PT2365828E - Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos - Google Patents
Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos Download PDFInfo
- Publication number
- PT2365828E PT2365828E PT98255235T PT09825523T PT2365828E PT 2365828 E PT2365828 E PT 2365828E PT 98255235 T PT98255235 T PT 98255235T PT 09825523 T PT09825523 T PT 09825523T PT 2365828 E PT2365828 E PT 2365828E
- Authority
- PT
- Portugal
- Prior art keywords
- growth factor
- monoclonal antibodies
- factor receptor
- fibroblast growth
- fibroblast
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11268608P | 2008-11-07 | 2008-11-07 | |
US16487009P | 2009-03-30 | 2009-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2365828E true PT2365828E (pt) | 2014-12-12 |
Family
ID=42153600
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT171911183T PT3290052T (pt) | 2008-11-07 | 2009-11-06 | Anticorpos monoclonais para o recetor 2 do fator de crescimento de fibroblastos |
PT141887851T PT2842573T (pt) | 2008-11-07 | 2009-11-06 | Anticorpos monoclonais para o recetor 2 do factor de crescimento de fibroblastos |
PT98255235T PT2365828E (pt) | 2008-11-07 | 2009-11-06 | Anticorpos monoclonais para o receptor 2 do factor de crescimento de fibroblastos |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT171911183T PT3290052T (pt) | 2008-11-07 | 2009-11-06 | Anticorpos monoclonais para o recetor 2 do fator de crescimento de fibroblastos |
PT141887851T PT2842573T (pt) | 2008-11-07 | 2009-11-06 | Anticorpos monoclonais para o recetor 2 do factor de crescimento de fibroblastos |
Country Status (21)
Country | Link |
---|---|
US (8) | US8101723B2 (pt) |
EP (4) | EP3783024A1 (pt) |
JP (7) | JP5627591B2 (pt) |
KR (1) | KR101699432B1 (pt) |
CN (1) | CN102131524B (pt) |
AU (1) | AU2009313357B2 (pt) |
BR (1) | BRPI0917315B8 (pt) |
CA (2) | CA3166399A1 (pt) |
DK (3) | DK2842573T3 (pt) |
ES (3) | ES2523740T3 (pt) |
HK (3) | HK1160012A1 (pt) |
HR (2) | HRP20171640T1 (pt) |
HU (1) | HUE035700T2 (pt) |
LT (2) | LT2842573T (pt) |
MX (1) | MX2011000455A (pt) |
NO (1) | NO2842573T3 (pt) |
PL (3) | PL2365828T3 (pt) |
PT (3) | PT3290052T (pt) |
RU (1) | RU2546254C9 (pt) |
SI (2) | SI3290052T1 (pt) |
WO (1) | WO2010054265A2 (pt) |
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WO2009100105A2 (en) * | 2008-02-04 | 2009-08-13 | Attogen Inc. | Inhibitors of oncogenic isoforms and uses thereof |
US9260525B2 (en) | 2008-02-04 | 2016-02-16 | Xiao-Jia Chang | Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof |
ES2523740T3 (es) | 2008-11-07 | 2014-12-01 | Galaxy Biotech, Llc | Anticuerpos monoclonales para el receptor del factor de crecimiento de fibroblastos 2 |
CN102905723A (zh) * | 2010-05-11 | 2013-01-30 | Aveo制药公司 | 抗fgfr2抗体 |
CN103201287B (zh) * | 2010-08-12 | 2016-04-13 | 艾托生物有限公司 | 成纤维细胞生长因子受体2的致癌异构体的抗体分子及其用途 |
EP2710042A2 (en) | 2011-05-16 | 2014-03-26 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
AR088941A1 (es) | 2011-11-23 | 2014-07-16 | Bayer Ip Gmbh | Anticuerpos anti-fgfr2 y sus usos |
MX2014007121A (es) * | 2011-12-14 | 2014-09-04 | Seattle Genetics Inc | Nuevos conjugados de principio activo-ligante (adc) y su uso. |
ES2664625T3 (es) * | 2012-03-08 | 2018-04-20 | Janssen Vaccines & Prevention B.V. | Moléculas de unión humanas que pueden unirse a los virus de la influenza b y neutralizarlos, y sus usos |
