JP2013544817A5 - - Google Patents
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- Publication number
- JP2013544817A5 JP2013544817A5 JP2013540443A JP2013540443A JP2013544817A5 JP 2013544817 A5 JP2013544817 A5 JP 2013544817A5 JP 2013540443 A JP2013540443 A JP 2013540443A JP 2013540443 A JP2013540443 A JP 2013540443A JP 2013544817 A5 JP2013544817 A5 JP 2013544817A5
- Authority
- JP
- Japan
- Prior art keywords
- glucan
- composition according
- gelling agent
- composition
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 28
- 229920001503 Glucan Polymers 0.000 claims 18
- 239000003349 gelling agent Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 7
- 239000007864 aqueous solution Substances 0.000 claims 6
- 208000025865 Ulcer Diseases 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- 231100000397 ulcer Toxicity 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 206010056340 Diabetic ulcer Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 230000035876 healing Effects 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000004927 skin cell Anatomy 0.000 claims 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920002498 Beta-glucan Polymers 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920001615 Tragacanth Polymers 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 239000000305 astragalus gummifer gum Substances 0.000 claims 1
- -1 bandages Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000002759 woven fabric Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1020193.7 | 2010-11-29 | ||
| GBGB1020193.7A GB201020193D0 (en) | 2010-11-29 | 2010-11-29 | Glucan compositions |
| PCT/GB2011/052359 WO2012073020A1 (en) | 2010-11-29 | 2011-11-29 | Glucan compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138805A Division JP2016180010A (ja) | 2010-11-29 | 2016-07-13 | グルカン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544817A JP2013544817A (ja) | 2013-12-19 |
| JP2013544817A5 true JP2013544817A5 (enExample) | 2014-09-04 |
| JP6027013B2 JP6027013B2 (ja) | 2016-11-16 |
Family
ID=43500785
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540443A Active JP6027013B2 (ja) | 2010-11-29 | 2011-11-29 | グルカン組成物 |
| JP2016138805A Pending JP2016180010A (ja) | 2010-11-29 | 2016-07-13 | グルカン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138805A Pending JP2016180010A (ja) | 2010-11-29 | 2016-07-13 | グルカン組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9956245B2 (enExample) |
| EP (2) | EP2646477B1 (enExample) |
| JP (2) | JP6027013B2 (enExample) |
| KR (1) | KR101680148B1 (enExample) |
| CN (1) | CN103347901B (enExample) |
| AU (1) | AU2011334627C1 (enExample) |
| CA (1) | CA2818650C (enExample) |
| DK (2) | DK2646477T3 (enExample) |
| ES (1) | ES2794048T3 (enExample) |
| GB (1) | GB201020193D0 (enExample) |
| RU (1) | RU2596496C2 (enExample) |
| WO (1) | WO2012073020A1 (enExample) |
| ZA (1) | ZA201303553B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229565A1 (en) | 2008-09-17 | 2011-09-22 | Karp Jeffrey M | Drug Delivery Composition Comprising a Self-Assembled Gelator |
| JP2013540757A (ja) | 2010-09-24 | 2013-11-07 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル |
| ES2887367T3 (es) * | 2013-10-09 | 2021-12-22 | Toray Industries | Inmunopotenciador |
| CN107949368A (zh) | 2015-07-28 | 2018-04-20 | 玫琳凯有限公司 | 局部皮肤用制剂 |
| US9962339B2 (en) | 2015-10-08 | 2018-05-08 | The Brigham And Women's Hospital, Inc. | Stabilized assembled nanostructures for delivery of encapsulated agents |
