JP2014193147A5 - - Google Patents
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- Publication number
- JP2014193147A5 JP2014193147A5 JP2014031571A JP2014031571A JP2014193147A5 JP 2014193147 A5 JP2014193147 A5 JP 2014193147A5 JP 2014031571 A JP2014031571 A JP 2014031571A JP 2014031571 A JP2014031571 A JP 2014031571A JP 2014193147 A5 JP2014193147 A5 JP 2014193147A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- protein
- nucleotide sequence
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091033319 polynucleotide Proteins 0.000 claims 39
- 239000002157 polynucleotide Substances 0.000 claims 39
- 102000040430 polynucleotide Human genes 0.000 claims 39
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 102000004169 proteins and genes Human genes 0.000 claims 20
- 239000002773 nucleotide Substances 0.000 claims 18
- 125000003729 nucleotide group Chemical group 0.000 claims 18
- 239000000758 substrate Substances 0.000 claims 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 claims 12
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 claims 12
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 claims 12
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 230000003197 catalytic effect Effects 0.000 claims 12
- 238000004020 luminiscence type Methods 0.000 claims 10
- MGTUVUVRFJVHAL-UHFFFAOYSA-N 2,8-dibenzyl-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3-ol Chemical compound Oc1c(Cc2ccccc2)nc2c(Cc3ccccc3)nc(cn12)-c1ccc(O)cc1 MGTUVUVRFJVHAL-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108700008625 Reporter Genes Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014031571A JP6511720B2 (ja) | 2013-02-28 | 2014-02-21 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013038350 | 2013-02-28 | ||
| JP2013038350 | 2013-02-28 | ||
| JP2014031571A JP6511720B2 (ja) | 2013-02-28 | 2014-02-21 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207131A Division JP6777133B2 (ja) | 2013-02-28 | 2018-11-02 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014193147A JP2014193147A (ja) | 2014-10-09 |
| JP2014193147A5 true JP2014193147A5 (enExample) | 2017-01-12 |
| JP6511720B2 JP6511720B2 (ja) | 2019-05-15 |
Family
ID=50482832
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014031571A Active JP6511720B2 (ja) | 2013-02-28 | 2014-02-21 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
| JP2018207131A Expired - Fee Related JP6777133B2 (ja) | 2013-02-28 | 2018-11-02 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207131A Expired - Fee Related JP6777133B2 (ja) | 2013-02-28 | 2018-11-02 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (4) | US9315783B2 (enExample) |
| JP (2) | JP6511720B2 (enExample) |
| GB (2) | GB2516326B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6040846B2 (ja) * | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
| JP6442825B2 (ja) * | 2013-12-26 | 2018-12-26 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| JP6824594B2 (ja) | 2014-09-11 | 2021-02-03 | Jnc株式会社 | 合成遺伝子の設計方法 |
| GB201702500D0 (en) * | 2017-02-16 | 2017-04-05 | Univ Sheffield | Stable vamp reporter assay |
| EP3395803A1 (en) * | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| CN116783302A (zh) | 2020-10-09 | 2023-09-19 | 深圳华大基因科技有限公司 | 用于基于生物发光的测序的方法和组合物 |
| US11827908B2 (en) | 2021-02-12 | 2023-11-28 | Shimadzu Corporation | Polypeptide having luciferase activity |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1156103B1 (en) | 2000-04-26 | 2010-08-11 | Chisso Corporation | Oplophorus luciferase |
| JP4613441B2 (ja) | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| WO2004042010A2 (en) | 2002-10-30 | 2004-05-21 | University Of Tennessee Research Foundation | Modified luciferase nucleic acids and methods of use |
| JP4609177B2 (ja) | 2005-04-28 | 2011-01-12 | チッソ株式会社 | カルシウム結合型発光蛋白質溶液の発光時間延長方法 |
| JP5176292B2 (ja) | 2006-06-22 | 2013-04-03 | Ｊｎｃ株式会社 | 発光活性測定方法 |
| US7723502B2 (en) | 2008-10-10 | 2010-05-25 | Marker Gene Technologies, Inc | Modified Luciola cruciata luciferase gene and protein |
| WO2010090319A1 (ja) | 2009-02-09 | 2010-08-12 | チッソ株式会社 | セレンテラジン類縁体及びその製造方法 |
| KR101665352B1 (ko) | 2009-05-01 | 2016-10-12 | 프로메가 코포레이션 | 광 출력이 향상된 합성 오플로포러스 루시퍼라제 |
| US8546147B2 (en) | 2009-07-13 | 2013-10-01 | Universita Degli Studi Di Siena | Imidazo[1,2-α]pyrazin-3(7H)-one derivatives bearing a new electron-rich structure |
| WO2011025980A1 (en) | 2009-08-29 | 2011-03-03 | Targeting Systems | Modified luciferases and uses thereof |
| AU2011323418B2 (en) * | 2010-11-02 | 2017-07-27 | Promega Corporation | Novel coelenterazine substrates and methods of use |
| JP5896624B2 (ja) * | 2011-05-13 | 2016-03-30 | オリンパス株式会社 | ホタル由来ルシフェラーゼ |
-
2014
- 2014-02-21 JP JP2014031571A patent/JP6511720B2/ja active Active
- 2014-02-25 US US14/188,838 patent/US9315783B2/en active Active
- 2014-02-26 GB GB1403374.0A patent/GB2516326B/en active Active
- 2014-02-26 GB GB1913094.7A patent/GB2574745B/en active Active
-
2016
- 2016-03-11 US US15/067,591 patent/US9404145B2/en active Active
- 2016-06-24 US US15/191,730 patent/US9506104B2/en active Active
- 2016-10-12 US US15/291,367 patent/US10006009B2/en active Active
-
2018
- 2018-11-02 JP JP2018207131A patent/JP6777133B2/ja not_active Expired - Fee Related
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