JP2014239686A5 - - Google Patents

Download PDF

Info

Publication number
JP2014239686A5
JP2014239686A5 JP2014144592A JP2014144592A JP2014239686A5 JP 2014239686 A5 JP2014239686 A5 JP 2014239686A5 JP 2014144592 A JP2014144592 A JP 2014144592A JP 2014144592 A JP2014144592 A JP 2014144592A JP 2014239686 A5 JP2014239686 A5 JP 2014239686A5
Authority
JP
Japan
Prior art keywords
amino acid
nucleotide sequence
insect cell
sequence
parvovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014144592A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014239686A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2014239686A publication Critical patent/JP2014239686A/ja
Publication of JP2014239686A5 publication Critical patent/JP2014239686A5/ja
Pending legal-status Critical Current

Links

JP2014144592A 2007-07-26 2014-07-14 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター Pending JP2014239686A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95208107P 2007-07-26 2007-07-26
EP07113257 2007-07-26
EP07113257.5 2007-07-26
US60/952,081 2007-07-26

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2010518140A Division JP5634262B2 (ja) 2007-07-26 2008-07-25 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター

Publications (2)

Publication Number Publication Date
JP2014239686A JP2014239686A (ja) 2014-12-25
JP2014239686A5 true JP2014239686A5 (Direct) 2015-07-09

Family

ID=38753583

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010518140A Active JP5634262B2 (ja) 2007-07-26 2008-07-25 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター
JP2014144592A Pending JP2014239686A (ja) 2007-07-26 2014-07-14 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2010518140A Active JP5634262B2 (ja) 2007-07-26 2008-07-25 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター

Country Status (19)

