JP2013545745A5 - - Google Patents
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- Publication number
- JP2013545745A5 JP2013545745A5 JP2013538326A JP2013538326A JP2013545745A5 JP 2013545745 A5 JP2013545745 A5 JP 2013545745A5 JP 2013538326 A JP2013538326 A JP 2013538326A JP 2013538326 A JP2013538326 A JP 2013538326A JP 2013545745 A5 JP2013545745 A5 JP 2013545745A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- levodopa
- arginine
- carbidopa
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 36
- 239000004475 Arginine Substances 0.000 claims 35
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 35
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 32
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 32
- 229960004502 levodopa Drugs 0.000 claims 32
- 229960004205 carbidopa Drugs 0.000 claims 30
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 30
- 235000010323 ascorbic acid Nutrition 0.000 claims 18
- 239000011668 ascorbic acid Substances 0.000 claims 18
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 16
- 229960003194 meglumine Drugs 0.000 claims 16
- 229960005070 ascorbic acid Drugs 0.000 claims 10
- 239000011734 sodium Substances 0.000 claims 9
- 229940072107 ascorbate Drugs 0.000 claims 8
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- 208000016285 Movement disease Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004260 Potassium ascorbate Substances 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 235000010376 calcium ascorbate Nutrition 0.000 claims 1
- 229940047036 calcium ascorbate Drugs 0.000 claims 1
- 239000011692 calcium ascorbate Substances 0.000 claims 1
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims 1
- 230000002183 duodenal effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 235000019275 potassium ascorbate Nutrition 0.000 claims 1
- 229940017794 potassium ascorbate Drugs 0.000 claims 1
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 229960005055 sodium ascorbate Drugs 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41363710P | 2010-11-15 | 2010-11-15 | |
| US61/413,637 | 2010-11-15 | ||
| US201161524064P | 2011-08-16 | 2011-08-16 | |
| US61/524,064 | 2011-08-16 | ||
| PCT/IL2011/000881 WO2012066538A1 (en) | 2010-11-15 | 2011-11-15 | Continuous administration of l-dopa, dopa decarboxylase inhibitors, catechol-o-methyl transferase inhibitors and compositions for same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016047187A Division JP6231145B2 (ja) | 2010-11-15 | 2016-03-10 | Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545745A JP2013545745A (ja) | 2013-12-26 |
| JP2013545745A5 true JP2013545745A5 (OSRAM) | 2014-12-04 |
| JP5902705B2 JP5902705B2 (ja) | 2016-04-13 |
Family
ID=45478410
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538326A Active JP5902705B2 (ja) | 2010-11-15 | 2011-11-15 | Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
| JP2016047187A Active JP6231145B2 (ja) | 2010-11-15 | 2016-03-10 | Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
| JP2017201780A Active JP6387171B2 (ja) | 2010-11-15 | 2017-10-18 | Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016047187A Active JP6231145B2 (ja) | 2010-11-15 | 2016-03-10 | Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
| JP2017201780A Active JP6387171B2 (ja) | 2010-11-15 | 2017-10-18 | Ｌ−ドーパ、ドーパデカルボキシラーゼ阻害剤、カテコール−ｏ−メチルトランスフェラーゼ阻害剤、およびそれらのための組成物の継続的投与 |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US9421267B2 (OSRAM) |
