JP2006523103A5 - - Google Patents
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- Publication number
- JP2006523103A5 JP2006523103A5 JP2006508809A JP2006508809A JP2006523103A5 JP 2006523103 A5 JP2006523103 A5 JP 2006523103A5 JP 2006508809 A JP2006508809 A JP 2006508809A JP 2006508809 A JP2006508809 A JP 2006508809A JP 2006523103 A5 JP2006523103 A5 JP 2006523103A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sequence
- isolated nucleic
- sense
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 69
- 102000039446 nucleic acids Human genes 0.000 claims 43
- 108020004707 nucleic acids Proteins 0.000 claims 43
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 24
- 102000053642 Catalytic RNA Human genes 0.000 claims 13
- 108090000994 Catalytic RNA Proteins 0.000 claims 13
- 230000000692 anti-sense effect Effects 0.000 claims 13
- 108091092562 ribozyme Proteins 0.000 claims 13
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 3
- 230000035897 transcription Effects 0.000 claims 3
- 238000013518 transcription Methods 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102100040487 Keratin, type I cytoskeletal 13 Human genes 0.000 claims 1
- 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 claims 1
- 108010065070 Keratin-13 Proteins 0.000 claims 1
- 108010070507 Keratin-7 Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 101000930477 Mus musculus Albumin Proteins 0.000 claims 1
- 102000009572 RNA Polymerase II Human genes 0.000 claims 1
- 108010009460 RNA Polymerase II Proteins 0.000 claims 1
- 102000014450 RNA Polymerase III Human genes 0.000 claims 1
- 108010078067 RNA Polymerase III Proteins 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 101710087237 Whey acidic protein Proteins 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108010042121 probasin Proteins 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44906603P | 2003-02-21 | 2003-02-21 | |
| PCT/US2004/005400 WO2005017127A2 (en) | 2003-02-21 | 2004-02-23 | Rna interference compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523103A JP2006523103A (ja) | 2006-10-12 |
| JP2006523103A5 true JP2006523103A5 (enExample) | 2007-04-12 |
Family
ID=34192976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508809A Pending JP2006523103A (ja) | 2003-02-21 | 2004-02-23 | Ｒｎａ干渉組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060269530A1 (enExample) |
| EP (1) | EP1611231A4 (enExample) |
| JP (1) | JP2006523103A (enExample) |
| AU (1) | AU2004265550A1 (enExample) |
| CA (1) | CA2516425A1 (enExample) |
| WO (1) | WO2005017127A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005537028A (ja) * | 2002-06-26 | 2005-12-08 | ザ ペン ステート リサーチ ファウンデーション | ヒト乳頭腫ウイルス感染症を治療する方法及び材料 |
| WO2016077687A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| WO2016077689A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| WO2016130943A1 (en) | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Hybrid oligonucleotides and uses thereof |
| EP3368089B1 (en) | 2015-10-26 | 2025-11-05 | Translate Bio Ma, Inc. | Nanoparticle formulations for delivery of nucleic acid complexes |
| BR112018073472A2 (pt) | 2016-05-18 | 2019-08-27 | Voyager Therapeutics Inc | composições e métodos de tratamento da doença de huntington |
| CA3024448C (en) | 2016-05-18 | 2025-09-09 | Voyager Therapeutics, Inc. | MODULATING POLYNUCLEOTIDES |
| WO2018204786A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| SG11201909868YA (en) | 2017-05-05 | 2019-11-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| SG11201909777YA (en) * | 2017-05-05 | 2019-11-28 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| WO2019079240A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| EP4454654A3 (en) | 2017-10-16 | 2025-02-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5500357A (en) * | 1990-11-02 | 1996-03-19 | Agency Of Industrial Science & Technology, Ministry Of International Trade & Industry | RNA transcription system using novel ribozyme |
| US5824519A (en) * | 1995-11-08 | 1998-10-20 | Medical University Of South Carolina | Tissue-specific and target RNA-specific ribozymes |
| US6013447A (en) * | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| EP1068350B1 (en) * | 1998-03-28 | 2008-02-13 | University Of Utah Research Foundation | Directed antisense libraries |
| US6458559B1 (en) * | 1998-04-22 | 2002-10-01 | Cornell Research Foundation, Inc. | Multivalent RNA aptamers and their expression in multicellular organisms |
| WO2000009673A1 (en) * | 1998-08-13 | 2000-02-24 | Johnson & Johnson Research Pty. Limited | Dnazymes and methods for treating hpv-related disorders |
| EP2314700A1 (en) * | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| US6271359B1 (en) * | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
| KR100909681B1 (ko) * | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자 |
| JP2004532616A (ja) * | 2000-12-28 | 2004-10-28 | ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド | 二本鎖ｒｎａ仲介遺伝子抑制 |
| AU2002343792A1 (en) * | 2001-11-28 | 2003-06-10 | Center For Advanced Science And Technology Incubation, Ltd. | siRNA EXPRESSION SYSTEM AND PROCESS FOR PRODUCING FUNCTIONAL GENE-KNOCKDOWN CELLS AND THE LIKE USING THE SAME |
| US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| JP2005537028A (ja) * | 2002-06-26 | 2005-12-08 | ザ ペン ステート リサーチ ファウンデーション | ヒト乳頭腫ウイルス感染症を治療する方法及び材料 |
| WO2004011624A2 (en) * | 2002-07-31 | 2004-02-05 | Nucleonics, Inc. | Double stranded rna structures and constructs, and methods for generating and using the same |
| AU2003264727A1 (en) * | 2002-09-04 | 2004-03-29 | Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Compositions and methods for tissue specific or inducible inhibition of gene expression |
-
2004
- 2004-02-23 EP EP04775796A patent/EP1611231A4/en not_active Withdrawn
- 2004-02-23 AU AU2004265550A patent/AU2004265550A1/en not_active Abandoned
- 2004-02-23 US US10/552,914 patent/US20060269530A1/en not_active Abandoned
- 2004-02-23 JP JP2006508809A patent/JP2006523103A/ja active Pending
- 2004-02-23 WO PCT/US2004/005400 patent/WO2005017127A2/en not_active Ceased
- 2004-02-23 CA CA002516425A patent/CA2516425A1/en not_active Abandoned
-
2009
- 2009-10-13 US US12/578,035 patent/US20100036107A1/en not_active Abandoned
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