JP2014141525A5 - - Google Patents

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JP2014141525A5
JP2014141525A5 JP2014087058A JP2014087058A JP2014141525A5 JP 2014141525 A5 JP2014141525 A5 JP 2014141525A5 JP 2014087058 A JP2014087058 A JP 2014087058A JP 2014087058 A JP2014087058 A JP 2014087058A JP 2014141525 A5 JP2014141525 A5 JP 2014141525A5
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drug carrier
stellate
stellate cell
drug
proliferation
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JP2014087058A
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JP2014141525A (ja
JP5808064B2 (ja
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JP2014087058A 2004-12-22 2014-04-21 線維化抑制のための薬物担体および薬物担体キット Expired - Lifetime JP5808064B2 (ja)

Priority Applications (1)

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JP2014087058A JP5808064B2 (ja) 2004-12-22 2014-04-21 線維化抑制のための薬物担体および薬物担体キット

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JP2004382791 2004-12-22
JP2004382791 2004-12-22
JP2014087058A JP5808064B2 (ja) 2004-12-22 2014-04-21 線維化抑制のための薬物担体および薬物担体キット

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JP2013025037A Division JP2013100350A (ja) 2004-12-22 2013-02-12 線維化抑制のための薬物担体および薬物担体キット

Related Child Applications (1)

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JP2015111038A Division JP2015187137A (ja) 2004-12-22 2015-06-01 線維化抑制のための薬物担体および薬物担体キット

Publications (3)

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JP2014141525A JP2014141525A (ja) 2014-08-07
JP2014141525A5 true JP2014141525A5 (enExample) 2015-02-19
JP5808064B2 JP5808064B2 (ja) 2015-11-10

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Family Applications (7)

Application Number Title Priority Date Filing Date
JP2006549061A Expired - Fee Related JP4121537B2 (ja) 2004-12-22 2005-12-22 線維化抑制のための薬物担体および薬物担体キット
JP2010049297A Expired - Fee Related JP5172880B2 (ja) 2004-12-22 2010-03-05 線維化抑制のための薬物担体および薬物担体キット
JP2011102395A Expired - Fee Related JP5421322B2 (ja) 2004-12-22 2011-04-28 線維化抑制のための薬物担体および薬物担体キット
JP2013025037A Pending JP2013100350A (ja) 2004-12-22 2013-02-12 線維化抑制のための薬物担体および薬物担体キット
JP2014087058A Expired - Lifetime JP5808064B2 (ja) 2004-12-22 2014-04-21 線維化抑制のための薬物担体および薬物担体キット
JP2015111038A Pending JP2015187137A (ja) 2004-12-22 2015-06-01 線維化抑制のための薬物担体および薬物担体キット
JP2016175393A Expired - Fee Related JP6433079B2 (ja) 2004-12-22 2016-09-08 線維化抑制のための薬物担体および薬物担体キット

Family Applications Before (4)

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JP2006549061A Expired - Fee Related JP4121537B2 (ja) 2004-12-22 2005-12-22 線維化抑制のための薬物担体および薬物担体キット
JP2010049297A Expired - Fee Related JP5172880B2 (ja) 2004-12-22 2010-03-05 線維化抑制のための薬物担体および薬物担体キット
JP2011102395A Expired - Fee Related JP5421322B2 (ja) 2004-12-22 2011-04-28 線維化抑制のための薬物担体および薬物担体キット
JP2013025037A Pending JP2013100350A (ja) 2004-12-22 2013-02-12 線維化抑制のための薬物担体および薬物担体キット

Family Applications After (2)

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JP2015111038A Pending JP2015187137A (ja) 2004-12-22 2015-06-01 線維化抑制のための薬物担体および薬物担体キット
JP2016175393A Expired - Fee Related JP6433079B2 (ja) 2004-12-22 2016-09-08 線維化抑制のための薬物担体および薬物担体キット

Country Status (16)

