JP2013544288A5 - - Google Patents

Download PDF

Info

Publication number
JP2013544288A5
JP2013544288A5 JP2013542199A JP2013542199A JP2013544288A5 JP 2013544288 A5 JP2013544288 A5 JP 2013544288A5 JP 2013542199 A JP2013542199 A JP 2013542199A JP 2013542199 A JP2013542199 A JP 2013542199A JP 2013544288 A5 JP2013544288 A5 JP 2013544288A5
Authority
JP
Japan
Prior art keywords
virus
viral
liquid
preparation
viral composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013542199A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013544288A (ja
JP6034797B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/063037 external-priority patent/WO2012075376A2/en
Publication of JP2013544288A publication Critical patent/JP2013544288A/ja
Publication of JP2013544288A5 publication Critical patent/JP2013544288A5/ja
Application granted granted Critical
Publication of JP6034797B2 publication Critical patent/JP6034797B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013542199A 2010-12-02 2011-12-02 凍結乾燥されたウイルス製剤 Active JP6034797B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41902010P 2010-12-02 2010-12-02
US61/419,020 2010-12-02
PCT/US2011/063037 WO2012075376A2 (en) 2010-12-02 2011-12-02 Lyophilized viral formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016170628A Division JP6433954B2 (ja) 2010-12-02 2016-09-01 凍結乾燥されたウイルス製剤

Publications (3)

Publication Number Publication Date
JP2013544288A JP2013544288A (ja) 2013-12-12
JP2013544288A5 true JP2013544288A5 (enExample) 2015-01-22
JP6034797B2 JP6034797B2 (ja) 2016-11-30

Family

ID=46162458

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2013542199A Active JP6034797B2 (ja) 2010-12-02 2011-12-02 凍結乾燥されたウイルス製剤
JP2016170628A Active JP6433954B2 (ja) 2010-12-02 2016-09-01 凍結乾燥されたウイルス製剤
JP2018153546A Withdrawn JP2018172443A (ja) 2010-12-02 2018-08-17 凍結乾燥されたウイルス製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016170628A Active JP6433954B2 (ja) 2010-12-02 2016-09-01 凍結乾燥されたウイルス製剤
JP2018153546A Withdrawn JP2018172443A (ja) 2010-12-02 2018-08-17 凍結乾燥されたウイルス製剤

Country Status (15)

Country Link
US (2) US9044498B2 (enExample)
EP (1) EP2646052B1 (enExample)
JP (3) JP6034797B2 (enExample)
KR (1) KR102023207B1 (enExample)
CN (1) CN103269716B (enExample)
AU (1) AU2011336410B2 (enExample)
CA (1) CA2819236A1 (enExample)
DK (1) DK2646052T3 (enExample)
EA (1) EA201390812A1 (enExample)
ES (1) ES2630012T3 (enExample)
IL (1) IL226646B (enExample)
MX (1) MX349294B (enExample)
SG (1) SG190419A1 (enExample)
TW (1) TW201233803A (enExample)
WO (1) WO2012075376A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2132315B1 (en) 2007-03-12 2015-07-15 Oncolytics Biotech Inc. Reoviruses having modified sequences
SG190419A1 (en) 2010-12-02 2013-06-28 Oncolytics Biotech Inc Lyophilized viral formulations
EP2646051A4 (en) * 2010-12-02 2014-05-28 Oncolytics Biotech Inc FORMULATIONS OF LIQUID VIRUSES
CN103492557B (zh) * 2011-04-29 2015-07-29 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法
US11273127B2 (en) 2014-05-06 2022-03-15 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for thermally stable multi-targeted antigens
GB201513010D0 (en) 2015-07-23 2015-09-09 Glaxosmithkline Biolog Sa Novel formulation
RU2769196C2 (ru) * 2016-11-04 2022-03-29 Такеда Фармасьютикал Компани Лимитед Составы с аденоассоциированным вирусом
SG11202003408TA (en) * 2017-10-16 2020-05-28 Serum Institute Of India Pvt Ltd Stable vaccine compositions comprising inter alia live attenuated recombinant flavivirus and process for preparation thereof
CN110279693B (zh) * 2019-07-25 2021-06-15 军事科学院军事医学研究院微生物流行病研究所 一种组合物在制备预防和/或治疗发热伴血小板减少综合征病毒的药物中的应用
CN112107678B (zh) * 2020-09-30 2022-11-18 辰欣药业股份有限公司 一种含有胸腺法新的冻干组合物及其制备方法
CN116270500B (zh) * 2021-12-30 2025-05-06 安徽贝金基因科技有限公司 一种高稳定性的溶瘤病毒组合物及其制备方法和其应用