EP2837685B1 (en) * | 2012-04-09 | 2020-09-09 | Daiichi Sankyo Company, Limited | Anti-fgfr2 antibody |
WO2014089193A1 (en) * | 2012-12-04 | 2014-06-12 | Aveo Pharmaceuticals, Inc. | Anti-fgfr2 antibodies |
HUE042184T2 (hu) * | 2012-12-21 | 2019-06-28 | Janssen Biotech Inc | Érzékeny multiplex immunvizsgálati eljárás szolúbilis fibroblaszt növekedési faktor receptorok kimutatására |
CN103145843B (zh) * | 2013-02-20 | 2014-10-29 | 暨南大学 | 抗成纤维细胞生长因子受体的单链抗体 |
KR20150123250A (ko) | 2013-03-06 | 2015-11-03 | 제넨테크, 인크. | 암 약물 내성의 치료 및 예방 방법 |
RU2740714C2 (ru) * | 2013-08-01 | 2021-01-20 | Файв Прайм Терапьютикс, Инк. | Афукозилированные антитела к рецептору фактора роста фибробластов fgfr2iiib |
KR20160066024A (ko) * | 2013-10-08 | 2016-06-09 | 다이이찌 산쿄 가부시키가이샤 | 항 fgfr2 항체와 타제의 조합 |
CN103757026B (zh) * | 2013-12-20 | 2017-04-05 | 广州圣露生物技术有限公司 | FGFR2b胞外段的基因序列、多肽及其应用 |
EP3154589A1 (en) | 2014-06-13 | 2017-04-19 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance |
CN104231079A (zh) * | 2014-09-12 | 2014-12-24 | 暨南大学 | 一种靶向bFGF高亲和力受体结合位点的抗体及其应用 |
TW201642904A (zh) * | 2015-04-08 | 2016-12-16 | 第一三共股份有限公司 | 含抗fgfr2抗體及其他藥劑之組成物 |
US10881734B2 (en) | 2015-04-20 | 2021-01-05 | Daiichi Sankyo Company, Limited | Monoclonal antibodies to human fibroblast growth factor receptor 2 (HFGFR2) and methods of use thereof |
RU2638457C2 (ru) * | 2015-09-28 | 2017-12-13 | Общество С Ограниченной Ответственностью "Онкомакс" | Антитела, специфически связывающие рецептор 1 типа фактора роста фибробластов, применение антител для лечения онкологического заболевания, способ получения антител |
EP3380523A1 (en) | 2015-11-23 | 2018-10-03 | Five Prime Therapeutics, Inc. | Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment |
CA3017776A1 (en) | 2016-03-15 | 2017-09-21 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
CN110621336A (zh) | 2017-05-16 | 2019-12-27 | 戊瑞治疗有限公司 | 癌症治疗中抗fgfr2抗体与化学治疗剂的组合 |
KR20200013247A (ko) | 2017-06-02 | 2020-02-06 | 아블린쓰 엔.브이. | 아그레칸 결합 면역글로불린 |
WO2019084064A2 (en) | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS |
WO2019084067A1 (en) * | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | ANTI-CD117 ANTIBODIES AND METHODS OF USE |
CA3079215A1 (en) | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+ cells |
AU2019355995A1 (en) | 2018-10-05 | 2021-04-08 | Five Prime Therapeutics, Inc. | Anti-FGFR2 antibody formulations |
AR120886A1 (es) * | 2019-12-24 | 2022-03-30 | Dizal Jiangsu Pharmaceutical Co Ltd | Anticuerpos anti-fgfr2b |
EP4232481A1 (en) | 2020-10-22 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Anti-fgfr2 antibodies and methods of use thereof |
TW202241951A (zh) * | 2020-12-29 | 2022-11-01 | 大陸商深圳福沃藥業有限公司 | 抗fgfr2抗體及其用途 |
TW202323299A (zh) * | 2021-10-08 | 2023-06-16 | 大陸商深圳福沃藥業有限公司 | Adcc增強型抗fgfr2抗體及其用途 |
TW202342527A (zh) | 2022-02-25 | 2023-11-01 | 美商安進公司 | 鱗狀非小細胞肺癌之治療 |
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2009
- 2009-11-06 ES ES09825523.5T patent/ES2523740T3/es active Active
- 2009-11-06 EP EP19193727.5A patent/EP3783024A1/en active Pending
- 2009-11-06 DK DK14188785.1T patent/DK2842573T3/en active
- 2009-11-06 BR BRPI0917315A patent/BRPI0917315B8/pt active IP Right Grant
- 2009-11-06 DK DK17191118.3T patent/DK3290052T3/da active
- 2009-11-06 EP EP09825523.5A patent/EP2365828B1/en active Active
- 2009-11-06 NO NO14188785A patent/NO2842573T3/no unknown
- 2009-11-06 SI SI200932035T patent/SI3290052T1/sl unknown