Country Link
US (3) US8173170B2 (enExample)
EP (4) EP4005601A1 (enExample)
JP (7) JP4121537B2 (enExample)
KR (2) KR101454286B1 (enExample)
CN (2) CN101102795B (enExample)
AU (1) AU2005320014B2 (enExample)
CA (2) CA2595517C (enExample)
CY (3) CY1114945T1 (enExample)
DK (3) DK2727583T3 (enExample)
ES (3) ES2443229T3 (enExample)
HU (2) HUE056941T2 (enExample)
LT (2) LT2730277T (enExample)
PL (3) PL1842557T3 (enExample)
PT (3) PT2727583T (enExample)
SI (2) SI2727583T1 (enExample)
WO (1) WO2006068232A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7358223B2 (en) 2004-10-04 2008-04-15 Nitto Denko Corporation Biodegradable cationic polymers
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
JP4533420B2 (ja) * 2004-12-22 2010-09-01 日東電工株式会社 線維化抑制のための薬物担体および薬物担体キット
EP4005601A1 (en) 2004-12-22 2022-06-01 Nitto Denko Corporation Drug carrier and drug carrier kit for inhibiting fibrosis
JP2009221164A (ja) * 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
US20130171240A1 (en) * 2004-12-22 2013-07-04 Nitto Denko Corporation Drug carrier and drug carrier kit for inhibiting fibrosis
US20160038593A1 (en) * 2004-12-22 2016-02-11 Nitto Denko Corporation Drug carrier and drug carrier kit for inhibiting fibrosis
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
US7941133B2 (en) * 2007-02-14 2011-05-10 At&T Intellectual Property I, L.P. Methods, systems, and computer program products for schedule management based on locations of wireless devices
TWI407971B (zh) * 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
US20080312174A1 (en) * 2007-06-05 2008-12-18 Nitto Denko Corporation Water soluble crosslinked polymers
US20110158908A1 (en) 2007-08-24 2011-06-30 Sapporo Medical University Cyclosporin a-binding protein
EP2207570A2 (en) * 2007-09-14 2010-07-21 Nitto Denko Corporation Drug carriers
US20100028416A1 (en) * 2008-07-30 2010-02-04 Nitto Denko Corporation Drug carriers
AR073582A1 (es) * 2008-09-12 2010-11-17 Nitto Denko Corp Agentes de produccion de imagenes de enfermedades fibroticas.conjugado. metodo
US8957199B2 (en) 2008-11-26 2015-02-17 Chugai Seiyaku Kabushiki Kaisha Oligoribonucleotide or peptide nucleic acid capable of inhibiting activity of hepatitis C virus
JP5944311B2 (ja) * 2009-06-16 2016-07-05 クルナ・インコーポレーテッド コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
WO2011072082A2 (en) 2009-12-09 2011-06-16 Nitto Denko Corporation Modulation of hsp47 expression
AU2011261434B2 (en) 2010-06-02 2015-11-26 Alnylam Pharmaceuticals, Inc. Compositions and methods directed to treating liver fibrosis
RU2635460C2 (ru) * 2010-06-17 2017-11-13 Нитто Денко Корпорейшн Средство для лечения фиброза почек
JP5950428B2 (ja) * 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
US20140134231A1 (en) 2010-10-11 2014-05-15 Sanford-Burnham Medical Research Institute Mir-211 expression and related pathways in human melanoma
IT1403248B1 (it) * 2010-11-12 2013-10-17 Scharper Therapeutics Srl Composizione per il trattamento di disfunzioni degli apparati fonatorio ed olfattorio
JP5517306B2 (ja) * 2011-01-26 2014-06-11 日東電工株式会社 肺線維症処置剤
WO2012108538A1 (ja) * 2011-02-10 2012-08-16 国立大学法人 長崎大学 急性肺損傷診断方法
CN103492572A (zh) 2011-03-03 2014-01-01 夸克医药公司 用于治疗肺疾病和损伤的组合物和方法
CN102805747B (zh) * 2011-06-01 2013-09-18 漳州片仔癀药业股份有限公司 2-(4-吗啉苯胺)-6-环己基氨基嘌呤及其药学上可接受的盐在制药中的用途
US9011903B2 (en) 2011-06-08 2015-04-21 Nitto Denko Corporation Cationic lipids for therapeutic agent delivery formulations
TWI658830B (zh) * 2011-06-08 2019-05-11 日東電工股份有限公司 Hsp47表現調控強化用類視色素脂質體
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
IN2014MN00908A (enExample) * 2011-11-18 2015-04-17 Nitto Denko Corp
CA2876148C (en) 2012-06-08 2021-01-12 Nitto Denko Corporation Lipids for therapeutic agent delivery formulations
CN102727478A (zh) * 2012-06-14 2012-10-17 合肥博太医药生物技术发展有限公司 视黄酸及其衍生物在制备防治肾纤维化药物中的应用
JP6067330B2 (ja) * 2012-10-31 2017-01-25 国立大学法人広島大学 Rhoキナーゼ阻害剤を含むビタミンA付加リポソーム製剤
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
WO2015020960A1 (en) 2013-08-09 2015-02-12 Novartis Ag Novel lncrna polynucleotides
JP5727557B2 (ja) * 2013-08-21 2015-06-03 日東電工株式会社 肺線維症処置剤
US9976142B2 (en) 2014-04-02 2018-05-22 Nitto Denko Corporation Targeting molecule and a use thereof
WO2015155810A1 (en) 2014-04-07 2015-10-15 Nitto Denko Corporation Novel polymer-based hydrotropes for hydrophobic drug delivery
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
JP5976874B2 (ja) * 2015-04-02 2016-08-24 日東電工株式会社 肺線維症処置剤
CN108367022A (zh) 2015-12-13 2018-08-03 日东电工株式会社 具有高活性和降低脱靶的sirna结构
JP6833456B2 (ja) * 2016-11-02 2021-02-24 日東電工株式会社 皮膚線維症処置剤
CN107080849A (zh) * 2017-03-23 2017-08-22 南京大学 肝损伤治疗的靶点和药物
WO2019023149A1 (en) 2017-07-24 2019-01-31 Salk Institute For Biological Studies USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES
CN111164068B (zh) 2018-08-21 2023-11-14 株式会社东芝 生物降解性化合物、脂质粒子、含有脂质粒子的组合物、及试剂盒
EP4365289A3 (en) 2018-11-16 2024-07-10 Nitto Denko Corporation Rna interference delivery formulation and methods for malignant tumors
CN109602748B (zh) * 2019-01-28 2022-01-18 沈阳药科大学 维生素b2在制备预防和治疗纤维化疾病药物中的用途
CN110237235B (zh) * 2019-06-04 2023-03-28 徐州医科大学 华支睾吸虫重组蛋白CsHscB在胆汁淤积性肝纤维化治疗药物中的应用
WO2025244135A1 (en) * 2024-05-24 2025-11-27 Fujifilm Corporation Lipid composition and method to deliver payload to extracellular matrix producing cells

