JP2013544510A5 - - Google Patents
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- JP2013544510A5 JP2013544510A5 JP2013535585A JP2013535585A JP2013544510A5 JP 2013544510 A5 JP2013544510 A5 JP 2013544510A5 JP 2013535585 A JP2013535585 A JP 2013535585A JP 2013535585 A JP2013535585 A JP 2013535585A JP 2013544510 A5 JP2013544510 A5 JP 2013544510A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- rna
- nucleotides
- length
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 123
- 239000002773 nucleotide Substances 0.000 claims 105
- 125000003729 nucleotide group Chemical group 0.000 claims 105
- 238000003776 cleavage reaction Methods 0.000 claims 51
- 230000007017 scission Effects 0.000 claims 51
- 108091033319 polynucleotide Proteins 0.000 claims 41
- 102000040430 polynucleotide Human genes 0.000 claims 41
- 239000002157 polynucleotide Substances 0.000 claims 41
- 102000004169 proteins and genes Human genes 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 38
- 238000011144 upstream manufacturing Methods 0.000 claims 34
- 210000004027 cell Anatomy 0.000 claims 30
- 239000000203 mixture Substances 0.000 claims 27
- 108090000829 Ribosome Inactivating Proteins Proteins 0.000 claims 21
- 230000002401 inhibitory effect Effects 0.000 claims 20
- 239000004055 small Interfering RNA Substances 0.000 claims 20
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 14
- 108020004459 Small interfering RNA Proteins 0.000 claims 12
- 108091081024 Start codon Proteins 0.000 claims 11
- 240000008042 Zea mays Species 0.000 claims 11
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 11
- 239000002679 microRNA Substances 0.000 claims 11
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 9
- 235000005822 corn Nutrition 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 8
- 108700011259 MicroRNAs Proteins 0.000 claims 8
- 108091027967 Small hairpin RNA Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 108010066676 Abrin Proteins 0.000 claims 6
- 108020004705 Codon Proteins 0.000 claims 6
- 108010039491 Ricin Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 108090000994 Catalytic RNA Proteins 0.000 claims 5
- 102000053642 Catalytic RNA Human genes 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 5
- 108091092562 ribozyme Proteins 0.000 claims 5
- 108020005544 Antisense RNA Proteins 0.000 claims 4
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 4
- 239000003184 complementary RNA Substances 0.000 claims 4
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 3
- 101710197219 Alpha-toxin Proteins 0.000 claims 3
- 244000036975 Ambrosia artemisiifolia Species 0.000 claims 3
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 claims 3
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 3
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 101800000585 Diphtheria toxin fragment A Proteins 0.000 claims 3
- 241000196324 Embryophyta Species 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 3
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 claims 3
- 240000005979 Hordeum vulgare Species 0.000 claims 3
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 3
- 101710124951 Phospholipase C Proteins 0.000 claims 3
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 3
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 3
- 108010084592 Saporins Proteins 0.000 claims 3
- 108010079723 Shiga Toxin Proteins 0.000 claims 3
- 102000006601 Thymidine Kinase Human genes 0.000 claims 3
- 108020004440 Thymidine kinase Proteins 0.000 claims 3
- 241000209140 Triticum Species 0.000 claims 3
- 235000021307 Triticum Nutrition 0.000 claims 3
- 108020000999 Viral RNA Proteins 0.000 claims 3
- 239000002776 alpha toxin Substances 0.000 claims 3
- 210000004102 animal cell Anatomy 0.000 claims 3
- 235000003484 annual ragweed Nutrition 0.000 claims 3
- 230000000840 anti-viral effect Effects 0.000 claims 3
- 235000006263 bur ragweed Nutrition 0.000 claims 3
- 230000001413 cellular effect Effects 0.000 claims 3
- 235000003488 common ragweed Nutrition 0.000 claims 3
- 210000004748 cultured cell Anatomy 0.000 claims 3
- 210000005260 human cell Anatomy 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 108091070501 miRNA Proteins 0.000 claims 3
- -1 momordine Proteins 0.000 claims 3
- 210000005170 neoplastic cell Anatomy 0.000 claims 3
- 235000009736 ragweed Nutrition 0.000 claims 3
- 108091028097 Cytoplasmic polyadenylation element Proteins 0.000 claims 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 2
- 235000009973 maize Nutrition 0.000 claims 2
- 239000009562 momordin Substances 0.000 claims 2
- 102000004533 Endonucleases Human genes 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 108020005350 Initiator Codon Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000014632 RNA localization Effects 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 230000030570 cellular localization Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 210000003712 lysosome Anatomy 0.000 claims 1