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5626851A (en) 1987-11-30 1997-05-06 The Wistar Institute Of Anatomy And Biology Rotavirus reassortant vaccine
US5096885A (en) 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
ES2097120T3 (es) 1989-07-24 1997-04-01 Bayer Ag Estabilizacion de proteinas altamente purificadas.
PT713397E (pt) 1992-03-24 2003-04-30 United Cancer Res Inst Vacina que contem virus vivos
AU2088992A (en) * 1992-05-05 1993-11-11 Research Foundation For Microbial Diseases Of Osaka University, The Stabilized live vaccine
AU7971194A (en) 1993-10-12 1995-05-04 Chiron Corporation Methods for preserving recombinant viruses
CN1152935A (zh) 1994-05-16 1997-06-25 麦克公司 乳头状瘤病毒疫苗
US7150984B2 (en) 1994-07-11 2006-12-19 The United States Of America As Represented By The Department Of Health And Human Services Attenuated human rotavirus vaccine
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
DK2275119T3 (da) 1995-07-27 2013-11-11 Genentech Inc Stabil, isotonisk lyofiliseret proteinformulering
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
GB9521806D0 (en) 1995-10-25 1996-01-03 Cortecs Ltd Preservation methods
US6165773A (en) 1995-10-25 2000-12-26 Provalis Uk Limited Methods of preserving viruses
FR2742756B1 (fr) 1995-12-22 1998-04-03 Pasteur Merieux Serums Vacc Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation
FR2751343B1 (fr) * 1996-07-16 1998-12-18 Transgene Sa Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament
ATE377428T1 (de) 1996-09-26 2007-11-15 Merck & Co Inc Rotavirus-impfstoff
US6616931B1 (en) 1996-09-26 2003-09-09 Merck & Co., Inc. Rotavirus vaccine formulations
US5932223A (en) * 1996-09-26 1999-08-03 Merck & Co., Inc. Rotavirus vaccine formulations
US6403098B1 (en) 1996-09-26 2002-06-11 Merck & Co., Inc. Rotavirus vaccine formulations
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US6544769B1 (en) 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
US20080261289A1 (en) 1996-12-13 2008-10-23 Schering-Plough Corporation Compositions comprising viruses and methods for concentrating virus preparations
US6290967B1 (en) 1996-12-20 2001-09-18 Merck & Co., Inc. Stabilizers for lyophilized vaccines
EP0946193A1 (en) 1996-12-20 1999-10-06 Merck & Co., Inc. Stabilizers for lyophilized vaccines
US6051238A (en) 1996-12-20 2000-04-18 Merck & Co., Inc. Stabilizers for lyophilized mumps vaccines
JP4358434B2 (ja) 1998-02-17 2009-11-04 シェーリング コーポレイション ウイルスを含む組成物、およびウイルス調製物を濃縮するための方法
GB9808922D0 (en) * 1998-04-24 1998-06-24 Cantab Pharmaceuticals Res Ltd Virus preparations
JP4414095B2 (ja) 1998-07-28 2010-02-10 アメリカ合衆国 多価ヒト−ウシ・ロタウイルス・ワクチン
CN1062770C (zh) * 1998-11-12 2001-03-07 卫生部长春生物制品研究所 甲肝-麻疹二联疫苗及其生产方法
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
EP1133316B1 (en) 1998-11-16 2009-01-21 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
EP1165132B1 (en) 1999-04-08 2011-10-19 Intercell USA, Inc. Dry formulation for transcutaneous immunization
US6541001B1 (en) 1999-08-24 2003-04-01 Teva Pharmaceutical Industries, Ltd. Vaccine composition and method of using the same
US6592869B2 (en) 1999-08-24 2003-07-15 Teva Pharmaceutical Industries, Ltd. Vaccine composition and method of using the same
EP1223915B1 (en) 1999-10-29 2005-12-21 Nektar Therapeutics Dry powder compositions having improved dispersivity
WO2001066137A1 (en) 2000-03-07 2001-09-13 Merck & Co., Inc. Adenovirus formulations
US7456009B2 (en) * 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
EP1289494A2 (en) 2000-06-08 2003-03-12 Powderject Vaccines, Inc. Powder compositions
US20020120228A1 (en) 2000-06-08 2002-08-29 Yuh-Fun Maa Powder compositions
TWI289158B (en) 2000-08-10 2007-11-01 Oncolytics Biotech Inc Method of producing infectious reovirus
GB0020089D0 (en) 2000-08-15 2000-10-04 Smithkline Beecham Biolog Vaccine Composition
DE60139026D1 (de) 2000-09-25 2009-07-30 Polymun Scient Immunbio Forsch Lebender influenza impfstoff und verfahren zu seiner herstellung
US20040033239A1 (en) 2001-03-06 2004-02-19 Evans Robert K Adenovirus formulations
EP1370643A1 (en) 2001-03-16 2003-12-17 Oncolytics Biotech, Inc. Method of extracting virus from cell culture
EP1399131A2 (en) 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Spray freeze-dried compositions
GB0124710D0 (en) 2001-10-15 2001-12-05 Quadrant Healthcare Uk Ltd Therapeutic composition
MXPA04004730A (es) 2001-11-19 2004-07-30 Becton Dickinson Co Composiciones farmaceuticas en forma particulada.
EP1453537A1 (en) 2001-12-12 2004-09-08 FH Faulding & Co. Limited Composition for viral preservation
US20030153065A1 (en) 2002-01-14 2003-08-14 Genvec, Inc. Composition and method for maintaining non-enveloped viral vectors
PL371261A1 (en) 2002-01-18 2005-06-13 Schering Aktiengesellschaft Stabilized formulations of adenovirus
AU2003234090A1 (en) 2002-04-11 2003-10-27 Medimmune Vaccines, Inc. Spray freeze dry of compositions for pulmonary administration
AU2003230908A1 (en) 2002-04-11 2003-10-27 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration
