MX2011000455A - Anticuerpos monoclonales especificos al receptor 2 del factor de crecimiento de fibroblastos. - Google Patents
Anticuerpos monoclonales especificos al receptor 2 del factor de crecimiento de fibroblastos.Info
- Publication number
- MX2011000455A MX2011000455A MX2011000455A MX2011000455A MX2011000455A MX 2011000455 A MX2011000455 A MX 2011000455A MX 2011000455 A MX2011000455 A MX 2011000455A MX 2011000455 A MX2011000455 A MX 2011000455A MX 2011000455 A MX2011000455 A MX 2011000455A
- Authority
- MX
- Mexico
- Prior art keywords
- mab
- gal
- fgfr2
- humanized
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G01N33/5759—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11268608P | 2008-11-07 | 2008-11-07 | |
| US16487009P | 2009-03-30 | 2009-03-30 | |
| PCT/US2009/063647 WO2010054265A2 (en) | 2008-11-07 | 2009-11-06 | Monoclonal antibodies to fibroblast growth factor receptor 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011000455A true MX2011000455A (es) | 2011-02-25 |
Family
ID=42153600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011000455A MX2011000455A (es) | 2008-11-07 | 2009-11-06 | Anticuerpos monoclonales especificos al receptor 2 del factor de crecimiento de fibroblastos. |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US8101723B2 (enExample) |
| EP (4) | EP2365828B1 (enExample) |
| JP (8) | JP5627591B2 (enExample) |
| KR (1) | KR101699432B1 (enExample) |
| CN (1) | CN102131524B (enExample) |
| AU (1) | AU2009313357B2 (enExample) |
| BR (1) | BRPI0917315B8 (enExample) |
| CA (1) | CA2733668C (enExample) |
| DK (3) | DK2842573T3 (enExample) |
| ES (3) | ES2523740T3 (enExample) |
| HR (2) | HRP20171640T1 (enExample) |
| HU (1) | HUE035700T2 (enExample) |
| LT (2) | LT2842573T (enExample) |
| MX (1) | MX2011000455A (enExample) |
| NO (1) | NO2842573T3 (enExample) |
| PL (3) | PL2842573T3 (enExample) |
| PT (3) | PT2365828E (enExample) |
| RU (1) | RU2546254C9 (enExample) |
| SI (2) | SI3290052T1 (enExample) |
| WO (1) | WO2010054265A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9260525B2 (en) | 2008-02-04 | 2016-02-16 | Xiao-Jia Chang | Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof |
| US20110059091A1 (en) * | 2008-02-04 | 2011-03-10 | Xiao-Jia Chang | Inhibitors of oncogenic isoforms and uses thereof |
| KR101699432B1 (ko) | 2008-11-07 | 2017-01-24 | 갤럭시 바이오테크, 엘엘씨 | 섬유아세포성장인자수용체 2에 대한 모노클로날 항체 |
| US8481688B2 (en) * | 2010-05-11 | 2013-07-09 | Aveo Pharmaceuticals, Inc. | Anti-FGFR2 antibodies |
| EP2603521A4 (en) * | 2010-08-12 | 2014-10-01 | Attogen Inc | ANTIBODY MOLECULARS FOR ONGOGEN FIBROBLAST GROWTH RECEPTOR 2 ISOFORMS AND ITS USES |
| JP6400470B2 (ja) | 2011-05-16 | 2018-10-03 | ジェネロン(シャンハイ)コーポレイション リミテッド | 多重特異性Fab融合タンパク質および使用法 |
| AR088941A1 (es) | 2011-11-23 | 2014-07-16 | Bayer Ip Gmbh | Anticuerpos anti-fgfr2 y sus usos |
