JP2013544288A5 - - Google Patents

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JP2013544288A5
JP2013544288A5 JP2013542199A JP2013542199A JP2013544288A5 JP 2013544288 A5 JP2013544288 A5 JP 2013544288A5 JP 2013542199 A JP2013542199 A JP 2013542199A JP 2013542199 A JP2013542199 A JP 2013542199A JP 2013544288 A5 JP2013544288 A5 JP 2013544288A5
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Japan
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virus
viral
liquid
preparation
viral composition
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JP2013542199A
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Japanese (ja)
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JP6034797B2 (ja
JP2013544288A (ja
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Priority claimed from PCT/US2011/063037 external-priority patent/WO2012075376A2/en
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Publication of JP2013544288A5 publication Critical patent/JP2013544288A5/ja
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JP2013542199A 2010-12-02 2011-12-02 凍結乾燥されたウイルス製剤 Active JP6034797B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41902010P 2010-12-02 2010-12-02
US61/419,020 2010-12-02
PCT/US2011/063037 WO2012075376A2 (en) 2010-12-02 2011-12-02 Lyophilized viral formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016170628A Division JP6433954B2 (ja) 2010-12-02 2016-09-01 凍結乾燥されたウイルス製剤

Publications (3)

Publication Number Publication Date
JP2013544288A JP2013544288A (ja) 2013-12-12
JP2013544288A5 true JP2013544288A5 (enExample) 2015-01-22
JP6034797B2 JP6034797B2 (ja) 2016-11-30

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JP2013542199A Active JP6034797B2 (ja) 2010-12-02 2011-12-02 凍結乾燥されたウイルス製剤
JP2016170628A Active JP6433954B2 (ja) 2010-12-02 2016-09-01 凍結乾燥されたウイルス製剤
JP2018153546A Withdrawn JP2018172443A (ja) 2010-12-02 2018-08-17 凍結乾燥されたウイルス製剤

Family Applications After (2)

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JP2016170628A Active JP6433954B2 (ja) 2010-12-02 2016-09-01 凍結乾燥されたウイルス製剤
JP2018153546A Withdrawn JP2018172443A (ja) 2010-12-02 2018-08-17 凍結乾燥されたウイルス製剤

Country Status (15)

Country Link
US (2) US9044498B2 (enExample)
EP (1) EP2646052B1 (enExample)
JP (3) JP6034797B2 (enExample)
KR (1) KR102023207B1 (enExample)
CN (1) CN103269716B (enExample)
AU (1) AU2011336410B2 (enExample)
CA (1) CA2819236A1 (enExample)
DK (1) DK2646052T3 (enExample)
EA (1) EA201390812A1 (enExample)
ES (1) ES2630012T3 (enExample)
IL (1) IL226646B (enExample)
MX (1) MX349294B (enExample)
SG (1) SG190419A1 (enExample)
TW (1) TW201233803A (enExample)
WO (1) WO2012075376A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803385B2 (en) * 2007-03-12 2010-09-28 Oncolytics Biotech Inc. Reoviruses having modified sequences
AU2011336413B2 (en) 2010-12-02 2015-01-22 Oncolytics Biotech Inc. Liquid viral formulations
MX349294B (es) * 2010-12-02 2017-07-21 Oncolytics Biotech Inc Formulaciones virales liofilizadas.
CN103492557B (zh) * 2011-04-29 2015-07-29 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法
US11273127B2 (en) 2014-05-06 2022-03-15 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for thermally stable multi-targeted antigens
GB201513010D0 (en) * 2015-07-23 2015-09-09 Glaxosmithkline Biolog Sa Novel formulation
IL266264B2 (en) * 2016-11-04 2023-11-01 Baxalta Inc Adeno-associated virus formulations
CA3079151A1 (en) * 2017-10-16 2019-04-25 Serum Institute Of India Private Limited Stable vaccine compositions comprising inter alia live attenuated recombinant flavivirus and process for preparation thereof
CN110279693B (zh) * 2019-07-25 2021-06-15 军事科学院军事医学研究院微生物流行病研究所 一种组合物在制备预防和/或治疗发热伴血小板减少综合征病毒的药物中的应用
CN112107678B (zh) * 2020-09-30 2022-11-18 辰欣药业股份有限公司 一种含有胸腺法新的冻干组合物及其制备方法
CN116270500B (zh) * 2021-12-30 2025-05-06 安徽贝金基因科技有限公司 一种高稳定性的溶瘤病毒组合物及其制备方法和其应用