- 2009-11-06 CA CA3166399A patent/CA3166399A1/en active Pending
- 2009-11-06 CN CN200980132269.2A patent/CN102131524B/zh active Active
- 2009-11-06 PT PT171911183T patent/PT3290052T/pt unknown
- 2009-11-06 PT PT141887851T patent/PT2842573T/pt unknown
- 2009-11-06 WO PCT/US2009/063647 patent/WO2010054265A2/en active Application Filing
- 2009-11-06 PT PT98255235T patent/PT2365828E/pt unknown
- 2009-11-06 EP EP14188785.1A patent/EP2842573B1/en active Active
- 2009-11-06 LT LTEP14188785.1T patent/LT2842573T/lt unknown
- 2009-11-06 SI SI200931763T patent/SI2842573T1/en unknown
- 2009-11-06 CA CA2733668A patent/CA2733668C/en active Active
- 2009-11-06 EP EP17191118.3A patent/EP3290052B1/en active Active
- 2009-11-06 PL PL09825523T patent/PL2365828T3/pl unknown
- 2009-11-06 MX MX2011000455A patent/MX2011000455A/es active IP Right Grant
- 2009-11-06 PL PL17191118T patent/PL3290052T3/pl unknown
- 2009-11-06 JP JP2011534932A patent/JP5627591B2/ja active Active
- 2009-11-06 PL PL14188785T patent/PL2842573T3/pl unknown
- 2009-11-06 KR KR1020117002577A patent/KR101699432B1/ko active IP Right Grant
- 2009-11-06 DK DK09825523.5T patent/DK2365828T3/en active
- 2009-11-06 ES ES17191118T patent/ES2770134T3/es active Active
- 2009-11-06 HU HUE14188785A patent/HUE035700T2/en unknown
- 2009-11-06 US US12/614,282 patent/US8101723B2/en active Active
- 2009-11-06 AU AU2009313357A patent/AU2009313357B2/en active Active
- 2009-11-06 RU RU2011141890/10A patent/RU2546254C9/ru active
- 2009-11-06 LT LTEP17191118.3T patent/LT3290052T/lt unknown
- 2009-11-06 ES ES14188785.1T patent/ES2646168T3/es active Active
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2011
- 2011-10-28 US US13/284,838 patent/US8603987B2/en active Active
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2012
- 2012-01-17 HK HK12100557.1A patent/HK1160012A1/xx unknown
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2013
- 2013-11-04 US US14/071,520 patent/US9382324B2/en active Active
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2014
- 2014-06-04 JP JP2014115617A patent/JP6342223B2/ja active Active
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2015
- 2015-09-04 HK HK15108641.9A patent/HK1207974A1/xx unknown
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2016
- 2016-06-02 US US15/172,033 patent/US9834609B2/en active Active
- 2016-08-03 JP JP2016152670A patent/JP6445496B2/ja active Active
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2017
- 2017-08-10 US US15/674,385 patent/US10138301B2/en active Active
- 2017-10-26 HR HRP20171640TT patent/HRP20171640T1/hr unknown
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2018
- 2018-07-10 HK HK18108939.7A patent/HK1249053A1/zh unknown
- 2018-10-18 US US16/164,530 patent/US10689448B2/en active Active
- 2018-11-29 JP JP2018223183A patent/JP6661734B2/ja active Active
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2020
- 2020-01-20 HR HRP20200090TT patent/HRP20200090T1/hr unknown
- 2020-02-06 JP JP2020018719A patent/JP6960485B2/ja active Active
- 2020-05-05 US US16/867,398 patent/US20200347141A1/en not_active Abandoned
-
2021
- 2021-10-11 JP JP2021166672A patent/JP7301106B2/ja active Active
-
2023
- 2023-03-10 US US18/182,242 patent/US20230242650A1/en active Pending
- 2023-06-20 JP JP2023100475A patent/JP2023116746A/ja active Pending
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