JP2013544511A5 - - Google Patents
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- JP2013544511A5 JP2013544511A5 JP2013535589A JP2013535589A JP2013544511A5 JP 2013544511 A5 JP2013544511 A5 JP 2013544511A5 JP 2013535589 A JP2013535589 A JP 2013535589A JP 2013535589 A JP2013535589 A JP 2013535589A JP 2013544511 A5 JP2013544511 A5 JP 2013544511A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- ebv
- hcmv
- mcmv
- rlcv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002679 microRNA Substances 0.000 claims 27
- 108091070501 miRNA Proteins 0.000 claims 21
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 16
- 230000002401 inhibitory effect Effects 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 108090000829 Ribosome Inactivating Proteins Proteins 0.000 claims 14
- 238000003776 cleavage reaction Methods 0.000 claims 12
- 230000007017 scission Effects 0.000 claims 12
- 241000700605 Viruses Species 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 8
- 108700011259 MicroRNAs Proteins 0.000 claims 6
- 108091081024 Start codon Proteins 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 239000003053 toxin Substances 0.000 claims 6
- 231100000765 toxin Toxicity 0.000 claims 6
- 108700012359 toxins Proteins 0.000 claims 6
- 108020004414 DNA Proteins 0.000 claims 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 4
- 108010066676 Abrin Proteins 0.000 claims 4
- 108020004705 Codon Proteins 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 4
- 102000009661 Repressor Proteins Human genes 0.000 claims 4
- 108010034634 Repressor Proteins Proteins 0.000 claims 4
- 108010039491 Ricin Proteins 0.000 claims 4
- 241001493065 dsRNA viruses Species 0.000 claims 4
- -1 hcmv-miR-ULll12 Proteins 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 2
- 101710197219 Alpha-toxin Proteins 0.000 claims 2
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 2
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 2
- 101800000585 Diphtheria toxin fragment A Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 claims 2
- 240000005979 Hordeum vulgare Species 0.000 claims 2
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 2
- 240000006240 Linum usitatissimum Species 0.000 claims 2
- 235000004431 Linum usitatissimum Nutrition 0.000 claims 2
- 101710124951 Phospholipase C Proteins 0.000 claims 2
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 2
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 2
- 108010084592 Saporins Proteins 0.000 claims 2
- 108010079723 Shiga Toxin Proteins 0.000 claims 2
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 2
- 102000006601 Thymidine Kinase Human genes 0.000 claims 2
- 108020004440 Thymidine kinase Proteins 0.000 claims 2
- 241000209140 Triticum Species 0.000 claims 2
- 235000021307 Triticum Nutrition 0.000 claims 2
- 240000008042 Zea mays Species 0.000 claims 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 2
- 239000002776 alpha toxin Substances 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 235000005822 corn Nutrition 0.000 claims 2
- 239000009562 momordin Substances 0.000 claims 2
- 210000005170 neoplastic cell Anatomy 0.000 claims 2
- 108700028325 pokeweed antiviral Proteins 0.000 claims 2
- 241001430294 unidentified retrovirus Species 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 108091033415 Epstein Barr virus miR-BART1 stem-loop Proteins 0.000 claims 1
- 108091060419 Epstein Barr virus miR-BART10 stem-loop Proteins 0.000 claims 1
- 108091060427 Epstein Barr virus miR-BART11 stem-loop Proteins 0.000 claims 1
- 108091060428 Epstein Barr virus miR-BART12 stem-loop Proteins 0.000 claims 1