Country Link
US (6) US8697417B2 (Direct)
EP (3) EP3561063A1 (Direct)
JP (2) JP5634262B2 (Direct)
KR (1) KR101597695B1 (Direct)
CN (1) CN101868547B (Direct)
AU (1) AU2008279883B2 (Direct)
BR (1) BRPI0814459B1 (Direct)
CA (1) CA2694406C (Direct)
DK (2) DK3093345T3 (Direct)
EA (1) EA022169B1 (Direct)
ES (1) ES2602585T3 (Direct)
HU (1) HUE029744T2 (Direct)
IL (1) IL203535A (Direct)
MX (1) MX2010000944A (Direct)
NZ (1) NZ582881A (Direct)
PL (2) PL3093345T3 (Direct)
PT (1) PT2173888T (Direct)
SI (2) SI2173888T1 (Direct)
WO (1) WO2009014445A2 (Direct)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3093345T3 (da) * 2007-07-26 2019-06-24 Uniqure Ip Bv Baculovirusvektorer omfattende gentagne kodende sekvenser med differentielle foretrukne kodoner
GB0911870D0 (en) 2009-07-08 2009-08-19 Ucl Business Plc Optimised coding sequence and promoter
WO2011112089A2 (en) 2010-03-11 2011-09-15 Amsterdam Molecular Therapeutics (Amt) Ip B.V. Mutated rep encoding sequences for use in aav production
WO2011122950A1 (en) 2010-04-01 2011-10-06 Amsterdam Molecular Therapeutics (Amt) Ip B.V. Monomeric duplex aav vectors
IT1400425B1 (it) 2010-06-08 2013-05-31 Amsterdam Molecular Therapeutics Bv Modified snrnas for use in therapy.
WO2012145509A2 (en) * 2011-04-19 2012-10-26 The Research Foundation Of State University Of New York Adeno-associated-virus rep sequences, vectors, and viruses
GB201210357D0 (en) 2012-06-12 2012-07-25 Ucl Business Plc Factor VIII sequences
JP6873699B2 (ja) 2013-10-24 2021-05-19 ユニキュアー アイピー ビー.ブイ. Aav5カプシドタンパク質を含むアデノ随伴ウイルス(aav)を用いた神経学的疾患の処置
KR102572449B1 (ko) 2014-03-10 2023-08-31 유니큐어 아이피 비.브이. 곤충 세포에서 생산된 더욱 향상된 aav 벡터
EP3151866B1 (en) 2014-06-09 2023-03-08 Voyager Therapeutics, Inc. Chimeric capsids
SG11201703148TA (en) 2014-11-05 2017-05-30 Voyager Therapeutics Inc Aadc polynucleotides for the treatment of parkinson's disease
GB201420139D0 (en) 2014-11-12 2014-12-24 Ucl Business Plc Factor IX gene therapy
CN114717264A (zh) 2014-11-14 2022-07-08 沃雅戈治疗公司 治疗肌萎缩性侧索硬化(als)的组合物和方法
CN107207556B (zh) 2014-11-14 2020-12-08 沃雅戈治疗公司 调节性多核苷酸
DK3591070T3 (da) 2014-11-28 2023-01-30 Uniqure Ip Bv DNA-forureninger i en sammensætning omfattende en parvovirusvirion
WO2016094783A1 (en) 2014-12-12 2016-06-16 Voyager Therapeutics, Inc. Compositions and methods for the production of scaav
JP6839094B2 (ja) 2014-12-24 2021-03-03 ユニクア・アイピー・ベーフェー RNAiで誘発されるハンチンチン遺伝子抑制
NZ744418A (en) * 2016-04-21 2025-10-31 Virovek Inc Aav production in insect cells, methods and compositions therefor
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
EP3448987A4 (en) 2016-04-29 2020-05-27 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
IL297576B2 (en) 2016-05-18 2024-02-01 Voyager Therapeutics Inc Compositions and methods of treating huntington's disease
KR102652994B1 (ko) 2016-05-18 2024-04-01 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
EP3491008A2 (en) * 2016-07-26 2019-06-05 BioMarin Pharmaceutical Inc. Novel adeno-associated virus capsid proteins
WO2018039375A1 (en) 2016-08-23 2018-03-01 Akouos, Inc. Compositions and methods for treating non-age-associated hearing impairment in a human subject
EP3506817A4 (en) 2016-08-30 2020-07-22 The Regents of The University of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
EP3554579A1 (en) 2016-12-16 2019-10-23 uniQure IP B.V. Immunoadsorption
CN111108198A (zh) 2017-05-05 2020-05-05 沃雅戈治疗公司 治疗亨廷顿病的组合物和方法
EP3618839A4 (en) 2017-05-05 2021-06-09 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
WO2019011893A1 (en) 2017-07-10 2019-01-17 Uniqure Ip B.V. MEANS AND METHODS OF GENE THERAPY BY ASSOCIATED ADENO VIRUS (AAV) IN HUMANS
AU2018302016A1 (en) 2017-07-17 2020-02-06 The Regents Of The University Of California Trajectory array guide system
EP3662060A2 (en) 2017-08-03 2020-06-10 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
WO2019067840A1 (en) 2017-09-29 2019-04-04 Voyager Therapeutics, Inc. RESTRICTING CENTRAL AND PERIPHERAL NEUROLOGICAL PHENOTYPE FROM FRIEDREICH ATAXIA BY INTRAVENOUS ADMINISTRATION
EP4454654A3 (en) 2017-10-16 2025-02-19 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
CA3077426A1 (en) 2017-10-16 2019-04-25 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
EP3732288A1 (en) 2017-12-29 2020-11-04 uniQure IP B.V. Modified viral vectors and methods of making and using the same
ES2957622T3 (es) 2018-01-17 2024-01-23 Meiragtx Uk Ii Ltd Proteína de cápside de rAAV modificada para terapia génica
GB201800903D0 (en) 2018-01-19 2018-03-07 Oxford Genetics Ltd Vectors
CA3099306A1 (en) 2018-05-15 2019-11-21 Voyager Therapeutics, Inc. Compositions and methods for the treatment of parkinson's disease
US20210230632A1 (en) 2018-05-15 2021-07-29 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
EP3807404A1 (en) 2018-06-13 2021-04-21 Voyager Therapeutics, Inc. Engineered 5' untranslated regions (5' utr) for aav production
EP3818161A1 (en) 2018-07-02 2021-05-12 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord
MX2021000810A (es) 2018-07-24 2021-04-28 Voyager Therapeutics Inc Sistemas y metodos para producir formulaciones de terapia genetica.
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides
GB201813528D0 (en) 2018-08-20 2018-10-03 Ucl Business Plc Factor IX encoding nucleotides
EP3850098A1 (en) 2018-09-12 2021-07-21 uniQure IP B.V. Rnai induced c9orf72 suppression for the treatment of als/ftd
US20220125073A1 (en) * 2018-09-20 2022-04-28 Tallgrass Biologics L.L.C. Treatment and control of colony collapse disorder
CN109295172A (zh) * 2018-09-26 2019-02-01 浙江海洋大学 大黄鱼清道夫受体家族基因的密码子偏好性分析方法
US12281321B2 (en) 2018-09-28 2025-04-22 Voyager Therapeutics, Inc. Frataxin expression constructs having engineered promoters and methods of use thereof
TW202035689A (zh) 2018-10-04 2020-10-01 美商航海家醫療公司 測量病毒載體粒子的效價及強度之方法
EP3861107A1 (en) 2018-10-05 2021-08-11 Voyager Therapeutics, Inc. Engineered nucleic acid constructs encoding aav production proteins
WO2020077165A1 (en) 2018-10-12 2020-04-16 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
EP3867389A1 (en) 2018-10-15 2021-08-25 Voyager Therapeutics, Inc. Expression vectors for large-scale production of raav in the baculovirus/sf9 system
CA3119721A1 (en) 2018-11-19 2020-05-28 Uniqure Ip B.V. A companion diagnostic to monitor the effects of gene therapy