| EP (3) | EP3326615B1 (OSRAM) |
| JP (3) | JP5902705B2 (OSRAM) |
| KR (1) | KR101859242B1 (OSRAM) |
| CN (2) | CN103442693A (OSRAM) |
| AU (1) | AU2011330757B2 (OSRAM) |
| BR (1) | BR112013011685B1 (OSRAM) |
| CA (1) | CA2817888C (OSRAM) |
| CL (1) | CL2013001368A1 (OSRAM) |
| CY (1) | CY1120005T1 (OSRAM) |
| DK (2) | DK2640358T3 (OSRAM) |
| ES (2) | ES2660772T3 (OSRAM) |
| HR (2) | HRP20180514T1 (OSRAM) |
| HU (2) | HUE037005T2 (OSRAM) |
| IL (1) | IL263954A (OSRAM) |
| LT (1) | LT2640358T (OSRAM) |
| MX (1) | MX348225B (OSRAM) |
| NZ (1) | NZ610911A (OSRAM) |
| PL (2) | PL2640358T3 (OSRAM) |
| PT (2) | PT3326615T (OSRAM) |
| RS (1) | RS57047B1 (OSRAM) |
| RU (2) | RU2740080C2 (OSRAM) |
| SG (2) | SG190258A1 (OSRAM) |
| SI (1) | SI2640358T1 (OSRAM) |
| SM (1) | SMT201800145T1 (OSRAM) |
| WO (1) | WO2012066538A1 (OSRAM) |
| ZA (1) | ZA201303509B (OSRAM) |
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| EP3777839A1 (en) | 2009-05-19 | 2021-02-17 | Neuroderm Ltd | Compositions for continuous administration of dopa decarboxylase inhibitors |
| NZ610911A (en) | 2010-11-15 | 2015-02-27 | Neuroderm Ltd | Continuous administration of l-dopa, dopa decarboxylase inhibitors, catechol-o-methyl transferase inhibitors and compositions for same |
| TR201808178T4 (tr) | 2010-11-15 | 2018-07-23 | Neuroderm Ltd | Aktif ajanların transdermal dağıtımı için bileşimler. |
| EP2854764B1 (en) | 2012-06-05 | 2018-12-12 | Neuroderm Ltd | Compositions comprising apomorphine and organic acids and uses thereof |
| US20160022573A1 (en) * | 2013-03-13 | 2016-01-28 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| JP6528281B2 (ja) * | 2014-01-29 | 2019-06-12 | 国立研究開発法人産業技術総合研究所 | シクロデキストリンの利用による抗がん活性が増強されたアシュワガンダ葉の水抽出物の調製方法、及びアシュワガンダ葉を含む医薬組成物 |
| EP3777833B1 (en) * | 2014-03-13 | 2023-10-18 | Neuroderm Ltd. | Dopa decarboxylase inhibitor compositions |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| CN107072973A (zh) | 2014-09-04 | 2017-08-18 | 劳波索尔制药有限公司 | 含左旋多巴、多巴胺脱羧酶抑制剂和comt抑制剂的药物组合物及其施用方法 |
| CA2965379A1 (en) | 2014-10-21 | 2016-04-28 | Abbvie Inc. | Carbidopa and l-dopa prodrugs and methods of use |
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| US10555922B2 (en) | 2015-09-04 | 2020-02-11 | Lobsor Pharmaceuticals Aktiebolag | Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor |
| JP2019515908A (ja) * | 2016-04-20 | 2019-06-13 | アッヴィ・インコーポレイテッド | カルビドパ及びｌ−ドパプロドラッグ並びに使用方法 |
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| AU2019237857B2 (en) | 2018-03-23 | 2024-11-21 | Lobsor Pharmaceuticals Aktiebolag | Continuous administration of pharmaceutical composition for treatment of neurodegenerative disorders |
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| CN111701024B (zh) * | 2020-05-26 | 2022-05-24 | 上海京新生物医药有限公司 | 一种左旋多巴制剂及其制备方法及其应用 |
| CN111643493B (zh) * | 2020-05-26 | 2023-01-10 | 上海京新生物医药有限公司 | 一种高浓度左旋多巴制剂及其制备方法及其应用 |
| US20230181508A1 (en) * | 2020-08-31 | 2023-06-15 | Purdue Pharma L.P. | Compositions and methods for levodopa delivery |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11213502B1 (en) * | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| EP4460289A4 (en) * | 2022-01-03 | 2025-09-03 | Neuroderm Ltd | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON'S DISEASE |
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| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
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