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US4911928A (en) * 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US20040028682A1 (en) * 1989-09-29 2004-02-12 Border Wayne A. Inhibiting transforming growth factor beta to prevent accumulation of extracellular matrix
FI921353A7 (fi) 1989-09-29 1992-03-27 La Jolla Cancer Res Foundation Tranformoiva kasvutekijä b:n inhibointi solunulkoisen matriisin kertym isen ehkäisemiseksi
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6610841B1 (en) 1997-12-18 2003-08-26 Gilead Sciences, Inc. Nucleotide-based prodrugs
US5668117A (en) 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US6746678B1 (en) 1991-02-22 2004-06-08 Howard K. Shapiro Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments
AU670777B2 (en) * 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
US5472954A (en) 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
US5583020A (en) 1992-11-24 1996-12-10 Ribozyme Pharmaceuticals, Inc. Permeability enhancers for negatively charged polynucleotides
US5820879A (en) 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
US5753261A (en) 1993-02-12 1998-05-19 Access Pharmaceuticals, Inc. Lipid-coated condensed-phase microparticle composition
US5785976A (en) 1993-03-05 1998-07-28 Pharmacia & Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5942230A (en) 1994-05-06 1999-08-24 The United States Of America As Represented By The Department Of Health And Human Services Composition of immunotoxins and retinoids and use thereof
US5534261A (en) 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same
US6187315B1 (en) 1995-03-03 2001-02-13 Atajje, Inc. Compositions and methods of treating cancer with tannin complexes
US6120794A (en) * 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
FR2742677B1 (fr) 1995-12-21 1998-01-16 Oreal Nanoparticules enrobees d'une phase lamellaire a base de tensioactif silicone et compositions les contenant
US5851538A (en) * 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US6183774B1 (en) * 1996-01-31 2001-02-06 Collaborative Laboratories, Inc. Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts
US5977163A (en) 1996-03-12 1999-11-02 Pg-Txl Company, L. P. Water soluble paclitaxel prodrugs
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US6238917B1 (en) 1996-04-02 2001-05-29 Commonwealth Scientific Industrial Research Organizaion Asymmetric hammerhead ribozymes
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
AU731832B2 (en) 1996-11-12 2001-04-05 Tamarkin Pharmaceutical Innovation Ltd Method for treatment of dermatological disorders
US5827886A (en) * 1997-05-07 1998-10-27 Thione International, Inc. Composition for relief of arthritis-induced symptoms
FR2763853B1 (fr) 1997-05-28 2000-01-07 Oreal Association d'un retinoide avec un polymere polyamine
AU707186B2 (en) 1997-07-01 1999-07-01 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
US6037481A (en) 1997-08-08 2000-03-14 Industria E Comercio De Cosmeticos Natura Ltda Process for stabilizing levogyre ascorbic acid (LAA), a stable aqueous LAA composition, a process for preparing a stable topical solution, an emulsion, a vitamin product, and a method for cosmetic, pharmaceutical or nutritional treatment
WO1999009045A1 (en) * 1997-08-20 1999-02-25 Somagenics, Inc. Antisense and antigene therapeutics with improved binding properties and methods for their use
US6072101A (en) 1997-11-19 2000-06-06 Amcol International Corporation Multicomponent superabsorbent gel particles
JPH11269076A (ja) 1998-01-22 1999-10-05 Seikagaku Kogyo Co Ltd 抗線維化剤
IL139761A0 (en) 1998-05-20 2002-02-10 Expression Genetics Inc A hepatocyte targeting polyethylene glyco-grafted poly-l-lysine polymeric gene carrier
GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