- 108091027206 Epstein Barr virus miR-BART15 stem-loop Proteins 0.000 claims 1
- 108091027205 Epstein Barr virus miR-BART16 stem-loop Proteins 0.000 claims 1
- 108091027124 Epstein Barr virus miR-BART17 stem-loop Proteins 0.000 claims 1
- 108091027126 Epstein Barr virus miR-BART18 stem-loop Proteins 0.000 claims 1
- 108091027121 Epstein Barr virus miR-BART19 stem-loop Proteins 0.000 claims 1
- 108091033419 Epstein Barr virus miR-BART2 stem-loop Proteins 0.000 claims 1
- 108091027120 Epstein Barr virus miR-BART20 stem-loop Proteins 0.000 claims 1
- 108091060437 Epstein Barr virus miR-BART3 stem-loop Proteins 0.000 claims 1
- 108091060430 Epstein Barr virus miR-BART4 stem-loop Proteins 0.000 claims 1
- 108091060435 Epstein Barr virus miR-BART5 stem-loop Proteins 0.000 claims 1
- 108091060433 Epstein Barr virus miR-BART6 stem-loop Proteins 0.000 claims 1
- 108091060434 Epstein Barr virus miR-BART7 stem-loop Proteins 0.000 claims 1
- 108091060421 Epstein Barr virus miR-BART8 stem-loop Proteins 0.000 claims 1
- 108091060418 Epstein Barr virus miR-BART9 stem-loop Proteins 0.000 claims 1
- 108091033428 Epstein Barr virus miR-BHRF1-1 stem-loop Proteins 0.000 claims 1
- 108091033429 Epstein Barr virus miR-BHRF1-3 stem-loop Proteins 0.000 claims 1
- 108060002716 Exonuclease Proteins 0.000 claims 1
- 108091032898 Human cytomegalovirus miR-UL148D stem-loop Proteins 0.000 claims 1
- 108091032780 Human cytomegalovirus miR-UL22A stem-loop Proteins 0.000 claims 1
- 108091032782 Human cytomegalovirus miR-UL36 stem-loop Proteins 0.000 claims 1
- 108091061670 Human cytomegalovirus miR-UL70 stem-loop Proteins 0.000 claims 1
- 108091032905 Human cytomegalovirus miR-US33 stem-loop Proteins 0.000 claims 1
- 108091032906 Human cytomegalovirus miR-US5-2 stem-loop Proteins 0.000 claims 1
- 108091046281 Human immunodeficiency virus 1 miR-H1 stem-loop Proteins 0.000 claims 1
- 108091046284 Human immunodeficiency virus 1 miR-N367 stem-loop Proteins 0.000 claims 1
- 108091064865 Human immunodeficiency virus 1 miR-TAR stem-loop Proteins 0.000 claims 1
- 108020005350 Initiator Codon Proteins 0.000 claims 1
- 108091053836 Kaposi sarcoma-associated herpesvirus miR-K12-1 stem-loop Proteins 0.000 claims 1
- 108091053834 Kaposi sarcoma-associated herpesvirus miR-K12-10b stem-loop Proteins 0.000 claims 1
- 108091053837 Kaposi sarcoma-associated herpesvirus miR-K12-2 stem-loop Proteins 0.000 claims 1
- 108091053823 Kaposi sarcoma-associated herpesvirus miR-K12-3 stem-loop Proteins 0.000 claims 1
- 108091053826 Kaposi sarcoma-associated herpesvirus miR-K12-4 stem-loop Proteins 0.000 claims 1
- 108091053911 Kaposi sarcoma-associated herpesvirus miR-K12-5 stem-loop Proteins 0.000 claims 1
- 108091053913 Kaposi sarcoma-associated herpesvirus miR-K12-6 stem-loop Proteins 0.000 claims 1
- 108091053846 Kaposi sarcoma-associated herpesvirus miR-K12-7 stem-loop Proteins 0.000 claims 1
- 108091053839 Kaposi sarcoma-associated herpesvirus miR-K12-8 stem-loop Proteins 0.000 claims 1
- 108091053838 Kaposi sarcoma-associated herpesvirus miR-K12-9 stem-loop Proteins 0.000 claims 1
- 108091044369 Mareks disease virus type 1 miR-M13 stem-loop Proteins 0.000 claims 1
- 108091046090 Mouse cytomegalovirus miR-M23-1 stem-loop Proteins 0.000 claims 1
- 108091046089 Mouse cytomegalovirus miR-M23-2 stem-loop Proteins 0.000 claims 1
- 108091046092 Mouse cytomegalovirus miR-M44-1 stem-loop Proteins 0.000 claims 1
- 108091045934 Mouse cytomegalovirus miR-M55-1 stem-loop Proteins 0.000 claims 1
- 108091046088 Mouse cytomegalovirus miR-M87-1 stem-loop Proteins 0.000 claims 1