CA2482448C (en) 2002-04-11 2014-07-08 Medimmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam
DK1501921T4 (da) 2002-04-30 2012-10-08 Oncolytics Biotech Inc Forbedrede virusrensningsmetoder
CA2503946C (en) 2002-11-01 2016-08-16 Glaxosmithkline Biologicals S.A. Drying process
US6752740B2 (en) 2002-11-12 2004-06-22 Jeffery T. Semmes Continuously variable transmission
CN1745170A (zh) 2002-12-17 2006-03-08 米迪缪尼疫苗股份有限公司 生物活性材料的高压喷雾干燥
US6931888B2 (en) 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
CA2522379C (en) 2003-04-10 2012-10-23 Chiron Corporation The severe acute respiratory syndrome coronavirus
BRPI0414073A (pt) * 2003-09-02 2006-10-24 Glaxosmithkline Biolog Sa método para induzir uma resposta imune contra infecção por rotavìrus a partir de um sorotipo de rotavìrus, e, uso de uma cepa de rotavìrus atenuado de um sorotipo
WO2005052116A2 (en) 2003-11-19 2005-06-09 Merck & Co., Inc. Preservative-containing virus formulations
ES2536322T3 (es) 2003-12-17 2015-05-22 Wyeth Llc Procedimiento para producir composiciones de VSR estables en almacenamiento
WO2005066333A1 (en) 2003-12-30 2005-07-21 Aventis Pasteur, Inc. Stabilizing compositions for recombinant viruses
GB0404586D0 (en) 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
BRPI0509117A (pt) 2004-03-04 2007-08-28 Wyeth Corp método de liofilização para melhorar a cristalização de excipientes
AU2005249530B2 (en) 2004-06-02 2012-04-12 Victor Bronshtein Preservation by vaporization
WO2006029467A1 (en) 2004-09-16 2006-03-23 Btf Pty Ltd Rapid freeze drying process
US20060067943A1 (en) 2004-09-28 2006-03-30 Yuh-Fun Maa Stabilization of alum-adjuvanted immunologically active agents
US7901921B2 (en) 2004-10-22 2011-03-08 Oncolytics Biotech Inc. Viral purification methods
US7914979B2 (en) * 2004-11-05 2011-03-29 Wellstat Biologics Corporation Stable and filterable enveloped virus formulations
GB2437385B (en) 2004-12-09 2009-08-05 Precimed Sa Surgical tool holder for facilitated sterilization
US20060141483A1 (en) * 2004-12-23 2006-06-29 Calton Gary J Stabilization of viral compositions
EP1853250B1 (en) 2005-02-18 2011-11-02 Abraxis BioScience, LLC Combinations and modes of administration of therapeutic agents and combination therapy
PT1954308E (pt) * 2005-09-16 2011-11-03 Merial Ltd Estabilizadores para vacinas liofilizadas
CN1765181A (zh) 2005-10-19 2006-05-03 路兴波 高效抗病毒制剂
ES2377356T3 (es) 2006-04-20 2012-03-26 Wyeth Llc Procedimiento de purificación para el aislamiento del virus purificado de la estomatitis vesicular de un cultivo celular
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
EP1854478A1 (en) 2006-05-12 2007-11-14 Cytos Biotechnology AG Nicotine-carrier vaccine formulation
EP1878791A1 (en) 2006-07-11 2008-01-16 Bia Separations D.O.O. Method for influenza virus purification
WO2008018411A1 (en) 2006-08-07 2008-02-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Method for production of live smallpox vaccine
EP2066350A4 (en) 2006-09-25 2010-04-07 Medimmune Llc STABILIZED ANTIBODY FORMULATIONS AND THEIR USES
CA2668417A1 (en) 2006-11-03 2008-05-15 Alphavax, Inc. Alphavirus and alphavirus replicon particle formulations and methods
MX2009004862A (es) 2006-11-07 2009-07-17 Sanofi Pasteur Biologics Co Estabilizacion de vacunas por liofilizacion.
AU2007343130C1 (en) 2006-12-27 2017-11-09 Zoetis Services Llc Methods of vaccine administration
US20080299182A1 (en) 2007-03-01 2008-12-04 Shuyuan Zhang Methods and formulations for topical gene therapy
EP2132315B1 (en) * 2007-03-12 2015-07-15 Oncolytics Biotech Inc. Reoviruses having modified sequences
GB0705245D0 (en) 2007-03-19 2007-04-25 Stabilitech Ltd Stable biological products
WO2008118691A2 (en) * 2007-03-22 2008-10-02 The Regents Of The University Of Colorado Method of preparing an immunologically-active adjuvant-bound dried vaccine composition
SG10201913741YA (en) 2007-04-06 2020-03-30 Takeda Vaccines Inc Methods and compositions for live attenuated viruses
TW200909581A (en) 2007-05-21 2009-03-01 Oncolytics Biotech Inc Mutant reoviruses and methods of making and using
US8241886B2 (en) * 2007-09-25 2012-08-14 Aridis Pharmaceuticals Formulations for preservation of rotavirus
CA2702083C (en) 2007-10-12 2021-11-30 Massachusetts Institute Of Technology Vaccine nanotechnology
WO2009056651A1 (en) 2007-11-02 2009-05-07 Cytos Biotechnology Ag Angiotensin-carrier formulation
JP4932940B2 (ja) 2007-11-12 2012-05-16 セラクローン サイエンシーズ， インコーポレイテッド インフルエンザの治療および診断のための組成物および方法
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
JP2011514337A (ja) * 2008-02-25 2011-05-06 ノババックス，インコーポレイテッド 糖ガラス化ウィルス様粒子（ｖｌｐ）
LT2805731T (lt) * 2009-09-03 2019-02-11 Ablynx N.V. Stabilios polipeptidų kompozicijos ir jų panaudojimas
EP2646051A4 (en) * 2010-12-02 2014-05-28 Oncolytics Biotech Inc FORMULATIONS OF LIQUID VIRUSES
SG190419A1 (en) 2010-12-02 2013-06-28 Oncolytics Biotech Inc Lyophilized viral formulations
CN103492557B (zh) * 2011-04-29 2015-07-29 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法
JP6065096B2 (ja) 2015-12-25 2017-01-25 ダイキン工業株式会社 調湿装置