US6217912B1 (en) 1998-07-13 2001-04-17 Expression Genetics, Inc. Polyester analogue of poly-L-lysine as a soluble, biodegradable gene delivery carrier
WO2000004875A2 (en) 1998-07-24 2000-02-03 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
KR100274842B1 (ko) 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
DK2048228T3 (en) * 1999-01-19 2016-05-09 Univ North Carolina Human liver progenitors
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
FR2790405B1 (fr) 1999-03-02 2001-04-20 Oreal Nanocapsules a base de polymeres dendritiques
US6328988B1 (en) 1999-04-23 2001-12-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
AU4144400A (en) 1999-04-27 2000-11-10 Mitsubishi Pharma Corporation Preventives/remedies for liver diseases
ES2223705T3 (es) 1999-04-28 2005-03-01 Board Of Regents, The University Of Texas System Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf.
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US7098030B2 (en) 1999-12-31 2006-08-29 Mirus Bio Corporation Polyampholytes for delivering polyions to a cell
US20020041898A1 (en) * 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
KR20010100194A (ko) 2000-03-13 2001-11-14 박호군 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법
DE10012151A1 (de) 2000-03-13 2001-09-27 Gsf Forschungszentrum Umwelt Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
CA2402613A1 (en) * 2000-03-29 2001-10-04 Igor Gonda Cationic liposomes
ATE302179T1 (de) 2000-05-02 2005-09-15 Hoffmann La Roche Gamma-selektive retinoide
US6896890B2 (en) 2000-05-05 2005-05-24 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing free and entrapped hydroquinone and retinol
US6471968B1 (en) 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
JP2002047211A (ja) 2000-08-04 2002-02-12 Japan Science & Technology Corp 脂溶性物質と生理活性高分子物質結合体および細胞核内への導入方法
US20040142474A1 (en) 2000-09-14 2004-07-22 Expression Genetics, Inc. Novel cationic lipopolymer as a biocompatible gene delivery agent
US6696038B1 (en) 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7427394B2 (en) 2000-10-10 2008-09-23 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
WO2002032413A2 (en) 2000-10-17 2002-04-25 Board Of Regents, The University Of Texas System A method to incorporate n-(4-hydroxyphenyl) retinamide in liposomes
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
JP2004523236A (ja) 2001-02-16 2004-08-05 インサイト・ゲノミックス・インコーポレイテッド 神経伝達関連タンパク質
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
WO2002083186A1 (en) 2001-04-13 2002-10-24 The Population Council, Inc. Nuclear receptor-mediated introduction of a pna into cell nuclei
JP4547696B2 (ja) 2001-06-07 2010-09-22 第一三共株式会社 肝硬変予防・治療剤
JP2002371006A (ja) 2001-06-11 2002-12-26 Mochida Pharmaceut Co Ltd 肺線維症予防および/または進行防止剤
WO2003005959A2 (en) 2001-07-12 2003-01-23 Rutgers, The State University Of New Jersey Amphiphilic star-like macromolecules for drug delivery
US6586524B2 (en) 2001-07-19 2003-07-01 Expression Genetics, Inc. Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
US7101995B2 (en) 2001-08-27 2006-09-05 Mirus Bio Corporation Compositions and processes using siRNA, amphipathic compounds and polycations
EP1443912B1 (en) 2001-10-12 2007-08-29 Elan Pharma International Limited Compositions having a combination of immediate release and controlled release characteristics
US7297515B1 (en) 2001-10-26 2007-11-20 Myriad Genetics, Inc. Zinc finger proteins
ES2284959T3 (es) * 2001-10-30 2007-11-16 Nektar Therapeutics Al, Corporation Conjugados polimericos solubles en agua de acido retinoico.
JP3803318B2 (ja) 2001-11-21 2006-08-02 株式会社RNAi 遺伝子発現阻害方法
EP1445312B1 (en) 2001-11-21 2012-12-26 Astellas Pharma Inc. Method of inhibiting gene expression
EP1465622A1 (en) 2001-11-26 2004-10-13 Arachnova Therapeutics Ltd. Use of ppar activators for the treatment of pulmonary fibrosis
