JP2013544511A - 特異的内在性ｍｉＲＮＡにより発現を活性化する組成物および方法 - Google Patents

特異的内在性ｍｉＲＮＡにより発現を活性化する組成物および方法 Download PDF

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JP2013544511A
JP2013544511A JP2013535589A JP2013535589A JP2013544511A JP 2013544511 A JP2013544511 A JP 2013544511A JP 2013535589 A JP2013535589 A JP 2013535589A JP 2013535589 A JP2013535589 A JP 2013535589A JP 2013544511 A JP2013544511 A JP 2013544511A
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アビトボル，ガイ
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ナノドク リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
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JP2013535589A 2010-10-28 2011-10-27 特異的内在性ｍｉＲＮＡにより発現を活性化する組成物および方法 Pending JP2013544511A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ILPCT/IL2010/000894 2010-10-28
PCT/IL2010/000894 WO2012056440A1 (en) 2010-10-28 2010-10-28 COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA
PCT/IL2011/000837 WO2012056457A2 (en) 2010-10-28 2011-10-27 Compositions and methods for activating expression by a specific endogenous mirna

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JP2013544511A true JP2013544511A (ja) 2013-12-19
JP2013544511A5 JP2013544511A5 (enExample) 2014-12-11

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US (1) US20130245096A1 (enExample)
EP (1) EP2632932A4 (enExample)
JP (1) JP2013544511A (enExample)
CN (1) CN103314003A (enExample)
AU (1) AU2011322114A1 (enExample)
CA (1) CA2824604A1 (enExample)
WO (2) WO2012056440A1 (enExample)

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JP2019527563A (ja) * 2016-07-26 2019-10-03 センティ バイオサイエンシズ インコーポレイテッド 時空間調節因子
KR20190120207A (ko) * 2017-02-20 2019-10-23 아레나-바이오 지비알 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법
WO2023100955A1 (ja) * 2021-11-30 2023-06-08 国立大学法人京都大学 Ｒｎａ分子
JP2023534293A (ja) * 2020-07-17 2023-08-08 チルドレンズ ホスピタル メディカル センター 脆弱ｘ症候群の治療のための方法及び組成物

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US8524248B2 (en) * 2007-12-14 2013-09-03 University of Pittsburgh—of the Commonwealth System of Higher Education Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US10501791B2 (en) 2011-10-14 2019-12-10 President And Fellows Of Harvard College Sequencing by structure assembly
ES2953308T3 (es) 2011-12-22 2023-11-10 Harvard College Composiciones y métodos para la detección de analitos
WO2014163886A1 (en) 2013-03-12 2014-10-09 President And Fellows Of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
WO2014042251A1 (ja) * 2012-09-13 2014-03-20 中外製薬株式会社 遺伝子ノックイン非ヒト動物
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
MY177814A (en) 2013-06-04 2020-09-23 Harvard College Rna-guided transcriptional regulation
CN104419749B (zh) * 2013-08-22 2017-02-15 江苏命码生物科技有限公司 一种用于预测干扰素治疗慢性hbv疗效的微小核糖核酸及其应用
CN106574292B (zh) * 2014-01-10 2021-07-09 国立大学法人京都大学 利用作为指示剂的miRNA的表达区分期望的细胞类型的方法
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
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JP6990176B2 (ja) 2015-10-05 2022-02-03 モデルナティエックス インコーポレイテッド メッセンジャーリボ核酸薬物の治療投与のための方法
GB2559526B (en) 2015-11-03 2021-02-17 Harvard College Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
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CN108753836B (zh) * 2018-06-04 2021-10-12 北京大学 一种利用rna干扰机制的基因调控或编辑系统
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019527563A (ja) * 2016-07-26 2019-10-03 センティ バイオサイエンシズ インコーポレイテッド 時空間調節因子
KR20190120207A (ko) * 2017-02-20 2019-10-23 아레나-바이오 지비알 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법
JP2020513194A (ja) * 2017-02-20 2020-05-07 アレーナービオ ゲーベーエル 真核生物におけるｒｎａ分子の細胞型特異的な翻訳に関する系及び方法
JP7153033B2 (ja) 2017-02-20 2022-10-13 アレーナ ビオテック ゲーエムベーハー 真核生物におけるｒｎａ分子の細胞型特異的な翻訳に関する系及び方法
KR102696359B1 (ko) 2017-02-20 2024-08-19 아레나 바이오테크 게엠베하 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법
JP2023534293A (ja) * 2020-07-17 2023-08-08 チルドレンズ ホスピタル メディカル センター 脆弱ｘ症候群の治療のための方法及び組成物
WO2023100955A1 (ja) * 2021-11-30 2023-06-08 国立大学法人京都大学 Ｒｎａ分子

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US20130245096A1 (en) 2013-09-19
WO2012056457A3 (en) 2012-08-02
EP2632932A2 (en) 2013-09-04
WO2012056457A2 (en) 2012-05-03
CN103314003A (zh) 2013-09-18
EP2632932A4 (en) 2014-12-17
AU2011322114A1 (en) 2013-05-30
CA2824604A1 (en) 2012-05-03
WO2012056440A1 (en) 2012-05-03

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