JP2013544510A - 細胞において外来性ｒｎａを特異的に切断するための組成物および方法 - Google Patents

細胞において外来性ｒｎａを特異的に切断するための組成物および方法 Download PDF

Info

Publication number
JP2013544510A
JP2013544510A JP2013535585A JP2013535585A JP2013544510A JP 2013544510 A JP2013544510 A JP 2013544510A JP 2013535585 A JP2013535585 A JP 2013535585A JP 2013535585 A JP2013535585 A JP 2013535585A JP 2013544510 A JP2013544510 A JP 2013544510A
Authority
JP
Japan
Prior art keywords
sequence
rna
nucleotides
composition
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013535585A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013544510A5 (enExample
Inventor
アビトボル，ガイ
Original Assignee
ナノドク リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ナノドク リミテッド filed Critical ナノドク リミテッド
Publication of JP2013544510A publication Critical patent/JP2013544510A/ja
Publication of JP2013544510A5 publication Critical patent/JP2013544510A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2013535585A 2010-10-28 2011-10-27 細胞において外来性ｒｎａを特異的に切断するための組成物および方法 Pending JP2013544510A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ILPCT/IL2010/000895 2010-10-28
PCT/IL2010/000895 WO2012056441A1 (en) 2010-10-28 2010-10-28 Compositions and methods for specific cleavage of exogenous rna in a cell
PCT/IL2011/000827 WO2012056449A2 (en) 2010-10-28 2011-10-27 Compositions and methods for specific cleavage of exogenous rna in a cell

Publications (2)

Publication Number Publication Date
JP2013544510A true JP2013544510A (ja) 2013-12-19
JP2013544510A5 JP2013544510A5 (enExample) 2014-12-11

Family

ID=45993240

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013535585A Pending JP2013544510A (ja) 2010-10-28 2011-10-27 細胞において外来性ｒｎａを特異的に切断するための組成物および方法

Country Status (8)

Country Link
US (1) US20130225660A1 (enExample)
EP (1) EP2632931A4 (enExample)
JP (1) JP2013544510A (enExample)
CN (1) CN103282372A (enExample)
AU (1) AU2011322106A1 (enExample)
CA (1) CA2815632A1 (enExample)
IL (1) IL226038A0 (enExample)
WO (2) WO2012056441A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190120207A (ko) * 2017-02-20 2019-10-23 아레나-바이오 지비알 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500011A (ja) 2006-08-08 2010-01-07 ガンサー ハートマン ５’リン酸オリゴヌクレオチドの構造および使用
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2017171654A1 (en) * 2016-04-01 2017-10-05 National University Of Singapore Trans-splicing rna (tsrna)
WO2022182697A1 (en) * 2021-02-23 2022-09-01 Board Of Regents, The University Of Texas System A novel rna-based approach to cancer treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080214488A1 (en) * 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
US20090234109A1 (en) * 2007-12-10 2009-09-17 Si-Ping Han Signal activated RNA interference

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
EP0883344B2 (en) * 1995-12-15 2010-06-09 VIRxSYS Corporation Therapeutic molecules generated by trans-splicing
EP1147188B1 (en) * 1999-01-26 2007-05-16 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Internal ribosome entry site (ires), vector containing same and the uses thereof
WO2004050680A2 (en) * 2002-05-08 2004-06-17 Intronn, Inc. Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses
US20030219407A1 (en) * 2002-05-15 2003-11-27 The Regents Of The University Of California RNA silencing in animals as an antiviral defense
AU2003247696A1 (en) * 2002-07-01 2004-01-19 E.I. Du Pont De Nemours And Company Method of controlling gene silencing using site-specific recombination
EP2000160A3 (en) * 2002-10-30 2009-03-11 Gambro Lundia AB Method and apparatuses for determining the efficiency of dialysis
EP2305813A3 (en) * 2002-11-14 2012-03-28 Dharmacon, Inc. Fuctional and hyperfunctional sirna
WO2005112620A2 (en) * 2004-05-18 2005-12-01 Massachusetts Institute Of Technology A cre-lox based method for conditional rna interference
EP1799825B1 (en) * 2004-10-05 2011-06-29 The California Institute of Technology Aptamer regulated nucleic acids and uses thereof
JP5053850B2 (ja) * 2004-10-08 2012-10-24 バークシス コーポレーション 抗体遺伝子導入および抗体ポリペプチド産生のためのｒｎａトランススプライシングの使用
CN101184840A (zh) * 2005-03-31 2008-05-21 卡兰朵医药公司 核糖核苷酸还原酶亚基2的抑制剂及其用途
PL1866414T3 (pl) * 2005-03-31 2012-10-31 Calando Pharmaceuticals Inc Inhibitory podjednostki 2 reduktazy rybonukleotydowej i ich zastosowania
WO2007149246A2 (en) * 2006-06-12 2007-12-27 Massachusetts Institute Of Technology Cre-lox based gene knockdown constructs and methods of use thereof
US8158595B2 (en) * 2006-11-09 2012-04-17 California Institute Of Technology Modular aptamer-regulated ribozymes
US8367815B2 (en) * 2007-08-28 2013-02-05 California Institute Of Technology Modular polynucleotides for ligand-controlled regulatory systems