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5626851A (en) 1987-11-30 1997-05-06 The Wistar Institute Of Anatomy And Biology Rotavirus reassortant vaccine
US5096885A (en) 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
ATE148165T1 (de) 1989-07-24 1997-02-15 Bayer Ag Stabilisierung von hochgereinigten proteinen
EP0713397B1 (en) 1992-03-24 2002-12-11 United Cancer Research Institute Vaccine containing live virus
CA2075521C (en) 1992-05-05 1995-11-28 Kuniaki Koyama Stabilized live vaccine
JPH09504429A (ja) 1993-10-12 1997-05-06 チロン ビアジーン,インコーポレイティド 組換えウイルスの保存方法
EP0757717B1 (en) 1994-05-16 2006-05-31 Merck & Co. Inc. Papillomavirus vaccines
AU3125795A (en) 1994-07-11 1996-02-09 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Attenuated human rotavirus vaccine
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
SI2275119T1 (sl) 1995-07-27 2013-12-31 Genentech, Inc. Stabilna izotonična liofilizirana proteinska formulacija
US6165773A (en) 1995-10-25 2000-12-26 Provalis Uk Limited Methods of preserving viruses
GB9521806D0 (en) 1995-10-25 1996-01-03 Cortecs Ltd Preservation methods
FR2742756B1 (fr) 1995-12-22 1998-04-03 Pasteur Merieux Serums Vacc Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation
FR2751343B1 (fr) 1996-07-16 1998-12-18 Transgene Sa Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament
US6616931B1 (en) 1996-09-26 2003-09-09 Merck & Co., Inc. Rotavirus vaccine formulations
US5932223A (en) * 1996-09-26 1999-08-03 Merck & Co., Inc. Rotavirus vaccine formulations
US6403098B1 (en) 1996-09-26 2002-06-11 Merck & Co., Inc. Rotavirus vaccine formulations
DE69738271T2 (de) 1996-09-26 2008-08-28 Merck & Co., Inc. Rotavirus-impfstoff
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US20080261289A1 (en) 1996-12-13 2008-10-23 Schering-Plough Corporation Compositions comprising viruses and methods for concentrating virus preparations
US6544769B1 (en) 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
US6051238A (en) 1996-12-20 2000-04-18 Merck & Co., Inc. Stabilizers for lyophilized mumps vaccines
WO1998028000A1 (en) 1996-12-20 1998-07-02 Merck & Co., Inc. Stabilizers for lyophilized vaccines
US6290967B1 (en) * 1996-12-20 2001-09-18 Merck & Co., Inc. Stabilizers for lyophilized vaccines
KR100912362B1 (ko) 1998-02-17 2009-08-19 쉐링 코포레이션 바이러스 제제의 정제방법
GB9808922D0 (en) * 1998-04-24 1998-06-24 Cantab Pharmaceuticals Res Ltd Virus preparations
KR100688434B1 (ko) 1998-07-28 2007-03-09 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 다가의 인간-소의 로타바이러스 백신
CN1062770C (zh) * 1998-11-12 2001-03-07 卫生部长春生物制品研究所 甲肝-麻疹二联疫苗及其生产方法
EP1977764A1 (en) 1998-11-16 2008-10-08 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
CA2368655A1 (en) 1999-04-08 2000-10-19 Gregory M. Glenn Dry formulation for transcutaneous immunization
CN100406004C (zh) 1999-08-24 2008-07-30 特瓦制药工业有限公司 疫苗组合物及其制药用途
US6592869B2 (en) 1999-08-24 2003-07-15 Teva Pharmaceutical Industries, Ltd. Vaccine composition and method of using the same
TWI310688B (en) 1999-10-29 2009-06-11 Nektar Therapeutics Dry powder compositions having improved dispersivity
CA2399321C (en) 2000-03-07 2013-04-30 Robert K. Evans Adenovirus formulations
US7456009B2 (en) * 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