US7060498B1 (en) 2001-11-28 2006-06-13 Genta Salus Llc Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
US20030147958A1 (en) 2002-01-29 2003-08-07 Cheol-Hee Ahn Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
US20040106125A1 (en) 2002-02-15 2004-06-03 Duggan Brendan M Neurotransmission-associated proteins
US7018655B2 (en) 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
US6740676B2 (en) 2002-03-19 2004-05-25 Allergan, Inc. 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US20030215395A1 (en) 2002-05-14 2003-11-20 Lei Yu Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
EP1504010B1 (en) 2002-05-15 2009-03-25 Endocyte, Inc. Vitamin-mitomycin conjugates
CN1307997C (zh) 2002-06-28 2007-04-04 图兰恩教育基金管理人 用于治疗肺纤维化的4-(4-甲基哌嗪-1-基甲基)-n-[4-甲基-3-(4-(吡啶-3-基)嘧啶-2-基氨基)苯基]-苯甲酰胺
EP1526865A4 (en) 2002-08-05 2009-09-02 Mirus Bio Corp COMPOUNDS FOR TARGETING HEPATIC CELLS
JP2004083436A (ja) 2002-08-23 2004-03-18 Minofuaagen Seiyaku:Kk 星細胞活性化抑制剤、及び、臓器線維症の予防又は治療剤
EP1531825A2 (en) 2002-08-29 2005-05-25 University Of Southampton Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
US6740336B2 (en) 2002-10-04 2004-05-25 Mirus Corporation Process for generating multilayered particles
JP4757493B2 (ja) 2002-11-13 2011-08-24 レイベン バイオテクノロジーズ,インコーポレイティド 抗原pipaおよびそれに結合する抗体
KR101045504B1 (ko) 2002-12-30 2011-06-30 넥타르 테라퓨틱스 약물 전달 부형제로서의 멀티-아암 폴리펩티드-폴리(에틸렌글리콜) 블록 공중합체
US20040138154A1 (en) 2003-01-13 2004-07-15 Lei Yu Solid surface for biomolecule delivery and high-throughput assay
EP2517730A3 (en) * 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1608735A4 (en) 2003-04-03 2008-11-05 Alnylam Pharmaceuticals RNAI CONJUGATES
EP1663171B9 (en) 2003-08-26 2009-08-19 SmithKline Beecham Corporation Heterofunctional copolymers of glycerol and polyethylene glycol, their conjugates and compositions
US7064127B2 (en) 2003-12-19 2006-06-20 Mount Sinai School Of Medicine Of New York University Treatment of hepatic fibrosis with imatinib mesylate
WO2005084702A1 (ja) 2004-03-02 2005-09-15 Hokkaido Technology Licensing Office Co., Ltd. 臓器線維症予防・治療剤
WO2006085987A2 (en) 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
US7358223B2 (en) 2004-10-04 2008-04-15 Nitto Denko Corporation Biodegradable cationic polymers
US8057821B2 (en) 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
DE602005012155D1 (de) 2004-11-03 2009-02-12 Liplasome Pharma As Arzneimittelabgabesysteme auf lipidbasis mit unnatürlichen phospholipase-a2-abbaubaren lipid-derivaten und ihre therapeutische verwendung
US7964571B2 (en) 2004-12-09 2011-06-21 Egen, Inc. Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
JP2009221164A (ja) 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
JP4533420B2 (ja) * 2004-12-22 2010-09-01 日東電工株式会社 線維化抑制のための薬物担体および薬物担体キット
EP4005601A1 (en) 2004-12-22 2022-06-01 Nitto Denko Corporation Drug carrier and drug carrier kit for inhibiting fibrosis
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
US7404969B2 (en) 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
JP5342834B2 (ja) 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
US7700541B2 (en) 2006-04-06 2010-04-20 Nitto Denko Corporation Biodegradable cationic polymers
WO2007143659A2 (en) 2006-06-05 2007-12-13 Massachusetts Institute Of Technology Crosslinked, degradable polymers and uses thereof
BRPI0714409A2 (pt) 2006-07-14 2013-03-12 Novartis Ag derivados de pirimidina como inibidores de alk-5
TWI407971B (zh) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
US20080312174A1 (en) 2007-06-05 2008-12-18 Nitto Denko Corporation Water soluble crosslinked polymers
EP2207570A2 (en) 2007-09-14 2010-07-21 Nitto Denko Corporation Drug carriers
US20100028416A1 (en) 2008-07-30 2010-02-04 Nitto Denko Corporation Drug carriers

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