公司 特异性结合FGFR2b的抗体及其与药物的缀合物

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
HU215581B (hu) * 1989-07-06 1999-01-28 Regents Of The University Of California Eljárás fibroblaszt növekedési faktor receptorok előállítására és terápiás alkalmazására
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5863888A (en) * 1990-07-06 1999-01-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Human Bek Fibroblast growth factor receptor
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6066718A (en) 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
WO1995010540A1 (en) * 1993-10-14 1995-04-20 Immunex Corporation Fas antagonists and uses thereof
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
WO1997048813A2 (en) 1996-06-18 1997-12-24 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fibroblast growth factor receptor activating gene 1 (frag1). fgfr2-frag1 fusions
US20030143676A1 (en) * 1999-03-25 2003-07-31 Genesis Research And Development Corporation Limited Fibroblast growth factor receptors and methods for their use
US6342219B1 (en) * 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody compositions for selectively inhibiting VEGF
JP2001302699A (ja) 2000-04-17 2001-10-31 Nichirei Corp ヒトkgfrに対する抗体
US20020115603A1 (en) 2000-06-22 2002-08-22 Chiron Corporation Methods and compositions for the treatment of peripheral artery disease
CA2450285C (en) * 2001-06-13 2016-08-02 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (egfr)
CA2450793A1 (en) 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
MXPA05000511A (es) 2001-07-12 2005-09-30 Jefferson Foote Anticuepros super humanizados.
EP1469878B1 (en) 2002-01-31 2011-03-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fgfr agonists
KR100493460B1 (ko) * 2002-08-29 2005-06-07 재단법인서울대학교산학협력재단 암 세포에서 발현되는 fgfr2 이성체
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
TWI476206B (zh) 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
EP1697420A2 (en) 2003-12-19 2006-09-06 Five Prime Therapeutics, Inc. Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
WO2005115363A2 (en) * 2004-05-25 2005-12-08 Yale University Method for treating skeletal disorders resulting from fgfr malfunction
CA2648021A1 (en) 2006-03-31 2007-10-11 Ordway Research Institute, Inc. Prognostic and diagnostic method for cancer therapy
AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
JP2009536834A (ja) * 2006-05-12 2009-10-22 ジェネンテック・インコーポレーテッド 癌の診断及び治療のための方法及び組成物
AU2007254853B2 (en) 2006-06-02 2011-11-17 Aveo Pharmaceuticals, Inc. Hepatocyte growth factor (HGF) binding proteins
US7649083B2 (en) 2006-06-02 2010-01-19 Aveo Pharmaceuticals, Inc. Hepatocyte growth factor (HGF) binding antibody
US8101721B2 (en) 2006-06-15 2012-01-24 Fibron Ltd. Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof
DK2066694T3 (en) 2006-09-29 2016-02-08 Oncomed Pharm Inc Compositions and Methods for Diagnosing and Treating Cancer
EP2094733A1 (en) * 2006-11-03 2009-09-02 U3 Pharma GmbH Fgfr4 antibodies
CA2680046A1 (en) * 2007-03-23 2008-10-02 The Translational Genomics Research Institute Methods of diagnosing, classifying and treating endometrial cancer and precancer
EP2205277B1 (en) 2007-10-22 2017-07-26 Genmab A/S Novel antibody therapies
WO2009100105A2 (en) 2008-02-04 2009-08-13 Attogen Inc. Inhibitors of oncogenic isoforms and uses thereof
EP2177615A1 (en) 2008-10-10 2010-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
HUE035700T2 (en) 2008-11-07 2018-05-28 Galaxy Biotech Llc Monoclonal antibodies to Fibroblast Growth Factor receptor 2
US20120301482A1 (en) 2009-08-25 2012-11-29 National Jewish Health Methods and compositions for treatment of lung injury

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