WO2020104480A1 (en) 2018-11-19 2020-05-28 Uniqure Biopharma B.V. Adeno-associated virus vectors for expressing fviii mimetics and uses thereof
EP3884050A1 (en) 2018-11-19 2021-09-29 uniQure IP B.V. Rnai induced reduction of ataxin-3 for the treatment of spinocerebellar ataxia type 3
AU2019382824A1 (en) 2018-11-19 2021-06-03 Uniqure Ip B.V. Method and means to deliver miRNA to target cells
TW202039858A (zh) 2019-01-18 2020-11-01 美商航海家醫療公司 用於生產aav顆粒之方法及系統
WO2020223274A1 (en) 2019-04-29 2020-11-05 Voyager Therapeutics, Inc. SYSTEMS AND METHODS FOR PRODUCING BACULOVIRAL INFECTED INSECT CELLS (BIICs) IN BIOREACTORS
DK3999119T3 (da) 2019-07-15 2024-10-28 Univ Of Heidelberg Modificerede AVV-capsidproteiner til behandling af slidgigtsygdom
EP4010465A1 (en) 2019-08-09 2022-06-15 Voyager Therapeutics, Inc. Cell culture medium for use in producing gene therapy products in bioreactors
EP4022070A1 (en) 2019-08-26 2022-07-06 Voyager Therapeutics, Inc. Controlled expression of viral proteins
WO2021041375A1 (en) * 2019-08-26 2021-03-04 Rootpath Genomics, Inc. Compositions and methods for producing adeno-associated viral vectors
WO2021053018A1 (en) 2019-09-16 2021-03-25 Uniqure Ip B.V. Targeting misspliced transcripts in genetic disorders
CN114981442A (zh) * 2019-12-04 2022-08-30 桑格摩生物治疗股份有限公司 用于生产重组aav的新颖组合物及方法
BR112022016596A2 (pt) 2020-02-21 2022-11-16 Akouos Inc Composições e métodos para o tratamento de debilitação auditiva não associada à idade em um indivíduo humano
WO2021195491A2 (en) * 2020-03-26 2021-09-30 Asklepios Biopharmaceutical, Inc. Inducible promoter for viral vector production
JP2023519138A (ja) * 2020-04-02 2023-05-10 ユニキュアー バイオファーマ ビー.ブイ. 新規細胞株
CN115997006A (zh) 2020-04-02 2023-04-21 优尼科生物制药有限公司 用于产生aav的双双功能载体
EP4133074A1 (en) 2020-04-07 2023-02-15 uniQure IP B.V. Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof
EP4135841A1 (en) 2020-04-15 2023-02-22 Voyager Therapeutics, Inc. Tau binding compounds
US20230227802A1 (en) 2020-07-27 2023-07-20 Voyager Therapeutics, Inc. Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
WO2022026410A2 (en) 2020-07-27 2022-02-03 Voyager Therapeutics, Inc Compositions and methods for the treatment of niemann-pick type c1 disease
EP4192514A1 (en) 2020-08-06 2023-06-14 Voyager Therapeutics, Inc. Cell culture medium for use in producing gene therapy products in bioreactors
WO2022187548A1 (en) 2021-03-03 2022-09-09 Voyager Therapeutics, Inc. Controlled expression of viral proteins
US20240141377A1 (en) 2021-03-03 2024-05-02 Voyager Therapeutics, Inc. Controlled expression of viral proteins
CN115427561B (zh) 2021-03-09 2024-06-04 辉大(上海)生物科技有限公司 工程化CRISPR/Cas13系统及其用途
WO2022214635A1 (en) 2021-04-08 2022-10-13 Stichting Vu Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders
US20240240206A1 (en) 2021-06-02 2024-07-18 Uniqure Biopharma B.V. Insect cell production of parvoviral vectors with modified capsid proteins
US20240374755A1 (en) 2021-06-02 2024-11-14 Uniqure Biopharma B.V. Adeno-associated virus vectors modified to bind High-Density Lipoprotein
US20240287545A1 (en) 2021-06-21 2024-08-29 Uniqure Biopharma B.V. Improved lysis procedures
WO2022268835A1 (en) 2021-06-21 2022-12-29 Uniqure Biopharma B.V. Gene constructs for silencing alpha-synuclein and uses thereof
WO2023283962A1 (en) 2021-07-16 2023-01-19 Huigene Therapeutics Co., Ltd. Modified aav capsid for gene therapy and methods thereof
EP4377466A4 (en) * 2021-07-28 2025-11-05 Biomarin Pharm Inc LARGE-SCALE ADENE-ASSOCIATED VIRUS PRODUCTION SYSTEMS
WO2023025920A1 (en) 2021-08-26 2023-03-02 Uniqure Biopharma B.V. Insect cell-produced high potency aav vectors with cns-tropism
EP4433490A2 (en) 2021-11-17 2024-09-25 Voyager Therapeutics, Inc. Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
WO2023147374A2 (en) 2022-01-25 2023-08-03 Voyager Therapeutics, Inc. Baculovirus expression system
CN114703203B (zh) * 2022-02-11 2024-08-06 上海渤因生物科技有限公司 杆状病毒载体及其用途
US20250230437A1 (en) 2022-04-12 2025-07-17 Uniqure Biopharma B.V. Novel systems for nucleic acid regulation
EP4508214A1 (en) 2022-04-12 2025-02-19 uniQure biopharma B.V. Nucleic acid regulation of c9orf72
US20250297252A1 (en) 2022-04-12 2025-09-25 Uniqure Biopharma B.V. Nucleic acid regulation of SNCA
JP2025513066A (ja) 2022-04-12 2025-04-22 ユニキュアー バイオファーマ ビー.ブイ. Apoeの核酸制御
WO2023240236A1 (en) 2022-06-10 2023-12-14 Voyager Therapeutics, Inc. Compositions and methods for the treatment of spinal muscular atrophy related disorders
WO2024054983A1 (en) 2022-09-08 2024-03-14 Voyager Therapeutics, Inc. Controlled expression of viral proteins
EP4644556A1 (en) 2022-12-28 2025-11-05 FUJIFILM Corporation Method for producing adeno-associated virus, and vector set
WO2024163012A1 (en) 2023-02-02 2024-08-08 Voyager Therapeutics, Inc. Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
WO2024218204A1 (en) 2023-04-18 2024-10-24 Uniqure Biopharma B.V. Gene delivery vehicles comprising rna and antibodies
WO2024218190A1 (en) 2023-04-18 2024-10-24 Uniqure Biopharma B.V. Generation of adeno-associated virus capsid libraries for insect cells
AU2024258047A1 (en) 2023-04-18 2025-10-23 Uniqure Biopharma B.V. Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs
TW202449167A (zh) 2023-04-26 2024-12-16 美商航海家醫療公司 用於治療肌肉萎縮性脊髓側索硬化症之組成物及方法
WO2024261220A1 (en) 2023-06-23 2024-12-26 Uniqure Biopharma B.V. Novel fragile x constructs
WO2025049993A1 (en) 2023-08-31 2025-03-06 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2025051805A1 (en) 2023-09-04 2025-03-13 Uniqure Biopharma B.V. Novel neurotropic recombinant adeno-associated virus particles
WO2025078606A1 (en) 2023-10-11 2025-04-17 Uniqure Biopharma B.V. Further novel systems for nucleic acid regulation
WO2025078598A1 (en) 2023-10-11 2025-04-17 Uniqure Biopharma B.V. Novel nucleic acid regulation of huntingtin gene
WO2025078602A1 (en) 2023-10-11 2025-04-17 Uniqure Biopharma B.V. Nucleic acid regulation of msh3 in repeat expansion disorders
WO2025114524A1 (en) 2023-11-30 2025-06-05 Uniqure Biopharma B.V. Formulations for viral drug products
WO2025171227A1 (en) 2024-02-08 2025-08-14 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2025219443A1 (en) 2024-04-19 2025-10-23 Uniqure Biopharma B.V. Nucleic acid for a1at regulation