| US20190307904A1 (en) | 2016-03-30 | 2019-10-10 | Convatec Technologies Inc. | Modified wound dressings |
| EP3978022A1 (en) | 2016-05-06 | 2022-04-06 | The Brigham and Women's Hospital, Inc. | Binary self assembled gels for controlled delivery of encapsulated agents to cartilage |
| CN107041892B (zh) * | 2016-07-12 | 2021-02-26 | 合肥九研医药科技开发有限公司 | 羟丙基甲基纤维素在上消化道黏膜损伤护理上的应用 |
| WO2018144991A1 (en) | 2017-02-03 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| US10881745B2 (en) | 2017-05-08 | 2021-01-05 | Alivio Therapeutics, Inc. | Formulation of nanostructured gels for increased agent loading and adhesion |
| CN108310452B (zh) * | 2018-04-11 | 2021-05-04 | 南京工业大学 | 一种温敏性葡聚糖基水凝胶及其制备方法 |
| KR102321066B1 (ko) * | 2018-06-22 | 2021-11-03 | (주)큐젠바이오텍 | 베타글루칸, 글리시틴 및 4',6,7-트리메톡시이소플라본을 포함하는 창상 치료 또는 피부 활성용 약학적 조성물 |
| US11839605B2 (en) | 2018-10-11 | 2023-12-12 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
| CN110090223B (zh) * | 2018-11-30 | 2022-12-20 | 浙江立恩生物科技有限公司 | β-葡聚糖的固体分散体及其制备方法 |
| CN110090224B (zh) * | 2018-11-30 | 2022-05-13 | 浙江立恩生物科技有限公司 | 促进伤口愈合的胶体敷料 |
| CN112402443B (zh) * | 2019-08-22 | 2024-12-31 | 广州立恩生物科技有限公司 | 用于预防和治疗口腔疾病的生物多糖及其应用 |
| CN112826977B (zh) * | 2020-12-31 | 2022-09-27 | 山东纳美德生物科技有限公司 | 一种液体敷料、皮肤外用组合物及其制备方法及应用 |
| US20240285700A1 (en) | 2021-06-24 | 2024-08-29 | Gro FOLKAN | Combination of an oncolytic virus, an anti-pd-1 inhibitor and an activator of the innate immune system for use in the treatment of prostate cancer |
| US11384160B1 (en) | 2021-07-30 | 2022-07-12 | Tissue repair ltd | Method of making a beta glucan compound |
| US11572420B1 (en) | 2021-07-30 | 2023-02-07 | Tissue repair ltd | Isolated biological polysaccharide compound, methods of use and methods of manufacture thereof |
| CN113736101B (zh) * | 2021-09-06 | 2022-12-23 | 福州大学 | 一种利用酵母菌发酵制备多功能水凝胶的方法 |
| JP2023173502A (ja) * | 2022-05-26 | 2023-12-07 | アサヒグループホールディングス株式会社 | 抗癌組成物 |
| CN116584552B (zh) * | 2023-05-19 | 2024-03-26 | 江南大学 | 一种基于葡聚糖自主装交联多维度乳液凝胶的制备及应用 |
| CN116549722B (zh) * | 2023-06-09 | 2023-11-10 | 东莞理工学院 | 一种细菌纤维素-木葡聚糖-右旋糖酐复合水凝胶伤口敷料及其制备方法 |
| CN117205326B (zh) * | 2023-09-26 | 2024-05-28 | 湖北中医药大学 | β-葡聚糖在制备治疗肠道疾病的口服给药递送系统中的应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5836630A (ja) * | 1981-08-28 | 1983-03-03 | Nippon Oil Co Ltd | ヒドロゲルの製造法 |
| US5082936A (en) | 1984-11-28 | 1992-01-21 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| GB8911177D0 (en) * | 1989-05-16 | 1989-07-05 | Vilain Jean | Alginate gel pharmaceutical product |
| JPH05503952A (ja) | 1989-09-08 | 1993-06-24 | アルファ ベータ テクノロジー，インコーポレイティッド | 可溶性グルカン類の製造方法 |
| DE69330308T2 (de) | 1992-12-02 | 2002-04-25 | Shiseido Co. Ltd., Tokio/Tokyo | Koppelmittel für eine ultraschall-sonde |
| JP3267410B2 (ja) * | 1993-09-24 | 2002-03-18 | 株式会社資生堂 | 超音波診断装置のプローブ用接触媒体 |
| NO300692B1 (no) | 1994-04-29 | 1997-07-07 | Biotec Mackzymal As | Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| JPH08269102A (ja) * | 1995-03-30 | 1996-10-15 | Shiseido Co Ltd | エンドトキシンフリーのβ１，３−グルカン及びその製造法並びに医療用ゲル素材 |
| US5980918A (en) * | 1997-10-24 | 1999-11-09 | Brennen Medical, Inc. | β-D-glucan topical composition |
| US6875754B1 (en) | 1999-03-12 | 2005-04-05 | Biotec Asa | Use of water-soluble β-(1,3) glucans as agents for producing therapeutic skin treatment agents |
| US6277392B1 (en) * | 1999-09-16 | 2001-08-21 | Carbon Medical Technologies, Inc. | Tissue injectable composition |
| DE10022095B4 (de) * | 2000-05-08 | 2005-07-14 | Südzucker AG Mannheim/Ochsenfurt | Gel aus einem Poly-α-1,4-Glucan und Stärke |
