JP2014193892A5 - - Google Patents
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- JP2014193892A5 JP2014193892A5 JP2014101360A JP2014101360A JP2014193892A5 JP 2014193892 A5 JP2014193892 A5 JP 2014193892A5 JP 2014101360 A JP2014101360 A JP 2014101360A JP 2014101360 A JP2014101360 A JP 2014101360A JP 2014193892 A5 JP2014193892 A5 JP 2014193892A5
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- affinity chromatography
- ligand
- amino acid
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- 238000001042 affinity chromatography Methods 0.000 claims 16
- 230000027455 binding Effects 0.000 claims 15
- 239000003446 ligand Substances 0.000 claims 14
- 235000001014 amino acid Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000012504 chromatography matrix Substances 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 241000191940 Staphylococcus Species 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000035693 Fab Effects 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 238000006062 fragmentation reaction Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Claims (6)
- 以下の（ａ）〜（ｃ）からなる群より選択されるアフィニティークロマトグラフィーリガンドを含むアフィニティークロマトグラフィーマトリックス、
（ａ）スタフィロコッカス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）プロテインＡ（ＳｐＡ）の１つ以上のＣドメインを含むアフィニティークロマトグラフィーリガンドであって、少なくとも１つのＣドメインが、位置１で始まる、Ｎ末端からの３つ又は４つの連続したアミノ酸の欠失を含み、リガンドの少なくとも１つのドメインが、さらに位置２９におけるアミノ酸突然変異を含む、アフィニティークロマトグラフィーリガンド、
（ｂ）スタフィロコッカス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）プロテインＡ（ＳｐＡ）の１つ以上のＢドメインを含むアフィニティークロマトグラフィーリガンドであって、少なくとも１つのＢドメインが、位置１で始まる、Ｎ末端からの３つ又は４つの連続したアミノ酸の欠失を含み、リガンドの少なくとも１つのドメインが、さらに位置２９におけるアミノ酸突然変異を含む、アフィニティークロマトグラフィーリガンド、及び
（ｃ）スタフィロコッカス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）プロテインＡ（ＳｐＡ）の１つ以上のＺドメインを含むアフィニティークロマトグラフィーリガンドであって、少なくとも１つのＺドメインが、位置１で始まる、Ｎ末端からの３つ又は４つの連続したアミノ酸の欠失を含み、リガンドの少なくとも１つのドメインが、さらに位置２９におけるアミノ酸突然変異を含む、アフィニティークロマトグラフィーリガンド。 - アフィニティークロマトグラフィーリガンドが、ＳｐＡの２つ以上のＢドメイン、またはＳｐＡの２つ以上のＣドメイン、またはＳｐＡの２つ以上のＺドメイン、または任意の順序における、Ｂ、ＺもしくはＣドメインの任意の組合せを含み、Ｂ、ＣまたはＺドメインの少なくとも１つが、位置１で始まる、Ｎ末端からの３つ又は４つのアミノ酸の欠失を含み、さらに位置２９におけるアミノ酸突然変異を含む、アフィニティークロマトグラフィーリガンドである、請求項１に記載のアフィニティークロマトグラフィーマトリックス。
- 請求項１の（ａ）〜（ｃ）における位置２９におけるアミノ酸突然変異がＦａｂ結合を低減する、請求項１又は２に記載のアフィニティークロマトグラフィーマトリックス。
- アミノ酸突然変異がグリシンアミノ酸残基又はアラニンアミノ酸残基を、リジンアミノ酸残基で置換することを含む、請求項３に記載のアフィニティークロマトグラフィーマトリックス。
- アフィニティークロマトグラフィーリガンドが固形担体と結合されている、請求項１〜４のいずれかに記載のアフィニティークロマトグラフィーマトリックス。
- リガンドが、野生型対応物に比べて、低減した断片化を示す、請求項１〜４のいずれかに記載のアフィニティークロマトグラフィーマトリックス。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494701P | 2011-06-08 | 2011-06-08 | |
| US61/494,701 | 2011-06-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012124067A Division JP5756428B2 (ja) | 2011-06-08 | 2012-05-31 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016140214A Division JP6189493B2 (ja) | 2011-06-08 | 2016-07-15 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014193892A JP2014193892A (ja) | 2014-10-09 |
| JP2014193892A5 true JP2014193892A5 (ja) | 2015-07-16 |
| JP6018120B2 JP6018120B2 (ja) | 2016-11-02 |
Family
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012124067A Active JP5756428B2 (ja) | 2011-06-08 | 2012-05-31 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
| JP2014101360A Active JP6018120B2 (ja) | 2011-06-08 | 2014-05-15 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
| JP2016140214A Active JP6189493B2 (ja) | 2011-06-08 | 2016-07-15 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
| JP2017148843A Active JP6586131B2 (ja) | 2011-06-08 | 2017-08-01 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012124067A Active JP5756428B2 (ja) | 2011-06-08 | 2012-05-31 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016140214A Active JP6189493B2 (ja) | 2011-06-08 | 2016-07-15 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
| JP2017148843A Active JP6586131B2 (ja) | 2011-06-08 | 2017-08-01 | 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8754196B2 (ja) |
| EP (2) | EP2532672B1 (ja) |
| JP (4) | JP5756428B2 (ja) |
| KR (3) | KR101464040B1 (ja) |
| CN (2) | CN102895960B (ja) |
| AU (3) | AU2012366229C1 (ja) |
| DK (2) | DK2532672T3 (ja) |
| ES (2) | ES2710204T3 (ja) |
| IL (2) | IL229774A (ja) |
| RU (2) | RU2595430C2 (ja) |
| SG (3) | SG10201604559TA (ja) |
| TW (3) | TWI638828B (ja) |
| WO (1) | WO2013109302A2 (ja) |
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