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US5871974A (en) * 1990-09-28 1999-02-16 Ixsys Inc. Surface expression libraries of heteromeric receptors
NZ308772A (en) 1995-05-17 1999-04-29 Du Pont Recombinant baculovirus insecticides
FR2774699B1 (fr) 1997-11-17 2003-10-03 Rhone Poulenc Rorer Sa Methode de reduction des evenements de recombinaison homologue
AU6490699A (en) 1998-09-24 2000-04-10 Ultrasonus Ab A mixing method and a mixing chamber
US6103526A (en) 1998-10-08 2000-08-15 Protein Sciences Corporation Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
ES2311464T3 (es) 1999-06-24 2009-02-16 The University Of British Columbia Terapia con variante de lipoproteina lipasa (lpl).
KR20020059370A (ko) * 1999-08-20 2002-07-12 추후보정 융합 라이브러리의 제작 및 사용을 위한 방법 및 조성물
EP1228234A2 (en) * 2000-03-14 2002-08-07 Neurologix, Inc. Production of chimeric capsid vectors
US20030129203A1 (en) * 2001-08-27 2003-07-10 Nautilus Biotech S.A. Mutant recombinant adeno-associated viruses
CA2467959C (en) 2001-11-09 2009-03-10 Robert M. Kotin Production of adeno-associated virus in insect cells
US6723551B2 (en) 2001-11-09 2004-04-20 The United States Of America As Represented By The Department Of Health And Human Services Production of adeno-associated virus in insect cells
CA2369985A1 (en) * 2002-01-18 2003-07-18 Duke University Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach
US20040063188A1 (en) 2002-02-14 2004-04-01 Novavax, Inc. Kit for treating gastrointestinal tract
WO2003074714A1 (en) 2002-03-05 2003-09-12 Stichting Voor De Technische Wetenschappen Baculovirus expression system
DE10260805A1 (de) 2002-12-23 2004-07-22 Geneart Gmbh Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins
US20070275449A1 (en) * 2003-10-15 2007-11-29 Vector Gene Technology Company Ltd. Method for Large-Scale Production, Isolation, Purification and the Uses of Multi-Type Recombinant Adeno-Associated Virus Vectors
US20060166363A1 (en) * 2004-01-27 2006-07-27 Sergei Zolotukhin Modified baculovirus expression system for production of pseudotyped rAAV vector
MX2007001292A (es) 2004-08-03 2007-07-04 Geneart Ag Metodo para modular la expresion genica al alterar el contendido de cpg.
SI1945779T1 (sl) * 2005-10-20 2013-07-31 Uniqure Ip B.V. Izboljĺ ani aav vektorji proizvedeni v celicah insekta
WO2007084773A2 (en) * 2006-01-20 2007-07-26 University Of North Carolina At Chapel Hill Enhanced production of infectious parvovirus vectors in insect cells
CN103849629B (zh) 2006-06-21 2017-06-09 尤尼克尔Ip股份有限公司 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体
DK3093345T3 (da) * 2007-07-26 2019-06-24 Uniqure Ip Bv Baculovirusvektorer omfattende gentagne kodende sekvenser med differentielle foretrukne kodoner