Similar Documents

Publication Publication Date Title
JP2013544288A5 (enExample)
JP2014502275A5 (enExample)
ES2676656T3 (es) Composición estabilizante de almacenamiento en seco para materiales biológicos
CN102727903B (zh) 一种高致病性猪繁殖与呼吸综合征活疫苗jxa1-r株耐热冻干保护剂及制备方法
JP4902103B2 (ja) 凍結乾燥フォームによる生物活性材料の保存
KR101557169B1 (ko) 냉동 건조 발포체에 의한 생활성 물질의 보존
CN103041383B (zh) 一种活疫苗的耐热冻干保护剂、活疫苗冻干粉及其制备方法
TWI812650B (zh) 包含特別是減毒活重組黃病毒的穩定疫苗組成物以及製備其的製程
JP4138314B2 (ja) ロタウイルスワクチン調合物
US20110177119A1 (en) Stable, dried rotavirus vaccine, compositions and process for preparation thereof
EP2143440A1 (fr) Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués
CN103041399B (zh) 一种耐热保护剂及其应用
JP6034797B2 (ja) 凍結乾燥されたウイルス製剤
JP2012531442A5 (enExample)
CN102727904A (zh) 一种高致病性猪繁殖与呼吸综合征-伪狂犬病二联活疫苗耐热保护剂及制备方法
CN106794145A (zh) 热稳定冻干轮状病毒疫苗制剂及其制备方法
US10806781B2 (en) Compositions and methods for live, attenuated alphavirus formulations
CN106063933A (zh) 通用疫苗冻干保护剂及其应用
JP2017510585A5 (enExample)
WO2019028976A1 (zh) 耐热保护剂、猪瘟可室温保存活疫苗及其制备方法和应用
CN103893776B (zh) 羊传染性脓疱病毒细胞弱毒疫苗耐热冻干保护剂及其制备方法和应用
CN114767842A (zh) 一种重组卡介苗的冻干制剂及其制备方法和用途
HK1236813A1 (en) A thermostable freeze dried rotavirus vaccine formulation and process to prepare thereof
EA046342B1 (ru) Стабильные составы вакцин, включающих, в частности, живой аттенуированный рекомбинантный флавивирус и процесс их приготовления