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080214488A1 (en) * 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
US20090234109A1 (en) * 2007-12-10 2009-09-17 Si-Ping Han Signal activated RNA interference

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARAGUCHI, TAKESHI ET AL.: ""Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA acti", NUCLEIC ACIDS RES., vol. 37, JPN6015041372, 2009, pages 43 - 1, ISSN: 0003175230 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190120207A (ko) * 2017-02-20 2019-10-23 아레나-바이오 지비알 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법
JP2020513194A (ja) * 2017-02-20 2020-05-07 アレーナービオ ゲーベーエル 真核生物におけるｒｎａ分子の細胞型特異的な翻訳に関する系及び方法
JP7153033B2 (ja) 2017-02-20 2022-10-13 アレーナ ビオテック ゲーエムベーハー 真核生物におけるｒｎａ分子の細胞型特異的な翻訳に関する系及び方法
KR102696359B1 (ko) 2017-02-20 2024-08-19 아레나 바이오테크 게엠베하 진핵생물에서 rna 분자의 세포형-특이적 번역을 위한 시스템 및 방법

Also Published As

Publication number Publication date
EP2632931A2 (en) 2013-09-04
WO2012056449A2 (en) 2012-05-03
WO2012056441A1 (en) 2012-05-03
CA2815632A1 (en) 2012-05-03
US20130225660A1 (en) 2013-08-29
IL226038A0 (en) 2013-06-27
WO2012056449A3 (en) 2012-07-19
EP2632931A4 (en) 2014-06-18
AU2011322106A1 (en) 2013-05-30
CN103282372A (zh) 2013-09-04

Similar Documents

Publication Publication Date Title
US20130245096A1 (en) COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA
JP2023126888A (ja) 環状ポリリボヌクレオチドを含む組成物及びその使用
JP2022081503A (ja) ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
DK1798285T3 (en) Method and drug for inhibiting the expression of a given gene
ES2969371T3 (es) Interferencia por ARN para el tratamiento de trastornos de ganancia de función
CN101307085B (zh) 抑制铁调素调节蛋白的siRNA、重组慢病毒及其应用
US20060228800A1 (en) Novel Transgenic Methods Using intronic RNA
CN109312338A (zh) 治疗单纯疱疹病毒的crispr/cas相关方法及组合物
US20130225660A1 (en) Compositions and methods for specific cleavage of exogenous rna in a cell
AU2016304795A1 (en) Engineered CRISPR-Cas9 compositions and methods of use
US12570977B2 (en) mRNA composition and production method for use in anti-viral and anti-cancer vaccines
EP2488641A2 (en) Supercoiled minicircle dna for gene therapy applications
US20250049960A1 (en) Multicomponent systems for site-specific genome modifications
TWI382849B (zh) 產生藉由基因靜默效應以用於皮膚維護之化妝品的方法以及編碼基因靜默效應物之基因重組核苷酸
CN121464217A (zh) 用于治疗KIF1A相关神经紊乱的靶向KIF1A错义突变的RNAi
JP7364198B2 (ja) ｉＰＳ細胞の生成に使用される新規ＲＮＡ組成物およびその製造方法
US20130085173A1 (en) Supercoiled minicircle dna for gene therapy applications
US20240117350A1 (en) Use of mirna-485 inhibitor to regulate psd95, synaptophysin, and caspase-3 expression
WO2024201420A1 (en) Mirna-484 inhibitors and uses thereof
Meganck Engineering Elements for Improved RNA Stability

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141024

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141024

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151020

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160315