Similar Documents

Publication Publication Date Title
JP2014239686A5 (Direct)
US20240093231A1 (en) Aav capsid production in insect cells
JP7727029B2 (ja) アデノ随伴ウイルスの肝臓特異的向性
JP6683397B2 (ja) 昆虫細胞で産生される、さらに改善されたaavベクター
JP2024045227A (ja) パルボウイルスベクターの高められた送達のための改変キャプシドタンパク質
FI3684423T3 (fi) Adenoassesioidun viruksen kapsidivariantteja ja niiden käyttömenetelmiä
TW202005978A (zh) 新穎肝靶向腺相關病毒載體
JP2017536116A5 (Direct)
KR20190032375A (ko) 신규 아데노-관련 바이러스 캡시드 단백질
JP2020510429A5 (Direct)
JP2020508667A5 (Direct)
FI3313991T3 (fi) Muunnettu tekijä IX sekä koostumukset, menetelmät ja käytöt geeninsiirtoa varten soluihin, elimiin ja kudoksiin
JP2012519008A5 (Direct)
JP2014012022A5 (Direct)
HK1244849B (en) Dna impurities in a composition comprising a parvoviral virion
JPWO2020223231A5 (Direct)
JPWO2020223236A5 (Direct)
TW202134440A (zh) 用於生產重組aav之新穎組合物及方法
CN111718418A (zh) 一种增强基因编辑的融合蛋白及其应用
WO2023225545A3 (en) Liver de-targeted recombinant aav capsid proteins
AR123956A1 (es) Cápsides de aav y composiciones que las contienen
RU2021133906A (ru) Мутант aav, обладающий способностью нацеливаться на головной мозг
CN121271808A (zh) 一种生产低空壳率腺相关病毒的重组杆状病毒及其应用
Hashemzadeh et al. Generation of mini-Tn7 transposone by cloning of CPV-VP2 into eukaryotic expression cassette, in E. coli
HK40044351A (en) Liver-specific tropism of adeno-associated viruses