| RU2014128467A (ru) | 2011-12-14 | 2016-02-10 | Сиэтл Дженетикс, Инк. | Новые коньюгаты связывающее соединение-активное соединение (adc) и их применение |
| EP2822968B1 (en) | 2012-03-08 | 2018-01-10 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof |
| CN104334724B (zh) * | 2012-04-09 | 2020-09-01 | 第一三共株式会社 | 抗-fgfr2抗体 |
| WO2014089193A1 (en) * | 2012-12-04 | 2014-06-12 | Aveo Pharmaceuticals, Inc. | Anti-fgfr2 antibodies |
| JP6488236B2 (ja) * | 2012-12-21 | 2019-03-20 | ヤンセン バイオテツク,インコーポレーテツド | 可溶型線維芽細胞増殖因子受容体の高感度多重イムノアッセイ |
| CN103145843B (zh) * | 2013-02-20 | 2014-10-29 | 暨南大学 | 抗成纤维细胞生长因子受体的单链抗体 |
| HK1213180A1 (zh) | 2013-03-06 | 2016-06-30 | 豪夫迈‧罗氏有限公司 | 治疗和预防癌症药物抗性的方法 |
| PL3027651T3 (pl) * | 2013-08-01 | 2019-08-30 | Five Prime Therapeutics, Inc. | Afukozylowane przeciwciała anty-fgfr2iiib |
| ES2768618T3 (es) * | 2013-10-08 | 2020-06-23 | Daiichi Sankyo Co Ltd | Combinación de anticuerpo anti-FGFR2 y otro agente |
| CN103757026B (zh) * | 2013-12-20 | 2017-04-05 | 广州圣露生物技术有限公司 | FGFR2b胞外段的基因序列、多肽及其应用 |
| JP2017517552A (ja) | 2014-06-13 | 2017-06-29 | ジェネンテック, インコーポレイテッド | 抗癌剤耐性の治療及び防止方法 |
| CN104231079A (zh) * | 2014-09-12 | 2014-12-24 | 暨南大学 | 一种靶向bFGF高亲和力受体结合位点的抗体及其应用 |
| JP6887944B2 (ja) * | 2015-04-08 | 2021-06-16 | 第一三共株式会社 | 抗fgfr2抗体と他剤を含む組成物 |
| EP3287522A4 (en) * | 2015-04-20 | 2019-03-27 | Daiichi Sankyo Company, Limited | DETECTION OF FGFR2 |
| RU2638457C2 (ru) * | 2015-09-28 | 2017-12-13 | Общество С Ограниченной Ответственностью "Онкомакс" | Антитела, специфически связывающие рецептор 1 типа фактора роста фибробластов, применение антител для лечения онкологического заболевания, способ получения антител |
| KR20250034528A (ko) | 2015-11-23 | 2025-03-11 | 파이브 프라임 테라퓨틱스, 인크. | 암 치료에서의 단독의, 또는 면역 자극제와 병용한, fgfr2 억제제 |
| US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| RS67296B1 (sr) | 2017-05-16 | 2025-11-28 | Five Prime Therapeutics Inc | Anti-fgfr2 antitela u kombinaciji sa sredstvima za hemoterapiju u lečenju karcinoma |
| EP3630818A1 (en) | 2017-06-02 | 2020-04-08 | Ablynx NV | Aggrecan binding immunoglobulins |
| WO2019084067A1 (en) * | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | ANTI-CD117 ANTIBODIES AND METHODS OF USE |
| AU2018354189A1 (en) | 2017-10-24 | 2020-04-23 | Crispr Therapeutics Ag | Compositions and methods for the depletion of CD117+ cells |
| MX2020004140A (es) | 2017-10-24 | 2020-08-13 | Magenta Therapeutics Inc | Composiciones y metodos para la eliminacion de celulas cd117+. |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| US20220010020A1 (en) | 2018-10-05 | 2022-01-13 | Five Prime Therapeutics, Inc. | Anti-FGFR2 Antibody Formulations |
| MX2022007960A (es) * | 2019-12-24 | 2022-07-12 | Dizal Jiangsu Pharmaceutical Co Ltd | Nuevos anticuerpos anti-fgfr2b. |
| AR120886A1 (es) * | 2019-12-24 | 2022-03-30 | Dizal Jiangsu Pharmaceutical Co Ltd | Anticuerpos anti-fgfr2b |