- 108091045849 Mouse cytomegalovirus miR-M95-1 stem-loop Proteins 0.000 claims 1
- 108091045925 Mouse cytomegalovirus miR-m01-1 stem-loop Proteins 0.000 claims 1
- 108091045926 Mouse cytomegalovirus miR-m01-2 stem-loop Proteins 0.000 claims 1
- 108091045918 Mouse cytomegalovirus miR-m01-3 stem-loop Proteins 0.000 claims 1
- 108091045919 Mouse cytomegalovirus miR-m01-4 stem-loop Proteins 0.000 claims 1
- 108091046091 Mouse cytomegalovirus miR-m21-1 stem-loop Proteins 0.000 claims 1
- 108091046087 Mouse cytomegalovirus miR-m22-1 stem-loop Proteins 0.000 claims 1
- 108091045935 Mouse cytomegalovirus miR-m59-1 stem-loop Proteins 0.000 claims 1
- 108091046086 Mouse cytomegalovirus miR-m59-2 stem-loop Proteins 0.000 claims 1
- 108091045933 Mouse cytomegalovirus miR-m88-1 stem-loop Proteins 0.000 claims 1
- 108091032781 Mouse gammaherpesvirus 68 miR-M1-1 stem-loop Proteins 0.000 claims 1
- 108091032859 Mouse gammaherpesvirus 68 miR-M1-2 stem-loop Proteins 0.000 claims 1
- 108091032856 Mouse gammaherpesvirus 68 miR-M1-3 stem-loop Proteins 0.000 claims 1
- 108091032848 Mouse gammaherpesvirus 68 miR-M1-4 stem-loop Proteins 0.000 claims 1
- 108091032851 Mouse gammaherpesvirus 68 miR-M1-5 stem-loop Proteins 0.000 claims 1
- 108091032858 Mouse gammaherpesvirus 68 miR-M1-6 stem-loop Proteins 0.000 claims 1
- 108091032847 Mouse gammaherpesvirus 68 miR-M1-7 stem-loop Proteins 0.000 claims 1
- 108091032783 Mouse gammaherpesvirus 68 miR-M1-8 stem-loop Proteins 0.000 claims 1
- 108091032854 Mouse gammaherpesvirus 68 miR-M1-9 stem-loop Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000014632 RNA localization Effects 0.000 claims 1
- 108091060422 Rhesus lymphocryptovirus miR-rL1-1 stem-loop Proteins 0.000 claims 1
- 108091060423 Rhesus lymphocryptovirus miR-rL1-2 stem-loop Proteins 0.000 claims 1
- 108091060424 Rhesus lymphocryptovirus miR-rL1-3 stem-loop Proteins 0.000 claims 1
- 108091060403 Rhesus lymphocryptovirus miR-rL1-4 stem-loop Proteins 0.000 claims 1
- 108091060404 Rhesus lymphocryptovirus miR-rL1-5 stem-loop Proteins 0.000 claims 1
- 108091060409 Rhesus lymphocryptovirus miR-rL1-6 stem-loop Proteins 0.000 claims 1
- 108091060410 Rhesus lymphocryptovirus miR-rL1-7 stem-loop Proteins 0.000 claims 1
- 108091060412 Rhesus lymphocryptovirus miR-rL1-8 stem-loop Proteins 0.000 claims 1
- 108091060413 Rhesus lymphocryptovirus miR-rL1-9 stem-loop Proteins 0.000 claims 1
- 108091087071 Rhesus monkey rhadinovirus miR-rR1-1 stem-loop Proteins 0.000 claims 1
- 108091087066 Rhesus monkey rhadinovirus miR-rR1-2 stem-loop Proteins 0.000 claims 1
- 108091087173 Rhesus monkey rhadinovirus miR-rR1-3 stem-loop Proteins 0.000 claims 1
- 108091087172 Rhesus monkey rhadinovirus miR-rR1-4 stem-loop Proteins 0.000 claims 1
- 108091087170 Rhesus monkey rhadinovirus miR-rR1-6 stem-loop Proteins 0.000 claims 1
- 108091087179 Rhesus monkey rhadinovirus miR-rR1-7 stem-loop Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000030570 cellular localization Effects 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 102000013165 exonuclease Human genes 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ILPCT/IL2010/000894 | 2010-10-28 | ||
| PCT/IL2010/000894 WO2012056440A1 (en) | 2010-10-28 | 2010-10-28 | COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA |
| PCT/IL2011/000837 WO2012056457A2 (en) | 2010-10-28 | 2011-10-27 | Compositions and methods for activating expression by a specific endogenous mirna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013544511A JP2013544511A (ja) | 2013-12-19 |
| JP2013544511A5 true JP2013544511A5 (enExample) | 2014-12-11 |
Family