US20020120228A1 (en) 2000-06-08 2002-08-29 Yuh-Fun Maa Powder compositions
EP1289494A2 (en) 2000-06-08 2003-03-12 Powderject Vaccines, Inc. Powder compositions
TWI289158B (en) 2000-08-10 2007-11-01 Oncolytics Biotech Inc Method of producing infectious reovirus
GB0020089D0 (en) 2000-08-15 2000-10-04 Smithkline Beecham Biolog Vaccine Composition
ES2327103T3 (es) 2000-09-25 2009-10-26 Polymun Scientific Immunbiologische Forschung Gmbh Vacuna viva de influenzavirus y procedimiento de fabricacion.
US20040033239A1 (en) 2001-03-06 2004-02-19 Evans Robert K Adenovirus formulations
JP4087712B2 (ja) 2001-03-16 2008-05-21 オンコリティクス バイオテック, インコーポレイティッド 細胞培養物からウイルスを抽出する方法
JP2004532277A (ja) 2001-06-08 2004-10-21 パウダージェクト ワクチンズ,インコーポレーテッド 噴霧凍結乾燥組成物
GB0124710D0 (en) 2001-10-15 2001-12-05 Quadrant Healthcare Uk Ltd Therapeutic composition
CN1607941A (zh) 2001-11-19 2005-04-20 贝克顿迪肯森公司 粒状药物组合物
EP1453537A1 (en) 2001-12-12 2004-09-08 FH Faulding & Co. Limited Composition for viral preservation
US20030153065A1 (en) 2002-01-14 2003-08-14 Genvec, Inc. Composition and method for maintaining non-enveloped viral vectors
MXPA04006995A (es) 2002-01-18 2005-07-13 Schering Ag Formulaciones estabilizadas de adenovirus.
CA2482448C (en) 2002-04-11 2014-07-08 Medimmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam
US20040042972A1 (en) 2002-04-11 2004-03-04 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration
WO2003087339A2 (en) 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Spray freeze dry of compositions for pulmonary administration
MXPA04010603A (es) 2002-04-30 2004-12-13 Oncolytics Biotech Inc Metodos mejorados de purificacion viral.
TW200501981A (en) 2002-11-01 2005-01-16 Glaxosmithkline Biolog Sa Drying method
US6752740B2 (en) 2002-11-12 2004-06-22 Jeffery T. Semmes Continuously variable transmission
CN1745170A (zh) 2002-12-17 2006-03-08 米迪缪尼疫苗股份有限公司 生物活性材料的高压喷雾干燥
US6931888B2 (en) 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
CA2522379C (en) 2003-04-10 2012-10-23 Chiron Corporation The severe acute respiratory syndrome coronavirus
PL2272532T3 (pl) 2003-09-02 2016-07-29 Glaxosmithkline Biologicals Sa Szczepionka rotawirusowa
WO2005052116A2 (en) 2003-11-19 2005-06-09 Merck & Co., Inc. Preservative-containing virus formulations
CA2549197C (en) * 2003-12-17 2015-04-14 Wyeth Methods for producing storage stable viruses and immunogenic compositions thereof
WO2005066333A1 (en) 2003-12-30 2005-07-21 Aventis Pasteur, Inc. Stabilizing compositions for recombinant viruses
GB0404586D0 (en) 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
CA2554018A1 (en) 2004-03-04 2005-09-29 Wyeth Lyophilization method to improve excipient crystallization
AU2005249530B2 (en) 2004-06-02 2012-04-12 Victor Bronshtein Preservation by vaporization
WO2006029467A1 (en) 2004-09-16 2006-03-23 Btf Pty Ltd Rapid freeze drying process
AR050959A1 (es) 2004-09-28 2006-12-06 Alza Corp Estabilizacion de agentes inmunologicamente activos adyuvados con alumbre
US7901921B2 (en) 2004-10-22 2011-03-08 Oncolytics Biotech Inc. Viral purification methods
RU2458125C2 (ru) * 2004-11-05 2012-08-10 Веллстат Байолоджикс Корпорейшн Способ стабилизации вируса ньюкаслской болезни для хранения в водном растворе и способ сохранения его стабильности
WO2006061708A2 (en) 2004-12-09 2006-06-15 Precimed S.A. Surgical tool holder for facilitated sterilization