- 230000001868 lysosomic effect Effects 0.000 claims 1
- 210000003470 mitochondria Anatomy 0.000 claims 1
- 210000004940 nucleus Anatomy 0.000 claims 1
- 210000002824 peroxisome Anatomy 0.000 claims 1
- 230000002797 proteolythic effect Effects 0.000 claims 1
- 230000004960 subcellular localization Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ILPCT/IL2010/000895 | 2010-10-28 | ||
| PCT/IL2010/000895 WO2012056441A1 (en) | 2010-10-28 | 2010-10-28 | Compositions and methods for specific cleavage of exogenous rna in a cell |
| PCT/IL2011/000827 WO2012056449A2 (en) | 2010-10-28 | 2011-10-27 | Compositions and methods for specific cleavage of exogenous rna in a cell |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013544510A JP2013544510A (ja) | 2013-12-19 |
| JP2013544510A5 true JP2013544510A5 (enExample) | 2014-12-11 |
Family
ID=45993240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535585A Pending JP2013544510A (ja) | 2010-10-28 | 2011-10-27 | 細胞において外来性ｒｎａを特異的に切断するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130225660A1 (enExample) |
| EP (1) | EP2632931A4 (enExample) |
| JP (1) | JP2013544510A (enExample) |
| CN (1) | CN103282372A (enExample) |
| AU (1) | AU2011322106A1 (enExample) |
| CA (1) | CA2815632A1 (enExample) |
| WO (2) | WO2012056441A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037173T2 (hu) | 2006-08-08 | 2018-08-28 | Univ Bonn Rheinische Friedrich Wilhelms | 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| US11517583B2 (en) * | 2016-04-01 | 2022-12-06 | National University Of Singapore | Trans-splicing RNA (tsRNA) |
| DE102017103383A1 (de) * | 2017-02-20 | 2018-08-23 | aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) | System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten |
| WO2022182697A1 (en) * | 2021-02-23 | 2022-09-01 | Board Of Regents, The University Of Texas System | A novel rna-based approach to cancer treatment |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
| DE69636937T3 (de) * | 1995-12-15 | 2011-01-05 | Virxsys Corp. | Durch trans-spaltung erhaltene therapeutische molekule |
| EP1147188B1 (en) * | 1999-01-26 | 2007-05-16 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Internal ribosome entry site (ires), vector containing same and the uses thereof |
| AU2003302216A1 (en) * | 2002-05-08 | 2004-06-23 | Virxsys Corporation | Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses |
| US20030219407A1 (en) * | 2002-05-15 | 2003-11-27 | The Regents Of The University Of California | RNA silencing in animals as an antiviral defense |
| WO2004003180A1 (en) * | 2002-07-01 | 2004-01-08 | E.I. Du Pont De Nemours And Company | Method of controlling gene silencing using site-specific recombination |
| EP2000160A3 (en) * | 2002-10-30 | 2009-03-11 | Gambro Lundia AB | Method and apparatuses for determining the efficiency of dialysis |
| EP2213738B1 (en) * | 2002-11-14 | 2012-10-10 | Dharmacon, Inc. | siRNA molecules targeting Bcl-2 |
| WO2005112620A2 (en) * | 2004-05-18 | 2005-12-01 | Massachusetts Institute Of Technology | A cre-lox based method for conditional rna interference |
| WO2006042112A2 (en) * | 2004-10-05 | 2006-04-20 | California Institute Of Technology | Aptamer regulated nucleic acids and uses thereof |
| CA2583306A1 (en) * | 2004-10-08 | 2006-08-10 | Intronn, Inc. | Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production |
| CA2603730A1 (en) * | 2005-03-31 | 2006-10-05 | Calando Pharmaceuticals, Inc. | Inhibitors of ribonucleotide reductase subunit 2 and uses thereof |
| CN101184840A (zh) * | 2005-03-31 | 2008-05-21 | 卡兰朵医药公司 | 核糖核苷酸还原酶亚基2的抑制剂及其用途 |
| US20090217397A1 (en) * | 2006-06-12 | 2009-08-27 | Patrick Stern | Cre-lox based gene knockdown constructs and methods of use thereof |
| US8158595B2 (en) * | 2006-11-09 | 2012-04-17 | California Institute Of Technology | Modular aptamer-regulated ribozymes |
| WO2008106658A2 (en) * | 2007-03-01 | 2008-09-04 | California Institute Of Technology | TRIGGERED RNAi |
| US8367815B2 (en) * | 2007-08-28 | 2013-02-05 | California Institute Of Technology | Modular polynucleotides for ligand-controlled regulatory systems |
| US9029524B2 (en) * | 2007-12-10 | 2015-05-12 | California Institute Of Technology | Signal activated RNA interference |
-
2010
- 2010-10-28 WO PCT/IL2010/000895 patent/WO2012056441A1/en not_active Ceased
-
2011
- 2011-10-27 CN CN2011800633117A patent/CN103282372A/zh active Pending
- 2011-10-27 JP JP2013535585A patent/JP2013544510A/ja active Pending
- 2011-10-27 EP EP11835735.9A patent/EP2632931A4/en not_active Withdrawn
- 2011-10-27 CA CA2815632A patent/CA2815632A1/en not_active Abandoned
- 2011-10-27 AU AU2011322106A patent/AU2011322106A1/en not_active Abandoned
- 2011-10-27 WO PCT/IL2011/000827 patent/WO2012056449A2/en not_active Ceased
- 2011-10-27 US US13/881,356 patent/US20130225660A1/en not_active Abandoned
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