ID=45993239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535589A Pending JP2013544511A (ja) | 2010-10-28 | 2011-10-27 | 特異的内在性ｍｉＲＮＡにより発現を活性化する組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130245096A1 (enExample) |
| EP (1) | EP2632932A4 (enExample) |
| JP (1) | JP2013544511A (enExample) |
| CN (1) | CN103314003A (enExample) |
| AU (1) | AU2011322114A1 (enExample) |
| CA (1) | CA2824604A1 (enExample) |
| WO (2) | WO2012056440A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037173T2 (hu) | 2006-08-08 | 2018-08-28 | Univ Bonn Rheinische Friedrich Wilhelms | 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása |
| US8524248B2 (en) | 2007-12-14 | 2013-09-03 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| JP2014531908A (ja) | 2011-10-14 | 2014-12-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 構造アッセンブリによる配列決定 |
| ES2952728T3 (es) | 2011-12-22 | 2023-11-03 | Harvard College | Métodos para la detección de analitos |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
| JP6282591B2 (ja) * | 2012-09-13 | 2018-02-21 | 中外製薬株式会社 | 遺伝子ノックイン非ヒト動物 |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| US10138509B2 (en) | 2013-03-12 | 2018-11-27 | President And Fellows Of Harvard College | Method for generating a three-dimensional nucleic acid containing matrix |
| RU2690935C2 (ru) | 2013-06-04 | 2019-06-06 | Президент Энд Фэллоуз Оф Харвард Коллидж | Направляемая рнк регуляция транскрипции |
| CN104419749B (zh) * | 2013-08-22 | 2017-02-15 | 江苏命码生物科技有限公司 | 一种用于预测干扰素治疗慢性hbv疗效的微小核糖核酸及其应用 |
| EP3613862A1 (en) * | 2014-01-10 | 2020-02-26 | Kyoto University | Method for distinguishing desired cell type using expression of mirna as indicator |
| WO2016007839A1 (en) * | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| WO2016100812A1 (en) * | 2014-12-19 | 2016-06-23 | Moderna Therapeutics, Inc. | Terminal modifications of polynucleotides |
| EP3270936A4 (en) | 2015-03-17 | 2018-08-08 | Chimera Bioengineering Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| CA3001003A1 (en) | 2015-10-05 | 2017-04-13 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| JP6882282B2 (ja) | 2015-11-03 | 2021-06-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 三次元核酸含有マトリックスの立体撮像のための方法と装置 |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| EP4613756A3 (en) | 2016-04-25 | 2025-11-12 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| EP3458077A4 (en) | 2016-05-17 | 2020-04-01 | Chimera Bioengineering Inc. | METHODS OF MANUFACTURING NEW AREAS OF ANTIGEN BINDING |
| CA3031670A1 (en) * | 2016-07-26 | 2018-02-01 | Senti Biosciences, Inc. | Spatiotemporal regulators |
| CN109923216B (zh) | 2016-08-31 | 2024-08-02 | 哈佛学院董事及会员团体 | 将生物分子的检测组合到使用荧光原位测序的单个试验的方法 |
| EP3507364A4 (en) | 2016-08-31 | 2020-05-20 | President and Fellows of Harvard College | METHODS OF GENERATING NUCLEIC ACID SEQUENCE LIBRARIES FOR IN SITU FLUORESCENT SEQUENCING DETECTION |
| CN112481217A (zh) | 2016-09-01 | 2021-03-12 | 嵌合体生物工程公司 | Gold优化的car t-细胞 |
| DE102017103383A1 (de) * | 2017-02-20 | 2018-08-23 | aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) | System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten |
| US11185568B2 (en) | 2017-04-14 | 2021-11-30 | President And Fellows Of Harvard College | Methods for generation of cell-derived microfilament network |
| US11795455B2 (en) * | 2017-07-31 | 2023-10-24 | Massachusetts Institute Of Technology | RNA cleavage-induced transcript stabilizer and uses thereof |
| CN110016501A (zh) * | 2018-01-09 | 2019-07-16 | 江苏命码生物科技有限公司 | 不明原因发热的标记物、检测方法及其应用 |
| CN111989108B (zh) | 2018-02-13 | 2024-07-16 | 嵌合体生物工程公司 | 利用rna去稳定元件协调基因表达 |