| JP2023528454A (ja) * | 2020-06-03 | 2023-07-04 | ザ・ブロード・インスティテュート・インコーポレイテッド | 線維芽細胞増殖因子受容体2に特異的に結合する二重パラトープアンタゴニスト抗体およびその使用方法 |
| WO2022087243A1 (en) | 2020-10-22 | 2022-04-28 | Regeneron Pharmaceuticals, Inc. | Anti-fgfr2 antibodies and methods of use thereof |
| US20240101683A1 (en) * | 2020-12-29 | 2024-03-28 | Shenzhen Forward Pharmaceuticals Co., Limited | Anti-FGFR2 Antibody and Use Thereof |
| EP4414387A4 (en) * | 2021-10-08 | 2025-10-29 | Shenzhen Forward Pharmaceuticals Co Ltd | ANTI-FGFR2 ANTIBODY WITH IMPROVED ADCC AND ITS USE |
| TW202342527A (zh) | 2022-02-25 | 2023-11-01 | 美商安進公司 | 鱗狀非小細胞肺癌之治療 |
| EP4594356A1 (en) * | 2022-09-30 | 2025-08-06 | 3H Pharmaceuticals Co., Ltd. | Anti-fgfr2b antibodies and uses thereof |
| TW202442685A (zh) * | 2023-04-28 | 2024-11-01 | 大陸商武漢人福創新藥物研發中心有限公司 | 抗FGFR2b單抗 |
| CN118994393A (zh) * | 2023-05-19 | 2024-11-22 | 广东东阳光药业股份有限公司 | 一种抗fgfr2抗体及其应用 |
| CN119855835A (zh) * | 2023-06-13 | 2025-04-18 | 南京维立志博生物科技股份有限公司 | 基于共同轻链产生双特异性抗体的方法 |
| TW202527998A (zh) * | 2023-12-18 | 2025-07-16 | 大陸商山東先聲生物製藥有限公司 | 抗FGFR2b抗體-藥物綴合物及其應用 |
| WO2025218662A1 (zh) * | 2024-04-16 | 2025-10-23 | 杭州中美华东制药有限公司 | 抗成纤维细胞生长因子受体2b的抗体及其用途 |
| WO2025232811A1 (zh) * | 2024-05-09 | 2025-11-13 | 正大天晴药业集团股份有限公司 | 靶向成纤维细胞生长因子受体2IIIb的抗体及其应用 |
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| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE179862T1 (de) | 1989-07-06 | 1999-05-15 | Univ California | Rezeptoren für fibroblasten-wachstumsfaktoren |
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| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
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| KR100493460B1 (ko) * | 2002-08-29 | 2005-06-07 | 재단법인서울대학교산학협력재단 | 암 세포에서 발현되는 fgfr2 이성체 |
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| KR101699432B1 (ko) | 2008-11-07 | 2017-01-24 | 갤럭시 바이오테크, 엘엘씨 | 섬유아세포성장인자수용체 2에 대한 모노클로날 항체 |
| WO2011025814A1 (en) | 2009-08-25 | 2011-03-03 | National Jewish Health | Methods and compositions for treatment of lung injury |
-
2009
- 2009-11-06 KR KR1020117002577A patent/KR101699432B1/ko active Active
- 2009-11-06 DK DK14188785.1T patent/DK2842573T3/en active
- 2009-11-06 EP EP09825523.5A patent/EP2365828B1/en active Active
- 2009-11-06 DK DK09825523.5T patent/DK2365828T3/en active
- 2009-11-06 HU HUE14188785A patent/HUE035700T2/en unknown
- 2009-11-06 PT PT98255235T patent/PT2365828E/pt unknown
- 2009-11-06 NO NO14188785A patent/NO2842573T3/no unknown
- 2009-11-06 AU AU2009313357A patent/AU2009313357B2/en active Active
- 2009-11-06 MX MX2011000455A patent/MX2011000455A/es active IP Right Grant
- 2009-11-06 SI SI200932035T patent/SI3290052T1/sl unknown
- 2009-11-06 ES ES09825523.5T patent/ES2523740T3/es active Active
- 2009-11-06 ES ES17191118T patent/ES2770134T3/es active Active
- 2009-11-06 LT LTEP14188785.1T patent/LT2842573T/lt unknown
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