CA2815632A1 - Compositions and methods for specific cleavage of exogenous rna in a cell - Google Patents

Compositions and methods for specific cleavage of exogenous rna in a cell Download PDF

Info

Publication number
CA2815632A1
CA2815632A1 CA2815632A CA2815632A CA2815632A1 CA 2815632 A1 CA2815632 A1 CA 2815632A1 CA 2815632 A CA2815632 A CA 2815632A CA 2815632 A CA2815632 A CA 2815632A CA 2815632 A1 CA2815632 A1 CA 2815632A1
Authority
CA
Canada
Prior art keywords
sequence
rna
interest
nucleotides
exogenous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2815632A
Other languages
English (en)
French (fr)
Inventor
Guy Abitbol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NANODOC Ltd
Original Assignee
NANODOC Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NANODOC Ltd filed Critical NANODOC Ltd
Publication of CA2815632A1 publication Critical patent/CA2815632A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2815632A 2010-10-28 2011-10-27 Compositions and methods for specific cleavage of exogenous rna in a cell Abandoned CA2815632A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IL2010/000895 WO2012056441A1 (en) 2010-10-28 2010-10-28 Compositions and methods for specific cleavage of exogenous rna in a cell
ILPCT/IL2010/000895 2010-10-28
PCT/IL2011/000827 WO2012056449A2 (en) 2010-10-28 2011-10-27 Compositions and methods for specific cleavage of exogenous rna in a cell

Publications (1)

Publication Number Publication Date
CA2815632A1 true CA2815632A1 (en) 2012-05-03

Family

ID=45993240

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2815632A Abandoned CA2815632A1 (en) 2010-10-28 2011-10-27 Compositions and methods for specific cleavage of exogenous rna in a cell

Country Status (7)

Country Link
US (1) US20130225660A1 (enExample)
EP (1) EP2632931A4 (enExample)
JP (1) JP2013544510A (enExample)
CN (1) CN103282372A (enExample)
AU (1) AU2011322106A1 (enExample)
CA (1) CA2815632A1 (enExample)
WO (2) WO2012056441A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2056845T3 (da) 2006-08-08 2017-11-27 Rheinische Friedrich-Wilhelms-Universität Bonn Struktur og anvendelse af 5'-phosphat-oligonukleotider
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
JP7229467B2 (ja) * 2016-04-01 2023-02-28 ナショナル ユニバーシティ オブ シンガポール トランス－スプライシングＲＮＡ（ｔｓＲＮＡ）
DE102017103383A1 (de) * 2017-02-20 2018-08-23 aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten
WO2022182697A1 (en) * 2021-02-23 2022-09-01 Board Of Regents, The University Of Texas System A novel rna-based approach to cancer treatment

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
AU730305B2 (en) * 1995-12-15 2001-03-01 Intronn Llc Therapeutic molecules generated by trans-splicing
WO2000044896A1 (en) * 1999-01-26 2000-08-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Internal ribosome entry site (ires), vector containing same and uses thereof
AU2003302216A1 (en) * 2002-05-08 2004-06-23 Virxsys Corporation Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses
US20030219407A1 (en) * 2002-05-15 2003-11-27 The Regents Of The University Of California RNA silencing in animals as an antiviral defense
US7267979B2 (en) * 2002-07-01 2007-09-11 Pioneer Hi-Bred International, Inc. Method of controlling gene silencing using site specific recombination
EP2000160A3 (en) * 2002-10-30 2009-03-11 Gambro Lundia AB Method and apparatuses for determining the efficiency of dialysis
EP1560931B1 (en) * 2002-11-14 2011-07-27 Dharmacon, Inc. Functional and hyperfunctional sirna
WO2005112620A2 (en) * 2004-05-18 2005-12-01 Massachusetts Institute Of Technology A cre-lox based method for conditional rna interference
JP5101288B2 (ja) * 2004-10-05 2012-12-19 カリフォルニア インスティテュート オブ テクノロジー アプタマー調節される核酸及びその利用
CA2583306A1 (en) * 2004-10-08 2006-08-10 Intronn, Inc. Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production
ATE541928T1 (de) * 2005-03-31 2012-02-15 Calando Pharmaceuticals Inc Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen
CN101184840A (zh) * 2005-03-31 2008-05-21 卡兰朵医药公司 核糖核苷酸还原酶亚基2的抑制剂及其用途
WO2007149246A2 (en) * 2006-06-12 2007-12-27 Massachusetts Institute Of Technology Cre-lox based gene knockdown constructs and methods of use thereof
WO2008058291A2 (en) * 2006-11-09 2008-05-15 California Institute Of Technology Modular aptamer-regulated ribozymes
US8318921B2 (en) * 2007-03-01 2012-11-27 California Institute Of Technology Triggered RNAi
US8367815B2 (en) * 2007-08-28 2013-02-05 California Institute Of Technology Modular polynucleotides for ligand-controlled regulatory systems
US9029524B2 (en) * 2007-12-10 2015-05-12 California Institute Of Technology Signal activated RNA interference

Also Published As

Publication number Publication date
WO2012056449A2 (en) 2012-05-03
EP2632931A4 (en) 2014-06-18
JP2013544510A (ja) 2013-12-19
WO2012056441A1 (en) 2012-05-03
US20130225660A1 (en) 2013-08-29
AU2011322106A1 (en) 2013-05-30
WO2012056449A3 (en) 2012-07-19
CN103282372A (zh) 2013-09-04
EP2632931A2 (en) 2013-09-04

Similar Documents

Publication Publication Date Title
US20130245096A1 (en) COMPOSITIONS AND METHODS FOR ACTIVATING EXPRESSION BY A SPECIFIC ENDOGENOUS miRNA
ES2969371T3 (es) Interferencia por ARN para el tratamiento de trastornos de ganancia de función
JP5986928B2 (ja) 遺伝子発現の特異的阻害のためのダイサー基質剤及び方法
CA2524569C (en) A method of regulating gene expression
CN101307085B (zh) 抑制铁调素调节蛋白的siRNA、重组慢病毒及其应用
US20130225660A1 (en) Compositions and methods for specific cleavage of exogenous rna in a cell
US8486910B2 (en) SnoRNAi-small nucleolar RNA degradation by RNA interference in trypanosomatids
CN107177591A (zh) 利用CRISPR技术编辑CCR5基因的sgRNA序列及其用途
KR20190129903A (ko) 압타머-조정된 RNase P 절단에 의한 유전자 발현의 조절
AU2012322521A1 (en) Targeting of miRNA precursors
US20240117350A1 (en) Use of mirna-485 inhibitor to regulate psd95, synaptophysin, and caspase-3 expression
US20130085173A1 (en) Supercoiled minicircle dna for gene therapy applications
US12365900B2 (en) miRNA switches for RNA-triggered control of RNA interference
US20230119699A1 (en) Diagnostic methods using sirt1 expression
WO2024201420A1 (en) Mirna-484 inhibitors and uses thereof
Meganck Engineering Elements for Improved RNA Stability
WO2024228118A1 (en) Mirna-485 inhibitors
CN119604617A (zh) 无帽无尾治疗性外源性mRNA及其生产方法
EP4118435A1 (en) Diagnostic methods using pgc-1? expression
Elmén Nucleic acid based therapeutic approaches

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20161027