US20060141483A1 (en) * 2004-12-23 2006-06-29 Calton Gary J Stabilization of viral compositions
KR20190062506A (ko) 2005-02-18 2019-06-05 아브락시스 바이오사이언스, 엘엘씨 치료제의 조합 및 투여 방식, 및 조합 요법
PT1954308E (pt) * 2005-09-16 2011-11-03 Merial Ltd Estabilizadores para vacinas liofilizadas
CN1765181A (zh) 2005-10-19 2006-05-03 路兴波 高效抗病毒制剂
SI2007883T1 (sl) 2006-04-20 2012-02-29 Wyeth Llc Procesi äśiĺ äśenja za osamitev preäśiĺ äśenega virusa vezikularnega stomatitisa iz celiäśne kulture
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
EP1854478A1 (en) 2006-05-12 2007-11-14 Cytos Biotechnology AG Nicotine-carrier vaccine formulation
EP1878791A1 (en) 2006-07-11 2008-01-16 Bia Separations D.O.O. Method for influenza virus purification
EP2055311B1 (en) 2006-08-07 2017-06-21 The Chemo-Sero-Therapeutic Research Institute Process for preparing live smallpox vaccine
KR20090060453A (ko) 2006-09-25 2009-06-12 메디뮨 엘엘씨 안정화된 항체 제제 및 그것의 용도
DK2099485T3 (en) 2006-11-03 2018-05-22 Alphavax Inc Alphavirus and alphavirus replica particle formulations and associated methods
CL2007003209A1 (es) 2006-11-07 2008-05-09 Acambis Inc Composicion que comprende una vacuna de flavivirus vivos atenuados; composicion que comprende un producto farmaceutico derivado de virus o proteina; un metodo para la elaboracion de una composicion terapeutica que comprende liofilizar las composicion
CN101573137B (zh) 2006-12-27 2014-05-14 硕腾P有限责任公司 适用于治疗犬的犬病的疫苗
WO2008106646A2 (en) 2007-03-01 2008-09-04 Introgen Therapeutics, Inc Methods and formulations for topical gene therapy
US7803385B2 (en) * 2007-03-12 2010-09-28 Oncolytics Biotech Inc. Reoviruses having modified sequences
GB0705245D0 (en) 2007-03-19 2007-04-25 Stabilitech Ltd Stable biological products
EP2829282B1 (en) * 2007-03-22 2017-10-25 The Regents of The University of Colorado, A Body Corporate Method of preparing an immunologically-active adjuvant-bound dried vaccine composition
CN110478479B (zh) 2007-04-06 2024-09-03 武田疫苗公司 用于活的减毒病毒的方法和组合物
AR066649A1 (es) 2007-05-21 2009-09-02 Oncolytics Biotech Inc Reovirus mutantes y metodos de elaboracion y uso de los mismos
EP2197283B1 (en) * 2007-09-25 2013-07-17 Aridis Pharmaceuticals Formulations for preservation of rota virus
EP2630966B1 (en) 2007-10-12 2017-04-19 Massachusetts Institute of Technology Vaccine nanotechnology
WO2009056651A1 (en) 2007-11-02 2009-05-07 Cytos Biotechnology Ag Angiotensin-carrier formulation
NZ585500A (en) 2007-11-12 2012-06-29 Theraclone Sciences Inc Antibodies which bind to an epitope in the extracellular domain of the matrix 2 ectodomain polypeptide of an influenza virus
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
WO2009108689A1 (en) * 2008-02-25 2009-09-03 Novavax, Inc. Sugar glassified virus like particles (vlps)
HRP20251316T1 (hr) * 2009-09-03 2025-12-05 Ablynx Nv Stabilne formulacije polipeptida i njihova upotreba
AU2011336413B2 (en) * 2010-12-02 2015-01-22 Oncolytics Biotech Inc. Liquid viral formulations
MX349294B (es) 2010-12-02 2017-07-21 Oncolytics Biotech Inc Formulaciones virales liofilizadas.
CN103492557B (zh) * 2011-04-29 2015-07-29 昂科利蒂克斯生物科技公司 使用凝胶渗透色谱法纯化病毒的方法
JP6065096B2 (ja) 2015-12-25 2017-01-25 ダイキン工業株式会社 調湿装置

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