| CN108753836B (zh) * | 2018-06-04 | 2021-10-12 | 北京大学 | 一种利用rna干扰机制的基因调控或编辑系统 |
| CN108841864B (zh) * | 2018-06-04 | 2021-10-15 | 北京大学 | 一种利用rna干扰机制的分子传感器 |
| CN112770776B (zh) | 2018-07-30 | 2025-08-19 | 瑞德库尔有限责任公司 | 用于样品处理或分析的方法和系统 |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| CN109628489B (zh) * | 2019-01-07 | 2022-09-23 | 新乡医学院 | 一种提高cho细胞重组蛋白表达水平的方法及其应用，表达载体、表达系统及其制备方法 |
| CN114786686A (zh) | 2019-08-18 | 2022-07-22 | 嵌合体生物工程公司 | Gold控制的转基因的联合疗法 |
| CN111057790B (zh) * | 2019-12-11 | 2022-08-30 | 石河子大学 | miRNA在制备用于检测KSHV潜伏感染的试剂盒中的用途 |
| AU2021308666A1 (en) * | 2020-07-17 | 2023-02-16 | Children's Hospital Medical Center | Methods and compositions for treatment of fragile X syndrome |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| WO2022182697A1 (en) * | 2021-02-23 | 2022-09-01 | Board Of Regents, The University Of Texas System | A novel rna-based approach to cancer treatment |
| EP4355882A2 (en) * | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Engineered polynucleotides for cell-type or microenvironment-specific expression |
| WO2023100955A1 (ja) * | 2021-11-30 | 2023-06-08 | 国立大学法人京都大学 | Ｒｎａ分子 |
| CN116716351B (zh) * | 2023-03-30 | 2024-02-23 | 湖北天勤生物技术研究院有限公司 | 用于构建食蟹猴阿尔兹海默症模型的组合物及其应用和构建方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067251B2 (en) * | 2000-03-28 | 2006-06-27 | University Of Rochester | Methods of directly selecting cells expressing inserts of interest |
| US20060275262A1 (en) * | 2001-07-26 | 2006-12-07 | Mathis James M | Conditionally replicating viruses and methods for cancer virotherapy |
| DE10158517A1 (de) * | 2001-11-29 | 2003-06-12 | Focusgenomics Gmbh | Verfahren zur Analyse der translationskontrollierten Genexpression |
| US20070265220A1 (en) * | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| AU2005323166B2 (en) * | 2004-12-21 | 2011-11-10 | Monsanto Technology, Llc | Recombinant DNA constructs and methods for controlling gene expression |
| US20060265771A1 (en) * | 2005-05-17 | 2006-11-23 | Lewis David L | Monitoring microrna expression and function |
| US20070179113A1 (en) * | 2005-05-19 | 2007-08-02 | Schering Aktiengesellachaft | GM-CSF gene therapy for Crohn's disease using an improved regulated expression system |
| US20070054872A1 (en) * | 2005-08-24 | 2007-03-08 | Mirus Bio Corporation | Regulatable or conditional expression systems |
| US20090156535A1 (en) * | 2007-09-27 | 2009-06-18 | The Trustees Of Princeton University | MicroRNAs for Modulating Herpes Virus Gene Expression |
| US20090286242A1 (en) * | 2007-12-10 | 2009-11-19 | Cold Spring Harbor Laboratory | MicroRNA Expression Profiling and Uses Thereof |
| US20110098346A1 (en) * | 2008-05-19 | 2011-04-28 | Agency For Science, Technology And Research | Nucleic acid molecule and method of targeting gene expression to gliomas |
| US9938540B2 (en) * | 2008-11-12 | 2018-04-10 | Ospedale San Raffaele S.R.L. | Gene vector for inducing transgene-specific immune tolerance |
-
2010
- 2010-10-28 WO PCT/IL2010/000894 patent/WO2012056440A1/en not_active Ceased
-
2011
- 2011-10-27 JP JP2013535589A patent/JP2013544511A/ja active Pending
- 2011-10-27 EP EP11835739.1A patent/EP2632932A4/en not_active Withdrawn
- 2011-10-27 WO PCT/IL2011/000837 patent/WO2012056457A2/en not_active Ceased
- 2011-10-27 CA CA2824604A patent/CA2824604A1/en not_active Abandoned
- 2011-10-27 AU AU2011322114A patent/AU2011322114A1/en not_active Abandoned
- 2011-10-27 CN CN2011800631535A patent/CN103314003A/zh active Pending
- 2011-10-27 US US13/881,350 patent/US20130245096A1/en not_active Abandoned
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