JP2013544510A - 細胞において外来性ｒｎａを特異的に切断するための組成物および方法 - Google Patents
細胞において外来性ｒｎａを特異的に切断するための組成物および方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IL2010/000895 WO2012056441A1 (en) | 2010-10-28 | 2010-10-28 | Compositions and methods for specific cleavage of exogenous rna in a cell |
| ILPCT/IL2010/000895 | 2010-10-28 | ||
| PCT/IL2011/000827 WO2012056449A2 (en) | 2010-10-28 | 2011-10-27 | Compositions and methods for specific cleavage of exogenous rna in a cell |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013544510A true JP2013544510A (ja) | 2013-12-19 |
| JP2013544510A5 JP2013544510A5 (enExample) | 2014-12-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535585A Pending JP2013544510A (ja) | 2010-10-28 | 2011-10-27 | 細胞において外来性ｒｎａを特異的に切断するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130225660A1 (enExample) |
| EP (1) | EP2632931A4 (enExample) |
| JP (1) | JP2013544510A (enExample) |
| CN (1) | CN103282372A (enExample) |
| AU (1) | AU2011322106A1 (enExample) |
| CA (1) | CA2815632A1 (enExample) |
| WO (2) | WO2012056441A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190120207A (ko) * | 2017-02-20 | 2019-10-23 | 아레나-바이오 지비알 | 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2056845T3 (da) | 2006-08-08 | 2017-11-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Struktur og anvendelse af 5'-phosphat-oligonukleotider |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| JP7229467B2 (ja) * | 2016-04-01 | 2023-02-28 | ナショナル ユニバーシティ オブ シンガポール | トランス－スプライシングＲＮＡ（ｔｓＲＮＡ） |
| WO2022182697A1 (en) * | 2021-02-23 | 2022-09-01 | Board Of Regents, The University Of Texas System | A novel rna-based approach to cancer treatment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080214488A1 (en) * | 2007-03-01 | 2008-09-04 | California Institute Of Technology | TRIGGERED RNAi |
| US20090234109A1 (en) * | 2007-12-10 | 2009-09-17 | Si-Ping Han | Signal activated RNA interference |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
| AU730305B2 (en) * | 1995-12-15 | 2001-03-01 | Intronn Llc | Therapeutic molecules generated by trans-splicing |
| WO2000044896A1 (en) * | 1999-01-26 | 2000-08-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Internal ribosome entry site (ires), vector containing same and uses thereof |
| AU2003302216A1 (en) * | 2002-05-08 | 2004-06-23 | Virxsys Corporation | Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses |
| US20030219407A1 (en) * | 2002-05-15 | 2003-11-27 | The Regents Of The University Of California | RNA silencing in animals as an antiviral defense |
| US7267979B2 (en) * | 2002-07-01 | 2007-09-11 | Pioneer Hi-Bred International, Inc. | Method of controlling gene silencing using site specific recombination |
| EP2000160A3 (en) * | 2002-10-30 | 2009-03-11 | Gambro Lundia AB | Method and apparatuses for determining the efficiency of dialysis |
| EP1560931B1 (en) * | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| WO2005112620A2 (en) * | 2004-05-18 | 2005-12-01 | Massachusetts Institute Of Technology | A cre-lox based method for conditional rna interference |
| JP5101288B2 (ja) * | 2004-10-05 | 2012-12-19 | カリフォルニア インスティテュート オブ テクノロジー | アプタマー調節される核酸及びその利用 |
| CA2583306A1 (en) * | 2004-10-08 | 2006-08-10 | Intronn, Inc. | Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production |
| ATE541928T1 (de) * | 2005-03-31 | 2012-02-15 | Calando Pharmaceuticals Inc | Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen |
| CN101184840A (zh) * | 2005-03-31 | 2008-05-21 | 卡兰朵医药公司 | 核糖核苷酸还原酶亚基2的抑制剂及其用途 |
| WO2007149246A2 (en) * | 2006-06-12 | 2007-12-27 | Massachusetts Institute Of Technology | Cre-lox based gene knockdown constructs and methods of use thereof |
| WO2008058291A2 (en) * | 2006-11-09 | 2008-05-15 | California Institute Of Technology | Modular aptamer-regulated ribozymes |
| US8367815B2 (en) * | 2007-08-28 | 2013-02-05 | California Institute Of Technology | Modular polynucleotides for ligand-controlled regulatory systems |
-
2010
- 2010-10-28 WO PCT/IL2010/000895 patent/WO2012056441A1/en not_active Ceased
-
2011
- 2011-10-27 JP JP2013535585A patent/JP2013544510A/ja active Pending
- 2011-10-27 EP EP11835735.9A patent/EP2632931A4/en not_active Withdrawn
- 2011-10-27 CA CA2815632A patent/CA2815632A1/en not_active Abandoned
- 2011-10-27 WO PCT/IL2011/000827 patent/WO2012056449A2/en not_active Ceased
- 2011-10-27 CN CN2011800633117A patent/CN103282372A/zh active Pending
- 2011-10-27 AU AU2011322106A patent/AU2011322106A1/en not_active Abandoned
- 2011-10-27 US US13/881,356 patent/US20130225660A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080214488A1 (en) * | 2007-03-01 | 2008-09-04 | California Institute Of Technology | TRIGGERED RNAi |
| US20090234109A1 (en) * | 2007-12-10 | 2009-09-17 | Si-Ping Han | Signal activated RNA interference |
Non-Patent Citations (1)
| Title |
|---|
| HARAGUCHI, TAKESHI ET AL.: ""Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA acti", NUCLEIC ACIDS RES., vol. 37, JPN6015041372, 2009, pages 43 - 1, ISSN: 0003175230 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190120207A (ko) * | 2017-02-20 | 2019-10-23 | 아레나-바이오 지비알 | 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법 |
| JP2020513194A (ja) * | 2017-02-20 | 2020-05-07 | アレーナービオ ゲーベーエル | 真核生物におけるｒｎａ分子の細胞型特異的な翻訳に関する系及び方法 |
| JP7153033B2 (ja) | 2017-02-20 | 2022-10-13 | アレーナ ビオテック ゲーエムベーハー | 真核生物におけるｒｎａ分子の細胞型特異的な翻訳に関する系及び方法 |
| KR102696359B1 (ko) | 2017-02-20 | 2024-08-19 | 아레나 바이오테크 게엠베하 | 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012056449A2 (en) | 2012-05-03 |
| EP2632931A4 (en) | 2014-06-18 |
| CA2815632A1 (en) | 2012-05-03 |
| WO2012056441A1 (en) | 2012-05-03 |
| US20130225660A1 (en) | 2013-08-29 |
| AU2011322106A1 (en) | 2013-05-30 |
| WO2012056449A3 (en) | 2012-07-19 |
| CN103282372A (zh) | 2013-09-04 |
| EP2632931A2 (en) | 2013-09-04 |
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