| JP2002018270A (ja) * | 2000-07-03 | 2002-01-22 | Hiroshi Yoshioka | 合成ハイドロゲル |
| EP1357919B1 (en) | 2001-01-16 | 2017-04-05 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| GB0225502D0 (en) | 2002-11-01 | 2002-12-11 | Zoolife Internat Ltd | Therapeutic and prophylactic preparations |
| US8105629B2 (en) * | 2004-02-25 | 2012-01-31 | Ihara & Company Ltd. | Collagen gel and process of producing the same |
| US20060079481A1 (en) | 2004-10-08 | 2006-04-13 | Rolf Engstad | Method of treating/preventing mucositis |
| JP2006169505A (ja) * | 2004-11-18 | 2006-06-29 | Daicel Chem Ind Ltd | 水性ゲル組成物及びその製造方法 |
| JP2006273912A (ja) * | 2005-03-28 | 2006-10-12 | Ipe:Kk | 抗菌性成形用組成物およびその成形物 |
| EP1898873A1 (en) | 2005-05-19 | 2008-03-19 | Kilda Biolink AS | Gelatin-containing topical composition |
| BRPI0619269A2 (pt) | 2005-11-30 | 2011-09-20 | Ciba Holding Inc | composição antibacteriana para contato com a mucosa ou outros tecidos da cavidade oral, composição para cuidados orais, uso de um escleroglucano, processo para preparação de uma formulação cosmética ou dermatológica, concentrado e, método de reduzir o número de bactérias e/ou minimizar a adesão de bactérias na mucosa oral |
| ITPD20060203A1 (it) * | 2006-05-22 | 2007-11-23 | Univ Degli Studi Trieste | Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi |
| US20090022799A1 (en) * | 2006-10-06 | 2009-01-22 | Shikha Pramanik Barman | Compositions that contain beta-glucan to be used for the prevention and treatment of disease and methods for their use |
| WO2008102151A1 (en) | 2007-02-21 | 2008-08-28 | Biotec Pharmacon Asa | Medical uses of glucans |
| CZ303471B6 (cs) * | 2007-10-03 | 2012-10-03 | Contipro Biotech S.R.O. | Prípravek pro hojení ran a prevenci adheze bandáže na ránu obsahující chitosan-glukan |
| US20090104141A1 (en) * | 2007-10-19 | 2009-04-23 | Cp Kelco Us, Inc. | Isothermal preparation of heat-resistant gellan gels with reduced syneresis |
| WO2009057802A1 (ja) * | 2007-11-01 | 2009-05-07 | Osaka City University | β-1,3-グルカン由来ポリアルデヒド／ポリアミンハイドロゲル |
| JP2011503161A (ja) * | 2007-11-13 | 2011-01-27 | バイオテック・ファルマコン・アーエスアー | 腸管の炎症性疾患を処置または予防する方法 |
| JP5746617B2 (ja) * | 2008-06-11 | 2015-07-08 | チ２ジェル リミテッドＣｈｉ２Ｇｅｌ Ｌｔｄ． | キトサン混合物を形成する注入可能なヒドロゲル |
| WO2010088924A1 (en) * | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| US20120288495A1 (en) | 2009-07-22 | 2012-11-15 | Biothera, Inc. | Therapeutic compositions and methods |
-
2010
- 2010-11-29 GB GBGB1020193.7A patent/GB201020193D0/en not_active Ceased
-
2011
- 2011-11-29 EP EP11796785.1A patent/EP2646477B1/en active Active
- 2011-11-29 CA CA2818650A patent/CA2818650C/en active Active
- 2011-11-29 EP EP16190864.5A patent/EP3130609B9/en active Active
- 2011-11-29 DK DK11796785.1T patent/DK2646477T3/en active
- 2011-11-29 ES ES16190864T patent/ES2794048T3/es active Active
- 2011-11-29 KR KR1020137016832A patent/KR101680148B1/ko active Active
- 2011-11-29 US US13/989,588 patent/US9956245B2/en active Active
- 2011-11-29 CN CN201180056839.1A patent/CN103347901B/zh active Active
- 2011-11-29 RU RU2013127184/15A patent/RU2596496C2/ru active
- 2011-11-29 DK DK16190864.5T patent/DK3130609T5/da active
- 2011-11-29 WO PCT/GB2011/052359 patent/WO2012073020A1/en not_active Ceased
- 2011-11-29 AU AU2011334627A patent/AU2011334627C1/en active Active
- 2011-11-29 JP JP2013540443A patent/JP6027013B2/ja active Active
-
2013
- 2013-05-16 ZA ZA2013/03553A patent/ZA201303553B/en unknown
-
2016
- 2016-07-13 JP JP2016138805A patent/JP2016180010A/ja active Pending
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